[article]
| Titre : |
Architecture of the Genetic Risk for Autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Pauline CHASTE, Auteur ; Bernie DEVLIN, Auteur |
| Article en page(s) : |
p.80-96 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques |
| Résumé : |
The past decade of investigation into the genetics of autism, marked by the identification of the first rare mutations in nonsyndromic autism and the development of genome-wide genotyping and sequencing techniques, has resulted in remarkable advances in our understanding of the genetic architecture of the risk for autism spectrum disorders (ASD). Indeed, from a population genetics perspective, it can be argued that an accurate synopsis of the genetic architecture of ASD is already in hand. Integrating all of the evidence, there can be no doubt that both rare and common variations play a role in the inherited risk for ASD. The picture of genetic risk that has emerged based on recent results is much more complex than many had imagined, and in many ways it looks like the polygenic model first proposed. Nevertheless, there seems to be some convergence on a limited number of cellular processes, which bodes well for the development of new treatments. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271 |
in Key Issues in Mental Health > 180 (2015) . - p.80-96
[article] Architecture of the Genetic Risk for Autism [Texte imprimé et/ou numérique] / Pauline CHASTE, Auteur ; Bernie DEVLIN, Auteur . - p.80-96. Langues : Anglais ( eng) in Key Issues in Mental Health > 180 (2015) . - p.80-96
| Index. décimale : |
AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques |
| Résumé : |
The past decade of investigation into the genetics of autism, marked by the identification of the first rare mutations in nonsyndromic autism and the development of genome-wide genotyping and sequencing techniques, has resulted in remarkable advances in our understanding of the genetic architecture of the risk for autism spectrum disorders (ASD). Indeed, from a population genetics perspective, it can be argued that an accurate synopsis of the genetic architecture of ASD is already in hand. Integrating all of the evidence, there can be no doubt that both rare and common variations play a role in the inherited risk for ASD. The picture of genetic risk that has emerged based on recent results is much more complex than many had imagined, and in many ways it looks like the polygenic model first proposed. Nevertheless, there seems to be some convergence on a limited number of cellular processes, which bodes well for the development of new treatments. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271 |
|
Architecture of the Genetic Risk for Autism in Key Issues in Mental Health, 180 (2015)