Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving / Jennifer S. STEVENS in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1159-1170 Titre : Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving Type de document : texte imprimé Auteurs : Jennifer S. STEVENS, Auteur ; Sanne J.H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur Article en page(s) : p.1159-1170 Langues : Anglais (eng) Mots-clés : amygdala  habituation  maternal buffering  resilience  violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving [texte imprimé] / Jennifer S. STEVENS, Auteur ; Sanne J.H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur . - p.1159-1170. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1159-1170 Mots-clés : amygdala  habituation  maternal buffering  resilience  violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene / Bekh BRADLEY in Development and Psychopathology, 23-2 (May 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-2 (May 2011) . - p.439-452 Titre : Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene Type de document : texte imprimé Auteurs : Bekh BRADLEY, Auteur ; Drew WESTEN, Auteur ; Kristina B. MERCER, Auteur ; Elisabeth B. BINDER, Auteur ; Tanja JOVANOVIC, Auteur ; Daniel CRAIN, Auteur ; Aliza WINGO, Auteur ; Christine HEIM, Auteur Année de publication : 2011 Article en page(s) : p.439-452 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to effectively regulate emotions and a secure attachment style are critical for maintaining mental health across the life span. The experience of childhood maltreatment interferes with normal development of emotional regulation and dramatically increases risk for a wide range of psychiatric disorders in adulthood. The central nervous system oxytocin systems are critically involved in mediating social attachment and buffering psychophysiological responses to stress. We therefore investigated the impact of childhood maltreatment and an oxytocin receptor (OXTR) single nucleotide polymorphism (rs53576) and their interaction on emotional dysregulation and attachment style in adulthood in a sample of low-income, African American men and women recruited from primary care clinics of an urban, public hospital. Consistent with prior research, we found that the severity of childhood maltreatment was associated with increased levels of emotional dysregulation in adulthood. Childhood maltreatment was also positively associated with ratings of disorganized/unresolved adult attachment style and negatively associated with ratings of secure adult attachment style. There was no direct association between rs53576 and emotional dysregulation or ratings of adult attachment style. However, there were significant interactions between rs53576 and childhood maltreatment in predicting level of adult emotional dysregulation and attachment style. Specifically, G/G genotype carriers were at risk for increased emotional dysregulation when exposed to three or more categories of childhood abuse. In addition, G/G genotype carriers exhibited enhanced disorganized adult attachment style when exposed to severe childhood abuse compared to A/A and A/G carriers. Our findings suggest that A allele carriers of OXTR rs53576 are resilient against the effects of severe childhood adversity, by protection against emotional dysregulation and disorganized attachment. En ligne : http://dx.doi.org/10.1017/S0954579411000162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene [texte imprimé] / Bekh BRADLEY, Auteur ; Drew WESTEN, Auteur ; Kristina B. MERCER, Auteur ; Elisabeth B. BINDER, Auteur ; Tanja JOVANOVIC, Auteur ; Daniel CRAIN, Auteur ; Aliza WINGO, Auteur ; Christine HEIM, Auteur . - 2011 . - p.439-452. Langues : Anglais (eng) in Development and Psychopathology > 23-2 (May 2011) . - p.439-452 Index. décimale : PER Périodiques Résumé : The ability to effectively regulate emotions and a secure attachment style are critical for maintaining mental health across the life span. The experience of childhood maltreatment interferes with normal development of emotional regulation and dramatically increases risk for a wide range of psychiatric disorders in adulthood. The central nervous system oxytocin systems are critically involved in mediating social attachment and buffering psychophysiological responses to stress. We therefore investigated the impact of childhood maltreatment and an oxytocin receptor (OXTR) single nucleotide polymorphism (rs53576) and their interaction on emotional dysregulation and attachment style in adulthood in a sample of low-income, African American men and women recruited from primary care clinics of an urban, public hospital. Consistent with prior research, we found that the severity of childhood maltreatment was associated with increased levels of emotional dysregulation in adulthood. Childhood maltreatment was also positively associated with ratings of disorganized/unresolved adult attachment style and negatively associated with ratings of secure adult attachment style. There was no direct association between rs53576 and emotional dysregulation or ratings of adult attachment style. However, there were significant interactions between rs53576 and childhood maltreatment in predicting level of adult emotional dysregulation and attachment style. Specifically, G/G genotype carriers were at risk for increased emotional dysregulation when exposed to three or more categories of childhood abuse. In addition, G/G genotype carriers exhibited enhanced disorganized adult attachment style when exposed to severe childhood abuse compared to A/A and A/G carriers. Our findings suggest that A allele carriers of OXTR rs53576 are resilient against the effects of severe childhood adversity, by protection against emotional dysregulation and disorganized attachment. En ligne : http://dx.doi.org/10.1017/S0954579411000162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Daily associations between peer victimization and anxious affect among adolescents: The role of social threat sensitivity / Hannah L. SCHACTER in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.431-440 Titre : Daily associations between peer victimization and anxious affect among adolescents: The role of social threat sensitivity Type de document : texte imprimé Auteurs : Hannah L. SCHACTER, Auteur ; Hilary A. MARUSAK, Auteur ; Leah GOWATCH, Auteur ; Tanja JOVANOVIC, Auteur Article en page(s) : p.431-440 Langues : Anglais (eng) Mots-clés : Adolescence anxiety daily diary peer victimization threat sensitivity Index. décimale : PER Périodiques Résumé : Adolescents frequently victimized by peers are two to three times more likely to develop an anxiety disorder than their non-victimized peers. However, the fine-grained mechanisms that explain how peer victimization confers risk for anxiety in adolescents’ daily lives are not well-understood. Leveraging an intensive longitudinal design, this study examined same- and cross-day links between peer victimization and anxiety, investigating social threat sensitivity as a potential underlying mechanism. One hundred ninety-five adolescents (Mage = 16.48, SDage = 0.35; 66% female, 27% male, 11% non-binary, identifying with another gender; 48% White, 20% Asian, 15% Black, 17% identifying with another race/ethnicity) completed brief daily assessments of peer victimization, social threat sensitivity, and anxious affect for 14 days. Multilevel analyses indicated that adolescents reported greater anxious affect on days when they experienced peer victimization compared to days without victimization. Although peer victimization did not predict anxious affect the following day, it was associated with increased anxious affect two days later. Social threat sensitivity significantly mediated the same-day, but not cross-day, association between peer victimization and anxious affect, controlling for prior-day threat sensitivity and anxiety. The findings suggest that heightened social vigilance partially accounts for anxious affect in adolescents facing peer victimization in daily life. En ligne : https://dx.doi.org/10.1017/S0954579425100394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Daily associations between peer victimization and anxious affect among adolescents: The role of social threat sensitivity [texte imprimé] / Hannah L. SCHACTER, Auteur ; Hilary A. MARUSAK, Auteur ; Leah GOWATCH, Auteur ; Tanja JOVANOVIC, Auteur . - p.431-440. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.431-440 Mots-clés : Adolescence anxiety daily diary peer victimization threat sensitivity Index. décimale : PER Périodiques Résumé : Adolescents frequently victimized by peers are two to three times more likely to develop an anxiety disorder than their non-victimized peers. However, the fine-grained mechanisms that explain how peer victimization confers risk for anxiety in adolescents’ daily lives are not well-understood. Leveraging an intensive longitudinal design, this study examined same- and cross-day links between peer victimization and anxiety, investigating social threat sensitivity as a potential underlying mechanism. One hundred ninety-five adolescents (Mage = 16.48, SDage = 0.35; 66% female, 27% male, 11% non-binary, identifying with another gender; 48% White, 20% Asian, 15% Black, 17% identifying with another race/ethnicity) completed brief daily assessments of peer victimization, social threat sensitivity, and anxious affect for 14 days. Multilevel analyses indicated that adolescents reported greater anxious affect on days when they experienced peer victimization compared to days without victimization. Although peer victimization did not predict anxious affect the following day, it was associated with increased anxious affect two days later. Social threat sensitivity significantly mediated the same-day, but not cross-day, association between peer victimization and anxious affect, controlling for prior-day threat sensitivity and anxiety. The findings suggest that heightened social vigilance partially accounts for anxious affect in adolescents facing peer victimization in daily life. En ligne : https://dx.doi.org/10.1017/S0954579425100394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Facing ambiguity: Social threat sensitivity mediates the association between peer victimization and adolescent anxiety / Hannah L. SCHACTER in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.112-120 Titre : Facing ambiguity: Social threat sensitivity mediates the association between peer victimization and adolescent anxiety Type de document : texte imprimé Auteurs : Hannah L. SCHACTER, Auteur ; Hilary A. MARUSAK, Auteur ; Breanna A. BORG, Auteur ; Tanja JOVANOVIC, Auteur Article en page(s) : p.112-120 Langues : Anglais (eng) Mots-clés : adolescence  anxiety  peer victimization  threat sensitivity Index. décimale : PER Périodiques Résumé : Peer victimization is a developmentally salient stressor that elevates adolescents' risk for anxiety disorders. However, modifiable mechanisms that explain this link and can be targeted via therapeutic interventions remain poorly understood. Drawing from psychobiological models implicating aberrant threat sensitivity in the development and maintenance of psychopathology, the current study investigated sensitivity to peer-related social threats as a mechanism underlying the association between peer victimization and anxiety. A sample of 197 dyads of early adolescents (Mage = 12.02; 46% female) and parents/guardians (Mage = 41.46; 90% female) completed online surveys assessing peer victimization, sensitivity to potential (i.e., ambiguous) social threats, and anxiety. Controlling for potentially confounding demographic and psychosocial factors, both self- and parent-reported peer victimization were positively associated with adolescent anxiety symptoms. Additionally, there were significant indirect effects from self- and parent-reported peer victimization to anxiety via social threat sensitivity. Supplemental analyses indicated unique effects of covert, but not overt, peer victimization on social threat sensitivity and anxiety. The findings provide initial evidence that peer victimization experiences lower adolescents' threshold for interpreting threats in ambiguous social situations, which contributes to heightened anxiety. These results implicate social threat sensitivity as a potential therapeutic target for interrupting links from peer victimization to psychological distress. En ligne : https://dx.doi.org/10.1017/S0954579422001018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Facing ambiguity: Social threat sensitivity mediates the association between peer victimization and adolescent anxiety [texte imprimé] / Hannah L. SCHACTER, Auteur ; Hilary A. MARUSAK, Auteur ; Breanna A. BORG, Auteur ; Tanja JOVANOVIC, Auteur . - p.112-120. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.112-120 Mots-clés : adolescence  anxiety  peer victimization  threat sensitivity Index. décimale : PER Périodiques Résumé : Peer victimization is a developmentally salient stressor that elevates adolescents' risk for anxiety disorders. However, modifiable mechanisms that explain this link and can be targeted via therapeutic interventions remain poorly understood. Drawing from psychobiological models implicating aberrant threat sensitivity in the development and maintenance of psychopathology, the current study investigated sensitivity to peer-related social threats as a mechanism underlying the association between peer victimization and anxiety. A sample of 197 dyads of early adolescents (Mage = 12.02; 46% female) and parents/guardians (Mage = 41.46; 90% female) completed online surveys assessing peer victimization, sensitivity to potential (i.e., ambiguous) social threats, and anxiety. Controlling for potentially confounding demographic and psychosocial factors, both self- and parent-reported peer victimization were positively associated with adolescent anxiety symptoms. Additionally, there were significant indirect effects from self- and parent-reported peer victimization to anxiety via social threat sensitivity. Supplemental analyses indicated unique effects of covert, but not overt, peer victimization on social threat sensitivity and anxiety. The findings provide initial evidence that peer victimization experiences lower adolescents' threshold for interpreting threats in ambiguous social situations, which contributes to heightened anxiety. These results implicate social threat sensitivity as a potential therapeutic target for interrupting links from peer victimization to psychological distress. En ligne : https://dx.doi.org/10.1017/S0954579422001018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Impacts of early life adversity on the neurocircuitry of emotional memory in children / Anais STENSON ; Sanne J.H. VAN ROOIJ ; Colin B. JOHNSON ; Timothy D. ELY ; Abigail POWERS ; Sean T. MINTON ; Charis WILTSHIRE ; Ye Ji KIM ; Rebecca HINRICHS ; Tanja JOVANOVIC ; Jennifer S. STEVENS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2126-2137 Titre : Impacts of early life adversity on the neurocircuitry of emotional memory in children Type de document : texte imprimé Auteurs : Anais STENSON, Auteur ; Sanne J.H. VAN ROOIJ, Auteur ; Colin B. JOHNSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Sean T. MINTON, Auteur ; Charis WILTSHIRE, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Tanja JOVANOVIC, Auteur ; Jennifer S. STEVENS, Auteur Article en page(s) : p.2126-2137 Langues : Anglais (eng) Mots-clés : Childhood trauma  Emotional episodic memory  early life adversity  fMRI  ventral visual cortex Index. décimale : PER Périodiques Résumé : Similar to adults with posttraumatic stress disorder, children with early life adversity show bias in memory for negative emotional stimuli. However, it is not well understood how childhood adversity impacts mechanisms underlying emotional memory. N = 56 children (8-14 years, 48% female) reported on adverse experiences including potentially traumatic events and underwent fMRI while attending to emotionally pleasant, neutral, or negative images. Post-scan, participants completed a cued recall test to assess memory for these images. Emotional difference-in-memory (DM) scores were computed by subtracting negative or positive from neutral recall performance. All children showed enhancing effects of emotion on recall, with no effect of trauma load. However, children with less trauma showed a larger emotional DM for both positive and negative stimuli when amygdala or anterior hippocampal activity was higher. In contrast, highly trauma-exposed children demonstrated a lower emotional DM with greater amygdala or hippocampal activity. This suggested that alternative neural mechanisms might support emotional enhancement of encoding in children with greater trauma load. Whole-brain analyses revealed that right fusiform activity during encoding positively correlated with both trauma load and successful later recall of positive images. Therefore, highly trauma-exposed children may use alternative, potentially adaptive neural pathways via the ventral visual stream to encode positive emotional events. En ligne : https://dx.doi.org/10.1017/S0954579424001718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Impacts of early life adversity on the neurocircuitry of emotional memory in children [texte imprimé] / Anais STENSON, Auteur ; Sanne J.H. VAN ROOIJ, Auteur ; Colin B. JOHNSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Sean T. MINTON, Auteur ; Charis WILTSHIRE, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Tanja JOVANOVIC, Auteur ; Jennifer S. STEVENS, Auteur . - p.2126-2137. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2126-2137 Mots-clés : Childhood trauma  Emotional episodic memory  early life adversity  fMRI  ventral visual cortex Index. décimale : PER Périodiques Résumé : Similar to adults with posttraumatic stress disorder, children with early life adversity show bias in memory for negative emotional stimuli. However, it is not well understood how childhood adversity impacts mechanisms underlying emotional memory. N = 56 children (8-14 years, 48% female) reported on adverse experiences including potentially traumatic events and underwent fMRI while attending to emotionally pleasant, neutral, or negative images. Post-scan, participants completed a cued recall test to assess memory for these images. Emotional difference-in-memory (DM) scores were computed by subtracting negative or positive from neutral recall performance. All children showed enhancing effects of emotion on recall, with no effect of trauma load. However, children with less trauma showed a larger emotional DM for both positive and negative stimuli when amygdala or anterior hippocampal activity was higher. In contrast, highly trauma-exposed children demonstrated a lower emotional DM with greater amygdala or hippocampal activity. This suggested that alternative neural mechanisms might support emotional enhancement of encoding in children with greater trauma load. Whole-brain analyses revealed that right fusiform activity during encoding positively correlated with both trauma load and successful later recall of positive images. Therefore, highly trauma-exposed children may use alternative, potentially adaptive neural pathways via the ventral visual stream to encode positive emotional events. En ligne : https://dx.doi.org/10.1017/S0954579424001718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Physiological markers of anxiety are increased in children of abused mothers / Tanja JOVANOVIC in Journal of Child Psychology and Psychiatry, 52-8 (August 2011)  

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