Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia / Li-Juan SHI in Autism Research, 13-4 (April 2020)  

Public ISBD [article]  inAutism Research > 13-4 (April 2020) . - p.591-602 Titre : Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia Type de document : texte imprimé Auteurs : Li-Juan SHI, Auteur ; Han-Yu ZHOU, Auteur ; Yan-Mei SHEN, Auteur ; Ya WANG, Auteur ; Yu-Min FANG, Auteur ; Yu-Qiong HE, Auteur ; Jian-Jun OU, Auteur ; Xue-Rong LUO, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.591-602 Langues : Anglais (eng) Mots-clés : auditory  autism spectrum disorder  response inhibition  schizophrenia  verbal  visual Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and schizophrenia (SZ) are both associated with response inhibition impairment. However, the relative pattern of deficits in these two disorders remains unclear. Twenty-three male children with ASD, 23 male children with SZ, and 32 typically developing male controls were recruited to complete a set of tasks measuring response inhibition in the visual, auditory, and verbal domains. We found that visual, auditory, and verbal response inhibitions were impaired in both children with ASD and children with SZ. Compared with typically developing controls, children with ASD made more commission errors whereas children with SZ responded much slower in the visual response inhibition task. Both clinical groups showed comparable impairment in verbal response inhibition, but children with SZ were more impaired in auditory response inhibition than children with ASD. These different patterns of response inhibition deficit between male children with ASD and SZ may help to differentiate between these two disorders and may be potential targets for intervention. Autism Res 2020, 13: 591-602. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that male children with autism spectrum disorder (ASD) made more commission errors whereas male children with schizophrenia (SZ) responded much slower in the visual response inhibition task. Both clinical groups exhibited comparable impairments in verbal response inhibition, but male children with SZ were more impaired in auditory response inhibition than male children with ASD. Our findings provide potential targets for intervention. En ligne : http://dx.doi.org/10.1002/aur.2231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia [texte imprimé] / Li-Juan SHI, Auteur ; Han-Yu ZHOU, Auteur ; Yan-Mei SHEN, Auteur ; Ya WANG, Auteur ; Yu-Min FANG, Auteur ; Yu-Qiong HE, Auteur ; Jian-Jun OU, Auteur ; Xue-Rong LUO, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur . - p.591-602. Langues : Anglais (eng) in Autism Research > 13-4 (April 2020) . - p.591-602 Mots-clés : auditory  autism spectrum disorder  response inhibition  schizophrenia  verbal  visual Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and schizophrenia (SZ) are both associated with response inhibition impairment. However, the relative pattern of deficits in these two disorders remains unclear. Twenty-three male children with ASD, 23 male children with SZ, and 32 typically developing male controls were recruited to complete a set of tasks measuring response inhibition in the visual, auditory, and verbal domains. We found that visual, auditory, and verbal response inhibitions were impaired in both children with ASD and children with SZ. Compared with typically developing controls, children with ASD made more commission errors whereas children with SZ responded much slower in the visual response inhibition task. Both clinical groups showed comparable impairment in verbal response inhibition, but children with SZ were more impaired in auditory response inhibition than children with ASD. These different patterns of response inhibition deficit between male children with ASD and SZ may help to differentiate between these two disorders and may be potential targets for intervention. Autism Res 2020, 13: 591-602. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that male children with autism spectrum disorder (ASD) made more commission errors whereas male children with schizophrenia (SZ) responded much slower in the visual response inhibition task. Both clinical groups exhibited comparable impairments in verbal response inhibition, but male children with SZ were more impaired in auditory response inhibition than male children with ASD. Our findings provide potential targets for intervention. En ligne : http://dx.doi.org/10.1002/aur.2231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Event-, time- and activity-based prospective memory in children with higher autistic traits / Xiao-min SU in Research in Autism Spectrum Disorders, 118 (October 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 118 (October 2024) . - 102498 Titre : Event-, time- and activity-based prospective memory in children with higher autistic traits Type de document : texte imprimé Auteurs : Xiao-min SU, Auteur ; Tian-Xiao YANG, Auteur ; Sascha ZUBER, Auteur ; Shuai-biao LI, Auteur ; Rong-Man YUAN, Auteur ; Chen-wei YUAN, Auteur ; Han-Xue YANG, Auteur ; Ya WANG, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : 102498 Langues : Anglais (eng) Mots-clés : Prospective memory  Autistic traits  Working memory  Inhibition Index. décimale : PER Périodiques Résumé : Background School-age children rely on prospective memory (PM) to complete various tasks in the future. Previous research suggests children with autism spectrum disorders exhibit PM impairment, but whether PM impairment extends to children with higher autistic traits remains unclear. In the present study, we aimed to compare PM performance in children with higher and lower autistic traits and to examine potentially differential associations to executive functions. Method Forty pairs of children with higher and lower autistic traits between age 6- to 12-years old completed event-, time-, and activity-based PM tasks, and two executive function tasks (i.e., inhibition and working memory). We also collected parents-rated PM abilities using the Prospective and Retrospective Memory Questionnaire for Children. Results The two groups showed similar performance in both executive function tasks, the 3 PM tasks and parents-reported PM in daily life. In children with lower autistic traits, performance of the time-based PM task was correlated with working memory whereas it was correlated with inhibition function in children with higher autistic traits. Moreover, children with higher autistic traits exhibited a continuous reduction of time monitoring behavior across trials, leading to worse performance in the last PM trial compared with children with lower autistic traits. Conclusion Children with higher autistic traits showed intact executive functioning and similar PM performance as children with lower autistic traits, but they relied on different types of executive functions to complete time-based PM tasks. Moreover, children with higher autistic traits showed reduced time monitoring behavior and unstable PM performance across time. En ligne : https://doi.org/10.1016/j.rasd.2024.102498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540 [article] Event-, time- and activity-based prospective memory in children with higher autistic traits [texte imprimé] / Xiao-min SU, Auteur ; Tian-Xiao YANG, Auteur ; Sascha ZUBER, Auteur ; Shuai-biao LI, Auteur ; Rong-Man YUAN, Auteur ; Chen-wei YUAN, Auteur ; Han-Xue YANG, Auteur ; Ya WANG, Auteur ; Raymond C.K. CHAN, Auteur . - 102498. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 118 (October 2024) . - 102498 Mots-clés : Prospective memory  Autistic traits  Working memory  Inhibition Index. décimale : PER Périodiques Résumé : Background School-age children rely on prospective memory (PM) to complete various tasks in the future. Previous research suggests children with autism spectrum disorders exhibit PM impairment, but whether PM impairment extends to children with higher autistic traits remains unclear. In the present study, we aimed to compare PM performance in children with higher and lower autistic traits and to examine potentially differential associations to executive functions. Method Forty pairs of children with higher and lower autistic traits between age 6- to 12-years old completed event-, time-, and activity-based PM tasks, and two executive function tasks (i.e., inhibition and working memory). We also collected parents-rated PM abilities using the Prospective and Retrospective Memory Questionnaire for Children. Results The two groups showed similar performance in both executive function tasks, the 3 PM tasks and parents-reported PM in daily life. In children with lower autistic traits, performance of the time-based PM task was correlated with working memory whereas it was correlated with inhibition function in children with higher autistic traits. Moreover, children with higher autistic traits exhibited a continuous reduction of time monitoring behavior across trials, leading to worse performance in the last PM trial compared with children with lower autistic traits. Conclusion Children with higher autistic traits showed intact executive functioning and similar PM performance as children with lower autistic traits, but they relied on different types of executive functions to complete time-based PM tasks. Moreover, children with higher autistic traits showed reduced time monitoring behavior and unstable PM performance across time. En ligne : https://doi.org/10.1016/j.rasd.2024.102498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

Exploring Psychotropic Medication Use in Hospitalized Children With Autism Spectrum Disorder in China: The Role of Intellectual Disability / Wenqing LI in Journal of Autism and Developmental Disorders, 56-9 (September 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-9 (September 2026) . - p.3643-3654 Titre : Exploring Psychotropic Medication Use in Hospitalized Children With Autism Spectrum Disorder in China: The Role of Intellectual Disability Type de document : texte imprimé Auteurs : Wenqing LI, Auteur ; Chenxi BAO, Auteur ; Yupei YE, Auteur ; Qingxiang LIU, Auteur ; Kangkang CHU, Auteur ; Ya WANG, Auteur ; Xiaoyan RUAN, Auteur ; Huimin LÃœ, Auteur ; Xi LIU, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.3643-3654 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children and adolescents with autism spectrum disorder (ASD) frequently present with mental health comorbidities and behavioral crises, necessitating inpatient care. However, evidence-based guidelines for psychotropic medication use in specialized inpatient settings remain limited, particularly in non-Western contexts. This study examined the clinical characteristics and prescribing patterns among 269 hospitalized ASD patients (2012–2023), with a focus on how intellectual disability (ID) influences medication decisions. A retrospective analysis was conducted using electronic medical records to assess mental disorders, behavioral challenges, and psychotropic medication use at discharge. Logistic regression analyses was performed to examine factors associated with medication prescribing patterns, including the impact of ID status. Psychotropic medication use was highly prevalent (96.7%), with antipsychotics (89.96%) being the most frequently prescribed class, followed by anxiolytics (35.32%) and antidepressants (33.09%). ID was significantly associated with distinct prescribing patterns: patients with ID had 63% lower odds of antidepressant use (aOR = 0.37, p = 0.001) and 80% lower odds of ADHD medication use (aOR = 0.20, p = 0.009), while being more likely to receive antipsychotics (aOR = 2.74, p = 0.049) and experience polypharmacy (aOR = 1.89, p = 0.028). Additionally, disruptive behaviors and age were key predictors of antipsychotic use, whereas suicidal thoughts/attempts or SIBs independently predicted antidepressant prescribing. These findings suggest that ID status plays a critical role in shaping psychotropic prescribing practices beyond symptom severity alone, potentially reflecting diagnostic overshadowing and safety concerns. Future research should focus on developing tailored clinical assessment tools and treatment protocols for ASD populations with and without ID, while enhancing individualized medication monitoring to optimize therapeutic outcomes. En ligne : https://doi.org/10.1007/s10803-025-06779-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] Exploring Psychotropic Medication Use in Hospitalized Children With Autism Spectrum Disorder in China: The Role of Intellectual Disability [texte imprimé] / Wenqing LI, Auteur ; Chenxi BAO, Auteur ; Yupei YE, Auteur ; Qingxiang LIU, Auteur ; Kangkang CHU, Auteur ; Ya WANG, Auteur ; Xiaoyan RUAN, Auteur ; Huimin LÃœ, Auteur ; Xi LIU, Auteur ; Xiaoyan KE, Auteur . - p.3643-3654. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-9 (September 2026) . - p.3643-3654 Index. décimale : PER Périodiques Résumé : Children and adolescents with autism spectrum disorder (ASD) frequently present with mental health comorbidities and behavioral crises, necessitating inpatient care. However, evidence-based guidelines for psychotropic medication use in specialized inpatient settings remain limited, particularly in non-Western contexts. This study examined the clinical characteristics and prescribing patterns among 269 hospitalized ASD patients (2012–2023), with a focus on how intellectual disability (ID) influences medication decisions. A retrospective analysis was conducted using electronic medical records to assess mental disorders, behavioral challenges, and psychotropic medication use at discharge. Logistic regression analyses was performed to examine factors associated with medication prescribing patterns, including the impact of ID status. Psychotropic medication use was highly prevalent (96.7%), with antipsychotics (89.96%) being the most frequently prescribed class, followed by anxiolytics (35.32%) and antidepressants (33.09%). ID was significantly associated with distinct prescribing patterns: patients with ID had 63% lower odds of antidepressant use (aOR = 0.37, p = 0.001) and 80% lower odds of ADHD medication use (aOR = 0.20, p = 0.009), while being more likely to receive antipsychotics (aOR = 2.74, p = 0.049) and experience polypharmacy (aOR = 1.89, p = 0.028). Additionally, disruptive behaviors and age were key predictors of antipsychotic use, whereas suicidal thoughts/attempts or SIBs independently predicted antidepressant prescribing. These findings suggest that ID status plays a critical role in shaping psychotropic prescribing practices beyond symptom severity alone, potentially reflecting diagnostic overshadowing and safety concerns. Future research should focus on developing tailored clinical assessment tools and treatment protocols for ASD populations with and without ID, while enhancing individualized medication monitoring to optimize therapeutic outcomes. En ligne : https://doi.org/10.1007/s10803-025-06779-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence / Amy E. MARGOLIS in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Titre : Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence Type de document : texte imprimé Auteurs : Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur Article en page(s) : p.851-860 Langues : Anglais (eng) Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence [texte imprimé] / Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur . - p.851-860. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders / Jun-yan YE in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1509-1528 Titre : A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Jun-yan YE, Auteur ; Xiao-jing QIN, Auteur ; Ji-fang CUI, Auteur ; Qian REN, Auteur ; Lu-xia JIA, Auteur ; Ya WANG, Auteur ; Christos PANTELIS, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.1509-1528 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings on diminished MTT ability may be confounded by a number of factors, including the individuals' language ability, factors related to the MTT task and the demographic factors of participants. The present study provided a meta-analysis of MTT ability in people with ASD. The results showed significant overall reductions in MTT ability in people with ASD. Moderator analyses revealed that the variables examined did not explain the reduction in MTT ability. These findings suggest that MTT ability is diminished in people with ASD and that the degree of this diminishment may not depend on the characteristics of measures or demographic variables of people with ASD. En ligne : https://doi.org/10.1007/s10803-021-05375-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders [texte imprimé] / Jun-yan YE, Auteur ; Xiao-jing QIN, Auteur ; Ji-fang CUI, Auteur ; Qian REN, Auteur ; Lu-xia JIA, Auteur ; Ya WANG, Auteur ; Christos PANTELIS, Auteur ; Raymond C.K. CHAN, Auteur . - p.1509-1528. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1509-1528 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings on diminished MTT ability may be confounded by a number of factors, including the individuals' language ability, factors related to the MTT task and the demographic factors of participants. The present study provided a meta-analysis of MTT ability in people with ASD. The results showed significant overall reductions in MTT ability in people with ASD. Moderator analyses revealed that the variables examined did not explain the reduction in MTT ability. These findings suggest that MTT ability is diminished in people with ASD and that the degree of this diminishment may not depend on the characteristics of measures or demographic variables of people with ASD. En ligne : https://doi.org/10.1007/s10803-021-05375-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Social attribution in children with high functioning autism and Asperger syndrome: An exploratory study in the Chinese setting / Raymond C.K. CHAN in Research in Autism Spectrum Disorders, 5-4 (October-December 2011)  

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Working Memory in Early-School-Age Children with Asperger’s Syndrome / Jifang CUI in Journal of Autism and Developmental Disorders, 40-8 (August 2010)  

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