| Titre : |
The Minicolumnopathy of Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Manuel F. CASANOVA, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.327-333 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Cortical development arises from the epistatic interaction of multiple gene polymorphisms and transcriptional programs, their epigenetic modifications, expression patterns of morphogens and other small molecules, and incipient patterns of synaptic activity, all subject to developmental noise. These mechanisms exhibit redundancy and crosstalk so that a stable phenotypic distribution is maintained in the face of stochastic effects and (epi-)genetic perturbations. The resulting constrained programs of differentiation, migration, and neuronal development provide a basis for emergent patterns of information flow within the developing minicolumn, which may in turn feed back to further refine the formation of its circuits. In autism, our research has shown the existence of supernumerary columns with significant diminution in their peripheral neuropil. This finding, along with descriptions of ‘epigenetic’ heterotopias, suggests a dysregulation of periventricular germinal cell divisions. The heterochronicity of periventricular cell divisions provides an uncoupling between the radial migrating system and the tangential migration of inhibitory elements. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
The Minicolumnopathy of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Manuel F. CASANOVA, Auteur . - 2013 . - p.327-333. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Cortical development arises from the epistatic interaction of multiple gene polymorphisms and transcriptional programs, their epigenetic modifications, expression patterns of morphogens and other small molecules, and incipient patterns of synaptic activity, all subject to developmental noise. These mechanisms exhibit redundancy and crosstalk so that a stable phenotypic distribution is maintained in the face of stochastic effects and (epi-)genetic perturbations. The resulting constrained programs of differentiation, migration, and neuronal development provide a basis for emergent patterns of information flow within the developing minicolumn, which may in turn feed back to further refine the formation of its circuits. In autism, our research has shown the existence of supernumerary columns with significant diminution in their peripheral neuropil. This finding, along with descriptions of ‘epigenetic’ heterotopias, suggests a dysregulation of periventricular germinal cell divisions. The heterochronicity of periventricular cell divisions provides an uncoupling between the radial migrating system and the tangential migration of inhibitory elements. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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The Minicolumnopathy of Autism Spectrum Disorders