Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma / Katherine B. EHRLICH in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Titre : Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur Article en page(s) : p.1547-1554 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the β2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma [texte imprimé] / Katherine B. EHRLICH, Auteur ; Gregory E. MILLER, Auteur ; Edith CHEN, Auteur . - p.1547-1554. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1547-1554 Index. décimale : PER Périodiques Résumé : Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the β2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time. En ligne : http://dx.doi.org/10.1017/S0954579415000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.63-71 Titre : Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial Type de document : texte imprimé Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Gregory E. MILLER, Auteur ; Katherine B. EHRLICH, Auteur ; Edith CHEN, Auteur Article en page(s) : p.63-71 Langues : Anglais (eng) Mots-clés : Black Americans  body weight  parent-child relations  preventive intervention  substance use Index. décimale : PER Périodiques Résumé : OBJECTIVE: Lifestyle variables such as drug use and excessive weight gain contribute to adult morbidity and mortality. This study was designed to determine whether participation in a preventive intervention designed to enhance supportive parenting can reduce drug use and body mass index (BMI) in young Black adults from disadvantaged neighborhoods. METHOD: This study was conducted in the rural southeastern United States. Black parents and their 11-year-old children (517 families) were assigned randomly to the Strong African American Families (SAAF) prevention trial or a control condition. Data assessing neighborhood socioeconomic status and supportive parenting were obtained when the youths were ages 11 and 16. When youths were ages 19-21 and 25, drug use and BMI were measured. RESULTS: As hypothesized, significant three-way interactions were detected among neighborhood disadvantage, prevention condition, and gender for BMI (B = 3.341, p = .009, 95% CI [0.832, 5.849]) and substance use (B = -0.169, p = .049, 95% CI [-0.337, -0.001]). Living in a disadvantaged neighborhood during adolescence was associated with increased drug use among young men in the control group (simple-slope = 0.215, p < .003) but not among those in the SAAF condition (simple-slope = 0.030, p = .650). Neighborhood disadvantage was associated with elevated BMI among young women in the control group (simple-slope = 3.343, p < .001), but not in the SAAF condition (simple-slope = 0.204, p = .820). CONCLUSIONS: The results suggest that participation during childhood in a preventive intervention to enhance supportive parenting can ameliorate the effects of life in a disadvantaged neighborhood on men's drug use and women's BMI across ages 19-25 years. These findings suggest a possible role for parenting enhancement programs in narrowing health disparities. En ligne : http://dx.doi.org/10.1111/jcpp.12968 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374 [article] Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial [texte imprimé] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Gregory E. MILLER, Auteur ; Katherine B. EHRLICH, Auteur ; Edith CHEN, Auteur . - p.63-71. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.63-71 Mots-clés : Black Americans  body weight  parent-child relations  preventive intervention  substance use Index. décimale : PER Périodiques Résumé : OBJECTIVE: Lifestyle variables such as drug use and excessive weight gain contribute to adult morbidity and mortality. This study was designed to determine whether participation in a preventive intervention designed to enhance supportive parenting can reduce drug use and body mass index (BMI) in young Black adults from disadvantaged neighborhoods. METHOD: This study was conducted in the rural southeastern United States. Black parents and their 11-year-old children (517 families) were assigned randomly to the Strong African American Families (SAAF) prevention trial or a control condition. Data assessing neighborhood socioeconomic status and supportive parenting were obtained when the youths were ages 11 and 16. When youths were ages 19-21 and 25, drug use and BMI were measured. RESULTS: As hypothesized, significant three-way interactions were detected among neighborhood disadvantage, prevention condition, and gender for BMI (B = 3.341, p = .009, 95% CI [0.832, 5.849]) and substance use (B = -0.169, p = .049, 95% CI [-0.337, -0.001]). Living in a disadvantaged neighborhood during adolescence was associated with increased drug use among young men in the control group (simple-slope = 0.215, p < .003) but not among those in the SAAF condition (simple-slope = 0.030, p = .650). Neighborhood disadvantage was associated with elevated BMI among young women in the control group (simple-slope = 3.343, p < .001), but not in the SAAF condition (simple-slope = 0.204, p = .820). CONCLUSIONS: The results suggest that participation during childhood in a preventive intervention to enhance supportive parenting can ameliorate the effects of life in a disadvantaged neighborhood on men's drug use and women's BMI across ages 19-25 years. These findings suggest a possible role for parenting enhancement programs in narrowing health disparities. En ligne : http://dx.doi.org/10.1111/jcpp.12968 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374

Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? / Katherine B. EHRLICH in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283 Titre : Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Kharah M. ROSS, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.1273-1283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? [texte imprimé] / Katherine B. EHRLICH, Auteur ; Kharah M. ROSS, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur . - p.1273-1283. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283 Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

The benefits of nurturant-involved parenting for children?s internalizing symptoms and cardiometabolic health in high-risk contexts / Katherine B. EHRLICH ; Justin A. LAVNER ; Elizabeth R. WIGGINS in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2420-2429 Titre : The benefits of nurturant-involved parenting for children?s internalizing symptoms and cardiometabolic health in high-risk contexts Type de document : texte imprimé Auteurs : Katherine B. EHRLICH, Auteur ; Justin A. LAVNER, Auteur ; Elizabeth R. WIGGINS, Auteur Article en page(s) : p.2420-2429 Mots-clés : cardiometabolic health  discrimination  internalizing symptoms  parenting  stress Index. décimale : PER Périodiques Résumé : Despite evidence that nurturant-involved parenting is linked with children s social, psychological, and physiological development, less is known about the specific contexts in which nurturant-involved parenting is most beneficial for children s mental and physical health. The present study examined how associations between nurturant-involved parenting and children s internalizing symptoms and cardiometabolic risk varied as a function of children s stress and discrimination. Participants included 165 Black and Latinx children (Mage = 11.5 years) and their guardians. Children reported on their ongoing stress, experiences of discrimination, and internalizing symptoms (depression and anxiety). Guardians provided information about their nurturant-involved parenting practices. Children s cardiometabolic risk was assessed as a composite reflecting a high level of systolic or diastolic blood pressure, waist circumference, HbA1c, triglycerides, and low HDL cholesterol. Regression analyses indicated that among youth who reported high levels of stress and discrimination, nurturant-involved parenting was negatively associated with cardiometabolic risk. Although children s stress and discrimination were significantly associated with their internalizing symptoms, neither stress nor discrimination moderated the relation between nurturant-involved parenting and internalizing symptoms. Results highlight the significant role that parents play in shaping children s health, particularly among youth experiencing high levels of stress and discrimination. En ligne : https://dx.doi.org/10.1017/S0954579423000652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] The benefits of nurturant-involved parenting for children?s internalizing symptoms and cardiometabolic health in high-risk contexts [texte imprimé] / Katherine B. EHRLICH, Auteur ; Justin A. LAVNER, Auteur ; Elizabeth R. WIGGINS, Auteur . - p.2420-2429. in Development and Psychopathology > 35-5 (December 2023) . - p.2420-2429 Mots-clés : cardiometabolic health  discrimination  internalizing symptoms  parenting  stress Index. décimale : PER Périodiques Résumé : Despite evidence that nurturant-involved parenting is linked with children s social, psychological, and physiological development, less is known about the specific contexts in which nurturant-involved parenting is most beneficial for children s mental and physical health. The present study examined how associations between nurturant-involved parenting and children s internalizing symptoms and cardiometabolic risk varied as a function of children s stress and discrimination. Participants included 165 Black and Latinx children (Mage = 11.5 years) and their guardians. Children reported on their ongoing stress, experiences of discrimination, and internalizing symptoms (depression and anxiety). Guardians provided information about their nurturant-involved parenting practices. Children s cardiometabolic risk was assessed as a composite reflecting a high level of systolic or diastolic blood pressure, waist circumference, HbA1c, triglycerides, and low HDL cholesterol. Regression analyses indicated that among youth who reported high levels of stress and discrimination, nurturant-involved parenting was negatively associated with cardiometabolic risk. Although children s stress and discrimination were significantly associated with their internalizing symptoms, neither stress nor discrimination moderated the relation between nurturant-involved parenting and internalizing symptoms. Results highlight the significant role that parents play in shaping children s health, particularly among youth experiencing high levels of stress and discrimination. En ligne : https://dx.doi.org/10.1017/S0954579423000652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms / Susan S. WOODHOUSE in Journal of Clinical Child & Adolescent Psychology, 39-1 (January-February 2010)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 39-1 (January-February 2010) . - p.51-63 Titre : The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms Type de document : texte imprimé Auteurs : Susan S. WOODHOUSE, Auteur ; Fatima RAMOS-MARCUSE, Auteur ; Katherine B. EHRLICH, Auteur ; Stephanie WARNER, Auteur ; Jude CASSIDY, Auteur Année de publication : 2010 Article en page(s) : p.51-63 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examined whether adolescent attachment security and attachment-related representations moderate and mediate, respectively, the link between parent symptoms (depressive and anxiety) and adolescent depressive symptoms. Participants were 189 (118 girls) eleventh graders and their parents in a community sample. Results showed that adolescent attachment moderated the connection between parent and adolescent symptoms; in most cases attachment security was more protective if both parents were high on anxiety symptoms or if one parent was high on anxiety but the other parent was low on depressive symptoms. Mediational analyses indicated that representations of their mothers as a secure base mediated the link between maternal and adolescent depressive symptoms. Perceptions of fathers as a secure base did not play a mediating role, although paternal depressive symptoms were associated with lower perceptions of the father as a secure base. Neither parent's anxiety symptoms were related to perceptions of the parent as a secure base or to adolescent depressive symptoms. En ligne : http://dx.doi.org/10.1080/15374410903401096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=976 [article] The Role of Adolescent Attachment in Moderating and Mediating the Links Between Parent and Adolescent Psychological Symptoms [texte imprimé] / Susan S. WOODHOUSE, Auteur ; Fatima RAMOS-MARCUSE, Auteur ; Katherine B. EHRLICH, Auteur ; Stephanie WARNER, Auteur ; Jude CASSIDY, Auteur . - 2010 . - p.51-63. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 39-1 (January-February 2010) . - p.51-63 Index. décimale : PER Périodiques Résumé : The present study examined whether adolescent attachment security and attachment-related representations moderate and mediate, respectively, the link between parent symptoms (depressive and anxiety) and adolescent depressive symptoms. Participants were 189 (118 girls) eleventh graders and their parents in a community sample. Results showed that adolescent attachment moderated the connection between parent and adolescent symptoms; in most cases attachment security was more protective if both parents were high on anxiety symptoms or if one parent was high on anxiety but the other parent was low on depressive symptoms. Mediational analyses indicated that representations of their mothers as a secure base mediated the link between maternal and adolescent depressive symptoms. Perceptions of fathers as a secure base did not play a mediating role, although paternal depressive symptoms were associated with lower perceptions of the father as a secure base. Neither parent's anxiety symptoms were related to perceptions of the parent as a secure base or to adolescent depressive symptoms. En ligne : http://dx.doi.org/10.1080/15374410903401096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=976

Trajectories of relationship stress and inflammatory processes in adolescence / Katherine B. EHRLICH in Development and Psychopathology, 28-1 (February 2016)  

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When inflammation and depression go together: The longitudinal effects of parent–child relationships / Steven R.H. BEACH in Development and Psychopathology, 29-5 (December 2017)  

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