An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior / Elisabeth CONRADT in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.881-890 Titre : An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; Catherine MONK, Auteur ; Michael S. KOBOR, Auteur Année de publication : 2018 Article en page(s) : p.881-890 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior [texte imprimé] / Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; Catherine MONK, Auteur ; Michael S. KOBOR, Auteur . - 2018 . - p.881-890. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.881-890 Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes / Elisabeth CONRADT in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Titre : Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah E. MAYLOTT, Auteur ; Barry M. LESTER, Auteur Article en page(s) : p.566-578 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes [texte imprimé] / Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah E. MAYLOTT, Auteur ; Barry M. LESTER, Auteur . - p.566-578. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity / Anna M. ZHOU in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Titre : From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity Type de document : texte imprimé Auteurs : Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur Article en page(s) : p.1482-1494 Langues : Anglais (eng) Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity [texte imprimé] / Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur . - p.1482-1494. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Incorporating epigenetic mechanisms to advance fetal programming theories / Elisabeth CONRADT in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.807-824 Titre : Incorporating epigenetic mechanisms to advance fetal programming theories Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; K. Lee RABY, Auteur ; L.M. DIAMOND, Auteur ; Bruce ELLIS, Auteur Article en page(s) : p.807-824 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child. While great strides have been made in identifying associations between prenatal insults, such as undernutrition or psychosocial stress, and negative developmental outcomes, far less is known about how adaptive responses to adversity regulate the developing phenotype to match stressful conditions. As the application of epigenetic methods to human behavior has exploded in the last decade, research has begun to shed light on the role of epigenetic mechanisms in explaining how prenatal conditions shape later susceptibilities to mental and physical health problems. In this review, we describe and attempt to integrate two dominant fetal programming models: the cumulative stress model (a disease-focused approach) and the match-mismatch model (an evolutionary-developmental approach). In conjunction with biological sensitivity to context theory, we employ these two models to generate new hypotheses regarding epigenetic mechanisms through which prenatal and postnatal experiences program child stress reactivity and, in turn, promote development of adaptive versus maladaptive phenotypic outcomes. We conclude by outlining priority questions and future directions for the fetal programming field. En ligne : http://dx.doi.org/10.1017/s0954579418000469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Incorporating epigenetic mechanisms to advance fetal programming theories [texte imprimé] / Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; K. Lee RABY, Auteur ; L.M. DIAMOND, Auteur ; Bruce ELLIS, Auteur . - p.807-824. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.807-824 Index. décimale : PER Périodiques Résumé : Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child. While great strides have been made in identifying associations between prenatal insults, such as undernutrition or psychosocial stress, and negative developmental outcomes, far less is known about how adaptive responses to adversity regulate the developing phenotype to match stressful conditions. As the application of epigenetic methods to human behavior has exploded in the last decade, research has begun to shed light on the role of epigenetic mechanisms in explaining how prenatal conditions shape later susceptibilities to mental and physical health problems. In this review, we describe and attempt to integrate two dominant fetal programming models: the cumulative stress model (a disease-focused approach) and the match-mismatch model (an evolutionary-developmental approach). In conjunction with biological sensitivity to context theory, we employ these two models to generate new hypotheses regarding epigenetic mechanisms through which prenatal and postnatal experiences program child stress reactivity and, in turn, promote development of adaptive versus maladaptive phenotypic outcomes. We conclude by outlining priority questions and future directions for the fetal programming field. En ligne : http://dx.doi.org/10.1017/s0954579418000469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women / Betty LIN in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.817-831 Titre : Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women Type de document : texte imprimé Auteurs : Betty LIN, Auteur ; Parisa R. KALIUSH, Auteur ; Elisabeth CONRADT, Auteur ; Sarah TERRELL, Auteur ; Dylan NEFF, Auteur ; Ashley K. ALLEN, Auteur ; Marcela C. SMID, Auteur ; Catherine MONK, Auteur ; Sheila E. CROWELL, Auteur Article en page(s) : p.817-831 Langues : Anglais (eng) Mots-clés : emotion dysregulation  pregnancy  psychophysiology  self-injurious thoughts and behaviors  women's mental health Index. décimale : PER Périodiques Résumé : The World Health Organization recently reported that maternal mental health is a major public health concern. As many as one in four women suffer from psychiatric disorders at some point during pregnancy or the first postpartum year. Furthermore, self-injurious thoughts and behaviors (SITBs) represent one of the leading causes of death among women during this time. Thus, efforts to identify women at risk for serious forms of psychopathology and especially for SITBs are of utmost importance. Despite this urgency, current single-diagnostic approaches fail to recognize a significant subset of women who are vulnerable to perinatal stress and distress. The current study was among the first to investigate emotion dysregulation—a multilevel, transdiagnostic risk factor for psychopathology—and its associations with stress, distress, and SITBs in a sample of pregnant women (26–40 weeks gestation) recruited to reflect a range of emotion dysregulation. Both self-reported emotion dysregulation and respiratory sinus arrhythmia, a biomarker of emotion dysregulation, demonstrated expected associations with measures of mental health, including depression, anxiety, borderline personality pathology, and SITBs. In addition, self-reported emotion dysregulation was associated with blunted respiratory sinus arrhythmia responsivity to an ecologically valid infant cry task. Findings add to the literature considering transdiagnostic risk during pregnancy using a multiple-levels-of-analysis approach. En ligne : http://dx.doi.org/10.1017/S0954579419000336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women [texte imprimé] / Betty LIN, Auteur ; Parisa R. KALIUSH, Auteur ; Elisabeth CONRADT, Auteur ; Sarah TERRELL, Auteur ; Dylan NEFF, Auteur ; Ashley K. ALLEN, Auteur ; Marcela C. SMID, Auteur ; Catherine MONK, Auteur ; Sheila E. CROWELL, Auteur . - p.817-831. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.817-831 Mots-clés : emotion dysregulation  pregnancy  psychophysiology  self-injurious thoughts and behaviors  women's mental health Index. décimale : PER Périodiques Résumé : The World Health Organization recently reported that maternal mental health is a major public health concern. As many as one in four women suffer from psychiatric disorders at some point during pregnancy or the first postpartum year. Furthermore, self-injurious thoughts and behaviors (SITBs) represent one of the leading causes of death among women during this time. Thus, efforts to identify women at risk for serious forms of psychopathology and especially for SITBs are of utmost importance. Despite this urgency, current single-diagnostic approaches fail to recognize a significant subset of women who are vulnerable to perinatal stress and distress. The current study was among the first to investigate emotion dysregulation—a multilevel, transdiagnostic risk factor for psychopathology—and its associations with stress, distress, and SITBs in a sample of pregnant women (26–40 weeks gestation) recruited to reflect a range of emotion dysregulation. Both self-reported emotion dysregulation and respiratory sinus arrhythmia, a biomarker of emotion dysregulation, demonstrated expected associations with measures of mental health, including depression, anxiety, borderline personality pathology, and SITBs. In addition, self-reported emotion dysregulation was associated with blunted respiratory sinus arrhythmia responsivity to an ecologically valid infant cry task. Findings add to the literature considering transdiagnostic risk during pregnancy using a multiple-levels-of-analysis approach. En ligne : http://dx.doi.org/10.1017/S0954579419000336 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Intergenerational transmission of emotion dysregulation: Part II. Developmental origins of newborn neurobehavior / Brendan OSTLUND in Development and Psychopathology, 31-3 (August 2019)  

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A multilevel developmental psychopathology model of childbirth and the perinatal transition / Elisabeth CONRADT ; Patricia K. KERIG ; Paula G. WILLIAMS ; Sheila E. CROWELL in Development and Psychopathology, 36-2 (May 2024)  

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Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex / Mengyu GAO in Development and Psychopathology, 33-5 (December 2021)  

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Testing the programming of temperament and psychopathology in two independent samples of children with prenatal substance exposure / Betty LIN in Development and Psychopathology, 30-3 (August 2018)  

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The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure / Elisabeth CONRADT in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

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Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence / Linda L. LAGASSE in Development and Psychopathology, 28-3 (August 2016)  

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Understanding emotion dysregulation from infancy to toddlerhood with a multilevel perspective: The buffering effect of maternal sensitivity / Mindy A. BROWN in Development and Psychopathology, 37-2 (May 2025)  

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Using development and psychopathology principles to inform the Research Domain Criteria (RDoC) framework / Elisabeth CONRADT in Development and Psychopathology, 33-5 (December 2021)  

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What?s next for the field of multigenerational mental health? The need for deep behavioral phenotyping via a prenatal mental health registry / Elisabeth CONRADT ; Sierra E. CARTER ; Sheila E. CROWELL in Development and Psychopathology, 36-5 (December 2024)  

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