5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls / Corina BENJET in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179 Titre : 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2010 Article en page(s) : p.173-179 Langues : Anglais (eng) Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls. Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory. Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles. Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 [article] 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur . - 2010 . - p.173-179. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179 Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls. Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory. Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles. Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941

Affective and physiological responses to stress in girls at elevated risk for depression / Christian E. WAUGH in Development and Psychopathology, 24-2 (May 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-2 (May 2012) . - p.661-675 Titre : Affective and physiological responses to stress in girls at elevated risk for depression Type de document : Texte imprimé et/ou numérique Auteurs : Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2012 Article en page(s) : p.661-675 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Affective and physiological responses to stress in girls at elevated risk for depression [Texte imprimé et/ou numérique] / Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur . - 2012 . - p.661-675. Langues : Anglais (eng) in Development and Psychopathology > 24-2 (May 2012) . - p.661-675 Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

Why is Past Depression the Best Predictor of Future Depression? Stress Generation as a Mechanism of Depression Continuity in Girls / Karen D. RUDOLPH in Journal of Clinical Child & Adolescent Psychology, 38-4 (July 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-4 (July 2009) . - p.473-485 Titre : Why is Past Depression the Best Predictor of Future Depression? Stress Generation as a Mechanism of Depression Continuity in Girls Type de document : Texte imprimé et/ou numérique Auteurs : Karen D. RUDOLPH, Auteur ; Megan FLYNN, Auteur ; Jamie L. ABAIED, Auteur ; Alison GROOT, Auteur ; Renee THOMPSON, Auteur Année de publication : 2009 Article en page(s) : p.473-485 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined whether a transactional interpersonal life stress model helps to explain the continuity in depression over time in girls. Youth (86 girls, 81 boys; M age = 12.41, SD = 1.19) and their caregivers participated in a three-wave longitudinal study. Depression and episodic life stress were assessed with semistructured interviews. Path analysis provided support for a transactional interpersonal life stress model in girls but not in boys, wherein depression predicted the generation of interpersonal stress, which predicted subsequent depression. Moreover, self-generated interpersonal stress partially accounted for the continuity of depression over time. Although depression predicted noninterpersonal stress generation in girls (but not in boys), noninterpersonal stress did not predict subsequent depression. En ligne : http://dx.doi.org/10.1080/15374410902976296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=785 [article] Why is Past Depression the Best Predictor of Future Depression? Stress Generation as a Mechanism of Depression Continuity in Girls [Texte imprimé et/ou numérique] / Karen D. RUDOLPH, Auteur ; Megan FLYNN, Auteur ; Jamie L. ABAIED, Auteur ; Alison GROOT, Auteur ; Renee THOMPSON, Auteur . - 2009 . - p.473-485. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-4 (July 2009) . - p.473-485 Index. décimale : PER Périodiques Résumé : This study examined whether a transactional interpersonal life stress model helps to explain the continuity in depression over time in girls. Youth (86 girls, 81 boys; M age = 12.41, SD = 1.19) and their caregivers participated in a three-wave longitudinal study. Depression and episodic life stress were assessed with semistructured interviews. Path analysis provided support for a transactional interpersonal life stress model in girls but not in boys, wherein depression predicted the generation of interpersonal stress, which predicted subsequent depression. Moreover, self-generated interpersonal stress partially accounted for the continuity of depression over time. Although depression predicted noninterpersonal stress generation in girls (but not in boys), noninterpersonal stress did not predict subsequent depression. En ligne : http://dx.doi.org/10.1080/15374410902976296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=785

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