[article] 
inResearch in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566

Titre :	Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur
Article en page(s) :	p.1557-1566
Langues :	Anglais (eng)
Mots-clés :	High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD
Index. décimale :	PER Périodiques
Résumé :	This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2014.07.021
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

[article] Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.1557-1566.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566

Mots-clés :	High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD
Index. décimale :	PER Périodiques
Résumé :	This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2014.07.021
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241