Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder / Annette ESTES in Autism Research, 4-3 (June 2011)  

Public ISBD [article]  inAutism Research > 4-3 (June 2011) . - p.212-220 Titre : Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur ; Bobbi F. SPARKS, Auteur ; Seth D. FRIEDMAN, Auteur ; Jay N. GIEDD, Auteur ; Geraldine DAWSON, Auteur ; Matthew BRYAN, Auteur ; Stephen R. DAGER, Auteur Année de publication : 2011 Article en page(s) : p.212-220 Langues : Anglais (eng) Mots-clés : neuroimaging  preschoolers  clinical psychology  repetitive behavior  autism spectrum disorders Index. décimale : PER Périodiques Résumé : We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3- to 4-year-old children with autism spectrum disorder (ASD; n = 77) and developmental delay without autism (DD; n = 34). Children were assessed through clinical evaluation and parent report using RSB-specific scales extracted from the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview, and the Aberrant Behavior Checklist. A subset of children with ASD (n = 45), DD (n = 14), and a group of children with typical development (TD; n = 25) were also assessed by magnetic resonance imaging. Children with ASD demonstrated elevated RSB across all measures compared to children with DD. Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group. However, nuclei were not significantly enlarged after controlling for cerebral volume. The DD group, in comparison to the ASD group, demonstrated smaller thalami and basal ganglia regions even when scaled for cerebral volume, with the exception of the left striatum, left putamen, and right putamen. Elevated RSB, as measured by the ADOS, was associated with decreased volumes in several brain regions: left thalamus, right globus pallidus, left and right putamen, right striatum and a trend for left globus pallidus and left striatum within the ASD group. These results confirm earlier reports that RSB is common early in the clinical course of ASD and, furthermore, demonstrate that such behaviors may be associated with decreased volumes of the basal ganglia and thalamus. En ligne : http://dx.doi.org/10.1002/aur.193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127 [article] Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder [Texte imprimé et/ou numérique] / Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur ; Bobbi F. SPARKS, Auteur ; Seth D. FRIEDMAN, Auteur ; Jay N. GIEDD, Auteur ; Geraldine DAWSON, Auteur ; Matthew BRYAN, Auteur ; Stephen R. DAGER, Auteur . - 2011 . - p.212-220. Langues : Anglais (eng) in Autism Research > 4-3 (June 2011) . - p.212-220 Mots-clés : neuroimaging  preschoolers  clinical psychology  repetitive behavior  autism spectrum disorders Index. décimale : PER Périodiques Résumé : We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3- to 4-year-old children with autism spectrum disorder (ASD; n = 77) and developmental delay without autism (DD; n = 34). Children were assessed through clinical evaluation and parent report using RSB-specific scales extracted from the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview, and the Aberrant Behavior Checklist. A subset of children with ASD (n = 45), DD (n = 14), and a group of children with typical development (TD; n = 25) were also assessed by magnetic resonance imaging. Children with ASD demonstrated elevated RSB across all measures compared to children with DD. Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group. However, nuclei were not significantly enlarged after controlling for cerebral volume. The DD group, in comparison to the ASD group, demonstrated smaller thalami and basal ganglia regions even when scaled for cerebral volume, with the exception of the left striatum, left putamen, and right putamen. Elevated RSB, as measured by the ADOS, was associated with decreased volumes in several brain regions: left thalamus, right globus pallidus, left and right putamen, right striatum and a trend for left globus pallidus and left striatum within the ASD group. These results confirm earlier reports that RSB is common early in the clinical course of ASD and, furthermore, demonstrate that such behaviors may be associated with decreased volumes of the basal ganglia and thalamus. En ligne : http://dx.doi.org/10.1002/aur.193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127

Brain Chemistry: Magnetic Resonance Spectroscopy / Stephen R. DAGER

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Brain Chemistry: Magnetic Resonance Spectroscopy Type de document : Texte imprimé et/ou numérique Auteurs : Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Todd RICHARDS, Auteur ; Dennis W.W. SHAW, Auteur Année de publication : 2011 Importance : p.576-592 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Brain Chemistry: Magnetic Resonance Spectroscopy [Texte imprimé et/ou numérique] / Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Todd RICHARDS, Auteur ; Dennis W.W. SHAW, Auteur . - 2011 . - p.576-592. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations / Stephen R. DAGER in Journal of Autism and Developmental Disorders, 42-4 (April 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.643-646 Titre : Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations Type de document : Texte imprimé et/ou numérique Auteurs : Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur Année de publication : 2012 Article en page(s) : p.643-646 Langues : Anglais (eng) Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain lactate Index. décimale : PER Périodiques Résumé : The authors respond to a recent letter (Rossignol and Frye 2011 ) critical of their paper, “Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder” (Corrigan et al. 2011 ). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1352-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations [Texte imprimé et/ou numérique] / Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur . - 2012 . - p.643-646. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.643-646 Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain lactate Index. décimale : PER Périodiques Résumé : The authors respond to a recent letter (Rossignol and Frye 2011 ) critical of their paper, “Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder” (Corrigan et al. 2011 ). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1352-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders / Stephen R. DAGER

Public ISBD contenu dans Autism / Andrew W. ZIMMERMAN Titre : Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Stephen R. DAGER, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Dennis W.W. SHAW, Auteur Année de publication : 2008 Importance : p.361-379 Langues : Anglais (eng) Mots-clés : Croissance  Chimie  Resonnance magnétique  Spectroscopie Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705 contenu dans Autism / Andrew W. ZIMMERMAN Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Stephen R. DAGER, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Dennis W.W. SHAW, Auteur . - 2008 . - p.361-379. Langues : Anglais (eng) Mots-clés : Croissance  Chimie  Resonnance magnétique  Spectroscopie Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705

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Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder / Neva M. CORRIGAN in Journal of Autism and Developmental Disorders, 42-1 (January 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Titre : Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur Année de publication : 2012 Article en page(s) : p.105-115 Langues : Anglais (eng) Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur . - 2012 . - p.105-115. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

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