| Titre : |
Getting from 1,000 Genes to a Triad of Symptoms: The Emerging Role of Systems Biology in Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Joseph D. BUXBAUM, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.461-471 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Systems biological approaches will be required in autism spectrum disorders (ASD) to understand how a highly diverse set of genes can, when altered, lead to a well-defined behavioral phenotype. As our understanding of convergent pathways increases, we will begin to understand more about brain development and the molecular basis for brain function and behavior. One important outcome from systems biological analyses is the ability to identify driver genes within pathways and networks. Driver genes can be used for the validation of networks, and also represent high-impact genes for drug development. In this way, systems biological approaches will also inform drug discovery efforts. We provide a brief summary of systems-level analyses of common and rare genetic variation in ASD and of genes that are differentially expressed in postmortem ASD brain samples. In addition, we highlight some issues that will need to be resolved before systems biological approaches will be reliably useful in ASD research |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
Getting from 1,000 Genes to a Triad of Symptoms: The Emerging Role of Systems Biology in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Joseph D. BUXBAUM, Auteur . - 2013 . - p.461-471. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Systems biological approaches will be required in autism spectrum disorders (ASD) to understand how a highly diverse set of genes can, when altered, lead to a well-defined behavioral phenotype. As our understanding of convergent pathways increases, we will begin to understand more about brain development and the molecular basis for brain function and behavior. One important outcome from systems biological analyses is the ability to identify driver genes within pathways and networks. Driver genes can be used for the validation of networks, and also represent high-impact genes for drug development. In this way, systems biological approaches will also inform drug discovery efforts. We provide a brief summary of systems-level analyses of common and rare genetic variation in ASD and of genes that are differentially expressed in postmortem ASD brain samples. In addition, we highlight some issues that will need to be resolved before systems biological approaches will be reliably useful in ASD research |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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Getting from 1,000 Genes to a Triad of Symptoms: The Emerging Role of Systems Biology in Autism Spectrum Disorders