Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders / Lauren CORNEW in Journal of Autism and Developmental Disorders, 42-12 (December 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2611-2621 Titre : Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lauren CORNEW, Auteur ; Karen R. DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Joseph P. MCCLEERY, Auteur ; Leslie J. CARVER, Auteur Année de publication : 2012 Article en page(s) : p.2611-2621 Langues : Anglais (eng) Mots-clés : Autism  Social referencing  Joint attention  Behavior regulation Index. décimale : PER Périodiques Résumé : Social referencing was investigated in 18-month-old siblings of children with autism spectrum disorders (ASD; 'high-risk infants'). Infants were exposed to novel toys, which were emotionally tagged via adults' facial and vocal signals. Infants' information seeking (initiation of joint attention with an adult) and their approach/withdrawal behavior toward the toys before versus after the adults' emotional signals was measured. Compared to both typically developing infants and high-risk infants without ASD, infants later diagnosed with ASD engaged in slower information seeking, suggesting that this aspect of referencing may be an early indicator of ASD. High-risk infants, both those who were and those who were not later diagnosed with ASD, exhibited impairments in regulating their behavior based on the adults' emotional signals, suggesting that this aspect of social referencing may reflect an endophenotype for ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1518-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184 [article] Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lauren CORNEW, Auteur ; Karen R. DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Joseph P. MCCLEERY, Auteur ; Leslie J. CARVER, Auteur . - 2012 . - p.2611-2621. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2611-2621 Mots-clés : Autism  Social referencing  Joint attention  Behavior regulation Index. décimale : PER Périodiques Résumé : Social referencing was investigated in 18-month-old siblings of children with autism spectrum disorders (ASD; 'high-risk infants'). Infants were exposed to novel toys, which were emotionally tagged via adults' facial and vocal signals. Infants' information seeking (initiation of joint attention with an adult) and their approach/withdrawal behavior toward the toys before versus after the adults' emotional signals was measured. Compared to both typically developing infants and high-risk infants without ASD, infants later diagnosed with ASD engaged in slower information seeking, suggesting that this aspect of referencing may be an early indicator of ASD. High-risk infants, both those who were and those who were not later diagnosed with ASD, exhibited impairments in regulating their behavior based on the adults' emotional signals, suggesting that this aspect of social referencing may reflect an endophenotype for ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1518-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184

Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Titre : Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.395-405 Langues : Anglais (eng) Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / J. Christopher EDGAR, Auteur ; Sarah Y. KHAN, Auteur ; Lisa BLASKEY, Auteur ; Vivian Y. CHOW, Auteur ; Michael REY, Auteur ; William GAETZ, Auteur ; Katelyn M. CANNON, Auteur ; Justin F. MONROE, Auteur ; Lauren CORNEW, Auteur ; Saba QASMIEH, Auteur ; Song LIU, Auteur ; John P. WELSH, Auteur ; Susan E. LEVY, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.395-405. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.395-405 Mots-clés : Auditory  Autism spectrum disorders  M100  Gamma  Evoked  Inter-trial coherence  Phase-locking  Magnetoencephalography Index. décimale : PER Périodiques Résumé : Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a ‘core’ abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate ‘neural tone’ and an inability to rapidly return to a resting state prior to the next stimulus. En ligne : http://dx.doi.org/10.1007/s10803-013-1904-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Resting-State Oscillatory Activity in Autism Spectrum Disorders / Lauren CORNEW in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1884-1894 Titre : Resting-State Oscillatory Activity in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lauren CORNEW, Auteur ; Timothy P.L. ROBERTS, Auteur ; Lisa BLASKEY, Auteur ; J. Christopher EDGAR, Auteur Année de publication : 2012 Article en page(s) : p.1884-1894 Langues : Anglais (eng) Mots-clés : Autism  Magnetoencephalography  Resting-state  Oscillations  Alpha  Gamma Index. décimale : PER Périodiques Résumé : Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and high frequency (20–120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest. En ligne : http://dx.doi.org/10.1007/s10803-011-1431-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Resting-State Oscillatory Activity in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lauren CORNEW, Auteur ; Timothy P.L. ROBERTS, Auteur ; Lisa BLASKEY, Auteur ; J. Christopher EDGAR, Auteur . - 2012 . - p.1884-1894. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1884-1894 Mots-clés : Autism  Magnetoencephalography  Resting-state  Oscillations  Alpha  Gamma Index. décimale : PER Périodiques Résumé : Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and high frequency (20–120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest. En ligne : http://dx.doi.org/10.1007/s10803-011-1431-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

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