Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort / S. RAZA in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2210-2218 Titre : Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort Type de document : Texte imprimé et/ou numérique Auteurs : S. RAZA, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Lori-Ann R. SACREY, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; K. REID, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur Article en page(s) : p.2210-2218 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Behavioral signs  Classification accuracy  Early screening  Infant siblings Index. décimale : PER Périodiques Résumé : This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months of age using the Q-CHAT-10 and underwent blind diagnostic assessment for ASD at 36 months of age. The results indicated that at 18 and 24 months, total score differentiated between HR toddlers subsequently diagnosed with ASD from other HR and LR toddlers. The sensitivity at both time points was acceptable; however, the specificity was below the level recommended for clinical application. En ligne : http://dx.doi.org/10.1007/s10803-019-03897-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394 [article] Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort [Texte imprimé et/ou numérique] / S. RAZA, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Lori-Ann R. SACREY, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; K. REID, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur . - p.2210-2218. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2210-2218 Mots-clés : Autism  Autism spectrum disorder  Behavioral signs  Classification accuracy  Early screening  Infant siblings Index. décimale : PER Périodiques Résumé : This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months of age using the Q-CHAT-10 and underwent blind diagnostic assessment for ASD at 36 months of age. The results indicated that at 18 and 24 months, total score differentiated between HR toddlers subsequently diagnosed with ASD from other HR and LR toddlers. The sensitivity at both time points was acceptable; however, the specificity was below the level recommended for clinical application. En ligne : http://dx.doi.org/10.1007/s10803-019-03897-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=394

Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort / Lori-Ann R. SACREY in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.697-706 Titre : Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; S. RAZA, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur Article en page(s) : p.697-706 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  adaptive behaviour  development  high risk studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations. En ligne : http://dx.doi.org/10.1111/jcpp.12985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Developmental trajectories of adaptive behavior in autism spectrum disorder: a high-risk sibling cohort [Texte imprimé et/ou numérique] / Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; S. RAZA, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur . - p.697-706. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.697-706 Mots-clés : Autism spectrum disorders  adaptive behaviour  development  high risk studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) often experience impairments in adaptive behavior. METHODS: Developmental trajectories of adaptive behavior in ASD were examined in children from high-risk (siblings of children diagnosed with ASD, n = 403) and low-risk (no family history of ASD, n = 163) families. Children were assessed prospectively at 12, 18, 24, and 36 months of age using the Vineland Adaptive Behavior Scales and underwent a blind independent diagnostic assessment for ASD at 36 months of age. RESULTS: The semi-parametric group-based modeling approach using standard scores on the Adaptive Behavior Composite revealed three distinct developmental trajectories: (a) Group 1 (21.2% of sample) showed average performance at 12 months and a declining trajectory; (b) Group 2 (52.8% of the sample) showed average performance at 12 months with a slightly declining trajectory; and (c) Group 3 (26.0% of the sample) showed a higher level of adaptive behavior at 12 months and a stable trajectory. The Mullen Scales of Early Learning Early Learning Composite and the Autism Observation Scale for Infants total score at 6 and 12 months predicted trajectory membership. CONCLUSIONS: The results emphasize heterogeneous development associated with ASD and the need for interventions tailored to individual presentations. En ligne : http://dx.doi.org/10.1111/jcpp.12985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder / Jessica BRIAN in Research in Autism Spectrum Disorders, 8-11 (November 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566 Titre : Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.1557-1566 Langues : Anglais (eng) Mots-clés : High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD Index. décimale : PER Périodiques Résumé : This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Emerging cognitive profiles in high-risk infants with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRIAN, Auteur ; C. RONCADIN, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; I. DRMIC, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.1557-1566. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1557-1566 Mots-clés : High-risk siblings  Cognitive development  Infants  Toddlers  Developmental trajectories  ASD Index. décimale : PER Périodiques Résumé : This paper examined early developmental trajectories in a large, longitudinal sample at high-risk for ASD (‘HR’) and low-risk (‘LR’) controls, and the association of trajectories with 3-year diagnosis. Developmental assessments were conducted at 6, 12, 24 months, and 3 years, with blinded “clinical best-estimate” expert diagnosis at age 3. HR infants were enrolled based only on familial risk. LR infants, from community sources, had no first- or second-degree ASD relatives. All infants were born at 36–42 weeks, weighing ?2500 g, with no identifiable neurological, genetic, or severe sensory/motor disorders. Analytic phase I: semi-parametric group-based modeling to identify distinct developmental trajectories (n = 680; 487 HR; 193 LR); phase II: Trajectory membership in relation to 3-year diagnosis (n = 424; 310 HR; 114 LR). Three distinct trajectories emerged (1) inclining; (2) stable-average; (3) declining; trajectory membership predicted diagnosis (?2 = 99.40; p lt; .001). Most ASD cases were in stable-average (50.6%) or declining trajectories (33.8%); most non-ASD-HR infants were in inclining (51.9%) or stable-average (40.3%) trajectories. The majority of LR controls were in the inclining trajectory (78.9%). Within the declining trajectory, over half had ASD (57.8%), but 40% were non-ASD-HR infants. Declining/plateauing raw scores were associated with, but not exclusive to, ASD. Findings underscore the importance of monitoring the emergence of ASD symptoms and overall development in high-risk children. Evidence of developmental slowing or decline may be associated not only with ASD, but with other suboptimal outcomes, warranting careful clinical follow-up. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.07.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder / Lori-Ann R. SACREY in Autism Research, 11-3 (March 2018)  

Public ISBD [article]  inAutism Research > 11-3 (March 2018) . - p.539-547 Titre : Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur Article en page(s) : p.539-547 Langues : Anglais (eng) Mots-clés : assessment  autism  autism spectrum disorder  behavioral signs  infant sibling  rater agreement Index. décimale : PER Périodiques Résumé : Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high-risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. The results suggest that parents may detect some clinically informative behaviors based on their day-to-day observations more readily than do clinicians during brief clinical assessments, a result that needs to be replicated in a non-sibling cohort. Autism Res 2018, 11: 539-547. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Parents of children at high-risk of autism spectrum disorder (ASD; have an older sibling with ASD) and clinicians were compared on their reporting of 19 early signs of autism. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. This suggests that parents may have important information regarding early development of their high-risk child. En ligne : http://dx.doi.org/10.1002/aur.1920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder [Texte imprimé et/ou numérique] / Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; W. ROBERTS, Auteur ; P. SZATMARI, Auteur ; T. VAILLANCOURT, Auteur ; C. RONCADIN, Auteur ; N. GARON, Auteur . - p.539-547. Langues : Anglais (eng) in Autism Research > 11-3 (March 2018) . - p.539-547 Mots-clés : assessment  autism  autism spectrum disorder  behavioral signs  infant sibling  rater agreement Index. décimale : PER Périodiques Résumé : Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high-risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. The results suggest that parents may detect some clinically informative behaviors based on their day-to-day observations more readily than do clinicians during brief clinical assessments, a result that needs to be replicated in a non-sibling cohort. Autism Res 2018, 11: 539-547. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Parents of children at high-risk of autism spectrum disorder (ASD; have an older sibling with ASD) and clinicians were compared on their reporting of 19 early signs of autism. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. This suggests that parents may have important information regarding early development of their high-risk child. En ligne : http://dx.doi.org/10.1002/aur.1920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort / Lonnie ZWAIGENBAUM in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443 Titre : Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur Article en page(s) : p.1435-1443 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder  Child  Child, Preschool  Cohort Studies  Humans  Infant  Prospective Studies  Siblings  Autism spectrum disorder  early detection  high-risk studies  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort [Texte imprimé et/ou numérique] / Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur . - p.1435-1443. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443 Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder  Child  Child, Preschool  Cohort Studies  Humans  Infant  Prospective Studies  Siblings  Autism spectrum disorder  early detection  high-risk studies  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13417 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

The Autism Parent Screen for Infants: Predicting risk of autism spectrum disorder based on parent-reported behavior observed at 6-24 months of age / Lori-Ann R. SACREY in Autism, 22-3 (April 2018)  

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Variability in Verbal and Nonverbal Communication in Infants at Risk for Autism Spectrum Disorder: Predictors and Outcomes / M. FRANCHINI in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

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