Evaluating the quality of peer interactions in children and adolescents with autism with the Penn Interactive Peer Play Scale (PIPPS) / R. M. JONES in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 28p. Titre : Evaluating the quality of peer interactions in children and adolescents with autism with the Penn Interactive Peer Play Scale (PIPPS) Type de document : Texte imprimé et/ou numérique Auteurs : R. M. JONES, Auteur ; A. PICKLES, Auteur ; C. LORD, Auteur Article en page(s) : 28p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Peer interactions  Penn Interactive Peer Play Scale (PIPPS)  Teacher ratings Index. décimale : PER Périodiques Résumé : BACKGROUND: A core difficulty for individuals with autism is making friends and successfully engaging and interacting with peers. The majority of measures to assess peer interactions are observations in a school setting or self-report. The present study examined the convergent validity of using a teacher rating scale, the Penn Interactive Peer Play Scale (PIPPS), for collecting information about the quality of peer interactions at school. METHODS: Teachers completed the PIPPS for 107 children with ASD when the child was 9 and 13 years of age. Clinicians completed diagnostic and cognitive assessments and caregivers completed the Autism Diagnostic Interview-Revised (ADI-R) when the child was 9. RESULTS: Parent report of reciprocal friendships from the ADI-R was associated with teacher report about how socially connected the child was at school on the PIPPS, indicating strong convergence between teachers and parents. Children with more severe restricted and repetitive behaviors and lower verbal abilities were less connected with peers. Children with access to typical peers had more connections with peers compared to those who were in a special education classroom. CONCLUSIONS: The findings suggest that teacher ratings from the PIPPS can accurately capture the quality of peer interactions in children and adolescents with ASD and may be useful for clinicians and researchers to evaluate peer engagement in the classroom. En ligne : http://dx.doi.org/10.1186/s13229-017-0144-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Evaluating the quality of peer interactions in children and adolescents with autism with the Penn Interactive Peer Play Scale (PIPPS) [Texte imprimé et/ou numérique] / R. M. JONES, Auteur ; A. PICKLES, Auteur ; C. LORD, Auteur . - 28p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 28p. Mots-clés : Autism spectrum disorder (ASD)  Peer interactions  Penn Interactive Peer Play Scale (PIPPS)  Teacher ratings Index. décimale : PER Périodiques Résumé : BACKGROUND: A core difficulty for individuals with autism is making friends and successfully engaging and interacting with peers. The majority of measures to assess peer interactions are observations in a school setting or self-report. The present study examined the convergent validity of using a teacher rating scale, the Penn Interactive Peer Play Scale (PIPPS), for collecting information about the quality of peer interactions at school. METHODS: Teachers completed the PIPPS for 107 children with ASD when the child was 9 and 13 years of age. Clinicians completed diagnostic and cognitive assessments and caregivers completed the Autism Diagnostic Interview-Revised (ADI-R) when the child was 9. RESULTS: Parent report of reciprocal friendships from the ADI-R was associated with teacher report about how socially connected the child was at school on the PIPPS, indicating strong convergence between teachers and parents. Children with more severe restricted and repetitive behaviors and lower verbal abilities were less connected with peers. Children with access to typical peers had more connections with peers compared to those who were in a special education classroom. CONCLUSIONS: The findings suggest that teacher ratings from the PIPPS can accurately capture the quality of peer interactions in children and adolescents with ASD and may be useful for clinicians and researchers to evaluate peer engagement in the classroom. En ligne : http://dx.doi.org/10.1186/s13229-017-0144-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts? / R. M. JONES in Autism Research, 12-4 (April 2019)  

Public ISBD [article]  inAutism Research > 12-4 (April 2019) . - p.628-635 Titre : How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts? Type de document : Texte imprimé et/ou numérique Auteurs : R. M. JONES, Auteur ; D. PLESA SKWERER, Auteur ; R. PAWAR, Auteur ; A. HAMO, Auteur ; Caroline CARBERRY, Auteur ; Eliana L. AJODAN, Auteur ; D. CAULLEY, Auteur ; M. R. SILVERMAN, Auteur ; S. MCADOO, Auteur ; S. MEYER, Auteur ; A. YODER, Auteur ; M. CLEMENTS, Auteur ; C. LORD, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.628-635 Langues : Anglais (eng) Mots-clés : Lena  acoustic recordings  autism spectrum disorder  automated language detection  communication Index. décimale : PER Périodiques Résumé : The LENA system was designed and validated to provide information about the language environment in children 0 to 4 years of age and its use has been expanded to populations with a number of communication profiles. Its utility in children 5 years of age and older is not yet known. The present study used acoustic data from two samples of children with autism spectrum disorders (ASD) to evaluate the reliability of LENA automated analyses for detecting speech utterances in older, school age children, and adolescents with ASD, in clinic and home environments. Participants between 5 and 18 years old who were minimally verbal (study 1) or had a range of verbal abilities (study 2) completed standardized assessments in the clinic (study 1 and 2) and in the home (study 2) while speech was recorded from a LENA device. We compared LENA segment labels with manual ground truth coding by human transcribers using two different methods. We found that the automated LENA algorithms were not successful (<50% reliable) in detecting vocalizations from older children and adolescents with ASD, and that the proportion of speaker misclassifications by the automated system increased significantly with the target-child's age. The findings in children and adolescents with ASD suggest possibly misleading results when expanding the use of LENA beyond the age ranges for which it was developed and highlight the need to develop novel automated methods that are more appropriate for older children. Autism Research 2019, 12: 628-635. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Current commercially available speech detection algorithms (LENA system) were previously validated in toddlers and children up to 48 months of age, and it is not known whether they are reliable in older children and adolescents. Our data suggest that LENA does not adequately capture speech in school age children and adolescents with autism and highlights the need to develop new automated methods for older children. En ligne : https://dx.doi.org/10.1002/aur.2071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts? [Texte imprimé et/ou numérique] / R. M. JONES, Auteur ; D. PLESA SKWERER, Auteur ; R. PAWAR, Auteur ; A. HAMO, Auteur ; Caroline CARBERRY, Auteur ; Eliana L. AJODAN, Auteur ; D. CAULLEY, Auteur ; M. R. SILVERMAN, Auteur ; S. MCADOO, Auteur ; S. MEYER, Auteur ; A. YODER, Auteur ; M. CLEMENTS, Auteur ; C. LORD, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.628-635. Langues : Anglais (eng) in Autism Research > 12-4 (April 2019) . - p.628-635 Mots-clés : Lena  acoustic recordings  autism spectrum disorder  automated language detection  communication Index. décimale : PER Périodiques Résumé : The LENA system was designed and validated to provide information about the language environment in children 0 to 4 years of age and its use has been expanded to populations with a number of communication profiles. Its utility in children 5 years of age and older is not yet known. The present study used acoustic data from two samples of children with autism spectrum disorders (ASD) to evaluate the reliability of LENA automated analyses for detecting speech utterances in older, school age children, and adolescents with ASD, in clinic and home environments. Participants between 5 and 18 years old who were minimally verbal (study 1) or had a range of verbal abilities (study 2) completed standardized assessments in the clinic (study 1 and 2) and in the home (study 2) while speech was recorded from a LENA device. We compared LENA segment labels with manual ground truth coding by human transcribers using two different methods. We found that the automated LENA algorithms were not successful (<50% reliable) in detecting vocalizations from older children and adolescents with ASD, and that the proportion of speaker misclassifications by the automated system increased significantly with the target-child's age. The findings in children and adolescents with ASD suggest possibly misleading results when expanding the use of LENA beyond the age ranges for which it was developed and highlight the need to develop novel automated methods that are more appropriate for older children. Autism Research 2019, 12: 628-635. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Current commercially available speech detection algorithms (LENA system) were previously validated in toddlers and children up to 48 months of age, and it is not known whether they are reliable in older children and adolescents. Our data suggest that LENA does not adequately capture speech in school age children and adolescents with autism and highlights the need to develop new automated methods for older children. En ligne : https://dx.doi.org/10.1002/aur.2071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study / Andrew J. O. WHITEHOUSE in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Titre : Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; E. MATTES, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; M. SAWYER, Auteur ; R. M. JONES, Auteur ; C. E. PENNELL, Auteur ; J. A. KEELAN, Auteur ; M. HICKEY, Auteur Article en page(s) : p.25 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; E. MATTES, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; M. SAWYER, Auteur ; R. M. JONES, Auteur ; C. E. PENNELL, Auteur ; J. A. KEELAN, Auteur ; M. HICKEY, Auteur . - p.25. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits / M. ARENELLA in Autism, 26-2 (February 2022)  

Public ISBD [article]  inAutism > 26-2 (February 2022) . - p.361-372 Titre : Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur Article en page(s) : p.361-372 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits [Texte imprimé et/ou numérique] / M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur . - p.361-372. Langues : Anglais (eng) in Autism > 26-2 (February 2022) . - p.361-372 Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Statistical Learning is Associated with Autism Symptoms and Verbal Abilities in Young Children with Autism / R. M. JONES in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3551-3561 Titre : Statistical Learning is Associated with Autism Symptoms and Verbal Abilities in Young Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : R. M. JONES, Auteur ; T. TARPEY, Auteur ; A. HAMO, Auteur ; Caroline CARBERRY, Auteur ; G. BROUWER, Auteur ; C. LORD, Auteur Article en page(s) : p.3551-3561 Langues : Anglais (eng) Mots-clés : Autism  Bayes classification  Cognitive abilities  Social communication  Statistical learning Index. décimale : PER Périodiques Résumé : Statistical learning-extracting regularities in the environment-may underlie complex social behavior. 124 children, 56 with autism and 68 typically developing, ages 2-8 years, completed a novel visual statistical learning task on an iPad. Averaged together, children with autism demonstrated less learning on the task compared to typically developing children. However, multivariate classification analyses characterized individual behavior patterns, and demonstrated a subset of children with autism had similar learning patterns to typically developing children and that subset of children had less severe autism symptoms. Therefore, statistically averaging data resulted in missing critical heterogeneity. Variability in statistical learning may help to understand differences in autism symptoms across individuals and could be used to tailor and inform treatment decisions. En ligne : http://dx.doi.org/10.1007/s10803-018-3625-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Statistical Learning is Associated with Autism Symptoms and Verbal Abilities in Young Children with Autism [Texte imprimé et/ou numérique] / R. M. JONES, Auteur ; T. TARPEY, Auteur ; A. HAMO, Auteur ; Caroline CARBERRY, Auteur ; G. BROUWER, Auteur ; C. LORD, Auteur . - p.3551-3561. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3551-3561 Mots-clés : Autism  Bayes classification  Cognitive abilities  Social communication  Statistical learning Index. décimale : PER Périodiques Résumé : Statistical learning-extracting regularities in the environment-may underlie complex social behavior. 124 children, 56 with autism and 68 typically developing, ages 2-8 years, completed a novel visual statistical learning task on an iPad. Averaged together, children with autism demonstrated less learning on the task compared to typically developing children. However, multivariate classification analyses characterized individual behavior patterns, and demonstrated a subset of children with autism had similar learning patterns to typically developing children and that subset of children had less severe autism symptoms. Therefore, statistically averaging data resulted in missing critical heterogeneity. Variability in statistical learning may help to understand differences in autism symptoms across individuals and could be used to tailor and inform treatment decisions. En ligne : http://dx.doi.org/10.1007/s10803-018-3625-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

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