577 recherche sur le mot-clé 'Traumatic-brain-injury'

Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 / Robert J. HAMM in Cognitive Brain Research, 1-4 (December 1993)

Public ISBD [article]  inCognitive Brain Research > 1-4 (December 1993) . - p.223-226 Titre : Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 Type de document : texte imprimé Auteurs : Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur Année de publication : 1993 Article en page(s) : p.223-226 Langues : Anglais (eng) Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782 [article] Cognitive impairment following traumatic brain injury: the effect of pre- and post-injury administration of scopolamine and MK-801 [texte imprimé] / Robert J. HAMM, Auteur ; Dianne M. O'DELL, Auteur ; Brian R. PIKE, Auteur ; Bruce G. LYETH, Auteur . - 1993 . - p.223-226. Langues : Anglais (eng) in Cognitive Brain Research > 1-4 (December 1993) . - p.223-226 Mots-clés : Traumatic-brain-injury Morris-water-maze Scopolamine;MK-801 Rat Index. décimale : PER Périodiques Résumé : In order to examine the effectiveness of pre- and post-injury administration of muscarinic cholinergic and NMDA antagonists in reducing cognitive deficits following traumatic brain injury (TBI), rats were injected with either scopolamine (1 mg/kg) or MK-801 (0.3 mg/kg) 15 min prior to or 15 min after fluid percussion TBI. Cognitive performance was assessed with the Morris water maze procedure on days 11–15 after TBI or sham injury. When scopolamine and MK-801 were injected 15 min before injury, Morris water maze deficits were significantly reduced (P < 0.01 and P < 0.05, respectively). When scopolamine and MK-801 were injected 15 min after TBI, neither drug was effective in attenuating Morris water maze deficits. Consistent with other research, these results suggest that the cognitive deficits produced by TBI are the consequence of a brief period of excessive excitation of cholinergic and NMDA receptor systems. The results of this experiment also suggest that the temporal therapeutic window for the treatment of cognitive dysfunction with receptor antagonist intervention appears to be quite brief ( < 15 min) in the rat. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782

Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health / Grace REVILL in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1849-1859 Titre : Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health Type de document : texte imprimé Auteurs : Grace REVILL, Auteur ; Norman POOLE, Auteur ; Christina CARLISI, Auteur ; Anthony S. DAVID, Auteur ; Vaughan BELL, Auteur Article en page(s) : p.1849-1859 Langues : Anglais (eng) Mots-clés : Traumatic brain injury  neuropsychology  neuropsychiatry  epidemiology Index. décimale : PER Périodiques Résumé : Background Evidence that mild traumatic brain injury (mTBI) causes psychiatric problems in children has been mixed. Investigating this issue has been difficult due to the lack of representative longitudinal data that includes adequate measures of mTBI, subsequent mental health symptoms and service use. Methods We used data from the ABCD longitudinal cohort study to examine the association between mTBI and psychiatric diagnoses, symptoms and psychiatric service use in over 11,000 children. In both children reporting (i) previous mTBI at baseline and (ii) previously uninjured children reporting new cases of mTBI since baseline, we examined psychiatric outcomes and service use at 2-year follow-up. We also compared mTBI cases to a comparison group of participants with orthopaedic injury but without mTBI. Mixed-effects models were used and adjusted for demographic and social covariates, with missing data imputed using random forest multiple imputation. To account for baseline mental health, we used propensity-score matching to identify a comparison sample matched on confounding variables and baseline outcome measures. Results When examined without adjustment for baseline mental health, both lifetime mTBI at baseline and new occurrence of mTBI at 2-year follow-up were reliably associated with an increased risk of DSM-5 anxiety and behavioural disorders, a range of psychiatric symptom scores and increased service use. Controlling for baseline mental health in the mTBI group using propensity-score matching eliminated all statistically reliable associations apart from anxiety disorder diagnosis and symptoms, which remain associated at 2-year follow-up. Evidence for association with medication use was inconsistent. Conclusions Consistent evidence supporting an association between paediatric mTBI and subsequent anxiety was found; however, similar associations were not observed for other mental health outcomes. Regardless of potential causality, children with mTBI are likely to present with high levels of mental health difficulties, and this remains an important comorbidity that clinicians should be aware of. En ligne : https://doi.org/10.1111/jcpp.70013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Childhood Mild Traumatic Brain Injury is Reliably Associated with Anxiety but Not Other Examined Psychiatric Outcomes at Two-Year Follow-up, After Adjusting for Prior Mental Health [texte imprimé] / Grace REVILL, Auteur ; Norman POOLE, Auteur ; Christina CARLISI, Auteur ; Anthony S. DAVID, Auteur ; Vaughan BELL, Auteur . - p.1849-1859. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1849-1859 Mots-clés : Traumatic brain injury  neuropsychology  neuropsychiatry  epidemiology Index. décimale : PER Périodiques Résumé : Background Evidence that mild traumatic brain injury (mTBI) causes psychiatric problems in children has been mixed. Investigating this issue has been difficult due to the lack of representative longitudinal data that includes adequate measures of mTBI, subsequent mental health symptoms and service use. Methods We used data from the ABCD longitudinal cohort study to examine the association between mTBI and psychiatric diagnoses, symptoms and psychiatric service use in over 11,000 children. In both children reporting (i) previous mTBI at baseline and (ii) previously uninjured children reporting new cases of mTBI since baseline, we examined psychiatric outcomes and service use at 2-year follow-up. We also compared mTBI cases to a comparison group of participants with orthopaedic injury but without mTBI. Mixed-effects models were used and adjusted for demographic and social covariates, with missing data imputed using random forest multiple imputation. To account for baseline mental health, we used propensity-score matching to identify a comparison sample matched on confounding variables and baseline outcome measures. Results When examined without adjustment for baseline mental health, both lifetime mTBI at baseline and new occurrence of mTBI at 2-year follow-up were reliably associated with an increased risk of DSM-5 anxiety and behavioural disorders, a range of psychiatric symptom scores and increased service use. Controlling for baseline mental health in the mTBI group using propensity-score matching eliminated all statistically reliable associations apart from anxiety disorder diagnosis and symptoms, which remain associated at 2-year follow-up. Evidence for association with medication use was inconsistent. Conclusions Consistent evidence supporting an association between paediatric mTBI and subsequent anxiety was found; however, similar associations were not observed for other mental health outcomes. Regardless of potential causality, children with mTBI are likely to present with high levels of mental health difficulties, and this remains an important comorbidity that clinicians should be aware of. En ligne : https://doi.org/10.1111/jcpp.70013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury / Nicholas P. RYAN in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1150-1161 Titre : Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury Type de document : texte imprimé Auteurs : Nicholas P. RYAN, Auteur ; Cathy CATROPPA, Auteur ; Nathan HUGHES, Auteur ; Felicity L. PAINTER, Auteur ; Stephen HEARPS, Auteur ; Miriam H. BEAUCHAMP, Auteur ; Vicki ANDERSON, Auteur Article en page(s) : p.1150-1161 Langues : Anglais (eng) Mots-clés : Brain/diagnostic imaging  Brain Injuries, Traumatic/diagnostic imaging  Child  Executive Function  Humans  Longitudinal Studies  Prospective Studies  Anti-social behavior  aggression  childhood traumatic brain injury  longitudinal design  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite increasing evidence of a link between early life brain injury and anti-social behavior, very few studies have assessed factors that explain this association in children with traumatic brain injury (TBI). One hypothesis suggests that childhood TBI elevates risk for anti-social behavior via disruption to anatomically distributed neural networks implicated in executive functioning (EF). In this longitudinal prospective study, we employed high-resolution structural neuroimaging to (a) evaluate the impact of childhood TBI on regional morphometry of the central executive network (CEN) and (b) evaluate the prediction that lower EF mediates the prospective relationship between structural differences within the CEN and postinjury anti-social behaviors. METHODS: This study involved 155 children, including 112 consecutively recruited, hospital-confirmed cases of mild-severe TBI and 43 typically developing control (TDC) children. T1-weighted brain magnetic resonance imaging (MRI) sequences were acquired sub-acutely in a subset of 137 children [TBI: n = 103; TDC: n = 34]. All participants were evaluated using direct assessment of EF 6 months postinjury, and parents provided ratings of anti-social behavior 12 months postinjury. RESULTS: Severe TBI was associated with postinjury volumetric differences within the CEN and its putative hub regions. When compared with TD controls, the TBI group had significantly worse EF, which was associated with more frequent anti-social behaviors and abnormal CEN morphometry. Mediation analysis indicated that reduced EF mediated the prospective association between postinjury volumetric differences within the CEN and more frequent anti-social behavior. CONCLUSIONS: Our longitudinal prospective findings suggest that detection of neurostructural abnormalities within the CEN may aid in the early identification of children at elevated risk for postinjury executive dysfunction, which may in turn contribute to chronic anti-social behaviors after early life brain injury. Findings underscore the potential value of early surveillance and preventive measures for children presenting with neurostructural and/or neurocognitive risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury [texte imprimé] / Nicholas P. RYAN, Auteur ; Cathy CATROPPA, Auteur ; Nathan HUGHES, Auteur ; Felicity L. PAINTER, Auteur ; Stephen HEARPS, Auteur ; Miriam H. BEAUCHAMP, Auteur ; Vicki ANDERSON, Auteur . - p.1150-1161. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1150-1161 Mots-clés : Brain/diagnostic imaging  Brain Injuries, Traumatic/diagnostic imaging  Child  Executive Function  Humans  Longitudinal Studies  Prospective Studies  Anti-social behavior  aggression  childhood traumatic brain injury  longitudinal design  structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite increasing evidence of a link between early life brain injury and anti-social behavior, very few studies have assessed factors that explain this association in children with traumatic brain injury (TBI). One hypothesis suggests that childhood TBI elevates risk for anti-social behavior via disruption to anatomically distributed neural networks implicated in executive functioning (EF). In this longitudinal prospective study, we employed high-resolution structural neuroimaging to (a) evaluate the impact of childhood TBI on regional morphometry of the central executive network (CEN) and (b) evaluate the prediction that lower EF mediates the prospective relationship between structural differences within the CEN and postinjury anti-social behaviors. METHODS: This study involved 155 children, including 112 consecutively recruited, hospital-confirmed cases of mild-severe TBI and 43 typically developing control (TDC) children. T1-weighted brain magnetic resonance imaging (MRI) sequences were acquired sub-acutely in a subset of 137 children [TBI: n = 103; TDC: n = 34]. All participants were evaluated using direct assessment of EF 6 months postinjury, and parents provided ratings of anti-social behavior 12 months postinjury. RESULTS: Severe TBI was associated with postinjury volumetric differences within the CEN and its putative hub regions. When compared with TD controls, the TBI group had significantly worse EF, which was associated with more frequent anti-social behaviors and abnormal CEN morphometry. Mediation analysis indicated that reduced EF mediated the prospective association between postinjury volumetric differences within the CEN and more frequent anti-social behavior. CONCLUSIONS: Our longitudinal prospective findings suggest that detection of neurostructural abnormalities within the CEN may aid in the early identification of children at elevated risk for postinjury executive dysfunction, which may in turn contribute to chronic anti-social behaviors after early life brain injury. Findings underscore the potential value of early surveillance and preventive measures for children presenting with neurostructural and/or neurocognitive risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Performance monitoring in children following traumatic brain injury / Tisha J. ORNSTEIN in Journal of Child Psychology and Psychiatry, 50-4 (April 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-4 (April 2009) . - p. 506-513 Titre : Performance monitoring in children following traumatic brain injury Type de document : texte imprimé Auteurs : Tisha J. ORNSTEIN, Auteur ; Shirley X. CHEN, Auteur ; Gordon D. LOGAN, Auteur ; Jeffrey E. MAX, Auteur ; Marcia BARNES, Auteur ; Maureen DENNIS, Auteur ; Linda EWING-COBBS, Auteur ; Gerri HANTEN, Auteur ; Harvey S. LEVIN, Auteur ; Russell SCHACHAR, Auteur Année de publication : 2009 Article en page(s) : p. 506-513 Langues : Anglais (eng) Mots-clés : Performance-monitoring traumatic-brain-injury children head-injury neuropsychology pediatrics Index. décimale : PER Périodiques Résumé : Background: Executive control deficits are common sequelae of childhood traumatic brain injury (TBI). The goal of the current study was to assess a specific executive control function, performance monitoring, in children following TBI. Methods: Thirty-one children with mild–moderate TBI, 18 with severe TBI, and 37 control children without TBI, of comparable age and sex, performed the stop signal task, a speeded choice reaction time task. On occasion, they were presented with a signal to stop their responses. Performance monitoring was defined as the extent of slowing in go-task reaction time following failure to stop responses. Results: The TBI group as a whole demonstrated less post-error slowing than did controls. This finding suggested impaired error monitoring performance. In addition, time since injury and socioeconomic status predicted less slowing after stopped responses. Conclusions: We suggest that alterations in performance monitoring expressed as the inability to notice, regulate and adjust behavior to changing situations are an effect of TBI in children. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01997.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=724 [article] Performance monitoring in children following traumatic brain injury [texte imprimé] / Tisha J. ORNSTEIN, Auteur ; Shirley X. CHEN, Auteur ; Gordon D. LOGAN, Auteur ; Jeffrey E. MAX, Auteur ; Marcia BARNES, Auteur ; Maureen DENNIS, Auteur ; Linda EWING-COBBS, Auteur ; Gerri HANTEN, Auteur ; Harvey S. LEVIN, Auteur ; Russell SCHACHAR, Auteur . - 2009 . - p. 506-513. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-4 (April 2009) . - p. 506-513 Mots-clés : Performance-monitoring traumatic-brain-injury children head-injury neuropsychology pediatrics Index. décimale : PER Périodiques Résumé : Background: Executive control deficits are common sequelae of childhood traumatic brain injury (TBI). The goal of the current study was to assess a specific executive control function, performance monitoring, in children following TBI. Methods: Thirty-one children with mild–moderate TBI, 18 with severe TBI, and 37 control children without TBI, of comparable age and sex, performed the stop signal task, a speeded choice reaction time task. On occasion, they were presented with a signal to stop their responses. Performance monitoring was defined as the extent of slowing in go-task reaction time following failure to stop responses. Results: The TBI group as a whole demonstrated less post-error slowing than did controls. This finding suggested impaired error monitoring performance. In addition, time since injury and socioeconomic status predicted less slowing after stopped responses. Conclusions: We suggest that alterations in performance monitoring expressed as the inability to notice, regulate and adjust behavior to changing situations are an effect of TBI in children. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01997.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=724

Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / Soichiro KITAMURA in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1886-1895 Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : texte imprimé Auteurs : Soichiro KITAMURA, Auteur ; Manabu MAKINODAN, Auteur ; Kiwamu MATSUOKA, Auteur ; Masato TAKAHASHI, Auteur ; Hiroaki YOSHIKAWA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Fumihiko YASUNO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Toshiteru MIYASAKA, Auteur ; Kimihiko KICHIKAWA, Auteur ; Naoko KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [texte imprimé] / Soichiro KITAMURA, Auteur ; Manabu MAKINODAN, Auteur ; Kiwamu MATSUOKA, Auteur ; Masato TAKAHASHI, Auteur ; Hiroaki YOSHIKAWA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Fumihiko YASUNO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Toshiteru MIYASAKA, Auteur ; Kimihiko KICHIKAWA, Auteur ; Naoko KISHIMOTO, Auteur . - p.1886-1895. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1886-1895 Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury / Panagiotis KRATIMENOS in Journal of Neurodevelopmental Disorders, 14 (2022)  

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Improving child and parenting outcomes following paediatric acquired brain injury: a randomised controlled trial of Stepping Stones Triple P plus Acceptance and Commitment Therapy / Felicity L. BROWN in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

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Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm / Samudragupta BORA in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

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Preventive intervention for trauma reactions in young injured children: results of a multi-site randomised controlled trial / Ann-Christin HAAG in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

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The mutual prospective influence of child and parental post-traumatic stress symptoms in pediatric patients / Markus A. LANDOLT in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)  

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