6 recherche sur le mot-clé 'Retinal-eccentricity'

Motion-onset visual-evoked potentials as a function of retinal eccentricity in man / Ljudmila SCHLYKOWA in Cognitive Brain Research, 1-3 (October 1993)

Public ISBD [article]  inCognitive Brain Research > 1-3 (October 1993) . - p.169-174 Titre : Motion-onset visual-evoked potentials as a function of retinal eccentricity in man Type de document : texte imprimé Auteurs : Ljudmila SCHLYKOWA, Auteur ; Bob W. VAN DIJK, Auteur ; Walter H. EHRENSTEIN, Auteur Année de publication : 1993 Article en page(s) : p.169-174 Langues : Anglais (eng) Mots-clés : Visual-motion Visual-evoked-potential Retinal-eccentricity Cortical-magnification-factor Man Index. décimale : PER Périodiques Résumé : Visual-evoked potentials were elicited by the motion-onset of a black-and-white square-wave grating of 2.4 cycles/deg that drifted from right to left at a velocity of 3 deg/s. The center of the 2x2 deg stimulus field was binocularly viewed either foveally or at eccentricities of 6, 12, or 20 deg in the lower visual field along the vertical meridian. Peak-to-peak amplitudes P1-N2 and N2-P2 were found to decrease non-linearly as a function of eccentricity. The VEP-amplitudes were standardized by setting each foveal value to 100%, and a relative measure was derived for peripheral values given by the ratio of the peripheral to the foveal values. The decrease of the relative VEP-values with eccentricity was significantly smaller than that of the relative cortical magnification factor of striate cortex in man, whereas it agreed fairly well with that of the relative point-image size of the area MT in Macaque monkey. In this respect, the motion-onset VEP is distinct from the pattern-reversal VEP, the amplitude of which decreases much more rapidly with retinal eccentricity; hence, it may involve different generating structures of the brain. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781 [article] Motion-onset visual-evoked potentials as a function of retinal eccentricity in man [texte imprimé] / Ljudmila SCHLYKOWA, Auteur ; Bob W. VAN DIJK, Auteur ; Walter H. EHRENSTEIN, Auteur . - 1993 . - p.169-174. Langues : Anglais (eng) in Cognitive Brain Research > 1-3 (October 1993) . - p.169-174 Mots-clés : Visual-motion Visual-evoked-potential Retinal-eccentricity Cortical-magnification-factor Man Index. décimale : PER Périodiques Résumé : Visual-evoked potentials were elicited by the motion-onset of a black-and-white square-wave grating of 2.4 cycles/deg that drifted from right to left at a velocity of 3 deg/s. The center of the 2x2 deg stimulus field was binocularly viewed either foveally or at eccentricities of 6, 12, or 20 deg in the lower visual field along the vertical meridian. Peak-to-peak amplitudes P1-N2 and N2-P2 were found to decrease non-linearly as a function of eccentricity. The VEP-amplitudes were standardized by setting each foveal value to 100%, and a relative measure was derived for peripheral values given by the ratio of the peripheral to the foveal values. The decrease of the relative VEP-values with eccentricity was significantly smaller than that of the relative cortical magnification factor of striate cortex in man, whereas it agreed fairly well with that of the relative point-image size of the area MT in Macaque monkey. In this respect, the motion-onset VEP is distinct from the pattern-reversal VEP, the amplitude of which decreases much more rapidly with retinal eccentricity; hence, it may involve different generating structures of the brain. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781

Electroretinography in adults with high-functioning autism spectrum disorder / Evelyne FRIEDEL in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2026-2037 Titre : Electroretinography in adults with high-functioning autism spectrum disorder Type de document : texte imprimé Auteurs : Evelyne FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Electroretinography in adults with high-functioning autism spectrum disorder [texte imprimé] / Evelyne FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur . - p.2026-2037. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2026-2037 Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders / Abdullah BOZKURT in Research in Autism Spectrum Disorders, 98 (October 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 98 (October 2022) . - 102050 Titre : Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders Type de document : texte imprimé Auteurs : Abdullah BOZKURT, Auteur ; Gokçe Nur SAY, Auteur ; Berkan SAHIN, Auteur ; Miraç Baris USTA, Auteur ; Merve KALYONCU, Auteur ; Nurullah KOCAK, Auteur ; Osmanli CANSU COBANOGLU, Auteur Article en page(s) : 102050 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography Index. décimale : PER Périodiques Résumé : Background The study compared retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume of children with autism spectrum disorder (ASD) to those of healthy control group and correlated the RNFL thickness with symptom severity in children with ASD. Method Forty children between the ages of 7 and 12 with normal intelligence levels and who were diagnosed with ASD as per DSM-5 were included in the ASD group. The control group consisted of healthy children, who were matched with subjects in the ASD group in terms of age and gender. The Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the severity of the disease in the cases diagnosed with ASD. The RNFL, macular thickness, and macular volume of all participants were measured optical coherence tomography (OCT). Results The temporal, temporal superior, nasal superior, temporal inferior, and global RNFL thicknesses were significantly lower in the ASD group than in the control group. There was no correlation between the RNFL thickness and ASD symptom severity. The macular thickness and volume were not significantly different between the groups. Conclusion Our data suggest that lower RNFL thickness may relate to atypical brain development in the ASD, and this can be measured in the retina. En ligne : https://doi.org/10.1016/j.rasd.2022.102050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders [texte imprimé] / Abdullah BOZKURT, Auteur ; Gokçe Nur SAY, Auteur ; Berkan SAHIN, Auteur ; Miraç Baris USTA, Auteur ; Merve KALYONCU, Auteur ; Nurullah KOCAK, Auteur ; Osmanli CANSU COBANOGLU, Auteur . - 102050. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102050 Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography Index. décimale : PER Périodiques Résumé : Background The study compared retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume of children with autism spectrum disorder (ASD) to those of healthy control group and correlated the RNFL thickness with symptom severity in children with ASD. Method Forty children between the ages of 7 and 12 with normal intelligence levels and who were diagnosed with ASD as per DSM-5 were included in the ASD group. The control group consisted of healthy children, who were matched with subjects in the ASD group in terms of age and gender. The Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the severity of the disease in the cases diagnosed with ASD. The RNFL, macular thickness, and macular volume of all participants were measured optical coherence tomography (OCT). Results The temporal, temporal superior, nasal superior, temporal inferior, and global RNFL thicknesses were significantly lower in the ASD group than in the control group. There was no correlation between the RNFL thickness and ASD symptom severity. The macular thickness and volume were not significantly different between the groups. Conclusion Our data suggest that lower RNFL thickness may relate to atypical brain development in the ASD, and this can be measured in the retina. En ligne : https://doi.org/10.1016/j.rasd.2022.102050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study / Yuexuan WANG in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1775-1795 Titre : Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study Type de document : texte imprimé Auteurs : Yuexuan WANG, Auteur ; Yonglu WANG, Auteur ; Zhaoqi ZHU, Auteur ; Zhengwang XIA, Auteur ; Ningyu WANG, Auteur ; Mingchao LI, Auteur ; Ziyun JIAO, Auteur ; Nairong PAN, Auteur ; Youqiang ZHANG, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur Article en page(s) : p.1775-1795 Langues : Anglais (eng) Mots-clés : angiography  autism spectrum disorder  functional magnetic resonance imaging  interdisciplinary understanding  optic disc  optical coherence tomography  retinal vasculature Index. décimale : PER Périodiques Résumé : ABSTRACT In this cross-sectional study, participants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and October 2024. A total of 200 eyes were ultimately enrolled in this study, sourced from 53 individuals with ASD, aged between 7 and 13 years, and an equal number of age- and sex-matched neurotypical (NT) controls. The aim of this research is to explore the changes in retinal and choroidal vasculature in children with ASD, evaluated through optical coherence tomography and its angiography, and to further investigate the potential value of retinal vascular characteristics in the auxiliary screening and diagnosis of ASD. We analyzed intergroup differences in perfusion density (PD), vessel density, flux index (FI), fractal dimension (FD), and vessel diameter (Dm) in the peripapillary region, further stratified by subquadrants and vessel types. The results show that ASD children exhibited significant differences compared to neurotypical controls, including increased PD and Dm in the supero-nasal quadrant (p=0.01), changes in capillary FI in the nasal quadrant (p=0.008), increased venous FD (p=0.009), and abnormal choroidal FI in the temporal quadrant (p=0.008). A random forest classification model constructed based on these key features demonstrated promising performance (AUC=0.7853) in distinguishing ASD from NT individuals, highlighting the potential of retinal vascular characteristics for auxiliary ASD screening. Moreover, retinal vascular parameters were significantly correlated (p=0.01) with blood oxygen level-dependent signals from functional magnetic resonance imaging in several brain regions, such as the amygdala (p=0.004 0.009) and temporal lobe (p=0.000 0.009). Further stepwise regression analysis indicates that key retinal vascular characteristics could partially predict core clinical features of ASD, such as social functioning (adjusted R 2 =0.091 0.104, quantified by total and subscale scores of Social Responsiveness Scale) and cognitive ability (adjusted R 2 =0.2785, quantified by total intelligence quotient scores). This study underscores the potential of retinal vascular features as biomarkers for ASD and provides a basis for future research on non-invasive retinal imaging-based approaches for ASD screening and diagnosis, while offering new perspectives for understanding the pathological mechanisms and clinical applications of ASD. En ligne : https://doi.org/10.1002/aur.70094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Fundus Peripapillary Vascular Changes in Autism Spectrum Disorder: A Cross-Sectional Study [texte imprimé] / Yuexuan WANG, Auteur ; Yonglu WANG, Auteur ; Zhaoqi ZHU, Auteur ; Zhengwang XIA, Auteur ; Ningyu WANG, Auteur ; Mingchao LI, Auteur ; Ziyun JIAO, Auteur ; Nairong PAN, Auteur ; Youqiang ZHANG, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur . - p.1775-1795. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1775-1795 Mots-clés : angiography  autism spectrum disorder  functional magnetic resonance imaging  interdisciplinary understanding  optic disc  optical coherence tomography  retinal vasculature Index. décimale : PER Périodiques Résumé : ABSTRACT In this cross-sectional study, participants were recruited through convenience sampling from the Children's Mental Health Research Center at The Affiliated Brain Hospital of Nanjing Medical University and the Department of Ophthalmology at The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, between December 2019 and October 2024. A total of 200 eyes were ultimately enrolled in this study, sourced from 53 individuals with ASD, aged between 7 and 13 years, and an equal number of age- and sex-matched neurotypical (NT) controls. The aim of this research is to explore the changes in retinal and choroidal vasculature in children with ASD, evaluated through optical coherence tomography and its angiography, and to further investigate the potential value of retinal vascular characteristics in the auxiliary screening and diagnosis of ASD. We analyzed intergroup differences in perfusion density (PD), vessel density, flux index (FI), fractal dimension (FD), and vessel diameter (Dm) in the peripapillary region, further stratified by subquadrants and vessel types. The results show that ASD children exhibited significant differences compared to neurotypical controls, including increased PD and Dm in the supero-nasal quadrant (p=0.01), changes in capillary FI in the nasal quadrant (p=0.008), increased venous FD (p=0.009), and abnormal choroidal FI in the temporal quadrant (p=0.008). A random forest classification model constructed based on these key features demonstrated promising performance (AUC=0.7853) in distinguishing ASD from NT individuals, highlighting the potential of retinal vascular characteristics for auxiliary ASD screening. Moreover, retinal vascular parameters were significantly correlated (p=0.01) with blood oxygen level-dependent signals from functional magnetic resonance imaging in several brain regions, such as the amygdala (p=0.004 0.009) and temporal lobe (p=0.000 0.009). Further stepwise regression analysis indicates that key retinal vascular characteristics could partially predict core clinical features of ASD, such as social functioning (adjusted R 2 =0.091 0.104, quantified by total and subscale scores of Social Responsiveness Scale) and cognitive ability (adjusted R 2 =0.2785, quantified by total intelligence quotient scores). This study underscores the potential of retinal vascular features as biomarkers for ASD and provides a basis for future research on non-invasive retinal imaging-based approaches for ASD screening and diagnosis, while offering new perspectives for understanding the pathological mechanisms and clinical applications of ASD. En ligne : https://doi.org/10.1002/aur.70094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders / Leonardo EMBERTI GIALLORETI in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882 Titre : Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur Année de publication : 2014 Article en page(s) : p.873-882 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter Index. décimale : PER Périodiques Résumé : Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology. En ligne : http://dx.doi.org/10.1007/s10803-013-1939-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders [texte imprimé] / Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur . - 2014 . - p.873-882. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882 Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter Index. décimale : PER Périodiques Résumé : Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology. En ligne : http://dx.doi.org/10.1007/s10803-013-1939-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Signal Transduction in Drosophila Photoreceptors / Rama RANGANATHAN in Annual Review of Neuroscience, 18 (1995)

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