Dépouillements

Editorial: Sweet nothings - the value of negative findings for scientific progress / A. J. T. OLDEHINKEL in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.829-830 Titre : Editorial: Sweet nothings - the value of negative findings for scientific progress Type de document : Texte imprimé et/ou numérique Auteurs : A. J. T. OLDEHINKEL, Auteur Article en page(s) : p.829-830 Langues : Anglais (eng) Mots-clés : Citation bias, Spin  Negative findings  Publication bias  Reporting bias Index. décimale : PER Périodiques Résumé : It is well-known that selective outcome reporting and publication distort the information that is made publicly available, and so undermine the reliability of what we consider evidence-based knowledge. Perhaps less known is that the risk of bias extends beyond the process of reporting and publishing results. Two further sources of bias are spin and selective citing. Spin relates to selective interpretation, meant to transform a basically negative conclusion into a more positively toned one; citation bias is the phenomenon that positive findings tend to be cited more than negative ones. The effects of these sources of imbalance accumulate, and the consequences can be huge. This issue of JCPP contains several articles with wholly or partly negative findings, which hopefully will be cited frequently. Publications regarding negative findings comprise an underrepresented and often undervalued minority, and therefore deserve all the support they can get. En ligne : http://dx.doi.org/10.1111/jcpp.12952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Editorial: Sweet nothings - the value of negative findings for scientific progress [Texte imprimé et/ou numérique] / A. J. T. OLDEHINKEL, Auteur . - p.829-830. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.829-830 Mots-clés : Citation bias, Spin  Negative findings  Publication bias  Reporting bias Index. décimale : PER Périodiques Résumé : It is well-known that selective outcome reporting and publication distort the information that is made publicly available, and so undermine the reliability of what we consider evidence-based knowledge. Perhaps less known is that the risk of bias extends beyond the process of reporting and publishing results. Two further sources of bias are spin and selective citing. Spin relates to selective interpretation, meant to transform a basically negative conclusion into a more positively toned one; citation bias is the phenomenon that positive findings tend to be cited more than negative ones. The effects of these sources of imbalance accumulate, and the consequences can be huge. This issue of JCPP contains several articles with wholly or partly negative findings, which hopefully will be cited frequently. Publications regarding negative findings comprise an underrepresented and often undervalued minority, and therefore deserve all the support they can get. En ligne : http://dx.doi.org/10.1111/jcpp.12952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Research Review: Cognitive bias modification of interpretations in youth and its effect on anxiety: a meta-analysis / G. KREBS in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.831-844 Titre : Research Review: Cognitive bias modification of interpretations in youth and its effect on anxiety: a meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : G. KREBS, Auteur ; V. PILE, Auteur ; S. GRANT, Auteur ; M. DEGLI ESPOSTI, Auteur ; P. MONTGOMERY, Auteur ; J. Y. F. LAU, Auteur Article en page(s) : p.831-844 Langues : Anglais (eng) Mots-clés : Cognitive bias modification  adolescents  anxiety  children  interpretation bias training Index. décimale : PER Périodiques Résumé : BACKGROUND: Emerging evidence suggests that cognitive bias modification of interpretations (CBM-I) is effective in altering interpretation biases and reducing anxiety in adults. Less is known about the impact of CBM-I in young people, but some recent findings, including a meta-analysis of combined cognitive bias modification of interpretation and attention techniques, have cast doubt on its clinical utility. Given the current debate, this meta-analysis sought to establish the independent effects of CBM-I on interpretations biases and anxiety in youth. METHODS: Studies were identified through a systematic literature search of PsycINFO, Ovid MEDLINE, PsycARTICLES, Web of Science and EMBASE between January 1992 and March 2017. Eligible studies aimed to target interpretation biases; did not combine CBM-I with another intervention; included a control condition; randomly allocated participants to conditions; assessed interpretation bias and/or anxiety as an outcome; included individuals up to age 18; and did not present previously reported data. Reference lists of included articles were checked for further eligible studies, and authors were contacted for unpublished data. RESULTS: We identified 26 studies meeting eligibility criteria that included in the meta-analysis. CBM-I had moderate effects on negative and positive interpretations (g = -0.70 and g = -0.52, respectively) and a small but significant effect on anxiety assessed after training (g = -0.17) and after a stressor (g = -0.34). No significant moderators were identified. CONCLUSIONS: In contrast to previous meta-analytic findings, our results indicate that CBM-I has potential but weak anxiolytic effects in youth. Our findings suggest that it may be premature to disregard the potential value of CBM-I research and further research in this field is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Research Review: Cognitive bias modification of interpretations in youth and its effect on anxiety: a meta-analysis [Texte imprimé et/ou numérique] / G. KREBS, Auteur ; V. PILE, Auteur ; S. GRANT, Auteur ; M. DEGLI ESPOSTI, Auteur ; P. MONTGOMERY, Auteur ; J. Y. F. LAU, Auteur . - p.831-844. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.831-844 Mots-clés : Cognitive bias modification  adolescents  anxiety  children  interpretation bias training Index. décimale : PER Périodiques Résumé : BACKGROUND: Emerging evidence suggests that cognitive bias modification of interpretations (CBM-I) is effective in altering interpretation biases and reducing anxiety in adults. Less is known about the impact of CBM-I in young people, but some recent findings, including a meta-analysis of combined cognitive bias modification of interpretation and attention techniques, have cast doubt on its clinical utility. Given the current debate, this meta-analysis sought to establish the independent effects of CBM-I on interpretations biases and anxiety in youth. METHODS: Studies were identified through a systematic literature search of PsycINFO, Ovid MEDLINE, PsycARTICLES, Web of Science and EMBASE between January 1992 and March 2017. Eligible studies aimed to target interpretation biases; did not combine CBM-I with another intervention; included a control condition; randomly allocated participants to conditions; assessed interpretation bias and/or anxiety as an outcome; included individuals up to age 18; and did not present previously reported data. Reference lists of included articles were checked for further eligible studies, and authors were contacted for unpublished data. RESULTS: We identified 26 studies meeting eligibility criteria that included in the meta-analysis. CBM-I had moderate effects on negative and positive interpretations (g = -0.70 and g = -0.52, respectively) and a small but significant effect on anxiety assessed after training (g = -0.17) and after a stressor (g = -0.34). No significant moderators were identified. CONCLUSIONS: In contrast to previous meta-analytic findings, our results indicate that CBM-I has potential but weak anxiolytic effects in youth. Our findings suggest that it may be premature to disregard the potential value of CBM-I research and further research in this field is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample / E. C. DUNN in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.845-854 Titre : Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample Type de document : Texte imprimé et/ou numérique Auteurs : E. C. DUNN, Auteur ; Katherine M. CRAWFORD, Auteur ; T. W. SOARE, Auteur ; K. S. BUTTON, Auteur ; M. R. RAFFELD, Auteur ; Adac SMITH, Auteur ; I. S. PENTON-VOAK, Auteur ; M. R. MUNAFO, Auteur Article en page(s) : p.845-854 Langues : Anglais (eng) Mots-clés : Alspac  Sensitive periods  adversity  children  emotion recognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk samples have consistently shown that children exposed to adversity are more likely than their unexposed peers to have emotion recognition skills deficits. However, only one population-based study has examined this association. METHODS: We analyzed data from children participating in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort (n = 6,506). We examined the association between eight adversities, assessed repeatedly from birth to age 8 (caregiver physical or emotional abuse; sexual or physical abuse; maternal psychopathology; one adult in the household; family instability; financial stress; parent legal problems; neighborhood disadvantage) and the ability to recognize facial displays of emotion measured using the faces subtest of the Diagnostic Assessment of Non-Verbal Accuracy (DANVA) at age 8.5 years. In addition to examining the role of exposure (vs. nonexposure) to each type of adversity, we also evaluated the role of the timing, duration, and recency of each adversity using a Least Angle Regression variable selection procedure. RESULTS: Over three-quarters of the sample experienced at least one adversity. We found no evidence to support an association between emotion recognition deficits and previous exposure to adversity, either in terms of total lifetime exposure, timing, duration, or recency, or when stratifying by sex. CONCLUSIONS: Results from the largest population-based sample suggest that even extreme forms of adversity are unrelated to emotion recognition deficits as measured by the DANVA, suggesting the possible immutability of emotion recognition in the general population. These findings emphasize the importance of population-based studies to generate generalizable results. En ligne : http://dx.doi.org/10.1111/jcpp.12881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample [Texte imprimé et/ou numérique] / E. C. DUNN, Auteur ; Katherine M. CRAWFORD, Auteur ; T. W. SOARE, Auteur ; K. S. BUTTON, Auteur ; M. R. RAFFELD, Auteur ; Adac SMITH, Auteur ; I. S. PENTON-VOAK, Auteur ; M. R. MUNAFO, Auteur . - p.845-854. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.845-854 Mots-clés : Alspac  Sensitive periods  adversity  children  emotion recognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk samples have consistently shown that children exposed to adversity are more likely than their unexposed peers to have emotion recognition skills deficits. However, only one population-based study has examined this association. METHODS: We analyzed data from children participating in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort (n = 6,506). We examined the association between eight adversities, assessed repeatedly from birth to age 8 (caregiver physical or emotional abuse; sexual or physical abuse; maternal psychopathology; one adult in the household; family instability; financial stress; parent legal problems; neighborhood disadvantage) and the ability to recognize facial displays of emotion measured using the faces subtest of the Diagnostic Assessment of Non-Verbal Accuracy (DANVA) at age 8.5 years. In addition to examining the role of exposure (vs. nonexposure) to each type of adversity, we also evaluated the role of the timing, duration, and recency of each adversity using a Least Angle Regression variable selection procedure. RESULTS: Over three-quarters of the sample experienced at least one adversity. We found no evidence to support an association between emotion recognition deficits and previous exposure to adversity, either in terms of total lifetime exposure, timing, duration, or recency, or when stratifying by sex. CONCLUSIONS: Results from the largest population-based sample suggest that even extreme forms of adversity are unrelated to emotion recognition deficits as measured by the DANVA, suggesting the possible immutability of emotion recognition in the general population. These findings emphasize the importance of population-based studies to generate generalizable results. En ligne : http://dx.doi.org/10.1111/jcpp.12881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Transdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study / C. C. CONWAY in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.855-862 Titre : Transdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study Type de document : Texte imprimé et/ou numérique Auteurs : C. C. CONWAY, Auteur ; E. B. RAPOSA, Auteur ; C. HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.855-862 Langues : Anglais (eng) Mots-clés : Classification  comorbidity  early adversity  stress  transdiagnostic Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse family environments confer susceptibility to virtually all psychiatric problems. This study evaluated two possible models to explain this diversity of associations. Stressful family circumstances during childhood could either activate general, transdiagnostic liabilities to mental disorder or promote numerous disorder-specific liabilities. METHODS: We recruited a high-risk sample of 815 mother-offspring pairs and assessed social stressors in the family context prospectively from the perinatal period through offspring age 5. We factor analyzed offspring mental disorder diagnoses at age 20 to parse transdiagnostic and disorder-specific dimensions of psychopathology. RESULTS: Structural analyses revealed nearly equivalent prospective effects of early family stress on overarching Internalizing (beta = .30) and Externalizing (beta = .29) dimensions. In contrast, there was no evidence of disorder-specific effects. CONCLUSIONS: Social stressors early in life activate transdiagnostic, and not disorder-specific, liabilities to psychopathology. A focus on higher-order dimensions of psychopathology could accelerate etiological research and intervention efforts for stress-linked mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12862 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Transdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study [Texte imprimé et/ou numérique] / C. C. CONWAY, Auteur ; E. B. RAPOSA, Auteur ; C. HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.855-862. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.855-862 Mots-clés : Classification  comorbidity  early adversity  stress  transdiagnostic Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse family environments confer susceptibility to virtually all psychiatric problems. This study evaluated two possible models to explain this diversity of associations. Stressful family circumstances during childhood could either activate general, transdiagnostic liabilities to mental disorder or promote numerous disorder-specific liabilities. METHODS: We recruited a high-risk sample of 815 mother-offspring pairs and assessed social stressors in the family context prospectively from the perinatal period through offspring age 5. We factor analyzed offspring mental disorder diagnoses at age 20 to parse transdiagnostic and disorder-specific dimensions of psychopathology. RESULTS: Structural analyses revealed nearly equivalent prospective effects of early family stress on overarching Internalizing (beta = .30) and Externalizing (beta = .29) dimensions. In contrast, there was no evidence of disorder-specific effects. CONCLUSIONS: Social stressors early in life activate transdiagnostic, and not disorder-specific, liabilities to psychopathology. A focus on higher-order dimensions of psychopathology could accelerate etiological research and intervention efforts for stress-linked mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12862 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample / M. RYDELL in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.863-871 Titre : Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample Type de document : Texte imprimé et/ou numérique Auteurs : M. RYDELL, Auteur ; S. LUNDSTRÖM, Auteur ; C. GILLBERG, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur Article en page(s) : p.863-871 Langues : Anglais (eng) Mots-clés : Adhd  epidemiology  lifetime prevalence  time trends Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies have reported increases in clinically diagnosed and treated attention deficit hyperactivity disorder (ADHD) during the last decade, but it is unclear if this reflects an increase in the underlying ADHD phenotype. We aimed to clarify if there has been an increase in the prevalence of ADHD-like traits in the general population from 2004 to 2014. METHOD: Data were collected from 9-year-old twins (19,271), participating in the population-based Child and Adolescent Twin Study in Sweden between 2004 and 2014. We assessed lifetime ADHD symptoms using the Autism-Tics, ADHD and other Comorbidities inventory. Research proxies for diagnostic-level ADHD and subthreshold ADHD were derived from this scale. We modeled the lifetime prevalence of diagnostic-level and subthreshold ADHD with logistic regression, and assessed mean ADHD scores each year with linear regression. Lifetime prevalence of clinically diagnosed ADHD was retrieved from the National Patient Register and modeled with logistic regression. RESULTS: The prevalence of diagnostic-level ADHD based on parent ratings did not differ significantly over time from 2004 to 2014 (OR 1.37; 95% CI: 0.77-2.45; p-value .233). Both subthreshold ADHD and mean ADHD scores increased significantly over time (both p-values <.001). Clinically diagnosed ADHD increased more than fivefold from 2004 to 2014 (OR 5.27, 95% CI: 1.85-14.96). CONCLUSIONS: We found no evidence of an increase in ADHD-like traits at the extreme end of the distribution from 2004 to 2014, but small increases in normal and subthreshold variations of ADHD-like traits were observed. This suggests that the increased rates of clinically diagnosed ADHD might reflect changes in diagnostic and treatment practices of ADHD, administrative changes in reporting diagnoses, greater awareness of ADHD, better access to healthcare, or current overdiagnosis, rather than an increase in the ADHD phenotype. En ligne : http://dx.doi.org/10.1111/jcpp.12882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Has the attention deficit hyperactivity disorder phenotype become more common in children between 2004 and 2014? Trends over 10 years from a Swedish general population sample [Texte imprimé et/ou numérique] / M. RYDELL, Auteur ; S. LUNDSTRÖM, Auteur ; C. GILLBERG, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur . - p.863-871. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.863-871 Mots-clés : Adhd  epidemiology  lifetime prevalence  time trends Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies have reported increases in clinically diagnosed and treated attention deficit hyperactivity disorder (ADHD) during the last decade, but it is unclear if this reflects an increase in the underlying ADHD phenotype. We aimed to clarify if there has been an increase in the prevalence of ADHD-like traits in the general population from 2004 to 2014. METHOD: Data were collected from 9-year-old twins (19,271), participating in the population-based Child and Adolescent Twin Study in Sweden between 2004 and 2014. We assessed lifetime ADHD symptoms using the Autism-Tics, ADHD and other Comorbidities inventory. Research proxies for diagnostic-level ADHD and subthreshold ADHD were derived from this scale. We modeled the lifetime prevalence of diagnostic-level and subthreshold ADHD with logistic regression, and assessed mean ADHD scores each year with linear regression. Lifetime prevalence of clinically diagnosed ADHD was retrieved from the National Patient Register and modeled with logistic regression. RESULTS: The prevalence of diagnostic-level ADHD based on parent ratings did not differ significantly over time from 2004 to 2014 (OR 1.37; 95% CI: 0.77-2.45; p-value .233). Both subthreshold ADHD and mean ADHD scores increased significantly over time (both p-values <.001). Clinically diagnosed ADHD increased more than fivefold from 2004 to 2014 (OR 5.27, 95% CI: 1.85-14.96). CONCLUSIONS: We found no evidence of an increase in ADHD-like traits at the extreme end of the distribution from 2004 to 2014, but small increases in normal and subthreshold variations of ADHD-like traits were observed. This suggests that the increased rates of clinically diagnosed ADHD might reflect changes in diagnostic and treatment practices of ADHD, administrative changes in reporting diagnoses, greater awareness of ADHD, better access to healthcare, or current overdiagnosis, rather than an increase in the ADHD phenotype. En ligne : http://dx.doi.org/10.1111/jcpp.12882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age / T. FALCK-YTTER in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.872-880 Titre : Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age Type de document : Texte imprimé et/ou numérique Auteurs : T. FALCK-YTTER, Auteur ; P. NYSTROM, Auteur ; G. GREDEBACK, Auteur ; T. GLIGA, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.872-880 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  biological motion  biomarker  infancy  multisensory processing  scientific replication Index. décimale : PER Périodiques Résumé : BACKGROUND: Effective multisensory processing develops in infancy and is thought to be important for the perception of unified and multimodal objects and events. Previous research suggests impaired multisensory processing in autism, but its role in the early development of the disorder is yet uncertain. Here, using a prospective longitudinal design, we tested whether reduced visual attention to audiovisual synchrony is an infant marker of later-emerging autism diagnosis. METHODS: We studied 10-month-old siblings of children with autism using an eye tracking task previously used in studies of preschoolers. The task assessed the effect of manipulations of audiovisual synchrony on viewing patterns while the infants were observing point light displays of biological motion. We analyzed the gaze data recorded in infancy according to diagnostic status at 3 years of age (DSM-5). RESULTS: Ten-month-old infants who later received an autism diagnosis did not orient to audiovisual synchrony expressed within biological motion. In contrast, both infants at low-risk and high-risk siblings without autism at follow-up had a strong preference for this type of information. No group differences were observed in terms of orienting to upright biological motion. CONCLUSIONS: This study suggests that reduced orienting to audiovisual synchrony within biological motion is an early sign of autism. The findings support the view that poor multisensory processing could be an important antecedent marker of this neurodevelopmental condition. En ligne : http://dx.doi.org/10.1111/jcpp.12863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age [Texte imprimé et/ou numérique] / T. FALCK-YTTER, Auteur ; P. NYSTROM, Auteur ; G. GREDEBACK, Auteur ; T. GLIGA, Auteur ; Sven BÖLTE, Auteur . - p.872-880. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.872-880 Mots-clés : Autism spectrum disorder  biological motion  biomarker  infancy  multisensory processing  scientific replication Index. décimale : PER Périodiques Résumé : BACKGROUND: Effective multisensory processing develops in infancy and is thought to be important for the perception of unified and multimodal objects and events. Previous research suggests impaired multisensory processing in autism, but its role in the early development of the disorder is yet uncertain. Here, using a prospective longitudinal design, we tested whether reduced visual attention to audiovisual synchrony is an infant marker of later-emerging autism diagnosis. METHODS: We studied 10-month-old siblings of children with autism using an eye tracking task previously used in studies of preschoolers. The task assessed the effect of manipulations of audiovisual synchrony on viewing patterns while the infants were observing point light displays of biological motion. We analyzed the gaze data recorded in infancy according to diagnostic status at 3 years of age (DSM-5). RESULTS: Ten-month-old infants who later received an autism diagnosis did not orient to audiovisual synchrony expressed within biological motion. In contrast, both infants at low-risk and high-risk siblings without autism at follow-up had a strong preference for this type of information. No group differences were observed in terms of orienting to upright biological motion. CONCLUSIONS: This study suggests that reduced orienting to audiovisual synchrony within biological motion is an early sign of autism. The findings support the view that poor multisensory processing could be an important antecedent marker of this neurodevelopmental condition. En ligne : http://dx.doi.org/10.1111/jcpp.12863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury / M. CASSELS in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.881-887 Titre : Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury Type de document : Texte imprimé et/ou numérique Auteurs : M. CASSELS, Auteur ; A. L. VAN HARMELEN, Auteur ; S. NEUFELD, Auteur ; I. GOODYER, Auteur ; P. B. JONES, Auteur ; P. WILKINSON, Auteur Article en page(s) : p.881-887 Langues : Anglais (eng) Mots-clés : Family functioning  adolescence  adversity  self-harm  self-injury Index. décimale : PER Périodiques Résumé : BACKGROUND: Non-suicidal self-injury (NSSI) is a common harmful behavior during adolescence. Exposure to childhood family adversity (CFA) is associated with subsequent emergence of NSSI during adolescence. However, the pathways through which this early environmental risk may operate are not clear. AIMS: We tested four alternative hypotheses to explain the association between CFA and adolescent-onset NSSI. METHODS: A community sample of n = 933 fourteen year olds with no history of NSSI were followed up for 3 years. RESULTS: Poor family functioning at age 14 mediated the association between CFA before age 5 and subsequent onset of NSSI between 14 and 17 years. CONCLUSIONS: The findings support the cumulative suboptimal environmental hazards (proximal family relationships as a mediator) hypothesis. Improving the family environment at age 14 may mitigate the effects of CFA on adolescent onset of NSSI. En ligne : http://dx.doi.org/10.1111/jcpp.12866 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury [Texte imprimé et/ou numérique] / M. CASSELS, Auteur ; A. L. VAN HARMELEN, Auteur ; S. NEUFELD, Auteur ; I. GOODYER, Auteur ; P. B. JONES, Auteur ; P. WILKINSON, Auteur . - p.881-887. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.881-887 Mots-clés : Family functioning  adolescence  adversity  self-harm  self-injury Index. décimale : PER Périodiques Résumé : BACKGROUND: Non-suicidal self-injury (NSSI) is a common harmful behavior during adolescence. Exposure to childhood family adversity (CFA) is associated with subsequent emergence of NSSI during adolescence. However, the pathways through which this early environmental risk may operate are not clear. AIMS: We tested four alternative hypotheses to explain the association between CFA and adolescent-onset NSSI. METHODS: A community sample of n = 933 fourteen year olds with no history of NSSI were followed up for 3 years. RESULTS: Poor family functioning at age 14 mediated the association between CFA before age 5 and subsequent onset of NSSI between 14 and 17 years. CONCLUSIONS: The findings support the cumulative suboptimal environmental hazards (proximal family relationships as a mediator) hypothesis. Improving the family environment at age 14 may mitigate the effects of CFA on adolescent onset of NSSI. En ligne : http://dx.doi.org/10.1111/jcpp.12866 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Delay aversion in attention deficit/hyperactivity disorder is mediated by amygdala and prefrontal cortex hyper-activation / J. VAN DESSEL in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.888-899 Titre : Delay aversion in attention deficit/hyperactivity disorder is mediated by amygdala and prefrontal cortex hyper-activation Type de document : Texte imprimé et/ou numérique Auteurs : J. VAN DESSEL, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; G. MIES, Auteur ; J. LEMIERE, Auteur ; S. VAN DER OORD, Auteur ; S. MORSINK, Auteur ; M. DANCKAERTS, Auteur Article en page(s) : p.888-899 Langues : Anglais (eng) Mots-clés : fMRI  Attention deficit/hyperactivity disorder  affective network  amygdala  delay aversion  dorsolateral prefrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Experimental research supports delay aversion as a motivational feature of attention deficit/hyperactivity disorder (ADHD). To investigate the neurobiology of delay aversion in ADHD, this study examined whether adolescents with ADHD display an unusually strong activation in affective brain regions in response to cues predicting forthcoming delay and whether these effects are (a) delay-dose dependent and (b) statistically mediate the association between ADHD and self-reported delay aversion. METHODS: Twenty-nine right-handed male adolescents with combined type ADHD and 32 typically developing controls (ages 10-18 years) performed a reaction time task in an MRI scanner. Pretarget cues indicated delay-related response consequences. One indicated that delay would follow the response irrespective of response speed (CERTAIN DELAY), a second that delay would only follow if the response was too slow (CONDITIONAL DELAY), and a third that no delay would follow the response whatever its speed (NO DELAY). Delay levels were 2, 6, or 14 s. Participants also rated their own delay aversion in everyday life. RESULTS: Individuals with ADHD rated themselves as more delay averse than controls. Significantly greater activation to CERTAIN DELAY cues relative to NO DELAY cues was found in participants with ADHD compared to controls (bilaterally) in amygdala, anterior insula, temporal pole, dorsolateral prefrontal cortex (DLPFC), and ventromedial prefrontal cortex. Amygdala and DLPFC activation strength were strongly and delay-dose dependently correlated with delay aversion ratings, and statistically mediated the relationship between ADHD status and delay aversion. CONCLUSIONS: When presented with cues predicting impending delay, adolescents with ADHD, relative to controls, displayed a delay-related increase in activation in amygdala and DLPFC, regions known to be implicated in the processing of aversive events. Future studies should examine the specificity of these effects to delay aversion compared to aversive events in general. En ligne : http://dx.doi.org/10.1111/jcpp.12868 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Delay aversion in attention deficit/hyperactivity disorder is mediated by amygdala and prefrontal cortex hyper-activation [Texte imprimé et/ou numérique] / J. VAN DESSEL, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; G. MIES, Auteur ; J. LEMIERE, Auteur ; S. VAN DER OORD, Auteur ; S. MORSINK, Auteur ; M. DANCKAERTS, Auteur . - p.888-899. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.888-899 Mots-clés : fMRI  Attention deficit/hyperactivity disorder  affective network  amygdala  delay aversion  dorsolateral prefrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Experimental research supports delay aversion as a motivational feature of attention deficit/hyperactivity disorder (ADHD). To investigate the neurobiology of delay aversion in ADHD, this study examined whether adolescents with ADHD display an unusually strong activation in affective brain regions in response to cues predicting forthcoming delay and whether these effects are (a) delay-dose dependent and (b) statistically mediate the association between ADHD and self-reported delay aversion. METHODS: Twenty-nine right-handed male adolescents with combined type ADHD and 32 typically developing controls (ages 10-18 years) performed a reaction time task in an MRI scanner. Pretarget cues indicated delay-related response consequences. One indicated that delay would follow the response irrespective of response speed (CERTAIN DELAY), a second that delay would only follow if the response was too slow (CONDITIONAL DELAY), and a third that no delay would follow the response whatever its speed (NO DELAY). Delay levels were 2, 6, or 14 s. Participants also rated their own delay aversion in everyday life. RESULTS: Individuals with ADHD rated themselves as more delay averse than controls. Significantly greater activation to CERTAIN DELAY cues relative to NO DELAY cues was found in participants with ADHD compared to controls (bilaterally) in amygdala, anterior insula, temporal pole, dorsolateral prefrontal cortex (DLPFC), and ventromedial prefrontal cortex. Amygdala and DLPFC activation strength were strongly and delay-dose dependently correlated with delay aversion ratings, and statistically mediated the relationship between ADHD status and delay aversion. CONCLUSIONS: When presented with cues predicting impending delay, adolescents with ADHD, relative to controls, displayed a delay-related increase in activation in amygdala and DLPFC, regions known to be implicated in the processing of aversive events. Future studies should examine the specificity of these effects to delay aversion compared to aversive events in general. En ligne : http://dx.doi.org/10.1111/jcpp.12868 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Decreased anterior cingulate activation in a motor task in youths with bipolar disorder / J. B. KING in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907 Titre : Decreased anterior cingulate activation in a motor task in youths with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur Article en page(s) : p.900-907 Langues : Anglais (eng) Mots-clés : Bipolar disorder  adolescents  anterior cingulate  fMRI  finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Decreased anterior cingulate activation in a motor task in youths with bipolar disorder [Texte imprimé et/ou numérique] / J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur . - p.900-907. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907 Mots-clés : Bipolar disorder  adolescents  anterior cingulate  fMRI  finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population / J. MARTIN in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.908-916 Titre : Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population Type de document : Texte imprimé et/ou numérique Auteurs : J. MARTIN, Auteur ; M. J. TAYLOR, Auteur ; M. RYDELL, Auteur ; L. RIGLIN, Auteur ; O. EYRE, Auteur ; Y. LU, Auteur ; S. LUNDSTRÖM, Auteur ; H. LARSSON, Auteur ; A. THAPAR, Auteur ; P. LICHTENSTEIN, Auteur Article en page(s) : p.908-916 Langues : Anglais (eng) Mots-clés : Adhd  Alspac  Catss  anxiety  depression  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. METHODS: We tested these two hypotheses, using common variant genetic data from two population-based cohorts. First, we tested whether females and males diagnosed with anxiety or depression differ in terms of their genetic risk for ADHD, assessed as polygenic risk scores (PRS). Second, we tested whether females and males with ADHD differed in ADHD genetic risk burden. We used three different diagnostic definitions: registry-based clinical diagnoses, screening-based research diagnoses and algorithm-based research diagnoses, to investigate possible referral biases. RESULTS: In individuals with a registry-based clinical diagnosis of anxiety or depression, females had higher ADHD PRS than males [OR(CI) = 1.39 (1.12-1.73)] but there was no sex difference for screening-based [OR(CI) = 1.15 (0.94-1.42)] or algorithm-based [OR(CI) = 1.04 (0.89-1.21)] diagnoses. There was also no sex difference in ADHD PRS in individuals with ADHD diagnoses that were registry-based [OR(CI) = 1.04 (0.84-1.30)], screening-based [OR(CI) = 0.96 (0.85-1.08)] or algorithm-based [OR(CI) = 1.15 (0.78-1.68)]. CONCLUSIONS: This study provides genetic evidence that ADHD risk may be more likely to manifest or be diagnosed as anxiety or depression in females than in males. Contrary to some earlier studies, the results do not support increased ADHD genetic risk in females with ADHD as compared to affected males. En ligne : http://dx.doi.org/10.1111/jcpp.12874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population [Texte imprimé et/ou numérique] / J. MARTIN, Auteur ; M. J. TAYLOR, Auteur ; M. RYDELL, Auteur ; L. RIGLIN, Auteur ; O. EYRE, Auteur ; Y. LU, Auteur ; S. LUNDSTRÖM, Auteur ; H. LARSSON, Auteur ; A. THAPAR, Auteur ; P. LICHTENSTEIN, Auteur . - p.908-916. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.908-916 Mots-clés : Adhd  Alspac  Catss  anxiety  depression  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. METHODS: We tested these two hypotheses, using common variant genetic data from two population-based cohorts. First, we tested whether females and males diagnosed with anxiety or depression differ in terms of their genetic risk for ADHD, assessed as polygenic risk scores (PRS). Second, we tested whether females and males with ADHD differed in ADHD genetic risk burden. We used three different diagnostic definitions: registry-based clinical diagnoses, screening-based research diagnoses and algorithm-based research diagnoses, to investigate possible referral biases. RESULTS: In individuals with a registry-based clinical diagnosis of anxiety or depression, females had higher ADHD PRS than males [OR(CI) = 1.39 (1.12-1.73)] but there was no sex difference for screening-based [OR(CI) = 1.15 (0.94-1.42)] or algorithm-based [OR(CI) = 1.04 (0.89-1.21)] diagnoses. There was also no sex difference in ADHD PRS in individuals with ADHD diagnoses that were registry-based [OR(CI) = 1.04 (0.84-1.30)], screening-based [OR(CI) = 0.96 (0.85-1.08)] or algorithm-based [OR(CI) = 1.15 (0.78-1.68)]. CONCLUSIONS: This study provides genetic evidence that ADHD risk may be more likely to manifest or be diagnosed as anxiety or depression in females than in males. Contrary to some earlier studies, the results do not support increased ADHD genetic risk in females with ADHD as compared to affected males. En ligne : http://dx.doi.org/10.1111/jcpp.12874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder / R. GANZOLA in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927 Titre : Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. GANZOLA, Auteur ; A. M. MCINTOSH, Auteur ; T. NICKSON, Auteur ; E. SPROOTEN, Auteur ; M. E. BASTIN, Auteur ; S. GILES, Auteur ; A. MACDONALD, Auteur ; J. SUSSMANN, Auteur ; S. DUCHESNE, Auteur ; H. C. WHALLEY, Auteur Article en page(s) : p.917-927 Langues : Anglais (eng) Mots-clés : Bipolar disorder  fractional anisotropy  high-familial risk  major depressive disorder  white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder [Texte imprimé et/ou numérique] / R. GANZOLA, Auteur ; A. M. MCINTOSH, Auteur ; T. NICKSON, Auteur ; E. SPROOTEN, Auteur ; M. E. BASTIN, Auteur ; S. GILES, Auteur ; A. MACDONALD, Auteur ; J. SUSSMANN, Auteur ; S. DUCHESNE, Auteur ; H. C. WHALLEY, Auteur . - p.917-927. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.917-927 Mots-clés : Bipolar disorder  fractional anisotropy  high-familial risk  major depressive disorder  white matter integrity Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart. This study used baseline imaging data, categorizing groups according to clinical outcome at follow-up. Diffusion tensor MRI data were acquired for 61 controls and 106 high-risk individuals, the latter divided into 78 high-risk subjects who remained well throughout the study ('high-risk well') and 28 individuals who subsequently developed MDD ('high-risk MDD'). Voxel-wise between-group comparison of fractional anisotropy (FA) based on diagnostic status was performed using tract-based spatial statistics (TBSS). RESULTS: Compared to controls, both high-risk groups showed widespread decreases in FA (pcorr < .05) at baseline. Although FA in the high-risk MDD group negatively correlated with subthreshold depressive symptoms at the time of scanning (pcorr < .05), there were no statistically significant differences at p-corrected levels between the two high-risk groups. CONCLUSIONS: These results suggest that decreased FA is related to the presence of familial risk for mood disorder along with subdiagnostic symptoms at the time of scanning rather than predictive of subsequent diagnosis. Due to the difficulties performing such longitudinal prospective studies, we note, however, that this latter analysis may be underpowered due to sample size within the high-risk MDD group. Further clinical follow-up may clarify these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12879 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368