An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders / Ann CLAWSON in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.363-375 Titre : An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ann CLAWSON, Auteur ; Peter E. CLAYSON, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Michael J. LARSON, Auteur Article en page(s) : p.363-375 Langues : Anglais (eng) Mots-clés : Autism  Interhemispheric transfer time  N1  P1  Event-related potential  Corpus callosum  White matter Index. décimale : PER Périodiques Résumé : Little is known about the functional impact of putative deficits in white-matter connectivity across the corpus callosum (CC) in individuals with autism spectrum disorders (ASDs). We utilized the temporal sensitivity of event-related potentials to examine the interhemispheric transfer time (IHTT) of basic visual information across the CC in youth with high-functioning ASD relative to healthy controls. We conducted two experiments: a visual letter matching experiment (n = 46) and a visual picture matching experiment, (n = 48) and utilized both electrophysiological (N1 and P1 amplitudes and latencies) and behavioral [response times (RTs), error rates] indices of IHTT. There were no significant group differences on either experiment for RTs, error rates, or N1 and P1 latencies, suggesting that on basic tasks the timing of information flow across the CC may not be altered in high functioning ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1895-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ann CLAWSON, Auteur ; Peter E. CLAYSON, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Michael J. LARSON, Auteur . - p.363-375. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.363-375 Mots-clés : Autism  Interhemispheric transfer time  N1  P1  Event-related potential  Corpus callosum  White matter Index. décimale : PER Périodiques Résumé : Little is known about the functional impact of putative deficits in white-matter connectivity across the corpus callosum (CC) in individuals with autism spectrum disorders (ASDs). We utilized the temporal sensitivity of event-related potentials to examine the interhemispheric transfer time (IHTT) of basic visual information across the CC in youth with high-functioning ASD relative to healthy controls. We conducted two experiments: a visual letter matching experiment (n = 46) and a visual picture matching experiment, (n = 48) and utilized both electrophysiological (N1 and P1 amplitudes and latencies) and behavioral [response times (RTs), error rates] indices of IHTT. There were no significant group differences on either experiment for RTs, error rates, or N1 and P1 latencies, suggesting that on basic tasks the timing of information flow across the CC may not be altered in high functioning ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1895-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Cognitive control and conflict adaptation in youth with high-functioning autism / Michael J. LARSON in Journal of Child Psychology and Psychiatry, 53-4 (April 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.440-448 Titre : Cognitive control and conflict adaptation in youth with high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Michael J. LARSON, Auteur ; Mikle SOUTH, Auteur ; Peter E. CLAYSON, Auteur ; Ann CLAWSON, Auteur Année de publication : 2012 Article en page(s) : p.440-448 Langues : Anglais (eng) Mots-clés : N2  event-related potential  autism  conflict adaptation  cognitive control Index. décimale : PER Périodiques Résumé : Background:  Youth diagnosed with autism spectrum disorders (ASD) often show deficits in cognitive control processes, potentially contributing to characteristic difficulties monitoring and regulating behavior. Modification of performance following conflict can be measured by examining conflict adaptation, the adjustment of cognitive resources based on previous-trial conflict. The electrophysiological correlates of these processes can be measured using the N2, a stimulus-locked component of the event-related potential (ERP). Methods:  High-density ERPs and behavioral data [i.e. response times (RTs) and error rates] were acquired while 28 youth with ASD and 36 typically developing controls completed a modified Eriksen flanker task. Results:  Behaviorally, groups showed similar conflict adaptation effects; youth with ASD showed larger RT slowing on switch trials. For electrophysiology, controls demonstrated larger N2 amplitudes for incongruent (high-conflict) trials following congruent (low-conflict) trials than for incongruent trials following incongruent trials. Importantly, youth with ASD showed no such differences in N2 amplitude based on previous-trial conflict. Conclusions:  Lack of electrophysiological conflict adaptation effects in youth with ASD indicates irregular neural processing associated with conflict adaptation. Individuals with ASD show declines in level of conflict evaluation and adaptation. Future research is necessary to accurately characterize and understand the behavioral implications of these cognitive control deficits relative to diagnostic severity, anxiety, and personality. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02498.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Cognitive control and conflict adaptation in youth with high-functioning autism [Texte imprimé et/ou numérique] / Michael J. LARSON, Auteur ; Mikle SOUTH, Auteur ; Peter E. CLAYSON, Auteur ; Ann CLAWSON, Auteur . - 2012 . - p.440-448. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.440-448 Mots-clés : N2  event-related potential  autism  conflict adaptation  cognitive control Index. décimale : PER Périodiques Résumé : Background:  Youth diagnosed with autism spectrum disorders (ASD) often show deficits in cognitive control processes, potentially contributing to characteristic difficulties monitoring and regulating behavior. Modification of performance following conflict can be measured by examining conflict adaptation, the adjustment of cognitive resources based on previous-trial conflict. The electrophysiological correlates of these processes can be measured using the N2, a stimulus-locked component of the event-related potential (ERP). Methods:  High-density ERPs and behavioral data [i.e. response times (RTs) and error rates] were acquired while 28 youth with ASD and 36 typically developing controls completed a modified Eriksen flanker task. Results:  Behaviorally, groups showed similar conflict adaptation effects; youth with ASD showed larger RT slowing on switch trials. For electrophysiology, controls demonstrated larger N2 amplitudes for incongruent (high-conflict) trials following congruent (low-conflict) trials than for incongruent trials following incongruent trials. Importantly, youth with ASD showed no such differences in N2 amplitude based on previous-trial conflict. Conclusions:  Lack of electrophysiological conflict adaptation effects in youth with ASD indicates irregular neural processing associated with conflict adaptation. Individuals with ASD show declines in level of conflict evaluation and adaptation. Future research is necessary to accurately characterize and understand the behavioral implications of these cognitive control deficits relative to diagnostic severity, anxiety, and personality. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02498.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Electrophysiological Endophenotypes and the Error-Related Negativity (ERN) in Autism Spectrum Disorder: A Family Study / Ann CLAWSON in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1436-1452 Titre : Electrophysiological Endophenotypes and the Error-Related Negativity (ERN) in Autism Spectrum Disorder: A Family Study Type de document : Texte imprimé et/ou numérique Auteurs : Ann CLAWSON, Auteur ; Mikle SOUTH, Auteur ; Scott A. BALDWIN, Auteur ; Michael J. LARSON, Auteur Article en page(s) : p.1436-1452 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Error-related negativity  Cognitive control  Endophenotype Index. décimale : PER Périodiques Résumé : We examined the error-related negativity (ERN) as an endophenotype of ASD by comparing the ERN in families of ASD probands to control families. We hypothesized that ASD probands and families would display reduced-amplitude ERN relative to controls. Participants included 148 individuals within 39 families consisting of a mother, father, sibling, and proband. Robust ANOVAs revealed non-significant differences in ERN amplitude and behavioral performance among ASD probands relative to control youth. In subsequent multiple regression analyses group and kinship (proband, sibling, mother, father) did not significantly predict ?ERN (error minus correct ERN) or behavioral performance. Results do not provide evidence for the ERN as an endophenotype of ASD. Future research is needed to examine state- or trait-related factors influencing ERN amplitudes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3066-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Electrophysiological Endophenotypes and the Error-Related Negativity (ERN) in Autism Spectrum Disorder: A Family Study [Texte imprimé et/ou numérique] / Ann CLAWSON, Auteur ; Mikle SOUTH, Auteur ; Scott A. BALDWIN, Auteur ; Michael J. LARSON, Auteur . - p.1436-1452. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1436-1452 Mots-clés : Autism spectrum disorder  Error-related negativity  Cognitive control  Endophenotype Index. décimale : PER Périodiques Résumé : We examined the error-related negativity (ERN) as an endophenotype of ASD by comparing the ERN in families of ASD probands to control families. We hypothesized that ASD probands and families would display reduced-amplitude ERN relative to controls. Participants included 148 individuals within 39 families consisting of a mother, father, sibling, and proband. Robust ANOVAs revealed non-significant differences in ERN amplitude and behavioral performance among ASD probands relative to control youth. In subsequent multiple regression analyses group and kinship (proband, sibling, mother, father) did not significantly predict ?ERN (error minus correct ERN) or behavioral performance. Results do not provide evidence for the ERN as an endophenotype of ASD. Future research is needed to examine state- or trait-related factors influencing ERN amplitudes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3066-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Gender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism / Goldie A. MCQUAID in Autism, 28-11 (November 2024)  

Public ISBD [article]  inAutism > 28-11 (November 2024) . - p.2806 - 2820 Titre : Gender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism Type de document : Texte imprimé et/ou numérique Auteurs : Goldie A. MCQUAID, Auteur ; Allison B. RATTO, Auteur ; Allison JACK, Auteur ; Alexis KHUU, Auteur ; Jessica V. SMITH, Auteur ; Sean C. DUANE, Auteur ; Ann CLAWSON, Auteur ; Nancy Raitano LEE, Auteur ; Alyssa VERBALIS, Auteur ; Kevin A. PELPHREY, Auteur ; Lauren KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; John F. STRANG, Auteur Article en page(s) : p.2806 - 2820 Langues : Anglais (eng) Mots-clés : age at diagnosis  autism  diagnosis  gender  sex Index. décimale : PER Périodiques Résumé : Later autism diagnosis is associated with increased mental health risks. Understanding disparities in diagnostic timing is important to reduce psychiatric burden for autistic people. One characteristic associated with later autism diagnosis is female sex assigned at birth. However, literature to date does not characterize, differentiate, or account for gender identity beyond assigned sex at birth. Gender diversity may be more common in autistic relative to neurotypical people, and autism is proportionally overrepresented in gender-diverse populations. We examined age at autism diagnosis by assigned sex at birth, gender identity, and gender diversity (gender-diverse vs cisgender) status, separately. Three independent cohorts representing different ascertainments were examined: a research-recruited academic medical center sample (N = 193; 8.0 - 18.0?years); a clinic-based sample (N = 1550; 1.3 - 25.4?years); and a community-enriched sample (N = 244, 18.2 - 30.0?years). The clinic-based and community-enriched samples revealed disparities in diagnostic timing: people assigned female at birth, people of female gender, and gender-diverse people were diagnosed with autism significantly later than persons assigned male at birth, persons of male gender, and cisgender persons, respectively. Birth-sex, gender identity, and gender diversity may each uniquely relate to disparities in autism diagnostic timing. The influence of ascertainment strategies, particularly in studies examining assigned sex at birth or gender identity, should be considered. Lay Abstract Later autism diagnosis is associated with risk for mental health problems. Understanding factors related to later autism diagnosis may help reduce mental health risks for autistic people. One characteristic associated with later autism diagnosis is female sex. However, studies often do not distinguish sex assigned at birth and gender identity. Gender diversity may be more common in autistic relative to neurotypical people, and autism is more common in gender-diverse populations. We studied age at autism diagnosis by sex assigned at birth, gender identity, and gender diversity (gender-diverse vs cisgender) status, separately. We studied three separate autistic samples, each of which differed in how they were diagnosed and how they were recruited. The samples included 193 persons (8.0 - 18.0?years) from a research-recruited academic medical center sample; 1,550 people (1.3 - 25.4?years) from a clinic-based sample; and 244 people (18.2 - 30.0?years) from a community-enriched sample. We found significant differences in the clinic-based and community-enriched samples. People assigned female sex at birth were diagnosed with autism significantly later than people assigned male at birth. People of female gender were diagnosed significantly later than people of male gender. Gender-diverse people were diagnosed significantly later than cisgender people. Sex assigned at birth, gender identity, and gender diversity may each show unique relationships with age of autism diagnosis. Differences in how autistic people are diagnosed and recruited are important to consider in studies that examine sex assigned at birth or gender identity. More research into autism diagnosis in adulthood is needed. En ligne : https://dx.doi.org/10.1177/13623613241243117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Gender, assigned sex at birth, and gender diversity: Windows into diagnostic timing disparities in autism [Texte imprimé et/ou numérique] / Goldie A. MCQUAID, Auteur ; Allison B. RATTO, Auteur ; Allison JACK, Auteur ; Alexis KHUU, Auteur ; Jessica V. SMITH, Auteur ; Sean C. DUANE, Auteur ; Ann CLAWSON, Auteur ; Nancy Raitano LEE, Auteur ; Alyssa VERBALIS, Auteur ; Kevin A. PELPHREY, Auteur ; Lauren KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; John F. STRANG, Auteur . - p.2806 - 2820. Langues : Anglais (eng) in Autism > 28-11 (November 2024) . - p.2806 - 2820 Mots-clés : age at diagnosis  autism  diagnosis  gender  sex Index. décimale : PER Périodiques Résumé : Later autism diagnosis is associated with increased mental health risks. Understanding disparities in diagnostic timing is important to reduce psychiatric burden for autistic people. One characteristic associated with later autism diagnosis is female sex assigned at birth. However, literature to date does not characterize, differentiate, or account for gender identity beyond assigned sex at birth. Gender diversity may be more common in autistic relative to neurotypical people, and autism is proportionally overrepresented in gender-diverse populations. We examined age at autism diagnosis by assigned sex at birth, gender identity, and gender diversity (gender-diverse vs cisgender) status, separately. Three independent cohorts representing different ascertainments were examined: a research-recruited academic medical center sample (N = 193; 8.0 - 18.0?years); a clinic-based sample (N = 1550; 1.3 - 25.4?years); and a community-enriched sample (N = 244, 18.2 - 30.0?years). The clinic-based and community-enriched samples revealed disparities in diagnostic timing: people assigned female at birth, people of female gender, and gender-diverse people were diagnosed with autism significantly later than persons assigned male at birth, persons of male gender, and cisgender persons, respectively. Birth-sex, gender identity, and gender diversity may each uniquely relate to disparities in autism diagnostic timing. The influence of ascertainment strategies, particularly in studies examining assigned sex at birth or gender identity, should be considered. Lay Abstract Later autism diagnosis is associated with risk for mental health problems. Understanding factors related to later autism diagnosis may help reduce mental health risks for autistic people. One characteristic associated with later autism diagnosis is female sex. However, studies often do not distinguish sex assigned at birth and gender identity. Gender diversity may be more common in autistic relative to neurotypical people, and autism is more common in gender-diverse populations. We studied age at autism diagnosis by sex assigned at birth, gender identity, and gender diversity (gender-diverse vs cisgender) status, separately. We studied three separate autistic samples, each of which differed in how they were diagnosed and how they were recruited. The samples included 193 persons (8.0 - 18.0?years) from a research-recruited academic medical center sample; 1,550 people (1.3 - 25.4?years) from a clinic-based sample; and 244 people (18.2 - 30.0?years) from a community-enriched sample. We found significant differences in the clinic-based and community-enriched samples. People assigned female sex at birth were diagnosed with autism significantly later than people assigned male at birth. People of female gender were diagnosed significantly later than people of male gender. Gender-diverse people were diagnosed significantly later than cisgender people. Sex assigned at birth, gender identity, and gender diversity may each show unique relationships with age of autism diagnosis. Differences in how autistic people are diagnosed and recruited are important to consider in studies that examine sex assigned at birth or gender identity. More research into autism diagnosis in adulthood is needed. En ligne : https://dx.doi.org/10.1177/13623613241243117 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Parent-child concordance on the Pubertal Development Scale in typically developing and autistic youth / Ann CLAWSON in Research in Autism Spectrum Disorders, 77 (September 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 77 (September 2020) . - 101610 Titre : Parent-child concordance on the Pubertal Development Scale in typically developing and autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Ann CLAWSON, Auteur ; John F. STRANG, Auteur ; Gregory L. WALLACE, Auteur ; Veronica GOMEZ-LOBO, Auteur ; Allison JACK, Auteur ; Sara J. WEBB, Auteur ; Kevin A. PELPHREY, Auteur Article en page(s) : 101610 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Puberty  Pubertal Development Scale Index. décimale : PER Périodiques Résumé : Background Characterizing puberty in autism spectrum disorder (ASD) is critical given the direct impacts of pubertal progression on neural, cognitive, and physical maturation. Limited information is available about the utility and parent-child concordance of the self-report and parent-report Pubertal Development Scale (PDS) in ASD, an economical and easily administered measure. Method The primary aim of this study was to examine the concordance between self-report and parent-report PDS ratings in autistic males and females ages 8–17y compared to typically developing (TD) youth, including using the PDS to derive informant-based estimates of adrenal and gonadal development. We hypothesized that there would be greater parent-youth discrepancies in pubertal ratings among autistic males. Our second aim was exploratory; we examined whether individual characteristics impact PDS concordance and hypothesized that lower intellectual and adaptive skills, higher autistic traits, and reduced self-awareness/monitoring would correlate with lower concordance. Results There were no significant diagnostic group differences in parent-youth concordance for overall PDS scores among males and females. Autistic males had significantly lower inter-item agreement with their parents than TD males and had lower agreement for both adrenal and gonadal aspects of pubertal maturation (adrenal ??=?.48; gonadal ??=?.55). Conclusions The PDS is a feasible measure in ASD. Greater parent-youth discrepancies in autistic males may be due to reduced parental awareness or reduced insight into pubertal maturation among autistic males. Future research is needed to further elucidate individual and/or environmental characteristics that influence youth- and parent-reported PDS scores, including differences in self-perception and insight. En ligne : https://doi.org/10.1016/j.rasd.2020.101610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Parent-child concordance on the Pubertal Development Scale in typically developing and autistic youth [Texte imprimé et/ou numérique] / Ann CLAWSON, Auteur ; John F. STRANG, Auteur ; Gregory L. WALLACE, Auteur ; Veronica GOMEZ-LOBO, Auteur ; Allison JACK, Auteur ; Sara J. WEBB, Auteur ; Kevin A. PELPHREY, Auteur . - 101610. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 77 (September 2020) . - 101610 Mots-clés : Autism spectrum disorder (ASD)  Puberty  Pubertal Development Scale Index. décimale : PER Périodiques Résumé : Background Characterizing puberty in autism spectrum disorder (ASD) is critical given the direct impacts of pubertal progression on neural, cognitive, and physical maturation. Limited information is available about the utility and parent-child concordance of the self-report and parent-report Pubertal Development Scale (PDS) in ASD, an economical and easily administered measure. Method The primary aim of this study was to examine the concordance between self-report and parent-report PDS ratings in autistic males and females ages 8–17y compared to typically developing (TD) youth, including using the PDS to derive informant-based estimates of adrenal and gonadal development. We hypothesized that there would be greater parent-youth discrepancies in pubertal ratings among autistic males. Our second aim was exploratory; we examined whether individual characteristics impact PDS concordance and hypothesized that lower intellectual and adaptive skills, higher autistic traits, and reduced self-awareness/monitoring would correlate with lower concordance. Results There were no significant diagnostic group differences in parent-youth concordance for overall PDS scores among males and females. Autistic males had significantly lower inter-item agreement with their parents than TD males and had lower agreement for both adrenal and gonadal aspects of pubertal maturation (adrenal ??=?.48; gonadal ??=?.55). Conclusions The PDS is a feasible measure in ASD. Greater parent-youth discrepancies in autistic males may be due to reduced parental awareness or reduced insight into pubertal maturation among autistic males. Future research is needed to further elucidate individual and/or environmental characteristics that influence youth- and parent-reported PDS scores, including differences in self-perception and insight. En ligne : https://doi.org/10.1016/j.rasd.2020.101610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

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