Dépouillements

Parents’ assessments of their child’s autism-related interventions / Daniel SHEPHERD in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.1-10 Titre : Parents’ assessments of their child’s autism-related interventions Type de document : Texte imprimé et/ou numérique Auteurs : Daniel SHEPHERD, Auteur ; Jason LANDON, Auteur ; Sonja GOEDEKE, Auteur ; Kelly TY, Auteur ; Rita CSAKO, Auteur Année de publication : 2018 Article en page(s) : p.1-10 Langues : Anglais (eng) Mots-clés : Parent report  Autism spectrum disorder  Intervention effectiveness  Parenting stress Index. décimale : PER Périodiques Résumé : Background Interventions for autism spectrum disorders (ASD) are typically evaluated on the basis of symptom-focused outcome measures. These measures tend to be clinician rated and derived in clinical studies, whilst broader parental experiences are often neglected. Method Here we report a study of 585 parents of children diagnosed with ASD, focusing on their assessments of their child’s ASD Interventions, and how they are perceived to impact parental stress. Results Overall, high proportions of parents reported disengagement with treatment. The highest completion rates were evident with speech-language therapy, and the lowest with intensive applied behaviour analysis (iABA). However, parents reported the highest expectations, satisfaction and stress reduction with iABA. These paradoxical findings are perhaps due to the relative cost and lack of funding directed towards iABA. Conclusions Our research suggests that parental expectations and the factors influencing them are worthy of further investigation. More pertinently, parental ratings of intervention effectiveness along with current intervention engagement are a vital and often overlooked component of understanding the effects of interventions on children with ASD and their families. En ligne : https://doi.org/10.1016/j.rasd.2018.02.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Parents’ assessments of their child’s autism-related interventions [Texte imprimé et/ou numérique] / Daniel SHEPHERD, Auteur ; Jason LANDON, Auteur ; Sonja GOEDEKE, Auteur ; Kelly TY, Auteur ; Rita CSAKO, Auteur . - 2018 . - p.1-10. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.1-10 Mots-clés : Parent report  Autism spectrum disorder  Intervention effectiveness  Parenting stress Index. décimale : PER Périodiques Résumé : Background Interventions for autism spectrum disorders (ASD) are typically evaluated on the basis of symptom-focused outcome measures. These measures tend to be clinician rated and derived in clinical studies, whilst broader parental experiences are often neglected. Method Here we report a study of 585 parents of children diagnosed with ASD, focusing on their assessments of their child’s ASD Interventions, and how they are perceived to impact parental stress. Results Overall, high proportions of parents reported disengagement with treatment. The highest completion rates were evident with speech-language therapy, and the lowest with intensive applied behaviour analysis (iABA). However, parents reported the highest expectations, satisfaction and stress reduction with iABA. These paradoxical findings are perhaps due to the relative cost and lack of funding directed towards iABA. Conclusions Our research suggests that parental expectations and the factors influencing them are worthy of further investigation. More pertinently, parental ratings of intervention effectiveness along with current intervention engagement are a vital and often overlooked component of understanding the effects of interventions on children with ASD and their families. En ligne : https://doi.org/10.1016/j.rasd.2018.02.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Links between traits associated with the broad autism phenotype and empathy and young adults’ ability to decode speaker intentionality / Lorna S. JAKOBSON in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.11-21 Titre : Links between traits associated with the broad autism phenotype and empathy and young adults’ ability to decode speaker intentionality Type de document : Texte imprimé et/ou numérique Auteurs : Lorna S. JAKOBSON, Auteur ; Pauline M. PEARSON, Auteur ; Zofia KOZUB, Auteur ; Colleen HARE, Auteur ; Sarah N. RIGBY, Auteur Année de publication : 2018 Article en page(s) : p.11-21 Langues : Anglais (eng) Mots-clés : Broad autism phenotype  Empathy  Nonverbal  Social  Emotion regulation Index. décimale : PER Périodiques Résumé : Background Expressions of social, but not non-social, traits associated with the broad autism phenotype (BAP) have been linked with social difficulties in parents of children with a formal diagnosis of autism spectrum disorder (ASD). How subclinical expression of BAP traits are related to social communication abilities in individuals in the general population is less well understood. Method We explored relationships between social and non-social BAP traits and the ability to use multimodal, nonverbal cues to infer a speaker’s intended meaning in a general sample of university students (N?=?70). Data on the empathic abilities of, and the emotion regulation strategies used by, participants were also collected. Results After controlling for verbal IQ, accuracy in labeling speakers’ intentions was positively associated with the non-social BAP trait of rigidity (an effect that past research suggests may be mediated by superior face processing ability), and with one’s drive to empathize with the thoughts and feelings of a fictional character. We suggest that being both imaginative and motivated to engage with others may have been key to participants’ success on the task. We also observed that the participants who found sarcasm, jocularity, and white lies particularly rude were those who tended to engage in more emotional suppression – a self-regulatory strategy that negatively biases the processing and expression of affect. Conclusions Together, these results expand our understanding of personality factors that influence social communication skills, and may inform future research into the role that particular symptom clusters play in the expression of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Links between traits associated with the broad autism phenotype and empathy and young adults’ ability to decode speaker intentionality [Texte imprimé et/ou numérique] / Lorna S. JAKOBSON, Auteur ; Pauline M. PEARSON, Auteur ; Zofia KOZUB, Auteur ; Colleen HARE, Auteur ; Sarah N. RIGBY, Auteur . - 2018 . - p.11-21. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.11-21 Mots-clés : Broad autism phenotype  Empathy  Nonverbal  Social  Emotion regulation Index. décimale : PER Périodiques Résumé : Background Expressions of social, but not non-social, traits associated with the broad autism phenotype (BAP) have been linked with social difficulties in parents of children with a formal diagnosis of autism spectrum disorder (ASD). How subclinical expression of BAP traits are related to social communication abilities in individuals in the general population is less well understood. Method We explored relationships between social and non-social BAP traits and the ability to use multimodal, nonverbal cues to infer a speaker’s intended meaning in a general sample of university students (N?=?70). Data on the empathic abilities of, and the emotion regulation strategies used by, participants were also collected. Results After controlling for verbal IQ, accuracy in labeling speakers’ intentions was positively associated with the non-social BAP trait of rigidity (an effect that past research suggests may be mediated by superior face processing ability), and with one’s drive to empathize with the thoughts and feelings of a fictional character. We suggest that being both imaginative and motivated to engage with others may have been key to participants’ success on the task. We also observed that the participants who found sarcasm, jocularity, and white lies particularly rude were those who tended to engage in more emotional suppression – a self-regulatory strategy that negatively biases the processing and expression of affect. Conclusions Together, these results expand our understanding of personality factors that influence social communication skills, and may inform future research into the role that particular symptom clusters play in the expression of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

“Communicative skills in Spanish children with Autism Spectrum Disorder and children with Attention Deficit Hyperactivity Disorder. Analysis through parents’ perceptions and narrative production” / Inmaculada BAIXAULI FORTEA in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.22-31 Titre : “Communicative skills in Spanish children with Autism Spectrum Disorder and children with Attention Deficit Hyperactivity Disorder. Analysis through parents’ perceptions and narrative production” Type de document : Texte imprimé et/ou numérique Auteurs : Inmaculada BAIXAULI FORTEA, Auteur ; Carmen BERENGUER FORNER, Auteur ; Carla COLOMER, Auteur ; Ana Miranda CASAS, Auteur ; Belén Roselló MIRANDA, Auteur Année de publication : 2018 Article en page(s) : p.22-31 Langues : Anglais (eng) Mots-clés : Communication  Pragmatics  Narrative  Attention Deficit Hyperactivity Disorder  Autism Spectrum Disorder Index. décimale : PER Périodiques Résumé : Background Communicative skills are one of the main deficits experienced by children with Autism Spectrum Disorder (ASD). The differential diagnosis is a complex issue that clinicians often face. For this reason, this study has two objectives: 1) to analyze the similarities and differences that children with Attention Deficit Hyperactivity Disorder (ADHD) and children with ASD present in their linguistic and communicative skills, through parent? perceptions and narrative production; 2) to identify the relative importance of the skills analyzed in discriminating children with ASD versus children with ADHD, as well as the classification power of each of the two measurement methods used. Method Participants were 37 children with typical development (TD), 52 with ASD, and 35 with ADHD. Their communicative competence was assessed through The Children's Communication Checklist Second Edition (CCC-2) (Bishop, 2003) and a narrative task. Results The results of the family ratings indicated that the difficulties were not as severe in ADHD as in ASD, where the deficit was much more pronounced in the interpretation of the context, non-verbal communication, and stereotyped language. On the narrative task, both groups displayed difficulties on expressing relevant information and inferential comprehension, and they differed on erroneous interpretations, with the children with ASD presenting worse performance. These variables showed a greater capacity to classify participants in the diagnostic categories studied. Conclusions These findings have direct clinical implications for optimizing the assessment process, making it possible to identify which specific language aspects can best differentiate between groups. En ligne : https://doi.org/10.1016/j.rasd.2018.02.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] “Communicative skills in Spanish children with Autism Spectrum Disorder and children with Attention Deficit Hyperactivity Disorder. Analysis through parents’ perceptions and narrative production” [Texte imprimé et/ou numérique] / Inmaculada BAIXAULI FORTEA, Auteur ; Carmen BERENGUER FORNER, Auteur ; Carla COLOMER, Auteur ; Ana Miranda CASAS, Auteur ; Belén Roselló MIRANDA, Auteur . - 2018 . - p.22-31. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.22-31 Mots-clés : Communication  Pragmatics  Narrative  Attention Deficit Hyperactivity Disorder  Autism Spectrum Disorder Index. décimale : PER Périodiques Résumé : Background Communicative skills are one of the main deficits experienced by children with Autism Spectrum Disorder (ASD). The differential diagnosis is a complex issue that clinicians often face. For this reason, this study has two objectives: 1) to analyze the similarities and differences that children with Attention Deficit Hyperactivity Disorder (ADHD) and children with ASD present in their linguistic and communicative skills, through parent? perceptions and narrative production; 2) to identify the relative importance of the skills analyzed in discriminating children with ASD versus children with ADHD, as well as the classification power of each of the two measurement methods used. Method Participants were 37 children with typical development (TD), 52 with ASD, and 35 with ADHD. Their communicative competence was assessed through The Children's Communication Checklist Second Edition (CCC-2) (Bishop, 2003) and a narrative task. Results The results of the family ratings indicated that the difficulties were not as severe in ADHD as in ASD, where the deficit was much more pronounced in the interpretation of the context, non-verbal communication, and stereotyped language. On the narrative task, both groups displayed difficulties on expressing relevant information and inferential comprehension, and they differed on erroneous interpretations, with the children with ASD presenting worse performance. These variables showed a greater capacity to classify participants in the diagnostic categories studied. Conclusions These findings have direct clinical implications for optimizing the assessment process, making it possible to identify which specific language aspects can best differentiate between groups. En ligne : https://doi.org/10.1016/j.rasd.2018.02.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Gender differences in parent-reported age at diagnosis of children with autism spectrum disorder / Alexandra M. PETROU in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.32-42 Titre : Gender differences in parent-reported age at diagnosis of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra M. PETROU, Auteur ; Jeremy R. PARR, Auteur ; Helen MCCONACHIE, Auteur Année de publication : 2018 Article en page(s) : p.32-42 Langues : Anglais (eng) Mots-clés : Autism  ASD  Girls  Gender  Age at diagnosis Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are more commonly observed in boys than in girls. There is growing awareness of ASD in girls and recognition that under-diagnosis is common. The current study aimed to investigate any evidence of reduction in the average age at diagnosis for girls by assessing whether: 1) girls’ age at diagnosis has reduced, compared to boys’, across two age cohorts – children born between 1996–1999 and 2002–2005; 2) age at diagnosis differed between boys and girls diagnosed across childhood; 3) any characteristics are associated with earlier age at diagnosis in girls. Methods Data were available from large UK databases of children with ASD: The Database of Children with Autism Spectrum Disorder Living in the North East (http://daslne.org) and the Autism Spectrum Database–UK (www.asd-uk.com). Results There was no differential reduction of parent-reported age at diagnosis for girls over time. For children receiving their diagnosis at age ?60 months, boys received diagnoses an average of one year earlier than did girls (98.2 months, SD?=?31.6 vs. 109.1 months, SD?=?36.4). For boys and girls, earlier diagnosis was associated with toileting problems and temper problems. Having additional diagnoses (e.g., dyslexia, dyspraxia, and epilepsy) was associated with later diagnosis. Conclusions Age at diagnosis has not decreased over time. Girls with ASD are diagnosed later than boys when aged 5 years or older. Health and education professionals would benefit from better understanding factors such as toileting problems, temper problems, and additional diagnoses that could potentially guide early identification of ASD in clinical practice for school-age girls. En ligne : https://doi.org/10.1016/j.rasd.2018.02.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Gender differences in parent-reported age at diagnosis of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Alexandra M. PETROU, Auteur ; Jeremy R. PARR, Auteur ; Helen MCCONACHIE, Auteur . - 2018 . - p.32-42. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.32-42 Mots-clés : Autism  ASD  Girls  Gender  Age at diagnosis Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are more commonly observed in boys than in girls. There is growing awareness of ASD in girls and recognition that under-diagnosis is common. The current study aimed to investigate any evidence of reduction in the average age at diagnosis for girls by assessing whether: 1) girls’ age at diagnosis has reduced, compared to boys’, across two age cohorts – children born between 1996–1999 and 2002–2005; 2) age at diagnosis differed between boys and girls diagnosed across childhood; 3) any characteristics are associated with earlier age at diagnosis in girls. Methods Data were available from large UK databases of children with ASD: The Database of Children with Autism Spectrum Disorder Living in the North East (http://daslne.org) and the Autism Spectrum Database–UK (www.asd-uk.com). Results There was no differential reduction of parent-reported age at diagnosis for girls over time. For children receiving their diagnosis at age ?60 months, boys received diagnoses an average of one year earlier than did girls (98.2 months, SD?=?31.6 vs. 109.1 months, SD?=?36.4). For boys and girls, earlier diagnosis was associated with toileting problems and temper problems. Having additional diagnoses (e.g., dyslexia, dyspraxia, and epilepsy) was associated with later diagnosis. Conclusions Age at diagnosis has not decreased over time. Girls with ASD are diagnosed later than boys when aged 5 years or older. Health and education professionals would benefit from better understanding factors such as toileting problems, temper problems, and additional diagnoses that could potentially guide early identification of ASD in clinical practice for school-age girls. En ligne : https://doi.org/10.1016/j.rasd.2018.02.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Contribution of chromosomal abnormalities at 10q and 22q to autism / Nagwa A. MEGUID in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.43-50 Titre : Contribution of chromosomal abnormalities at 10q and 22q to autism Type de document : Texte imprimé et/ou numérique Auteurs : Nagwa A. MEGUID, Auteur ; Maha M. EID, Auteur ; Amal M. MOHAMED, Auteur ; Heba GHANOUM, Auteur ; Nivine A. HELMY, Auteur ; Ola M. EID, Auteur Année de publication : 2018 Article en page(s) : p.43-50 Langues : Anglais (eng) Mots-clés : Autism  Chromosomal abnormalities  Chromosome 10q  Chromosome 22q Index. décimale : PER Périodiques Résumé : Autism’s etiology is heterogeneous. It derives generically from a complex of interactions between genetic, epigenetic and environmental factors. Chromosomal rearrangements at almost all chromosomes have been reported among individuals with autism spectrum disorders (ASD). In this report, we represent three autistic patients with chromosomal abnormalities at 10q and 22q with an interesting case of 10q duplication rather than deletion. This report explores the contribution of the affected genomic regions to ASD. It may contribute to the field of research categorizing candidate loci for ASD, which would be useful in genotype– phenotype analyses for ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.03.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Contribution of chromosomal abnormalities at 10q and 22q to autism [Texte imprimé et/ou numérique] / Nagwa A. MEGUID, Auteur ; Maha M. EID, Auteur ; Amal M. MOHAMED, Auteur ; Heba GHANOUM, Auteur ; Nivine A. HELMY, Auteur ; Ola M. EID, Auteur . - 2018 . - p.43-50. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.43-50 Mots-clés : Autism  Chromosomal abnormalities  Chromosome 10q  Chromosome 22q Index. décimale : PER Périodiques Résumé : Autism’s etiology is heterogeneous. It derives generically from a complex of interactions between genetic, epigenetic and environmental factors. Chromosomal rearrangements at almost all chromosomes have been reported among individuals with autism spectrum disorders (ASD). In this report, we represent three autistic patients with chromosomal abnormalities at 10q and 22q with an interesting case of 10q duplication rather than deletion. This report explores the contribution of the affected genomic regions to ASD. It may contribute to the field of research categorizing candidate loci for ASD, which would be useful in genotype– phenotype analyses for ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.03.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Dietary status and nutrient intake of children with autism spectrum disorder: A case-control study / Kelly BARNHILL in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.51-59 Titre : Dietary status and nutrient intake of children with autism spectrum disorder: A case-control study Type de document : Texte imprimé et/ou numérique Auteurs : Kelly BARNHILL, Auteur ; Alan GUTIERREZ, Auteur ; Maliki GHOSSAINY, Auteur ; Zabin MAREDIYA, Auteur ; Morgan DEVLIN, Auteur ; Prageet SACHDEV, Auteur ; C. Nathan MARTI, Auteur ; Laura HEWITSON, Auteur Année de publication : 2018 Article en page(s) : p.51-59 Langues : Anglais (eng) Mots-clés : Autism  Diet  Nutrition  Vitamins  Minerals  Macronutrients  Micronutrients  Nutrient intake Index. décimale : PER Périodiques Résumé : Background Parents and caregivers of children with Autism Spectrum Disorders (ASD) often report that their children are picky or problem eaters. Additionally, it has been reported that children with ASD often experience gastrointestinal problems such as constipation, diarrhea, flatulence, cramping, bloating, and pain. These factors raise concerns for the nutritional status of children with ASD, given that refusal to consume particular foods coupled with the inability to tolerate, digest, and/or absorb these foods can compromise overall nutritional status. Method This case-control study investigated dietary intake of 86 children with ASD aged 2–8 years and 57 age-matched peers without ASD. Caregivers of participants who met inclusion criteria completed a health history questionnaire, provided information on dietary intake and feeding behavior, and completed a nutrition physical. Results The majority of participants (both with and without ASD) met or exceeded macronutrient intake recommendations and dietary percentages for total energy, protein, carbohydrate, and fat consumption. Approximately 25% of participants consumed an inadequate or borderline amount of total calories per day based on Dietary Reference Intake (DRI) guidelines created by US Institute of Medicine (IOM). The majority of participants consumed inadequate amounts of vitamins A, D, E, folic acid and calcium. Furthermore, children with ASD consumed lower levels of protein and calcium, and were deficient in a number of B vitamins, including B1, B2, B3, B6, and folate, compared to similarly-aged children without ASD. Conclusion Given the impact of nutrition on growth and health status, a formal dietary assessment for all children with ASD is recommended. En ligne : https://doi.org/10.1016/j.rasd.2018.03.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Dietary status and nutrient intake of children with autism spectrum disorder: A case-control study [Texte imprimé et/ou numérique] / Kelly BARNHILL, Auteur ; Alan GUTIERREZ, Auteur ; Maliki GHOSSAINY, Auteur ; Zabin MAREDIYA, Auteur ; Morgan DEVLIN, Auteur ; Prageet SACHDEV, Auteur ; C. Nathan MARTI, Auteur ; Laura HEWITSON, Auteur . - 2018 . - p.51-59. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.51-59 Mots-clés : Autism  Diet  Nutrition  Vitamins  Minerals  Macronutrients  Micronutrients  Nutrient intake Index. décimale : PER Périodiques Résumé : Background Parents and caregivers of children with Autism Spectrum Disorders (ASD) often report that their children are picky or problem eaters. Additionally, it has been reported that children with ASD often experience gastrointestinal problems such as constipation, diarrhea, flatulence, cramping, bloating, and pain. These factors raise concerns for the nutritional status of children with ASD, given that refusal to consume particular foods coupled with the inability to tolerate, digest, and/or absorb these foods can compromise overall nutritional status. Method This case-control study investigated dietary intake of 86 children with ASD aged 2–8 years and 57 age-matched peers without ASD. Caregivers of participants who met inclusion criteria completed a health history questionnaire, provided information on dietary intake and feeding behavior, and completed a nutrition physical. Results The majority of participants (both with and without ASD) met or exceeded macronutrient intake recommendations and dietary percentages for total energy, protein, carbohydrate, and fat consumption. Approximately 25% of participants consumed an inadequate or borderline amount of total calories per day based on Dietary Reference Intake (DRI) guidelines created by US Institute of Medicine (IOM). The majority of participants consumed inadequate amounts of vitamins A, D, E, folic acid and calcium. Furthermore, children with ASD consumed lower levels of protein and calcium, and were deficient in a number of B vitamins, including B1, B2, B3, B6, and folate, compared to similarly-aged children without ASD. Conclusion Given the impact of nutrition on growth and health status, a formal dietary assessment for all children with ASD is recommended. En ligne : https://doi.org/10.1016/j.rasd.2018.03.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Investigating plasma amino acids for differentiating individuals with autism spectrum disorder and typically developing peers / Troy VARGASON in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.60-72 Titre : Investigating plasma amino acids for differentiating individuals with autism spectrum disorder and typically developing peers Type de document : Texte imprimé et/ou numérique Auteurs : Troy VARGASON, Auteur ; Uwe KRUGER, Auteur ; Deborah L. MCGUINNESS, Auteur ; James B. ADAMS, Auteur ; Elizabeth GEIS, Auteur ; Eva GEHN, Auteur ; Devon COLEMAN, Auteur ; Juergen HAHN, Auteur Année de publication : 2018 Article en page(s) : p.60-72 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Plasma amino acids  Fisher discriminant analysis  Classification  Multivariate statistics  Cross-validation Index. décimale : PER Périodiques Résumé : Background Plasma amino acid measurements have been extensively investigated in individuals with autism spectrum disorder (ASD). Results thus far have been inconclusive as studies generally disagree on which amino acids are different in individuals with ASD versus their typically developing (TD) peers, due in part to methodological limitations of several studies. Method This paper investigates plasma amino acids in children and adults with ASD using data from Arizona State University’s Comprehensive Nutritional and Dietary Intervention Study. Measurements from 64 individuals with ASD and 49 TD controls were analyzed using univariate and multivariate statistical techniques. Results Univariate analysis indicated increased median levels of glutamate (+21%, p?=?0.014) and serine (+8%, p?=?0.043), and increased mean levels of hydroxyproline (+17%, p?=?0.018) for the ASD cohort, although these differences were insignificant after correcting for multiple comparisons. A multivariate approach was used to classify study participants into ASD/TD cohorts using Fisher discriminant analysis (FDA) and its nonlinear extension, kernel Fisher discriminant analysis (KFDA). Model fitting with FDA using all available measurements produced Type I and Type II errors of 27.0% and 27.8%, respectively. KFDA was most effective when using hydroxyproline, leucine, and threonine as inputs; however, leave-one-out cross-validation with this nonlinear model only resulted in 70.3% sensitivity and 77.6% specificity. Conclusions The finding of elevated glutamate in ASD is in agreement with several other studies. Overall, however, these results suggest that plasma amino acid measurements are of limited use for purposes of ASD classification, which may explain some of the inconsistencies in results presented in the literature. En ligne : https://doi.org/10.1016/j.rasd.2018.03.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Investigating plasma amino acids for differentiating individuals with autism spectrum disorder and typically developing peers [Texte imprimé et/ou numérique] / Troy VARGASON, Auteur ; Uwe KRUGER, Auteur ; Deborah L. MCGUINNESS, Auteur ; James B. ADAMS, Auteur ; Elizabeth GEIS, Auteur ; Eva GEHN, Auteur ; Devon COLEMAN, Auteur ; Juergen HAHN, Auteur . - 2018 . - p.60-72. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.60-72 Mots-clés : Autism spectrum disorder  Plasma amino acids  Fisher discriminant analysis  Classification  Multivariate statistics  Cross-validation Index. décimale : PER Périodiques Résumé : Background Plasma amino acid measurements have been extensively investigated in individuals with autism spectrum disorder (ASD). Results thus far have been inconclusive as studies generally disagree on which amino acids are different in individuals with ASD versus their typically developing (TD) peers, due in part to methodological limitations of several studies. Method This paper investigates plasma amino acids in children and adults with ASD using data from Arizona State University’s Comprehensive Nutritional and Dietary Intervention Study. Measurements from 64 individuals with ASD and 49 TD controls were analyzed using univariate and multivariate statistical techniques. Results Univariate analysis indicated increased median levels of glutamate (+21%, p?=?0.014) and serine (+8%, p?=?0.043), and increased mean levels of hydroxyproline (+17%, p?=?0.018) for the ASD cohort, although these differences were insignificant after correcting for multiple comparisons. A multivariate approach was used to classify study participants into ASD/TD cohorts using Fisher discriminant analysis (FDA) and its nonlinear extension, kernel Fisher discriminant analysis (KFDA). Model fitting with FDA using all available measurements produced Type I and Type II errors of 27.0% and 27.8%, respectively. KFDA was most effective when using hydroxyproline, leucine, and threonine as inputs; however, leave-one-out cross-validation with this nonlinear model only resulted in 70.3% sensitivity and 77.6% specificity. Conclusions The finding of elevated glutamate in ASD is in agreement with several other studies. Overall, however, these results suggest that plasma amino acid measurements are of limited use for purposes of ASD classification, which may explain some of the inconsistencies in results presented in the literature. En ligne : https://doi.org/10.1016/j.rasd.2018.03.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356

Exploring anxiety symptomatology in school-aged autistic children using an autism-specific assessment / Jacquiline DEN HOUTING in Research in Autism Spectrum Disorders, 50 (June 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 50 (June 2018) . - p.73-82 Titre : Exploring anxiety symptomatology in school-aged autistic children using an autism-specific assessment Type de document : Texte imprimé et/ou numérique Auteurs : Jacquiline DEN HOUTING, Auteur ; Dawn ADAMS, Auteur ; Jacqueline ROBERTS, Auteur ; Deb KEEN, Auteur Année de publication : 2018 Article en page(s) : p.73-82 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Anxiety  Assessment  Parent report  Anxiety scale for children with Autism Spectrum Disorder Index. décimale : PER Périodiques Résumé : Background Accurate assessment of anxiety symptomatology in autistic children can be difficult, in part due to a lack of appropriate assessment tools. The newly-developed Anxiety Scale for Children with Autism Spectrum Disorder (ASC-ASD) is designed specifically for the assessment of anxiety symptomatology in autistic children. The aim of this study was to use the ASC-ASD to explore the profile of typical and atypical anxiety symptomatology in autistic children; to explore associations of anxiety symptomatology with adaptive behaviour and autistic characteristics; and to identify level of agreement between ASC-ASD scores and parent-reported anxiety diagnoses. Method 100 parents of 9–12?year old autistic children completed the ASC-ASD, Vineland Adaptive Behavior Scales ? Second Edition, and Social Communication Questionnaire as part of a longitudinal study. Results High rates of anxiety symptomatology were found, with 63% of parents rating their children in the clinical range. Atypical symptoms of anxiety were endorsed at high frequency. Items within the Uncertainty subscale were most frequently endorsed, and items within the Anxious Arousal scale were endorsed least often. Children with a parent-reported diagnosis of anxiety disorder scored significantly higher on the ASC-ASD than those without an anxiety diagnosis. Conclusions This is one of the first studies to explore anxiety symptomatology in autistic children using an autism-specific measure of anxiety. Findings suggest that the ASC-ASD may be a useful tool for the assessment of anxiety symptomatology in autistic children. En ligne : https://doi.org/10.1016/j.rasd.2018.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356 [article] Exploring anxiety symptomatology in school-aged autistic children using an autism-specific assessment [Texte imprimé et/ou numérique] / Jacquiline DEN HOUTING, Auteur ; Dawn ADAMS, Auteur ; Jacqueline ROBERTS, Auteur ; Deb KEEN, Auteur . - 2018 . - p.73-82. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 50 (June 2018) . - p.73-82 Mots-clés : Autism Spectrum Disorder  Anxiety  Assessment  Parent report  Anxiety scale for children with Autism Spectrum Disorder Index. décimale : PER Périodiques Résumé : Background Accurate assessment of anxiety symptomatology in autistic children can be difficult, in part due to a lack of appropriate assessment tools. The newly-developed Anxiety Scale for Children with Autism Spectrum Disorder (ASC-ASD) is designed specifically for the assessment of anxiety symptomatology in autistic children. The aim of this study was to use the ASC-ASD to explore the profile of typical and atypical anxiety symptomatology in autistic children; to explore associations of anxiety symptomatology with adaptive behaviour and autistic characteristics; and to identify level of agreement between ASC-ASD scores and parent-reported anxiety diagnoses. Method 100 parents of 9–12?year old autistic children completed the ASC-ASD, Vineland Adaptive Behavior Scales ? Second Edition, and Social Communication Questionnaire as part of a longitudinal study. Results High rates of anxiety symptomatology were found, with 63% of parents rating their children in the clinical range. Atypical symptoms of anxiety were endorsed at high frequency. Items within the Uncertainty subscale were most frequently endorsed, and items within the Anxious Arousal scale were endorsed least often. Children with a parent-reported diagnosis of anxiety disorder scored significantly higher on the ASC-ASD than those without an anxiety diagnosis. Conclusions This is one of the first studies to explore anxiety symptomatology in autistic children using an autism-specific measure of anxiety. Findings suggest that the ASC-ASD may be a useful tool for the assessment of anxiety symptomatology in autistic children. En ligne : https://doi.org/10.1016/j.rasd.2018.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=356