Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes / Elisabeth CONRADT in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Titre : Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah MAYLOTT, Auteur ; Barry M. LESTER, Auteur Article en page(s) : p.566-578 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Annual Research Review: Prenatal opioid exposure - a two-generation approach to conceptualizing neurodevelopmental outcomes [Texte imprimé et/ou numérique] / Elisabeth CONRADT, Auteur ; Marie CAMEROTA, Auteur ; Sarah MAYLOTT, Auteur ; Barry M. LESTER, Auteur . - p.566-578. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.566-578 Index. décimale : PER Périodiques Résumé : Opioid use during pregnancy impacts the health and well-being of two generations: the pregnant person and the child. The factors that increase risk for opioid use in the adult, as well as those that perpetuate risk for the caregiver and child, oftentimes replicate across generations and may be more likely to affect child neurodevelopment than the opioid exposure itself. In this article, we review the prenatal opioid exposure literature with the perspective that this is not a singular event but an intergenerational cascade of events. We highlight several mechanisms of transmission across generations: biological factors, including genetics and epigenetics and the gut-brain axis; parent-child mechanisms, such as prepregnancy experience of child maltreatment, quality of parenting, infant behaviors, neonatal opioid withdrawal diagnosis, and broader environmental contributors including poverty, violence exposure, stigma, and Child Protective Services involvement. We conclude by describing ways in which intergenerational transmission can be disrupted by early intervention. En ligne : https://doi.org/10.1111/jcpp.13761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Atypical Cry Acoustics in 6-Month-Old Infants at Risk for Autism Spectrum Disorder / Stephen J. SHEINKOPF in Autism Research, 5-5 (October 2012)  

Public ISBD [article]  inAutism Research > 5-5 (October 2012) . - p.331-339 Titre : Atypical Cry Acoustics in 6-Month-Old Infants at Risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephen J. SHEINKOPF, Auteur ; Jana M. IVERSON, Auteur ; Melissa L. RINALDI, Auteur ; Barry M. LESTER, Auteur Article en page(s) : p.331-339 Langues : Anglais (eng) Mots-clés : autism  infancy  cry  vocalizations  acoustic analysis Index. décimale : PER Périodiques Résumé : This study examined differences in acoustic characteristics of infant cries in a sample of babies at risk for autism and a low-risk comparison group. Cry samples derived from vocal recordings of 6-month-old infants at risk for autism spectrum disorder (ASD; n=21) and low-risk infants (n=18) were subjected to acoustic analyses using analysis software designed for this purpose. Cries were categorized as either pain-related or non-pain-related based on videotape coding. At-risk infants produced pain-related cries with higher and more variable fundamental frequency (F 0) than low-risk infants. At-risk infants later classified with ASD at 36 months had among the highest F 0 values for both types of cries and produced cries that were more poorly phonated than those of nonautistic infants, reflecting cries that were less likely to be produced in a voiced mode. These results provide preliminary evidence that disruptions in cry acoustics may be part of an atypical vocal signature of autism in early life. Autism Res 2012, ••: ••–••. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1244 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Atypical Cry Acoustics in 6-Month-Old Infants at Risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Stephen J. SHEINKOPF, Auteur ; Jana M. IVERSON, Auteur ; Melissa L. RINALDI, Auteur ; Barry M. LESTER, Auteur . - p.331-339. Langues : Anglais (eng) in Autism Research > 5-5 (October 2012) . - p.331-339 Mots-clés : autism  infancy  cry  vocalizations  acoustic analysis Index. décimale : PER Périodiques Résumé : This study examined differences in acoustic characteristics of infant cries in a sample of babies at risk for autism and a low-risk comparison group. Cry samples derived from vocal recordings of 6-month-old infants at risk for autism spectrum disorder (ASD; n=21) and low-risk infants (n=18) were subjected to acoustic analyses using analysis software designed for this purpose. Cries were categorized as either pain-related or non-pain-related based on videotape coding. At-risk infants produced pain-related cries with higher and more variable fundamental frequency (F 0) than low-risk infants. At-risk infants later classified with ASD at 36 months had among the highest F 0 values for both types of cries and produced cries that were more poorly phonated than those of nonautistic infants, reflecting cries that were less likely to be produced in a voiced mode. These results provide preliminary evidence that disruptions in cry acoustics may be part of an atypical vocal signature of autism in early life. Autism Res 2012, ••: ••–••. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1244 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Effects of prenatal substance exposure on infant temperament vary by context / Robin L. LOCKE in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.309-326 Titre : Effects of prenatal substance exposure on infant temperament vary by context Type de document : Texte imprimé et/ou numérique Auteurs : Robin L. LOCKE, Auteur ; Linda L. LAGASSE, Auteur ; Ronald SEIFER, Auteur ; Barry M. LESTER, Auteur ; Seetha SHANKARAN, Auteur ; Henrietta S. BADA, Auteur ; Charles R. BAUER, Auteur Article en page(s) : p.309-326 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This was a prospective longitudinal multisite study of the effects of prenatal cocaine and/or opiate exposure on temperament in 4-month-olds of the Maternal Lifestyle Study (N = 958: 366 cocaine exposed, 37 opiate exposed, 33 exposed to both drugs, 522 matched comparison). The study evaluated positivity and negativity during The Behavior Assessment of Infant Temperament (Garcia Coll et al., 1988). Parents rated temperament (Infant Behavior Questionnaire; Rothbart, 1981). Cocaine-exposed infants showed less positivity overall, mainly during activity and threshold items, more negativity during sociability items, and less negativity during irritability and threshold items. Latent profile analysis indicated individual temperament patterns were best described by three groups: low/moderate overall reactivity, high social negative reactivity, and high nonsocial negative reactivity. Infants with heavy cocaine exposure were more likely in high social negative reactivity profile, were less negative during threshold items, and required longer soothing intervention. Cocaine- and opiate-exposed infants scored lower on Infant Behavior Questionnaire smiling and laughter and duration of orienting scales. Opiate-exposed infants were rated as less respondent to soothing. By including a multitask measure of temperament we were able to show context-specific behavioral dysregulation in prenatally cocaine-exposed infants. The findings indicate flatter temperament may be specific to nonsocial contexts, whereas social interactions may be more distressing for cocaine-exposed infants. En ligne : http://dx.doi.org/10.1017/S0954579415000504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Effects of prenatal substance exposure on infant temperament vary by context [Texte imprimé et/ou numérique] / Robin L. LOCKE, Auteur ; Linda L. LAGASSE, Auteur ; Ronald SEIFER, Auteur ; Barry M. LESTER, Auteur ; Seetha SHANKARAN, Auteur ; Henrietta S. BADA, Auteur ; Charles R. BAUER, Auteur . - p.309-326. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.309-326 Index. décimale : PER Périodiques Résumé : This was a prospective longitudinal multisite study of the effects of prenatal cocaine and/or opiate exposure on temperament in 4-month-olds of the Maternal Lifestyle Study (N = 958: 366 cocaine exposed, 37 opiate exposed, 33 exposed to both drugs, 522 matched comparison). The study evaluated positivity and negativity during The Behavior Assessment of Infant Temperament (Garcia Coll et al., 1988). Parents rated temperament (Infant Behavior Questionnaire; Rothbart, 1981). Cocaine-exposed infants showed less positivity overall, mainly during activity and threshold items, more negativity during sociability items, and less negativity during irritability and threshold items. Latent profile analysis indicated individual temperament patterns were best described by three groups: low/moderate overall reactivity, high social negative reactivity, and high nonsocial negative reactivity. Infants with heavy cocaine exposure were more likely in high social negative reactivity profile, were less negative during threshold items, and required longer soothing intervention. Cocaine- and opiate-exposed infants scored lower on Infant Behavior Questionnaire smiling and laughter and duration of orienting scales. Opiate-exposed infants were rated as less respondent to soothing. By including a multitask measure of temperament we were able to show context-specific behavioral dysregulation in prenatally cocaine-exposed infants. The findings indicate flatter temperament may be specific to nonsocial contexts, whereas social interactions may be more distressing for cocaine-exposed infants. En ligne : http://dx.doi.org/10.1017/S0954579415000504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder / Stephen J. SHEINKOPF in Autism Research and Treatment, (November 2013)  

Public ISBD [article]  inAutism Research and Treatment > (November 2013) . - 7 p. Titre : Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephen J. SHEINKOPF, Auteur ; A. Rebecca NEAL-BEEVERS, Auteur ; Todd P. LEVINE, Auteur ; Cynthia MILLER-LONCAR, Auteur ; Barry M. LESTER, Auteur Année de publication : 2013 Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychophysiology studies of heart rate and heart rate variability can be employed to study regulatory processes in children with autism. The objective of this study was to test for differences in respiratory sinus arrhythmia (RSA; a measure of heart rate variability) and to examine the relationship between physiologic responses and measures of social behavior. Participants included 2- to 6-year-old children with Autistic Disorder and children without autism. Heart rate and RSA were derived from ECG recordings made during a baseline period and then a stranger approach paradigm. Social and adaptive behavior was assessed by parent report. Groups did not differ in mean heart rate or RSA at baseline or in response to social challenge. However, children with autism were more likely to show a physiologic response to intrusive portions of the stranger approach than to less intrusive portions of this procedure. Nonautistic children were equally likely to respond to intrusive and less intrusive social events. Within the autistic group, physiologic response to the intrusive stranger approach corresponded to higher ratings of social adaptive behaviors. These results suggest that physiologic responses to social challenge may help understand differences in social behavioral outcomes in children with autism. En ligne : http://dx.doi.org/10.1155/2013/868396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder [Texte imprimé et/ou numérique] / Stephen J. SHEINKOPF, Auteur ; A. Rebecca NEAL-BEEVERS, Auteur ; Todd P. LEVINE, Auteur ; Cynthia MILLER-LONCAR, Auteur ; Barry M. LESTER, Auteur . - 2013 . - 7 p. Langues : Anglais (eng) in Autism Research and Treatment > (November 2013) . - 7 p. Index. décimale : PER Périodiques Résumé : Psychophysiology studies of heart rate and heart rate variability can be employed to study regulatory processes in children with autism. The objective of this study was to test for differences in respiratory sinus arrhythmia (RSA; a measure of heart rate variability) and to examine the relationship between physiologic responses and measures of social behavior. Participants included 2- to 6-year-old children with Autistic Disorder and children without autism. Heart rate and RSA were derived from ECG recordings made during a baseline period and then a stranger approach paradigm. Social and adaptive behavior was assessed by parent report. Groups did not differ in mean heart rate or RSA at baseline or in response to social challenge. However, children with autism were more likely to show a physiologic response to intrusive portions of the stranger approach than to less intrusive portions of this procedure. Nonautistic children were equally likely to respond to intrusive and less intrusive social events. Within the autistic group, physiologic response to the intrusive stranger approach corresponded to higher ratings of social adaptive behaviors. These results suggest that physiologic responses to social challenge may help understand differences in social behavioral outcomes in children with autism. En ligne : http://dx.doi.org/10.1155/2013/868396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Physiologic arousal to social stress in children with Autism Spectrum Disorders: A pilot study / Todd P. LEVINE in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.177-183 Titre : Physiologic arousal to social stress in children with Autism Spectrum Disorders: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Todd P. LEVINE, Auteur ; Stephen J. SHEINKOPF, Auteur ; Matthew PESCOSOLIDO, Auteur ; Alison RODINO, Auteur ; Gregory ELIA, Auteur ; Barry M. LESTER, Auteur Année de publication : 2012 Article en page(s) : p.177-183 Langues : Anglais (eng) Mots-clés : Psychophysiology  Trier Social Stress Test  High functioning autism  Stress Index. décimale : PER Périodiques Résumé : Little is known about arousal to socially stressful situations in children with Autism Spectrum Disorders. This preliminary study investigates physiologic arousal in children with high functioning autism (HFA, n = 19) compared to a comparison group (n = 11) before, during, and after the Trier Social Stress Test. The HFA group was more likely to have a decrease in salivary cortisol following the stressor, while the comparison group was more likely to have an increase (p = .02). However, there was no difference in electrodermal activity, a measure of sympathetic arousal, or vagal tone, a measure of parasympathetic activity, between groups. These findings implicate a differential neuroendocrine response to social stress in children with HFA despite similar sympathetic and parasympathetic responses during a stressor. Further studies are required to substantiate this finding. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.04.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Physiologic arousal to social stress in children with Autism Spectrum Disorders: A pilot study [Texte imprimé et/ou numérique] / Todd P. LEVINE, Auteur ; Stephen J. SHEINKOPF, Auteur ; Matthew PESCOSOLIDO, Auteur ; Alison RODINO, Auteur ; Gregory ELIA, Auteur ; Barry M. LESTER, Auteur . - 2012 . - p.177-183. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.177-183 Mots-clés : Psychophysiology  Trier Social Stress Test  High functioning autism  Stress Index. décimale : PER Périodiques Résumé : Little is known about arousal to socially stressful situations in children with Autism Spectrum Disorders. This preliminary study investigates physiologic arousal in children with high functioning autism (HFA, n = 19) compared to a comparison group (n = 11) before, during, and after the Trier Social Stress Test. The HFA group was more likely to have a decrease in salivary cortisol following the stressor, while the comparison group was more likely to have an increase (p = .02). However, there was no difference in electrodermal activity, a measure of sympathetic arousal, or vagal tone, a measure of parasympathetic activity, between groups. These findings implicate a differential neuroendocrine response to social stress in children with HFA despite similar sympathetic and parasympathetic responses during a stressor. Further studies are required to substantiate this finding. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.04.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence / Philip A. FISHER in Development and Psychopathology, 23-3 (August 2011)  

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The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure / Elisabeth CONRADT in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

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The Effects of Maternal Epidural Anesthesia on Neonatal Behavior During the First Month / Carol M. SEPKOSKI in Developmental Medicine & Child Neurology, 34-12 (December 1992)

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Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence / Linda L. LAGASSE in Development and Psychopathology, 28-3 (August 2016)  

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Vagal tone as a resilience factor in children with prenatal cocaine exposure / Stephen J. SHEINKOPF in Development and Psychopathology, 19-3 (Summer 2007)  

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