Research Review: Epidemiological modelling of attention-deficit/hyperactivity disorder and conduct disorder for the Global Burden of Disease Study 2010 / Holly E. ERSKINE in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1263-1274 Titre : Research Review: Epidemiological modelling of attention-deficit/hyperactivity disorder and conduct disorder for the Global Burden of Disease Study 2010 Type de document : Texte imprimé et/ou numérique Auteurs : Holly E. ERSKINE, Auteur ; Alize J. FERRARI, Auteur ; Paul NELSON, Auteur ; Guilherme V. POLANCZYK, Auteur ; Abraham D. FLAXMAN, Auteur ; Theo VOS, Auteur ; Harvey A. WHITEFORD, Auteur ; James G. SCOTT, Auteur Article en page(s) : p.1263-1274 Langues : Anglais (eng) Mots-clés : Global burden of disease study 2010  attention-deficit/hyperactivity disorder  conduct disorder  prevalence  statistical modelling Index. décimale : PER Périodiques Résumé : Background The most recent Global Burden of Disease Study (GBD 2010) is the first to include attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) for burden quantification. We present the epidemiological profiles of ADHD and CD across three time periods for 21 world regions. Methods A systematic review of global epidemiology was conducted for each disorder (based on a literature search of the Medline, PsycInfo and EMBASE databases). A Bayesian metaregression tool was used to derive prevalence estimates by age and sex in three time periods (1990, 2005 and 2010) for 21 world regions including those with little or no data. Prior expert knowledge and covariates were applied to each model to adjust suboptimal data. Final prevalence output for ADHD were adjusted to reflect an equivalent value if studies had measured point prevalence using multiple informants while final prevalence output for CD were adjusted to reflect a value equivalent to CD only. Results Prevalence was pooled for males and females aged 5–19 years with no difference found in global prevalence between the three time periods. Male prevalence of ADHD in 2010 was 2.2% (2.0–2.3) while female prevalence was 0.7% (0.6–0.7). Male prevalence of CD in 2010 was 3.6% (3.3–4.0) while female prevalence was 1.5% (1.4–1.7). ADHD and CD were estimated to be present worldwide with ADHD prevalence showing some regional variation while CD prevalence remained relatively consistent worldwide. Conclusions We present the first prevalence estimates of both ADHD and CD globally and for all world regions. Data were sparse with large parts of the world having no estimates of either disorder. Epidemiological studies are urgently needed in certain parts of the world. Our findings directly informed burden quantification for GBD 2010. As mental disorders gained increased recognition after the first GBD study in 1990, the inclusion of ADHD and CD in GBD 2010 ensures their importance will be recognized alongside other childhood disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Research Review: Epidemiological modelling of attention-deficit/hyperactivity disorder and conduct disorder for the Global Burden of Disease Study 2010 [Texte imprimé et/ou numérique] / Holly E. ERSKINE, Auteur ; Alize J. FERRARI, Auteur ; Paul NELSON, Auteur ; Guilherme V. POLANCZYK, Auteur ; Abraham D. FLAXMAN, Auteur ; Theo VOS, Auteur ; Harvey A. WHITEFORD, Auteur ; James G. SCOTT, Auteur . - p.1263-1274. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1263-1274 Mots-clés : Global burden of disease study 2010  attention-deficit/hyperactivity disorder  conduct disorder  prevalence  statistical modelling Index. décimale : PER Périodiques Résumé : Background The most recent Global Burden of Disease Study (GBD 2010) is the first to include attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) for burden quantification. We present the epidemiological profiles of ADHD and CD across three time periods for 21 world regions. Methods A systematic review of global epidemiology was conducted for each disorder (based on a literature search of the Medline, PsycInfo and EMBASE databases). A Bayesian metaregression tool was used to derive prevalence estimates by age and sex in three time periods (1990, 2005 and 2010) for 21 world regions including those with little or no data. Prior expert knowledge and covariates were applied to each model to adjust suboptimal data. Final prevalence output for ADHD were adjusted to reflect an equivalent value if studies had measured point prevalence using multiple informants while final prevalence output for CD were adjusted to reflect a value equivalent to CD only. Results Prevalence was pooled for males and females aged 5–19 years with no difference found in global prevalence between the three time periods. Male prevalence of ADHD in 2010 was 2.2% (2.0–2.3) while female prevalence was 0.7% (0.6–0.7). Male prevalence of CD in 2010 was 3.6% (3.3–4.0) while female prevalence was 1.5% (1.4–1.7). ADHD and CD were estimated to be present worldwide with ADHD prevalence showing some regional variation while CD prevalence remained relatively consistent worldwide. Conclusions We present the first prevalence estimates of both ADHD and CD globally and for all world regions. Data were sparse with large parts of the world having no estimates of either disorder. Epidemiological studies are urgently needed in certain parts of the world. Our findings directly informed burden quantification for GBD 2010. As mental disorders gained increased recognition after the first GBD study in 1990, the inclusion of ADHD and CD in GBD 2010 ensures their importance will be recognized alongside other childhood disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010 / Holly E. ERSKINE in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.328-336 Titre : The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010 Type de document : Texte imprimé et/ou numérique Auteurs : Holly E. ERSKINE, Auteur ; Alize J. FERRARI, Auteur ; Guilherme V. POLANCZYK, Auteur ; Terrie E. MOFFITT, Auteur ; Christopher J. L. MURRAY, Auteur ; Theo VOS, Auteur ; Harvey A. WHITEFORD, Auteur ; James G. SCOTT, Auteur Article en page(s) : p.328-336 Mots-clés : Global burden of disease study 2010  conduct disorder  attention-deficit/hyperactivity disorder  disability-adjusted life year  years lived with disability Index. décimale : PER Périodiques Résumé : Objective The Global Burden of Disease Study 2010 (GBD 2010) is the first to include conduct disorder (CD) and attention-deficit/hyperactivity disorder (ADHD) for burden quantification. Method A previous systematic review pooled the available epidemiological data for CD and ADHD, and predicted prevalence by country, region, age and sex for each disorder. Prevalence was then multiplied by a disability weight to calculate years lived with disability (YLDs). As no evidence of deaths resulting directly from either CD or ADHD was found, no years of life lost (YLLs) were calculated. Therefore, the number of disability-adjusted life years (DALYs) was equal to that of YLDs. Results Globally, CD was responsible for 5.75 million YLDs/DALYs with ADHD responsible for a further 491,500. Collectively, CD and ADHD accounted for 0.80% of total global YLDs and 0.25% of total global DALYs. In terms of global DALYs, CD was the 72nd leading contributor and among the 15 leading causes in children aged 5–19 years. Between 1990 and 2010, global DALYs attributable to CD and ADHD remained stable after accounting for population growth and ageing. Conclusions The global burden of CD and ADHD is significant, particularly in male children. Appropriate allocation of resources to address the high morbidity associated with CD and ADHD is necessary to reduce global burden. However, burden estimation was limited by data lacking for all four epidemiological parameters and by methodological challenges in quantifying disability. Future studies need to address these limitations in order to increase the accuracy of burden quantification. En ligne : http://dx.doi.org/10.1111/jcpp.12186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=229 [article] The global burden of conduct disorder and attention-deficit/hyperactivity disorder in 2010 [Texte imprimé et/ou numérique] / Holly E. ERSKINE, Auteur ; Alize J. FERRARI, Auteur ; Guilherme V. POLANCZYK, Auteur ; Terrie E. MOFFITT, Auteur ; Christopher J. L. MURRAY, Auteur ; Theo VOS, Auteur ; Harvey A. WHITEFORD, Auteur ; James G. SCOTT, Auteur . - p.328-336. in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.328-336 Mots-clés : Global burden of disease study 2010  conduct disorder  attention-deficit/hyperactivity disorder  disability-adjusted life year  years lived with disability Index. décimale : PER Périodiques Résumé : Objective The Global Burden of Disease Study 2010 (GBD 2010) is the first to include conduct disorder (CD) and attention-deficit/hyperactivity disorder (ADHD) for burden quantification. Method A previous systematic review pooled the available epidemiological data for CD and ADHD, and predicted prevalence by country, region, age and sex for each disorder. Prevalence was then multiplied by a disability weight to calculate years lived with disability (YLDs). As no evidence of deaths resulting directly from either CD or ADHD was found, no years of life lost (YLLs) were calculated. Therefore, the number of disability-adjusted life years (DALYs) was equal to that of YLDs. Results Globally, CD was responsible for 5.75 million YLDs/DALYs with ADHD responsible for a further 491,500. Collectively, CD and ADHD accounted for 0.80% of total global YLDs and 0.25% of total global DALYs. In terms of global DALYs, CD was the 72nd leading contributor and among the 15 leading causes in children aged 5–19 years. Between 1990 and 2010, global DALYs attributable to CD and ADHD remained stable after accounting for population growth and ageing. Conclusions The global burden of CD and ADHD is significant, particularly in male children. Appropriate allocation of resources to address the high morbidity associated with CD and ADHD is necessary to reduce global burden. However, burden estimation was limited by data lacking for all four epidemiological parameters and by methodological challenges in quantifying disability. Future studies need to address these limitations in order to increase the accuracy of burden quantification. En ligne : http://dx.doi.org/10.1111/jcpp.12186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=229

The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children / Cathrine MIHALOPOULOS in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.1026-1033 Titre : The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children Type de document : Texte imprimé et/ou numérique Auteurs : Cathrine MIHALOPOULOS, Auteur ; Theo VOS, Auteur ; Ronald M. RAPEE, Auteur ; Jane PIRKIS, Auteur ; Mary Lou CHATTERTON, Auteur ; Yu-Chen LEE, Auteur ; Rob CARTER, Auteur Article en page(s) : p.1026-1033 Langues : Anglais (eng) Mots-clés : Economic evaluation  anxiety disorders  children  prevention Index. décimale : PER Périodiques Résumé : Background Prevention and early intervention for anxiety disorders has lagged behind many other forms of mental disorder. Recent research has demonstrated the efficacy of a parent-focussed psycho-educational programme. The programme is directed at parents of inhibited preschool children and has been shown to reduce anxiety disorders at 1 and 3 years following intervention. The current study assesses the cost-effectiveness of this intervention to determine whether it could provide value-for-money across a population. Method A cost-utility economic framework, using Disability-Adjusted-Life-Years (DALYs) as the outcome, was adopted. Economic modelling techniques were used to assess the incremental cost-effectiveness ratio (ICER) of the intervention within the Australian population context, which was modelled as add-on to current practice. The perspective was the health sector. Uncertainty was measured using multivariate probabilistic testing and key assumptions were tested using univariate sensitivity analysis. Results The median ICER for the intervention was AUD$8,000 per DALY averted with 99.8% of the uncertainty iterations falling below the threshold value-for-money criterion of AUD$50,000 per DALY averted. The results were robust to sensitivity testing. Conclusions Screening young children in a preschool setting for an inhibited temperament and providing a brief intervention to the parents of children with high levels of inhibition appears to provide very good value-for-money and worth considering in any package of preventive care. Further evaluation of this intervention under routine health service conditions will strengthen conclusions. Acceptability issues associated with this intervention, particularly to preschool staff and parents, need to be considered before wide-scale adoption is undertaken. En ligne : http://dx.doi.org/10.1111/jcpp.12438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children [Texte imprimé et/ou numérique] / Cathrine MIHALOPOULOS, Auteur ; Theo VOS, Auteur ; Ronald M. RAPEE, Auteur ; Jane PIRKIS, Auteur ; Mary Lou CHATTERTON, Auteur ; Yu-Chen LEE, Auteur ; Rob CARTER, Auteur . - p.1026-1033. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.1026-1033 Mots-clés : Economic evaluation  anxiety disorders  children  prevention Index. décimale : PER Périodiques Résumé : Background Prevention and early intervention for anxiety disorders has lagged behind many other forms of mental disorder. Recent research has demonstrated the efficacy of a parent-focussed psycho-educational programme. The programme is directed at parents of inhibited preschool children and has been shown to reduce anxiety disorders at 1 and 3 years following intervention. The current study assesses the cost-effectiveness of this intervention to determine whether it could provide value-for-money across a population. Method A cost-utility economic framework, using Disability-Adjusted-Life-Years (DALYs) as the outcome, was adopted. Economic modelling techniques were used to assess the incremental cost-effectiveness ratio (ICER) of the intervention within the Australian population context, which was modelled as add-on to current practice. The perspective was the health sector. Uncertainty was measured using multivariate probabilistic testing and key assumptions were tested using univariate sensitivity analysis. Results The median ICER for the intervention was AUD$8,000 per DALY averted with 99.8% of the uncertainty iterations falling below the threshold value-for-money criterion of AUD$50,000 per DALY averted. The results were robust to sensitivity testing. Conclusions Screening young children in a preschool setting for an inhibited temperament and providing a brief intervention to the parents of children with high levels of inhibition appears to provide very good value-for-money and worth considering in any package of preventive care. Further evaluation of this intervention under routine health service conditions will strengthen conclusions. Acceptability issues associated with this intervention, particularly to preschool staff and parents, need to be considered before wide-scale adoption is undertaken. En ligne : http://dx.doi.org/10.1111/jcpp.12438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

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