Autism and emotional face-viewing / Jakob Ã…SBERG JOHNELS in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.901-910 Titre : Autism and emotional face-viewing Type de document : texte imprimé Auteurs : Jakob Ã…SBERG JOHNELS, Auteur ; Daniel HOVEY, Auteur ; Nicole ZÃœRCHER, Auteur ; Loyse HIPPOLYTE, Auteur ; Eric LEMONNIER, Auteur ; Christopher GILLBERG, Auteur ; Nouchine HADJIKHANI, Auteur Article en page(s) : p.901-910 Langues : Anglais (eng) Mots-clés : autism  eye-tracking  mouth  face  autism quotient  social  endophenotype Index. décimale : PER Périodiques Résumé : Atypical patterns of face-scanning in individuals with autism spectrum disorder (ASD) may contribute to difficulties in social interactions, but there is little agreement regarding what exactly characterizes face-viewing in ASD. In addition, little research has examined how face-viewing is modulated by the emotional expression of the stimuli, in individuals with or without ASD. We used eye-tracking to explore viewing patterns during perception of dynamic emotional facial expressions in relatively large groups of individuals with (n = 57) and without ASD (n = 58) and examined diagnostic- and age-related effects, after subgrouping children and adolescents (≤18 years), on the one hand, and adults (>18 years), on the other. Results showed that children/adolescents with ASD fixated the mouth of happy and angry faces less than their typically developing (TD) peers, and conversely looked more to the eyes of happy faces. Moreover, while all groups fixated the mouth in happy faces more than in other expressions, children/adolescents with ASD did relatively less so. Correlation analysis showed a similar lack of relative orientation towards the mouth of smiling faces in TD children/adolescents with high autistic traits, as measured by the Autism-Spectrum Quotient (AQ). Among adults, participants with ASD only attended less to the eyes for neutral faces. Our study shows that the emotional content of a face influences gaze behaviour, and that this effect is not fully developed in children/adolescents with ASD. Interestingly, this lack of differentiation observed in the younger ASD group was also seen in younger TD individuals with higher AQ scores. En ligne : http://dx.doi.org/10.1002/aur.1730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Autism and emotional face-viewing [texte imprimé] / Jakob Ã…SBERG JOHNELS, Auteur ; Daniel HOVEY, Auteur ; Nicole ZÃœRCHER, Auteur ; Loyse HIPPOLYTE, Auteur ; Eric LEMONNIER, Auteur ; Christopher GILLBERG, Auteur ; Nouchine HADJIKHANI, Auteur . - p.901-910. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.901-910 Mots-clés : autism  eye-tracking  mouth  face  autism quotient  social  endophenotype Index. décimale : PER Périodiques Résumé : Atypical patterns of face-scanning in individuals with autism spectrum disorder (ASD) may contribute to difficulties in social interactions, but there is little agreement regarding what exactly characterizes face-viewing in ASD. In addition, little research has examined how face-viewing is modulated by the emotional expression of the stimuli, in individuals with or without ASD. We used eye-tracking to explore viewing patterns during perception of dynamic emotional facial expressions in relatively large groups of individuals with (n = 57) and without ASD (n = 58) and examined diagnostic- and age-related effects, after subgrouping children and adolescents (≤18 years), on the one hand, and adults (>18 years), on the other. Results showed that children/adolescents with ASD fixated the mouth of happy and angry faces less than their typically developing (TD) peers, and conversely looked more to the eyes of happy faces. Moreover, while all groups fixated the mouth in happy faces more than in other expressions, children/adolescents with ASD did relatively less so. Correlation analysis showed a similar lack of relative orientation towards the mouth of smiling faces in TD children/adolescents with high autistic traits, as measured by the Autism-Spectrum Quotient (AQ). Among adults, participants with ASD only attended less to the eyes for neutral faces. Our study shows that the emotional content of a face influences gaze behaviour, and that this effect is not fully developed in children/adolescents with ASD. Interestingly, this lack of differentiation observed in the younger ASD group was also seen in younger TD individuals with higher AQ scores. En ligne : http://dx.doi.org/10.1002/aur.1730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study / Nouchine HADJIKHANI in Autism, 19-2 (February 2015)  

Public ISBD [article]  inAutism > 19-2 (February 2015) . - p.149-157 Titre : Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study Type de document : texte imprimé Auteurs : Nouchine HADJIKHANI, Auteur ; Nicole R. ZÃœRCHER, Auteur ; Ophelie ROGIER, Auteur ; Torsten RUEST, Auteur ; Loyse HIPPOLYTE, Auteur ; Yehezkel BEN-ARI, Auteur ; Eric LEMONNIER, Auteur Article en page(s) : p.149-157 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  bumetanide  emotion  face perception  fMRI  GABA  treatment Index. décimale : PER Périodiques Résumé : Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl–)i and excitatory action of GABA. In a previous double-blind randomized study, we have shown that the diuretic NKCC1 chloride importer antagonist bumetanide, that decreases (Cl–)i and reinforces GABAergic inhibition, reduces the severity of autism symptoms. Here, we report results from an open-label trial pilot study in which we used functional magnetic resonance imaging and neuropsychological testing to determine the effects of 10 months bumetanide treatment in adolescents and young adults with autism. We show that bumetanide treatment improves emotion recognition and enhances the activation of brain regions involved in social and emotional perception during the perception of emotional faces. The improvement of emotion processing by bumetanide reinforces the usefulness of bumetanide as a promising treatment to improve social interactions in autism. En ligne : http://dx.doi.org/10.1177/1362361313514141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study [texte imprimé] / Nouchine HADJIKHANI, Auteur ; Nicole R. ZÃœRCHER, Auteur ; Ophelie ROGIER, Auteur ; Torsten RUEST, Auteur ; Loyse HIPPOLYTE, Auteur ; Yehezkel BEN-ARI, Auteur ; Eric LEMONNIER, Auteur . - p.149-157. Langues : Anglais (eng) in Autism > 19-2 (February 2015) . - p.149-157 Mots-clés : Autism spectrum disorders  bumetanide  emotion  face perception  fMRI  GABA  treatment Index. décimale : PER Périodiques Résumé : Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl–)i and excitatory action of GABA. In a previous double-blind randomized study, we have shown that the diuretic NKCC1 chloride importer antagonist bumetanide, that decreases (Cl–)i and reinforces GABAergic inhibition, reduces the severity of autism symptoms. Here, we report results from an open-label trial pilot study in which we used functional magnetic resonance imaging and neuropsychological testing to determine the effects of 10 months bumetanide treatment in adolescents and young adults with autism. We show that bumetanide treatment improves emotion recognition and enhances the activation of brain regions involved in social and emotional perception during the perception of emotional faces. The improvement of emotion processing by bumetanide reinforces the usefulness of bumetanide as a promising treatment to improve social interactions in autism. En ligne : http://dx.doi.org/10.1177/1362361313514141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder / Christopher J. SMITH in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3036-3044 Titre : A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Christopher J. SMITH, Auteur ; A. BHANOT, Auteur ; E. NORMAN, Auteur ; Jennifer E. MULLETT, Auteur ; Staci D. BILBO, Auteur ; Christopher J. MCDOUGLE, Auteur ; Nicole R. ZÃœRCHER, Auteur ; J.M. HOOKER, Auteur Article en page(s) : p.3036-3044 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Magnetic resonance imaging  Neuroimaging  Positron emission tomography  Training protocols Index. décimale : PER Périodiques Résumé : Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. We hope to raise awareness of the need for more information exchange between research groups about lessons learned in this context in order to include the entire disease spectrum in neuroimaging studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04010-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder [texte imprimé] / Christopher J. SMITH, Auteur ; A. BHANOT, Auteur ; E. NORMAN, Auteur ; Jennifer E. MULLETT, Auteur ; Staci D. BILBO, Auteur ; Christopher J. MCDOUGLE, Auteur ; Nicole R. ZÃœRCHER, Auteur ; J.M. HOOKER, Auteur . - p.3036-3044. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.3036-3044 Mots-clés : Autism spectrum disorder  Magnetic resonance imaging  Neuroimaging  Positron emission tomography  Training protocols Index. décimale : PER Périodiques Résumé : Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. We hope to raise awareness of the need for more information exchange between research groups about lessons learned in this context in order to include the entire disease spectrum in neuroimaging studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04010-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

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