Adolescent-Specific Motivation Deficits in Autism Versus Typical Development / Dienke J. BOS in Journal of Autism and Developmental Disorders, 50-1 (January 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.364-372 Titre : Adolescent-Specific Motivation Deficits in Autism Versus Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : Dienke J. BOS, Auteur ; Benjamin M. SILVER, Auteur ; Emily D. BARNES, Auteur ; Eliana L. AJODAN, Auteur ; Melanie R. SILVERMAN, Auteur ; Elysha CLARK-WHITNEY, Auteur ; Thaddeus TARPEY, Auteur ; Rebecca M. JONES, Auteur Article en page(s) : p.364-372 Langues : Anglais (eng) Mots-clés : Adolescence  Autism  Cognitive control  Development Index. décimale : PER Périodiques Résumé : Differences in motivation during adolescence relative to childhood and adulthood in autism was tested in a cross-sectional study. 156 Typically developing individuals and 79 individuals with autism ages 10-30 years of age completed a go/nogo task with social and non-social cues. To assess age effects, linear and quadratic models were used. Consistent with prior studies, typically developing adolescents and young adults demonstrated more false alarms for positive relative to neutral social cues. In autism, there were no changes in attention across age for social or non-social cues. Findings suggest reduced orienting to motivating cues during late adolescence and early adulthood in autism. The findings provide a unique perspective to explain the challenges for adolescents with autism transitioning to adulthood. En ligne : http://dx.doi.org/10.1007/s10803-019-04258-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Adolescent-Specific Motivation Deficits in Autism Versus Typical Development [Texte imprimé et/ou numérique] / Dienke J. BOS, Auteur ; Benjamin M. SILVER, Auteur ; Emily D. BARNES, Auteur ; Eliana L. AJODAN, Auteur ; Melanie R. SILVERMAN, Auteur ; Elysha CLARK-WHITNEY, Auteur ; Thaddeus TARPEY, Auteur ; Rebecca M. JONES, Auteur . - p.364-372. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.364-372 Mots-clés : Adolescence  Autism  Cognitive control  Development Index. décimale : PER Périodiques Résumé : Differences in motivation during adolescence relative to childhood and adulthood in autism was tested in a cross-sectional study. 156 Typically developing individuals and 79 individuals with autism ages 10-30 years of age completed a go/nogo task with social and non-social cues. To assess age effects, linear and quadratic models were used. Consistent with prior studies, typically developing adolescents and young adults demonstrated more false alarms for positive relative to neutral social cues. In autism, there were no changes in attention across age for social or non-social cues. Findings suggest reduced orienting to motivating cues during late adolescence and early adulthood in autism. The findings provide a unique perspective to explain the challenges for adolescents with autism transitioning to adulthood. En ligne : http://dx.doi.org/10.1007/s10803-019-04258-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Children with ADHD symptoms show decreased activity in ventral striatum during the anticipation of reward, irrespective of ADHD diagnosis / Branko M. VAN HULST in Journal of Child Psychology and Psychiatry, 58-2 (February 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.206-214 Titre : Children with ADHD symptoms show decreased activity in ventral striatum during the anticipation of reward, irrespective of ADHD diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Branko M. VAN HULST, Auteur ; Patrick DE ZEEUW, Auteur ; Dienke J. BOS, Auteur ; Yvonne RIJKS, Auteur ; Sebastiaan F. W. NEGGERS, Auteur ; Sarah DURSTON, Auteur Année de publication : 2017 Article en page(s) : p.206-214 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  fMRI  reward processing  striatum  trans-diagnostic mechanisms  reward anticipation  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Changes in reward processing are thought to be involved in the etiology of attention-deficit/hyperactivity disorder (ADHD), as well as other developmental disorders. In addition, different forms of therapy for ADHD rely on reinforcement principles. As such, improved understanding of reward processing in ADHD could eventually lead to more effective treatment options. However, differences in reward processing may not be specific to ADHD, but may be a trans-diagnostic feature of disorders that involve ADHD-like symptoms. Methods In this event-related fMRI study, we used a child-friendly version of the monetary incentive delay task to assess performance and brain activity during reward anticipation. Also, we collected questionnaire data to assess reward sensitivity in daily life. For final analyses, data were available for 27 typically developing children, 24 children with ADHD, and 25 children with an autism spectrum disorder (ASD) and ADHD symptoms. Results We found decreased activity in ventral striatum during anticipation of reward in children with ADHD symptoms, both for children with ADHD as their primary diagnosis and in children with autism spectrum disorder and ADHD symptoms. We found that higher parent-rated sensitivity to reward was associated with greater anticipatory activity in ventral striatum for children with ADHD symptoms. In contrast, there was no relationship between the degree of ADHD symptoms and activity in ventral striatum. Conclusions We provide evidence of biological and behavioral differences in reward sensitivity in children with ADHD symptoms, regardless of their primary diagnosis. Ultimately, a dimensional brain-behavior model of reward sensitivity in children with symptoms of ADHD may be useful to refine treatment options dependent on reward processing. En ligne : http://dx.doi.org/10.1111/jcpp.12643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299 [article] Children with ADHD symptoms show decreased activity in ventral striatum during the anticipation of reward, irrespective of ADHD diagnosis [Texte imprimé et/ou numérique] / Branko M. VAN HULST, Auteur ; Patrick DE ZEEUW, Auteur ; Dienke J. BOS, Auteur ; Yvonne RIJKS, Auteur ; Sebastiaan F. W. NEGGERS, Auteur ; Sarah DURSTON, Auteur . - 2017 . - p.206-214. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.206-214 Mots-clés : Attention-deficit/hyperactivity disorder  fMRI  reward processing  striatum  trans-diagnostic mechanisms  reward anticipation  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background Changes in reward processing are thought to be involved in the etiology of attention-deficit/hyperactivity disorder (ADHD), as well as other developmental disorders. In addition, different forms of therapy for ADHD rely on reinforcement principles. As such, improved understanding of reward processing in ADHD could eventually lead to more effective treatment options. However, differences in reward processing may not be specific to ADHD, but may be a trans-diagnostic feature of disorders that involve ADHD-like symptoms. Methods In this event-related fMRI study, we used a child-friendly version of the monetary incentive delay task to assess performance and brain activity during reward anticipation. Also, we collected questionnaire data to assess reward sensitivity in daily life. For final analyses, data were available for 27 typically developing children, 24 children with ADHD, and 25 children with an autism spectrum disorder (ASD) and ADHD symptoms. Results We found decreased activity in ventral striatum during anticipation of reward in children with ADHD symptoms, both for children with ADHD as their primary diagnosis and in children with autism spectrum disorder and ADHD symptoms. We found that higher parent-rated sensitivity to reward was associated with greater anticipatory activity in ventral striatum for children with ADHD symptoms. In contrast, there was no relationship between the degree of ADHD symptoms and activity in ventral striatum. Conclusions We provide evidence of biological and behavioral differences in reward sensitivity in children with ADHD symptoms, regardless of their primary diagnosis. Ultimately, a dimensional brain-behavior model of reward sensitivity in children with symptoms of ADHD may be useful to refine treatment options dependent on reward processing. En ligne : http://dx.doi.org/10.1111/jcpp.12643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299

Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder / Dienke J. BOS in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.810-818 Titre : Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dienke J. BOS, Auteur ; Bob ORANJE, Auteur ; Michelle ACHTERBERG, Auteur ; Chantal VLASKAMP, Auteur ; Sara AMBROSINO, Auteur ; Marcel A. DE REUS, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Sarah DURSTON, Auteur Article en page(s) : p.810-818 Langues : Anglais (eng) Mots-clés : Attention deficit/hyperactivity disorder  functional connectivity  structural connectivity  Default Mode Network  developmental delay Index. décimale : PER Périodiques Résumé : Background Attention deficit/hyperactivity disorder (ADHD) has frequently been associated with changes in resting-state functional connectivity, and decreased white matter (WM) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting-state networks (RSNs) in children with and without ADHD. We hypothesized the RSNs of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure. Methods Resting-state fMRI and diffusion-weighted imaging data were acquired from 35 participants with ADHD and 36 matched typically developing peers, aged 6 through 18 years. Functional connectivity was assessed using independent component analysis. Network topology and WM connectivity were further investigated using graph theoretical measures and tract-based spatial statistics (TBSS). Results Resting-state fMRI analyses showed increased functional connectivity in right inferior frontal gyrus (IFG), and bilateral medial prefrontal cortex (mPFC) within the Default Mode and frontal control networks. Furthermore, a more diffuse spatial pattern of functional connectivity was found in children with ADHD. We found no group differences in structural connectivity as assessed with TBSS or graph theoretical measures. Conclusions Resting-state networks show a more diffuse pattern of connectivity in children with ADHD. The increases in functional connectivity in right IFG and bilateral mPFC in children with ADHD may reflect reduced or delayed functional segregation of prefrontal brain regions. As these functional changes were not accompanied by changes in WM, they may precede the development of the frequently reported changes in WM structure. En ligne : http://dx.doi.org/10.1111/jcpp.12712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Dienke J. BOS, Auteur ; Bob ORANJE, Auteur ; Michelle ACHTERBERG, Auteur ; Chantal VLASKAMP, Auteur ; Sara AMBROSINO, Auteur ; Marcel A. DE REUS, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Sarah DURSTON, Auteur . - p.810-818. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.810-818 Mots-clés : Attention deficit/hyperactivity disorder  functional connectivity  structural connectivity  Default Mode Network  developmental delay Index. décimale : PER Périodiques Résumé : Background Attention deficit/hyperactivity disorder (ADHD) has frequently been associated with changes in resting-state functional connectivity, and decreased white matter (WM) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting-state networks (RSNs) in children with and without ADHD. We hypothesized the RSNs of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure. Methods Resting-state fMRI and diffusion-weighted imaging data were acquired from 35 participants with ADHD and 36 matched typically developing peers, aged 6 through 18 years. Functional connectivity was assessed using independent component analysis. Network topology and WM connectivity were further investigated using graph theoretical measures and tract-based spatial statistics (TBSS). Results Resting-state fMRI analyses showed increased functional connectivity in right inferior frontal gyrus (IFG), and bilateral medial prefrontal cortex (mPFC) within the Default Mode and frontal control networks. Furthermore, a more diffuse spatial pattern of functional connectivity was found in children with ADHD. We found no group differences in structural connectivity as assessed with TBSS or graph theoretical measures. Conclusions Resting-state networks show a more diffuse pattern of connectivity in children with ADHD. The increases in functional connectivity in right IFG and bilateral mPFC in children with ADHD may reflect reduced or delayed functional segregation of prefrontal brain regions. As these functional changes were not accompanied by changes in WM, they may precede the development of the frequently reported changes in WM structure. En ligne : http://dx.doi.org/10.1111/jcpp.12712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

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