Titre : |
Mitochondria and Autism Spectrum Disorders |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Robert K. NAVIAUX, Auteur |
Année de publication : |
2013 |
Importance : |
p.179-193 |
Langues : |
Anglais (eng) |
Index. décimale : |
SCI-D SCI-D - Neurosciences |
Résumé : |
Recently, the connections between mitochondria and autism spectrum disorders (ASD) have become increasingly clear. The nature of this connection is more complex than previously thought. A simple reduction in mitochondrial function does not cause ASD. A small but informative fraction of autism is caused by single-gene defects or DNA copy number variations, with the large majority of ASD being the result of variation in hundreds of genes and loci, interacting with environmental and other factors. The crossroads of genes and environment is metabolism. Mitocellular hormesis is the adaptation of cellular and mitochondrial metabolism to environmental change. Changes in nutrition, infectious agents, environmental toxicants, intellectual attention, and physical activity each play a role in mitocellular hormesis during children’s development. Definite mitochondrial disease is responsible for less than 5% of ASD, however, pathological disturbances in mitochondrial metabolism leading to excitotoxicity may lie at the heart of a larger proportion of ASD. |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
Mitochondria and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Robert K. NAVIAUX, Auteur . - 2013 . - p.179-193. Langues : Anglais ( eng)
Index. décimale : |
SCI-D SCI-D - Neurosciences |
Résumé : |
Recently, the connections between mitochondria and autism spectrum disorders (ASD) have become increasingly clear. The nature of this connection is more complex than previously thought. A simple reduction in mitochondrial function does not cause ASD. A small but informative fraction of autism is caused by single-gene defects or DNA copy number variations, with the large majority of ASD being the result of variation in hundreds of genes and loci, interacting with environmental and other factors. The crossroads of genes and environment is metabolism. Mitocellular hormesis is the adaptation of cellular and mitochondrial metabolism to environmental change. Changes in nutrition, infectious agents, environmental toxicants, intellectual attention, and physical activity each play a role in mitocellular hormesis during children’s development. Definite mitochondrial disease is responsible for less than 5% of ASD, however, pathological disturbances in mitochondrial metabolism leading to excitotoxicity may lie at the heart of a larger proportion of ASD. |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
|