Adolescent age moderates genetic and environmental influences on parent–adolescent positivity and negativity: Implications for genotype–environment correlation / Kristine MARCEAU in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.149-166 Titre : Adolescent age moderates genetic and environmental influences on parent–adolescent positivity and negativity: Implications for genotype–environment correlation Type de document : texte imprimé Auteurs : Kristine MARCEAU, Auteur ; Valerie S. KNOPIK, Auteur ; Jenae M. NEIDERHISER, Auteur ; Paul LICHTENSTEIN, Auteur ; Erica L. SPOTTS, Auteur ; Jody M. GANIBAN, Auteur ; David REISS, Auteur Article en page(s) : p.149-166 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined how genotype–environment correlation processes differ as a function of adolescent age. We tested whether adolescent age moderates genetic and environmental influences on positivity and negativity in mother–adolescent and father–adolescent relationships using parallel samples of twin parents from the Twin and Offspring Study in Sweden and twin/sibling adolescents from the Nonshared Environment in Adolescent Development Study. We inferred differences in the role of passive and nonpassive genotype–environment correlation based on biometric moderation findings. The findings indicated that nonpassive gene–environment correlation played a stronger role for positivity in mother– and father–adolescent relationships in families with older adolescents than in families with younger adolescents, and that passive gene–environment correlation played a stronger role for positivity in the mother–adolescent relationship in families with younger adolescents than in families with older adolescents. Implications of these findings for the timing and targeting of interventions on family relationships are discussed. En ligne : http://dx.doi.org/10.1017/S0954579415000358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Adolescent age moderates genetic and environmental influences on parent–adolescent positivity and negativity: Implications for genotype–environment correlation [texte imprimé] / Kristine MARCEAU, Auteur ; Valerie S. KNOPIK, Auteur ; Jenae M. NEIDERHISER, Auteur ; Paul LICHTENSTEIN, Auteur ; Erica L. SPOTTS, Auteur ; Jody M. GANIBAN, Auteur ; David REISS, Auteur . - p.149-166. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.149-166 Index. décimale : PER Périodiques Résumé : We examined how genotype–environment correlation processes differ as a function of adolescent age. We tested whether adolescent age moderates genetic and environmental influences on positivity and negativity in mother–adolescent and father–adolescent relationships using parallel samples of twin parents from the Twin and Offspring Study in Sweden and twin/sibling adolescents from the Nonshared Environment in Adolescent Development Study. We inferred differences in the role of passive and nonpassive genotype–environment correlation based on biometric moderation findings. The findings indicated that nonpassive gene–environment correlation played a stronger role for positivity in mother– and father–adolescent relationships in families with older adolescents than in families with younger adolescents, and that passive gene–environment correlation played a stronger role for positivity in the mother–adolescent relationship in families with younger adolescents than in families with older adolescents. Implications of these findings for the timing and targeting of interventions on family relationships are discussed. En ligne : http://dx.doi.org/10.1017/S0954579415000358 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings / Max OWENS in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.385-397 Titre : Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings Type de document : texte imprimé Auteurs : Max OWENS, Auteur ; Ashley J. HARRISON, Auteur ; Katie L. BURKHOUSE, Auteur ; John E. MCGEARY, Auteur ; Valerie S. KNOPIK, Auteur ; Rohan H.C. PALMER, Auteur ; Brandon E. GIBB, Auteur Article en page(s) : p.385-397 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic–pituitary–adrenal axis reactivity. Participants included children (8–14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples. En ligne : http://dx.doi.org/10.1017/S0954579415000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings [texte imprimé] / Max OWENS, Auteur ; Ashley J. HARRISON, Auteur ; Katie L. BURKHOUSE, Auteur ; John E. MCGEARY, Auteur ; Valerie S. KNOPIK, Auteur ; Rohan H.C. PALMER, Auteur ; Brandon E. GIBB, Auteur . - p.385-397. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.385-397 Index. décimale : PER Périodiques Résumé : Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic–pituitary–adrenal axis reactivity. Participants included children (8–14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples. En ligne : http://dx.doi.org/10.1017/S0954579415000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Intergenerational transmission of psychopathology: An examination of symptom severity and directionality / Kristine MARCEAU in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1767-1780 Titre : Intergenerational transmission of psychopathology: An examination of symptom severity and directionality Type de document : texte imprimé Auteurs : Kristine MARCEAU, Auteur ; Li YU, Auteur ; Valerie S. KNOPIK, Auteur ; Jody M. GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur Article en page(s) : p.1767-1780 Langues : Anglais (eng) Mots-clés : children-of-twins  comorbidity  directionality  externalizing  intergenerational transmission  internalizing  severity Index. décimale : PER Périodiques Résumé : The present study examined the intergenerational transmission of internalizing and externalizing symptom severity, which indexes comorbidity, and symptom directionality, which indicates differentiation toward externalizing versus internalizing problems. Data are from 854 male and female, same-sex adult twin pairs born between 1926 and 1971 (32 “60 years old, M = 44.9 years, SD = 4.9 years) from the Twin and Offspring Study in Sweden and their adolescent offspring (11 “22 years old, M = 15.7 years, SD = 2.4 years, 52% female). Children-of-twins models revealed additive (9%) and dominant (45%) genetic and nonshared environmental (47%) influences on twins’ symptom severity, and additive genetic (39%) and nonshared environmental (61%) influences on twins’ symptom directionality. Both comorbid problems and preponderance of symptoms of a particular “ internalizing versus externalizing “ spectrum were correlated across parent and child generations, although associations were modest especially for directionality (i.e., transmission of specific symptom type). By interpreting findings alongside a recent study of adolescent twins, we demonstrate that the intergenerational transmission of symptom severity and symptom directionality are both unlikely to be attributable to genetic transmission, are both likely to be influenced by direct phenotypic transmission and/or nonpassive rGE, and the intergenerational transmission of symptom severity is also likely to be influenced by passive rGE. En ligne : http://dx.doi.org/10.1017/S0954579422000852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Intergenerational transmission of psychopathology: An examination of symptom severity and directionality [texte imprimé] / Kristine MARCEAU, Auteur ; Li YU, Auteur ; Valerie S. KNOPIK, Auteur ; Jody M. GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur . - p.1767-1780. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1767-1780 Mots-clés : children-of-twins  comorbidity  directionality  externalizing  intergenerational transmission  internalizing  severity Index. décimale : PER Périodiques Résumé : The present study examined the intergenerational transmission of internalizing and externalizing symptom severity, which indexes comorbidity, and symptom directionality, which indicates differentiation toward externalizing versus internalizing problems. Data are from 854 male and female, same-sex adult twin pairs born between 1926 and 1971 (32 “60 years old, M = 44.9 years, SD = 4.9 years) from the Twin and Offspring Study in Sweden and their adolescent offspring (11 “22 years old, M = 15.7 years, SD = 2.4 years, 52% female). Children-of-twins models revealed additive (9%) and dominant (45%) genetic and nonshared environmental (47%) influences on twins’ symptom severity, and additive genetic (39%) and nonshared environmental (61%) influences on twins’ symptom directionality. Both comorbid problems and preponderance of symptoms of a particular “ internalizing versus externalizing “ spectrum were correlated across parent and child generations, although associations were modest especially for directionality (i.e., transmission of specific symptom type). By interpreting findings alongside a recent study of adolescent twins, we demonstrate that the intergenerational transmission of symptom severity and symptom directionality are both unlikely to be attributable to genetic transmission, are both likely to be influenced by direct phenotypic transmission and/or nonpassive rGE, and the intergenerational transmission of symptom severity is also likely to be influenced by passive rGE. En ligne : http://dx.doi.org/10.1017/S0954579422000852 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps? / Lauren MICALIZZI in Development and Psychopathology, 30-4 (October 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-4 (October 2018) . - p.1333-1354 Titre : Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps? Type de document : texte imprimé Auteurs : Lauren MICALIZZI, Auteur ; Valerie S. KNOPIK, Auteur Article en page(s) : p.1333-1354 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children exposed to maternal smoking during pregnancy (MSDP) exhibit difficulties in executive function (EF) from infancy through adolescence. Due to the developmental significance of EF as a predictor of adaptive functioning throughout the life span, the MSDP–EF relation has clear public health implications. In this paper, we provide a comprehensive review of the literature on the relationship between MSDP and offspring EF across development; consider brain-based assessments, animal models, and genetically informed studies in an effort to elucidate plausible pathways of effects; discuss implications for prevention and intervention; and make calls to action for future research. En ligne : http://dx.doi.org/10.1017/S0954579417001687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps? [texte imprimé] / Lauren MICALIZZI, Auteur ; Valerie S. KNOPIK, Auteur . - p.1333-1354. Langues : Anglais (eng) in Development and Psychopathology > 30-4 (October 2018) . - p.1333-1354 Index. décimale : PER Périodiques Résumé : Children exposed to maternal smoking during pregnancy (MSDP) exhibit difficulties in executive function (EF) from infancy through adolescence. Due to the developmental significance of EF as a predictor of adaptive functioning throughout the life span, the MSDP–EF relation has clear public health implications. In this paper, we provide a comprehensive review of the literature on the relationship between MSDP and offspring EF across development; consider brain-based assessments, animal models, and genetically informed studies in an effort to elucidate plausible pathways of effects; discuss implications for prevention and intervention; and make calls to action for future research. En ligne : http://dx.doi.org/10.1017/S0954579417001687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth / Lauren MICALIZZI in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.76-86 Titre : Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth Type de document : texte imprimé Auteurs : Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H.C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : Gcta  adolescence  genetics  heritability  inattention  neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth [texte imprimé] / Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H.C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur . - p.76-86. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.76-86 Mots-clés : Gcta  adolescence  genetics  heritability  inattention  neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

The epigenetics of maternal cigarette smoking during pregnancy and effects on child development / Valerie S. KNOPIK in Development and Psychopathology, 24-4 (November 2012)  

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The roles of familial transmission and smoking during pregnancy on executive function skills: A sibling-comparison study / Valerie S. KNOPIK in Development and Psychopathology, 34-5 (December 2022)  

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