Intrinsic neural circuitry of depression in adolescent females / Jingwen JIN in Journal of Child Psychology and Psychiatry, 61-4 (April 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.480-491 Titre : Intrinsic neural circuitry of depression in adolescent females Type de document : Texte imprimé et/ou numérique Auteurs : Jingwen JIN, Auteur ; Jared X. VAN SNELLENBERG, Auteur ; Greg PERLMAN, Auteur ; Christine DELORENZO, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur ; Aprajita MOHANTY, Auteur Article en page(s) : p.480-491 Langues : Anglais (eng) Mots-clés : Depression  adolescence  fMRI  neural network Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females. METHODS: In this longitudinal study, we recorded resting-state functional connectivity (RSFC) in 174 adolescent females. Using a cross-validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (within-circuit model), (b) connectivity of this network to the whole brain (extended-circuit model), and (c) a network consisting of the entire brain (whole-brain model) to depression symptoms assessed concurrently and 18 months later. RESULTS: In testing subsets, the within-circuit RSFC profiles were associated with depression symptoms concurrently and 18 months later, while the extended-circuit and whole-brain model did not explain any additional variance in depression symptoms. Connectivity related to anterior cingulate and ventromedial prefrontal cortex contributed most to the association. CONCLUSIONS: Our results demonstrate that RSFC-based brain networks that include amygdala, striatum, and PFC are stable neural signatures of concurrent and future depression symptoms, representing a significant step toward identifying the neural mechanism of depression in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.13123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Intrinsic neural circuitry of depression in adolescent females [Texte imprimé et/ou numérique] / Jingwen JIN, Auteur ; Jared X. VAN SNELLENBERG, Auteur ; Greg PERLMAN, Auteur ; Christine DELORENZO, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur ; Aprajita MOHANTY, Auteur . - p.480-491. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.480-491 Mots-clés : Depression  adolescence  fMRI  neural network Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females. METHODS: In this longitudinal study, we recorded resting-state functional connectivity (RSFC) in 174 adolescent females. Using a cross-validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (within-circuit model), (b) connectivity of this network to the whole brain (extended-circuit model), and (c) a network consisting of the entire brain (whole-brain model) to depression symptoms assessed concurrently and 18 months later. RESULTS: In testing subsets, the within-circuit RSFC profiles were associated with depression symptoms concurrently and 18 months later, while the extended-circuit and whole-brain model did not explain any additional variance in depression symptoms. Connectivity related to anterior cingulate and ventromedial prefrontal cortex contributed most to the association. CONCLUSIONS: Our results demonstrate that RSFC-based brain networks that include amygdala, striatum, and PFC are stable neural signatures of concurrent and future depression symptoms, representing a significant step toward identifying the neural mechanism of depression in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.13123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

The latent structure of child depression: a taxometric analysis / J. Anthony RICHEY in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1147-1155 Titre : The latent structure of child depression: a taxometric analysis Type de document : Texte imprimé et/ou numérique Auteurs : J. Anthony RICHEY, Auteur ; Christopher J. LONIGAN, Auteur ; Norman B. SCHMIDT, Auteur ; Beth M. PHILLIPS, Auteur ; Salvatore J. CATANZARO, Auteur ; Jeff LAURENT, Auteur ; Rebecca R. GERHARDSTEIN, Auteur ; Roman KOTOV, Auteur Année de publication : 2009 Article en page(s) : p.1147-1155 Langues : Anglais (eng) Mots-clés : Depression taxometrics CDI Index. décimale : PER Périodiques Résumé : Background: The current study examined the categorical versus continuous nature of child and adolescent depression among three samples of children and adolescents ranging from 5 to 19 years. Methods: Depression was measured using the Children's Depression Inventory (CDI). Indicators derived from the CDI were based on factor analytic research on the CDI and included indices of: 1) social withdrawal, 2) anhedonia, 3) incompetence/maladjustment and 4) negative self-esteem. Results: Taxometric procedures provided convergent support for the existence of a latent taxon across three independent samples. Internal and external consistency tests as well as Monte Carlo simulations supported the validity of the results. Conclusions: Multiple nonredundant procedures and samples were all consistently indicative of taxonicity in child depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02085.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=829 [article] The latent structure of child depression: a taxometric analysis [Texte imprimé et/ou numérique] / J. Anthony RICHEY, Auteur ; Christopher J. LONIGAN, Auteur ; Norman B. SCHMIDT, Auteur ; Beth M. PHILLIPS, Auteur ; Salvatore J. CATANZARO, Auteur ; Jeff LAURENT, Auteur ; Rebecca R. GERHARDSTEIN, Auteur ; Roman KOTOV, Auteur . - 2009 . - p.1147-1155. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1147-1155 Mots-clés : Depression taxometrics CDI Index. décimale : PER Périodiques Résumé : Background: The current study examined the categorical versus continuous nature of child and adolescent depression among three samples of children and adolescents ranging from 5 to 19 years. Methods: Depression was measured using the Children's Depression Inventory (CDI). Indicators derived from the CDI were based on factor analytic research on the CDI and included indices of: 1) social withdrawal, 2) anhedonia, 3) incompetence/maladjustment and 4) negative self-esteem. Results: Taxometric procedures provided convergent support for the existence of a latent taxon across three independent samples. Internal and external consistency tests as well as Monte Carlo simulations supported the validity of the results. Conclusions: Multiple nonredundant procedures and samples were all consistently indicative of taxonicity in child depression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02085.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=829

Three-variable systems: An integrative moderation and mediation framework for developmental psychopathology / Brandon L. GOLDSTEIN in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.12-23 Titre : Three-variable systems: An integrative moderation and mediation framework for developmental psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brandon L. GOLDSTEIN, Auteur ; Megan C. FINSAAS, Auteur ; Thomas M. OLINO, Auteur ; Roman KOTOV, Auteur ; Damion J. GRASSO, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.12-23 Langues : Anglais (eng) Mots-clés : developmental psychopathology  longitudinal research  mediation  moderation  risk factors Index. décimale : PER Périodiques Résumé : In this article, we consider an often overlooked model that combines mediation and moderation to explain how a third variable can relate to a risk factor-psychopathology relationship. We refer to it as moderation and mediation in a three-variable system. We describe how this model is relevant to studying vulnerability factors and how it may advance developmental psychopathology research. To illustrate the value of this approach, we provide several examples where this model may be applicable, such as the relationships among parental externalizing pathology, harsh parenting, and offspring psychopathology as well as between neuroticism, stressful life events, and depression. We discuss possible reasons why this model has not gained traction and attempt to clarify and dispel those concerns. We provide guidance and recommendations for when to consider this model for a given data set and point toward existing resources for testing this model that have been developed by statisticians and other methodologists. Lastly, we describe important caveats, limitations, and considerations for making this approach most useful for developmental research. Overall, our goal in presenting this information to developmental psychopathology researchers is to encourage testing moderation and mediation in a three-variable system with the aim of advancing analytic strategies for studying vulnerability factors. En ligne : https://doi.org/10.1017/S0954579421000493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Three-variable systems: An integrative moderation and mediation framework for developmental psychopathology [Texte imprimé et/ou numérique] / Brandon L. GOLDSTEIN, Auteur ; Megan C. FINSAAS, Auteur ; Thomas M. OLINO, Auteur ; Roman KOTOV, Auteur ; Damion J. GRASSO, Auteur ; Daniel N. KLEIN, Auteur . - p.12-23. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.12-23 Mots-clés : developmental psychopathology  longitudinal research  mediation  moderation  risk factors Index. décimale : PER Périodiques Résumé : In this article, we consider an often overlooked model that combines mediation and moderation to explain how a third variable can relate to a risk factor-psychopathology relationship. We refer to it as moderation and mediation in a three-variable system. We describe how this model is relevant to studying vulnerability factors and how it may advance developmental psychopathology research. To illustrate the value of this approach, we provide several examples where this model may be applicable, such as the relationships among parental externalizing pathology, harsh parenting, and offspring psychopathology as well as between neuroticism, stressful life events, and depression. We discuss possible reasons why this model has not gained traction and attempt to clarify and dispel those concerns. We provide guidance and recommendations for when to consider this model for a given data set and point toward existing resources for testing this model that have been developed by statisticians and other methodologists. Lastly, we describe important caveats, limitations, and considerations for making this approach most useful for developmental research. Overall, our goal in presenting this information to developmental psychopathology researchers is to encourage testing moderation and mediation in a three-variable system with the aim of advancing analytic strategies for studying vulnerability factors. En ligne : https://doi.org/10.1017/S0954579421000493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

---

1 (1 - 3 / 3)