Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder / Chimei M. LEE in Autism Research, 16-6 (June 2023)  

Public ISBD [article]  inAutism Research > 16-6 (June 2023) . - p.1210-1224 Titre : Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder Type de document : texte imprimé Auteurs : Chimei M. LEE, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Laura A. CARPENTER, Auteur ; Jill HARRIS, Auteur ; Stephen M. KANNE, Auteur ; Cora M. TAYLOR, Auteur ; Dustin E. SARVER, Auteur ; Kevin G. STEPHENSON, Auteur ; Lisa H. SHULMAN, Auteur ; Ericka L. WODKA, Auteur ; Amy N. ESLER, Auteur ; THE SPARK CONSORTIUM, Auteur Article en page(s) : p.1210-1224 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cognitive ability  intellectual disability  parent report  standardized measure Index. décimale : PER Périodiques Résumé : Abstract Assessing cognitive development is critical in clinical research of autism spectrum disorder (ASD). However, collecting cognitive data from clinically administered assessments can add a significant burden to clinical research in ASD due to the substantial cost and time required, and it is often prohibitive in large-scale studies. There is a need for more efficient, but reliable, methods to estimate cognitive functioning for researchers, clinicians, and families. To examine the degree to which caregiver estimates of cognitive level agree with actual measured intelligence/developmental scores and understand factors that may impact that agreement, 1,555 autistic individuals (81.74% male; age 18 months 18 years) were selected from a large cohort (Simons Foundation Powering Autism Research for Knowledge, SPARK). Results suggest that querying parents about recent testing results and developmental diagnoses can provide valid and useful information on cognitive ability. The agreement of parental estimates varied with age, measured cognitive ability, autistic traits, and adaptive skills. In the context of large-scale research efforts, parent-reported cognitive impairment may be a good proxy for categorical IQ range for survey-based studies when specific IQ scores are not available, circumventing the logistical and financial obstacles of obtaining neuropsychological or neurodevelopmental testing. En ligne : https://doi.org/10.1002/aur.2934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder [texte imprimé] / Chimei M. LEE, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Laura A. CARPENTER, Auteur ; Jill HARRIS, Auteur ; Stephen M. KANNE, Auteur ; Cora M. TAYLOR, Auteur ; Dustin E. SARVER, Auteur ; Kevin G. STEPHENSON, Auteur ; Lisa H. SHULMAN, Auteur ; Ericka L. WODKA, Auteur ; Amy N. ESLER, Auteur ; THE SPARK CONSORTIUM, Auteur . - p.1210-1224. Langues : Anglais (eng) in Autism Research > 16-6 (June 2023) . - p.1210-1224 Mots-clés : autism spectrum disorder  cognitive ability  intellectual disability  parent report  standardized measure Index. décimale : PER Périodiques Résumé : Abstract Assessing cognitive development is critical in clinical research of autism spectrum disorder (ASD). However, collecting cognitive data from clinically administered assessments can add a significant burden to clinical research in ASD due to the substantial cost and time required, and it is often prohibitive in large-scale studies. There is a need for more efficient, but reliable, methods to estimate cognitive functioning for researchers, clinicians, and families. To examine the degree to which caregiver estimates of cognitive level agree with actual measured intelligence/developmental scores and understand factors that may impact that agreement, 1,555 autistic individuals (81.74% male; age 18 months 18 years) were selected from a large cohort (Simons Foundation Powering Autism Research for Knowledge, SPARK). Results suggest that querying parents about recent testing results and developmental diagnoses can provide valid and useful information on cognitive ability. The agreement of parental estimates varied with age, measured cognitive ability, autistic traits, and adaptive skills. In the context of large-scale research efforts, parent-reported cognitive impairment may be a good proxy for categorical IQ range for survey-based studies when specific IQ scores are not available, circumventing the logistical and financial obstacles of obtaining neuropsychological or neurodevelopmental testing. En ligne : https://doi.org/10.1002/aur.2934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

Brief Report: Can Metrics of Reporting Bias Enhance Early Autism Screening Measures? / Cora M. TAYLOR in Journal of Autism and Developmental Disorders, 44-9 (September 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2375-2380 Titre : Brief Report: Can Metrics of Reporting Bias Enhance Early Autism Screening Measures? Type de document : texte imprimé Auteurs : Cora M. TAYLOR, Auteur ; Alison VEHORN, Auteur ; Hylan NOBLE, Auteur ; Amy S. WEITLAUF, Auteur ; Zachary WARREN, Auteur Article en page(s) : p.2375-2380 Langues : Anglais (eng) Mots-clés : Autism  Screening  Early identification  Internal metrics Index. décimale : PER Périodiques Résumé : The goal of the current study was to develop and pilot the utility of two simple internal response bias metrics, over-reporting and under-reporting, in terms of additive clinical value within common screening practices for early detection of autism spectrum disorder risk. Participants were caregivers and children under 36 months of age (n = 145) participating in first-time diagnostic appointments across our clinical research center due to developmental concerns. Caregivers were asked to complete the Modified Checklist for Autism in Toddlers (MCHAT) as well as a questionnaire embedding six response bias indicator questions. These questions were items that in previous clinical studies had been endorsed by an overwhelming majority of parents within clinically identified populations. Results indicated that removal of self-reports indicative of potential response bias dramatically reduced both false positives and false negatives on the MCHAT within this sample. This suggests that future work developing internal metrics of response bias may be promising in addressing limits of current screening measures and practices. En ligne : http://dx.doi.org/10.1007/s10803-014-2099-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Brief Report: Can Metrics of Reporting Bias Enhance Early Autism Screening Measures? [texte imprimé] / Cora M. TAYLOR, Auteur ; Alison VEHORN, Auteur ; Hylan NOBLE, Auteur ; Amy S. WEITLAUF, Auteur ; Zachary WARREN, Auteur . - p.2375-2380. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2375-2380 Mots-clés : Autism  Screening  Early identification  Internal metrics Index. décimale : PER Périodiques Résumé : The goal of the current study was to develop and pilot the utility of two simple internal response bias metrics, over-reporting and under-reporting, in terms of additive clinical value within common screening practices for early detection of autism spectrum disorder risk. Participants were caregivers and children under 36 months of age (n = 145) participating in first-time diagnostic appointments across our clinical research center due to developmental concerns. Caregivers were asked to complete the Modified Checklist for Autism in Toddlers (MCHAT) as well as a questionnaire embedding six response bias indicator questions. These questions were items that in previous clinical studies had been endorsed by an overwhelming majority of parents within clinically identified populations. Results indicated that removal of self-reports indicative of potential response bias dramatically reduced both false positives and false negatives on the MCHAT within this sample. This suggests that future work developing internal metrics of response bias may be promising in addressing limits of current screening measures and practices. En ligne : http://dx.doi.org/10.1007/s10803-014-2099-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

MED13L-related disorder characterized by severe motor speech impairment / Marissa W. MITCHEL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : MED13L-related disorder characterized by severe motor speech impairment Type de document : texte imprimé Auteurs : Marissa W. MITCHEL, Auteur ; Stefanie TURNER, Auteur ; Lauren K. WALSH, Auteur ; Rebecca I. TORENE, Auteur ; Scott M. MYERS, Auteur ; Cora M. TAYLOR, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Male  Female  Adolescent  Cross-Sectional Studies  Child, Preschool  Young Adult  Mediator Complex/genetics  Intellectual Disability/genetics/physiopathology  Speech Disorders/genetics/physiopathology  Dysarthria/physiopathology/genetics  Med13l  Apraxia of speech  Dysarthria  Motor impairment  Speech disorders  consent for study participation was obtained from all participants or their legal  representatives. Ethics approval for this study was obtained from the Geisinger  Institutional Review Board (#00008345) under protocol #2013–0446. This research  was conducted in accordance with the Declaration of Helsinki. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: MED13L-related disorder is associated with intellectual disability, motor delay, and speech deficits. Previous studies have focused on broad clinical descriptions of individuals, but limited information regarding specific speech diagnoses and results of direct testing has been published to date. We conducted deep phenotyping to characterize the speech, language, motor, cognitive, and adaptive phenotypes of individuals with MED13L-related disorder. METHODS: In this cross-sectional study, we administered standardized articulation, language, motor, and cognitive testing to 17 children and adolescents (mean age 9y 9m; SD 4y 5m; range 4y 2m to 19y 7m). In-person testing was supplemented with broad developmental, medical, and behavioral information collected virtually from a cohort of 67 individuals. RESULTS: All individuals who completed in-person articulation testing met diagnostic criteria for speech apraxia, dysarthria, or both. Language impairment was present in all of the in-person cohort and reported for almost all (97%) of the virtual cohort. Those who were able to complete motor testing demonstrated significant deficits in visual motor integration (mean 57.08, SD 9.26). Full scale IQs fell in the borderline to intellectual disability range, consistent with reported cognitive impairment in 97% of the virtual cohort. Notable medical features included hypotonia (83%), vision problems (72%), recurrent otitis media (58%), gastrointestinal problems (57%), and seizures (31%). CONCLUSIONS: MED13L-related disorder is characterized by a high rate of motor speech disorders that occur in the context of globally impaired motor, language, and cognitive skills. Children would benefit from early referrals to speech therapy to assess their speech, language, and support needs. En ligne : https://dx.doi.org/10.1186/s11689-025-09645-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] MED13L-related disorder characterized by severe motor speech impairment [texte imprimé] / Marissa W. MITCHEL, Auteur ; Stefanie TURNER, Auteur ; Lauren K. WALSH, Auteur ; Rebecca I. TORENE, Auteur ; Scott M. MYERS, Auteur ; Cora M. TAYLOR, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Child  Male  Female  Adolescent  Cross-Sectional Studies  Child, Preschool  Young Adult  Mediator Complex/genetics  Intellectual Disability/genetics/physiopathology  Speech Disorders/genetics/physiopathology  Dysarthria/physiopathology/genetics  Med13l  Apraxia of speech  Dysarthria  Motor impairment  Speech disorders  consent for study participation was obtained from all participants or their legal  representatives. Ethics approval for this study was obtained from the Geisinger  Institutional Review Board (#00008345) under protocol #2013–0446. This research  was conducted in accordance with the Declaration of Helsinki. Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: MED13L-related disorder is associated with intellectual disability, motor delay, and speech deficits. Previous studies have focused on broad clinical descriptions of individuals, but limited information regarding specific speech diagnoses and results of direct testing has been published to date. We conducted deep phenotyping to characterize the speech, language, motor, cognitive, and adaptive phenotypes of individuals with MED13L-related disorder. METHODS: In this cross-sectional study, we administered standardized articulation, language, motor, and cognitive testing to 17 children and adolescents (mean age 9y 9m; SD 4y 5m; range 4y 2m to 19y 7m). In-person testing was supplemented with broad developmental, medical, and behavioral information collected virtually from a cohort of 67 individuals. RESULTS: All individuals who completed in-person articulation testing met diagnostic criteria for speech apraxia, dysarthria, or both. Language impairment was present in all of the in-person cohort and reported for almost all (97%) of the virtual cohort. Those who were able to complete motor testing demonstrated significant deficits in visual motor integration (mean 57.08, SD 9.26). Full scale IQs fell in the borderline to intellectual disability range, consistent with reported cognitive impairment in 97% of the virtual cohort. Notable medical features included hypotonia (83%), vision problems (72%), recurrent otitis media (58%), gastrointestinal problems (57%), and seizures (31%). CONCLUSIONS: MED13L-related disorder is characterized by a high rate of motor speech disorders that occur in the context of globally impaired motor, language, and cognitive skills. Children would benefit from early referrals to speech therapy to assess their speech, language, and support needs. En ligne : https://dx.doi.org/10.1186/s11689-025-09645-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

A pilot investigation of an iOS-based app for toilet training children with autism spectrum disorder / Daniel W. MRUZEK in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.359-370 Titre : A pilot investigation of an iOS-based app for toilet training children with autism spectrum disorder Type de document : texte imprimé Auteurs : Daniel W. MRUZEK, Auteur ; Stephen MCALEAVEY, Auteur ; Whitney A. LORING, Auteur ; Eric BUTTER, Auteur ; Tristram SMITH, Auteur ; Erin MCDONNELL, Auteur ; Lynne LEVATO, Auteur ; Courtney A. APONTE, Auteur ; Rebekah P. TRAVIS, Auteur ; Rachel AIELLO, Auteur ; Cora M. TAYLOR, Auteur ; Jonathan W. WILKINS, Auteur ; Patricia CORBETT-DICK, Auteur ; Dianne M. FINKELSTEIN, Auteur ; Alyssa M. YORK, Auteur ; Katherine ZANIBBI, Auteur Article en page(s) : p.359-370 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  enuresis  randomized controlled trial  technology  toilet training  urine alarm Index. décimale : PER Périodiques Résumé : We developed an iOS-based app with a transmitter/disposable sensor and corresponding manualized intervention for children with autism spectrum disorder. The app signaled the onset of urination, time-stamped accidents for analysis, reminded parents to reinforce intervals of continence, provided a visual outlet for parents to communicate reinforcement, and afforded opportunity for timely feedback from clinicians. We compared this intervention with an intervention that uses standard behavioral treatment in a pilot randomized controlled trial of 33 children with autism spectrum disorder aged 3-6 years with urinary incontinence. Parents in both groups received initial training and four booster consultations over 3 months. Results support the feasibility of parent-mediated toilet training studies (e.g., 84% retention rate, 92% fidelity of parent-implemented intervention). Parents used the app and related technology with few difficulties or malfunctions. There were no statistically significant group differences for rate of urine accidents, toilet usage, or satisfaction at close of intervention or 3-month follow-up; however, the alarm group trended toward greater rate of skill acquisition with significantly less day-to-day intervention. Further development of alarm and related technology and future comparative studies with a greater number of participants are warranted. En ligne : http://dx.doi.org/10.1177/1362361317741741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] A pilot investigation of an iOS-based app for toilet training children with autism spectrum disorder [texte imprimé] / Daniel W. MRUZEK, Auteur ; Stephen MCALEAVEY, Auteur ; Whitney A. LORING, Auteur ; Eric BUTTER, Auteur ; Tristram SMITH, Auteur ; Erin MCDONNELL, Auteur ; Lynne LEVATO, Auteur ; Courtney A. APONTE, Auteur ; Rebekah P. TRAVIS, Auteur ; Rachel AIELLO, Auteur ; Cora M. TAYLOR, Auteur ; Jonathan W. WILKINS, Auteur ; Patricia CORBETT-DICK, Auteur ; Dianne M. FINKELSTEIN, Auteur ; Alyssa M. YORK, Auteur ; Katherine ZANIBBI, Auteur . - p.359-370. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.359-370 Mots-clés : autism spectrum disorder  enuresis  randomized controlled trial  technology  toilet training  urine alarm Index. décimale : PER Périodiques Résumé : We developed an iOS-based app with a transmitter/disposable sensor and corresponding manualized intervention for children with autism spectrum disorder. The app signaled the onset of urination, time-stamped accidents for analysis, reminded parents to reinforce intervals of continence, provided a visual outlet for parents to communicate reinforcement, and afforded opportunity for timely feedback from clinicians. We compared this intervention with an intervention that uses standard behavioral treatment in a pilot randomized controlled trial of 33 children with autism spectrum disorder aged 3-6 years with urinary incontinence. Parents in both groups received initial training and four booster consultations over 3 months. Results support the feasibility of parent-mediated toilet training studies (e.g., 84% retention rate, 92% fidelity of parent-implemented intervention). Parents used the app and related technology with few difficulties or malfunctions. There were no statistically significant group differences for rate of urine accidents, toilet usage, or satisfaction at close of intervention or 3-month follow-up; however, the alarm group trended toward greater rate of skill acquisition with significantly less day-to-day intervention. Further development of alarm and related technology and future comparative studies with a greater number of participants are warranted. En ligne : http://dx.doi.org/10.1177/1362361317741741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

A pilot study to identify autism related traits in spontaneous facial actions using computer vision / Manar D. SAMAD in Research in Autism Spectrum Disorders, 65 (September 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 65 (September 2019) . - p.14-24 Titre : A pilot study to identify autism related traits in spontaneous facial actions using computer vision Type de document : texte imprimé Auteurs : Manar D. SAMAD, Auteur ; Norou DIAWARA, Auteur ; Jonna L. BOBZIEN, Auteur ; Cora M. TAYLOR, Auteur ; John W. HARRINGTON, Auteur ; Khan M. IFTEKHARUDDIN, Auteur Article en page(s) : p.14-24 Langues : Anglais (eng) Mots-clés : ASD  Behavioral marker  Differential traits  Facial action units  Computer vision  Spontaneous expressions Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorders (ASD) may be differentiated from typically developing controls (TDC) based on phenotypic features in spontaneous facial expressions. Computer vision technology can automatically track subtle facial actions to gain quantitative insights into ASD related behavioral abnormalities. Method This study proposes a novel psychovisual human-study to elicit spontaneous facial expressions in response to a variety of social and emotional contexts. We introduce a markerless facial motion capture and computer vision methods to track spontaneous and subtle activations of facial muscles. The facial muscle activations are encoded into ten representative facial action units (FAU) to gain quantitative, granular, and contextual insights into the psychophysical development of the participating individuals. Statistical tests are performed to identify differential traits in individuals with ASD after comparing those in a cohort of age-matched TDC individuals. Results The proposed framework has revealed significant difference (p < 0.001) in the activation of ten FAU and contrasting activations of FAU between the group with ASD and the TDC group. Unlike the TDC group, the group with ASD has shown unusual prevalence of mouth frown (FAU 15) and low correlations in temporal activations of several FAU pairs: 6–12, 10–12, and 10–20. The interpretation of different FAU activations suggests quantitative evidence of expression bluntness, lack of expression mimicry, incongruent reaction to negative emotions in the group with ASD. Conclusion Our generalized framework may be used to quantify psychophysical traits in individuals with ASD and replicate in similar studies that require quantitative measurements of behavioral responses. En ligne : https://doi.org/10.1016/j.rasd.2019.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] A pilot study to identify autism related traits in spontaneous facial actions using computer vision [texte imprimé] / Manar D. SAMAD, Auteur ; Norou DIAWARA, Auteur ; Jonna L. BOBZIEN, Auteur ; Cora M. TAYLOR, Auteur ; John W. HARRINGTON, Auteur ; Khan M. IFTEKHARUDDIN, Auteur . - p.14-24. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 65 (September 2019) . - p.14-24 Mots-clés : ASD  Behavioral marker  Differential traits  Facial action units  Computer vision  Spontaneous expressions Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorders (ASD) may be differentiated from typically developing controls (TDC) based on phenotypic features in spontaneous facial expressions. Computer vision technology can automatically track subtle facial actions to gain quantitative insights into ASD related behavioral abnormalities. Method This study proposes a novel psychovisual human-study to elicit spontaneous facial expressions in response to a variety of social and emotional contexts. We introduce a markerless facial motion capture and computer vision methods to track spontaneous and subtle activations of facial muscles. The facial muscle activations are encoded into ten representative facial action units (FAU) to gain quantitative, granular, and contextual insights into the psychophysical development of the participating individuals. Statistical tests are performed to identify differential traits in individuals with ASD after comparing those in a cohort of age-matched TDC individuals. Results The proposed framework has revealed significant difference (p < 0.001) in the activation of ten FAU and contrasting activations of FAU between the group with ASD and the TDC group. Unlike the TDC group, the group with ASD has shown unusual prevalence of mouth frown (FAU 15) and low correlations in temporal activations of several FAU pairs: 6–12, 10–12, and 10–20. The interpretation of different FAU activations suggests quantitative evidence of expression bluntness, lack of expression mimicry, incongruent reaction to negative emotions in the group with ASD. Conclusion Our generalized framework may be used to quantify psychophysical traits in individuals with ASD and replicate in similar studies that require quantitative measurements of behavioral responses. En ligne : https://doi.org/10.1016/j.rasd.2019.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

---

1 (1 - 5 / 5) Par page : 25 50 100 200