| Titre : |
Nonhuman Primate Models for Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.379-390 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
Nonhuman Primate Models for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Melissa D. BAUMAN, Auteur ; David G. AMARAL, Auteur . - 2013 . - p.379-390. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Autism is a complex neurodevelopmental disorder characterized by impairments in social interaction and verbal and nonverbal communication, and the occurrence of pathological repetitive behaviors or circumscribed interests. As discussed more completely in other chapters, the defining characteristics are manifest in a spectrum of severity, leading to the term autism spectrum disorders (ASD) to encompass this heterogeneity. ASD are challenging to study in human populations because of the heterogeneity of symptoms, lack of consistent biomarkers, and the complex interplay between genetic and environmental risk factors. In recent years, some progress has been made in developing animal models of autism. These animal models provide an experimental system to evaluate hypotheses that, for ethical and practical reasons, are impossible to test using human subjects. However, a major challenge for complex brain disorders such as autism is to model a human disorder that has impairments of complex cognitive functions in a nonhuman species. In this chapter, we summarize different approaches to modeling features of autism in nonhuman primates, focusing on the rhesus macaque (Macacca mulatta). We review expectations for a valid nonhuman primate model of autism, evaluate the strengths and weaknesses of current nonhuman primate models, and highlight promising future directions for integrating neuroscience research into these models. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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