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Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder / Hunna J. WATSON in Journal of Child Psychology and Psychiatry, 49-5 (May 2008)

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inJournal of Child Psychology and Psychiatry > 49-5 (May 2008) . - p.489-498

Titre :

Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder

Type de document :

texte imprimé

Auteurs :

Hunna J. WATSON, Auteur ; Clare S. REES, Auteur

Année de publication :

2008

Article en page(s) :

p.489-498

Langues :

Anglais (eng)

Mots-clés :

Child/adolescent-obsessive-compulsive-disorder pediatric meta-analysis cognitive-behavioral-therapy drug-therapy pharmacology psychotherapy

Index. décimale :

PER Périodiques

Résumé :

Objective: To conduct a meta-analysis on randomized, controlled treatment trials of pediatric obsessive-compulsive disorder (OCD).

Method: Studies were included if they employed randomized, controlled methodology and treated young people (19 years or under) with OCD. A comprehensive literature search identified 13 RCTs containing 10 pharmacotherapy to control comparisons (N = 1016) and five cognitive-behavioral therapy (CBT) to control comparisons (N = 161).

Results: Random effects modeling yielded statistically significant pooled effect size (ES) estimates for pharmacotherapy (ES = .48, 95% CI = .36 to .61, p < .00001) and CBT (ES = 1.45, 95% CI = .68 to 2.22, p = .002). The results were robust to publication bias.

Conclusions: This is the first meta-analysis of treatment RCTs for pediatric OCD. CBT and pharmacotherapy were the only treatments effective beyond control in alleviating OCD symptoms. CBT showed a greater ES than pharmacotherapy. Previous meta-analyses that included uncontrolled trials exaggerated the efficacy of both treatments.

En ligne :

http://dx.doi.org/10.1111/j.1469-7610.2007.01875.x

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