Services for children with autism in the Kingdom of Saudi Arabia / Fahad M. ALNEMARY in Autism, 21-5 (July 2017)  

Public ISBD [article]  inAutism > 21-5 (July 2017) . - p.592-602 Titre : Services for children with autism in the Kingdom of Saudi Arabia Type de document : Texte imprimé et/ou numérique Auteurs : Fahad M. ALNEMARY, Auteur ; Hesham M. ALDHALAAN, Auteur ; Gabriela SIMON-CEREIJIDO, Auteur ; Faisal M. ALNEMARY, Auteur Article en page(s) : p.592-602 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Little information is available about autism spectrum disorder services in the Kingdom of Saudi Arabia. A sample of 205 parents completed an online survey about the use of autism spectrum disorder services for their children. The results revealed that on average, children began services by 3.3?years. Most parents reported utilizing non-medical treatments followed by biomedical treatments and cultural and religious treatment. The age at the initiation of services and the type of treatments used differed by parent?s income, educational attainment, the extent of knowledge about autism spectrum disorders, and geographic location. Some child characteristics also influenced the use of services. The disparities in service utilization in Saudi Arabia point to the need to develop policy and interventions that can mitigate the paucity of services for children with autism spectrum disorders. More research is needed to better understand service use and the decision-making processes that underlie treatment selection by parents of children with autism spectrum disorders in the Kingdom of Saudi Arabia. En ligne : http://dx.doi.org/10.1177/1362361316664868 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Services for children with autism in the Kingdom of Saudi Arabia [Texte imprimé et/ou numérique] / Fahad M. ALNEMARY, Auteur ; Hesham M. ALDHALAAN, Auteur ; Gabriela SIMON-CEREIJIDO, Auteur ; Faisal M. ALNEMARY, Auteur . - p.592-602. Langues : Anglais (eng) in Autism > 21-5 (July 2017) . - p.592-602 Index. décimale : PER Périodiques Résumé : Little information is available about autism spectrum disorder services in the Kingdom of Saudi Arabia. A sample of 205 parents completed an online survey about the use of autism spectrum disorder services for their children. The results revealed that on average, children began services by 3.3?years. Most parents reported utilizing non-medical treatments followed by biomedical treatments and cultural and religious treatment. The age at the initiation of services and the type of treatments used differed by parent?s income, educational attainment, the extent of knowledge about autism spectrum disorders, and geographic location. Some child characteristics also influenced the use of services. The disparities in service utilization in Saudi Arabia point to the need to develop policy and interventions that can mitigate the paucity of services for children with autism spectrum disorders. More research is needed to better understand service use and the decision-making processes that underlie treatment selection by parents of children with autism spectrum disorders in the Kingdom of Saudi Arabia. En ligne : http://dx.doi.org/10.1177/1362361316664868 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model / Hafiz M. MAHMOOD in Autism Research, 13-8 (August 2020)  

Public ISBD [article]  inAutism Research > 13-8 (August 2020) . - p.1311-1334 Titre : The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model Type de document : Texte imprimé et/ou numérique Auteurs : Hafiz M. MAHMOOD, Auteur ; Hesham M. ALDHALAAN, Auteur ; Tahani K. ALSHAMMARI, Auteur ; Mashael A. ALQASEM, Auteur ; Musaad A. ALSHAMMARI, Auteur ; Norah A. ALBEKAIRI, Auteur ; Shakir D. ALSHARARI, Auteur Article en page(s) : p.1311-1334 Langues : Anglais (eng) Mots-clés : BTBR T?+?tf/J  autism  nicotine  nicotinic receptor Index. décimale : PER Périodiques Résumé : Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T?+?tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T?+?tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three-chamber social interaction, self-grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2?weeks in BTBR T?+?tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T?+?tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T?+?tf/J mice. Overall, the findings indicate that the pharmacological modulation of nicotinic receptors is involved in modulating core behavioral phenotypes in the BTBR T?+?tf/J mouse model. LAY SUMMARY: The involvement of brain nicotinic neurotransmission system plays a crucial role in regulating autism-related behavioral features. In addition, the brain of the autistic-like mouse model has a low acetylcholine level. Here, we report that nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy. Autism Res 2020, 13: 1311-1334. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model [Texte imprimé et/ou numérique] / Hafiz M. MAHMOOD, Auteur ; Hesham M. ALDHALAAN, Auteur ; Tahani K. ALSHAMMARI, Auteur ; Mashael A. ALQASEM, Auteur ; Musaad A. ALSHAMMARI, Auteur ; Norah A. ALBEKAIRI, Auteur ; Shakir D. ALSHARARI, Auteur . - p.1311-1334. Langues : Anglais (eng) in Autism Research > 13-8 (August 2020) . - p.1311-1334 Mots-clés : BTBR T?+?tf/J  autism  nicotine  nicotinic receptor Index. décimale : PER Périodiques Résumé : Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T?+?tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T?+?tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three-chamber social interaction, self-grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2?weeks in BTBR T?+?tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T?+?tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T?+?tf/J mice. Overall, the findings indicate that the pharmacological modulation of nicotinic receptors is involved in modulating core behavioral phenotypes in the BTBR T?+?tf/J mouse model. LAY SUMMARY: The involvement of brain nicotinic neurotransmission system plays a crucial role in regulating autism-related behavioral features. In addition, the brain of the autistic-like mouse model has a low acetylcholine level. Here, we report that nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy. Autism Res 2020, 13: 1311-1334. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Validation of the Arabic version of the Social Communication Questionnaire / Mohammed ALDOSARI in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1655-1662 Titre : Validation of the Arabic version of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Mohammed ALDOSARI, Auteur ; E. FOMBONNE, Auteur ; Hesham M. ALDHALAAN, Auteur ; M. OUDA, Auteur ; S. ELHAG, Auteur ; H. ALSHAMMARI, Auteur ; I. GHAZAL, Auteur ; A. ALSALEH, Auteur ; T. ALQADOUMI, Auteur ; R. THOMSON, Auteur ; M. AL KHASAWNEH, Auteur ; M. TOLEFAT, Auteur ; Fouad ALSHABAN, Auteur Article en page(s) : p.1655-1662 Langues : Anglais (eng) Mots-clés : Arabic  Social Communication Questionnaire  autism spectrum disorder  cutoff values  early intervention  epidemiology  screening  validity Index. décimale : PER Périodiques Résumé : Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. This study validated the Arabic version of the Social Communication Questionnaire. The total study sample included 206 children with autism spectrum disorder and 206 typically developing children (73.8% male; mean age: 8.5 (standard deviation = 2.6) years). The mean Social Communication Questionnaire total score was significantly higher in autism spectrum disorder children than in typically developing children (p < 0.0001). Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups (p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. The total Social Communication Questionnaire score did not vary by age or gender. Internal consistency was excellent (alpha = 0.92). In the receiver operating characteristic analysis, the area under the curve for the total score showed excellent discrimination between autism spectrum disorder and typically developing children (area under the curve = 0.95; 95% confidence interval: 0.93-0.97). The areas under the curve for the scale subscores were 0.923 (95% confidence interval: 0.898-0.949) for the social interaction score, 0.872 (95% confidence interval: 0.838-0.905) for the communication score, and 0.856 (95% confidence interval: 0.819-0.893) for the repetitive behaviors score. The findings support the use of the Arabic Social Communication Questionnaire to successfully differentiate children with clinically diagnosed autism spectrum disorder using the established cutoff value for the English version. En ligne : http://dx.doi.org/10.1177/1362361318816065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Validation of the Arabic version of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Mohammed ALDOSARI, Auteur ; E. FOMBONNE, Auteur ; Hesham M. ALDHALAAN, Auteur ; M. OUDA, Auteur ; S. ELHAG, Auteur ; H. ALSHAMMARI, Auteur ; I. GHAZAL, Auteur ; A. ALSALEH, Auteur ; T. ALQADOUMI, Auteur ; R. THOMSON, Auteur ; M. AL KHASAWNEH, Auteur ; M. TOLEFAT, Auteur ; Fouad ALSHABAN, Auteur . - p.1655-1662. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1655-1662 Mots-clés : Arabic  Social Communication Questionnaire  autism spectrum disorder  cutoff values  early intervention  epidemiology  screening  validity Index. décimale : PER Périodiques Résumé : Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. This study validated the Arabic version of the Social Communication Questionnaire. The total study sample included 206 children with autism spectrum disorder and 206 typically developing children (73.8% male; mean age: 8.5 (standard deviation = 2.6) years). The mean Social Communication Questionnaire total score was significantly higher in autism spectrum disorder children than in typically developing children (p < 0.0001). Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups (p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. The total Social Communication Questionnaire score did not vary by age or gender. Internal consistency was excellent (alpha = 0.92). In the receiver operating characteristic analysis, the area under the curve for the total score showed excellent discrimination between autism spectrum disorder and typically developing children (area under the curve = 0.95; 95% confidence interval: 0.93-0.97). The areas under the curve for the scale subscores were 0.923 (95% confidence interval: 0.898-0.949) for the social interaction score, 0.872 (95% confidence interval: 0.838-0.905) for the communication score, and 0.856 (95% confidence interval: 0.819-0.893) for the repetitive behaviors score. The findings support the use of the Arabic Social Communication Questionnaire to successfully differentiate children with clinically diagnosed autism spectrum disorder using the established cutoff value for the English version. En ligne : http://dx.doi.org/10.1177/1362361318816065 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Validation of the Arabic Version of the Two Sensory Processing Measure Questionnaires / Shahad M. ALKHALIFAH in Research in Autism Spectrum Disorders, 78 (October 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 78 (October 2020) . - 101652 Titre : Validation of the Arabic Version of the Two Sensory Processing Measure Questionnaires Type de document : Texte imprimé et/ou numérique Auteurs : Shahad M. ALKHALIFAH, Auteur ; Hana ALARIFI, Auteur ; Muhammad ALHEIZAN, Auteur ; Hesham M. ALDHALAAN, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : 101652 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  sensory processing  psychometric  SPM  SPM-P  Saudi Arabia Index. décimale : PER Périodiques Résumé : Background There are few standardized and validated tools to evaluate sensory processing difficulties in Arabic countries. The purpose of this study was to evaluate the psychometric properties of Arabic versions of the Home and Preschool- Home versions of the Sensory Processing Measure(SPM), an instrument widely used for clinical and research purposes. Method The overall study sample included 276 children (mean age?=?6.7 years; range: 2 to 12), with 192 children (151 males) with a clinical diagnosis of autism spectrum disorder (ASD) and 84 typically developing (TD; 48 males) children. The SPM-Home sub-sample consisted of 117 children and the SPM-Preschool-Home sample consisted of 159 children. Results Mean scores of the total SPM-Home and of the subscale scores were significantly (p? En ligne : https://doi.org/10.1016/j.rasd.2020.101652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Validation of the Arabic Version of the Two Sensory Processing Measure Questionnaires [Texte imprimé et/ou numérique] / Shahad M. ALKHALIFAH, Auteur ; Hana ALARIFI, Auteur ; Muhammad ALHEIZAN, Auteur ; Hesham M. ALDHALAAN, Auteur ; Eric FOMBONNE, Auteur . - 101652. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101652 Mots-clés : autism spectrum disorder  sensory processing  psychometric  SPM  SPM-P  Saudi Arabia Index. décimale : PER Périodiques Résumé : Background There are few standardized and validated tools to evaluate sensory processing difficulties in Arabic countries. The purpose of this study was to evaluate the psychometric properties of Arabic versions of the Home and Preschool- Home versions of the Sensory Processing Measure(SPM), an instrument widely used for clinical and research purposes. Method The overall study sample included 276 children (mean age?=?6.7 years; range: 2 to 12), with 192 children (151 males) with a clinical diagnosis of autism spectrum disorder (ASD) and 84 typically developing (TD; 48 males) children. The SPM-Home sub-sample consisted of 117 children and the SPM-Preschool-Home sample consisted of 159 children. Results Mean scores of the total SPM-Home and of the subscale scores were significantly (p? En ligne : https://doi.org/10.1016/j.rasd.2020.101652 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

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