Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome / Lauren M. MCGRATH in Journal of Autism and Developmental Disorders, 46-6 (June 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2174-2185 Titre : Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. MCGRATH, Auteur ; Joyce M. OATES, Auteur ; Yael G. DAI, Auteur ; Helen F. DODD, Auteur ; Jessica L. WAXLER, Auteur ; Caitlin C. CLEMENTS, Auteur ; Sydney WEILL, Auteur ; Alison HOFFNAGLE, Auteur ; Erin ANDERSON, Auteur ; Rebecca MACRAE, Auteur ; Jennifer MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur ; Barbara R. POBER, Auteur ; Jordan W. SMOLLER, Auteur Article en page(s) : p.2174-2185 Langues : Anglais (eng) Mots-clés : Williams syndrome  Anxiety  Attention bias  Social dot-probe  Emotional faces Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) often experience significant anxiety. A promising approach to anxiety intervention has emerged from cognitive studies of attention bias to threat. To investigate the utility of this intervention in WS, this study examined attention bias to happy and angry faces in individuals with WS (N = 46). Results showed a significant difference in attention bias patterns as a function of IQ and anxiety. Individuals with higher IQ or higher anxiety showed a significant bias toward angry, but not happy faces, whereas individuals with lower IQ or lower anxiety showed the opposite pattern. These results suggest that attention bias interventions to modify a threat bias may be most effectively targeted to anxious individuals with WS with relatively high IQ. En ligne : http://dx.doi.org/10.1007/s10803-016-2748-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome [Texte imprimé et/ou numérique] / Lauren M. MCGRATH, Auteur ; Joyce M. OATES, Auteur ; Yael G. DAI, Auteur ; Helen F. DODD, Auteur ; Jessica L. WAXLER, Auteur ; Caitlin C. CLEMENTS, Auteur ; Sydney WEILL, Auteur ; Alison HOFFNAGLE, Auteur ; Erin ANDERSON, Auteur ; Rebecca MACRAE, Auteur ; Jennifer MULLETT, Auteur ; Christopher J. MCDOUGLE, Auteur ; Barbara R. POBER, Auteur ; Jordan W. SMOLLER, Auteur . - p.2174-2185. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2174-2185 Mots-clés : Williams syndrome  Anxiety  Attention bias  Social dot-probe  Emotional faces Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) often experience significant anxiety. A promising approach to anxiety intervention has emerged from cognitive studies of attention bias to threat. To investigate the utility of this intervention in WS, this study examined attention bias to happy and angry faces in individuals with WS (N = 46). Results showed a significant difference in attention bias patterns as a function of IQ and anxiety. Individuals with higher IQ or higher anxiety showed a significant bias toward angry, but not happy faces, whereas individuals with lower IQ or lower anxiety showed the opposite pattern. These results suggest that attention bias interventions to modify a threat bias may be most effectively targeted to anxious individuals with WS with relatively high IQ. En ligne : http://dx.doi.org/10.1007/s10803-016-2748-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Bringing a developmental perspective to anxiety genetics / Lauren M. MCGRATH in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1179-1193 Titre : Bringing a developmental perspective to anxiety genetics Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. MCGRATH, Auteur ; Sydney WEILL, Auteur ; Elise B. ROBINSON, Auteur ; Rebecca MACRAE, Auteur ; Jordan W. SMOLLER, Auteur Année de publication : 2012 Article en page(s) : p.1179-1193 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Despite substantial recent advancements in psychiatric genetic research, progress in identifying the genetic basis of anxiety disorders has been limited. We review the candidate gene and genome-wide literatures in anxiety, which have made limited progress to date. We discuss several reasons for this hindered progress, including small samples sizes, heterogeneity, complicated comorbidity profiles, and blurred lines between normative and pathological anxiety. To address many of these challenges, we suggest a developmental, multivariate framework that can inform and enhance anxiety phenotypes for genetic research. We review the psychiatric and genetic epidemiological evidence that supports such a framework, including the early onset and chronic course of anxiety disorders, shared genetic risk factors among disorders both within and across time, and developmentally dynamic genetic influences. We propose three strategies for developmentally sensitive phenotyping: examination of early temperamental risk factors, use of latent factors to model underlying anxiety liability, and use of developmental trajectories as phenotypes. Expanding the range of phenotypic approaches will be important for advancing studies of the genetic architecture of anxiety disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Bringing a developmental perspective to anxiety genetics [Texte imprimé et/ou numérique] / Lauren M. MCGRATH, Auteur ; Sydney WEILL, Auteur ; Elise B. ROBINSON, Auteur ; Rebecca MACRAE, Auteur ; Jordan W. SMOLLER, Auteur . - 2012 . - p.1179-1193. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1179-1193 Index. décimale : PER Périodiques Résumé : Despite substantial recent advancements in psychiatric genetic research, progress in identifying the genetic basis of anxiety disorders has been limited. We review the candidate gene and genome-wide literatures in anxiety, which have made limited progress to date. We discuss several reasons for this hindered progress, including small samples sizes, heterogeneity, complicated comorbidity profiles, and blurred lines between normative and pathological anxiety. To address many of these challenges, we suggest a developmental, multivariate framework that can inform and enhance anxiety phenotypes for genetic research. We review the psychiatric and genetic epidemiological evidence that supports such a framework, including the early onset and chronic course of anxiety disorders, shared genetic risk factors among disorders both within and across time, and developmentally dynamic genetic influences. We propose three strategies for developmentally sensitive phenotyping: examination of early temperamental risk factors, use of latent factors to model underlying anxiety liability, and use of developmental trajectories as phenotypes. Expanding the range of phenotypic approaches will be important for advancing studies of the genetic architecture of anxiety disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

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