Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population / Maryam BOUTRUS in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2115-2123 Titre : Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; Z. GILANI, Auteur ; M. T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; D. W. TAN, Auteur ; P. R. EASTWOOD, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.2115-2123 Langues : Anglais (eng) Mots-clés : Autistic Disorder/complications/pathology  Cephalometry  Face/diagnostic imaging/pathology  Facial Asymmetry/diagnostic imaging/psychology  Female  Humans  Imaging, Three-Dimensional  Male  Phenotype  Photography  Young Adult  Autism  Facial asymmetry  Morphology  Neurodevelopment  Neurotypical Index. décimale : PER Périodiques Résumé : Atypical facial morphology, particularly increased facial asymmetry, has been identified in some individuals with Autism Spectrum Conditions (ASC). Many cognitive, behavioural and biological features associated with ASC also occur on a continuum in the general population. The aim of the present study was to examine subthreshold levels of autistic traits and facial morphology in non-autistic individuals. Facial asymmetry was measured using three-dimensional facial photogrammetry, and the Autism-spectrum Quotient was used to measure autistic-like traits in a community-ascertained sample of young adults (n?=?289). After accounting for covariates, there were no significant associations observed between autistic-like traits and facial asymmetry, suggesting that any potential facial morphology differences linked to ASC may be limited to the clinical condition. En ligne : http://dx.doi.org/10.1007/s10803-020-04661-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; Z. GILANI, Auteur ; M. T. MAYBERY, Auteur ; Gail A. ALVARES, Auteur ; D. W. TAN, Auteur ; P. R. EASTWOOD, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.2115-2123. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2115-2123 Mots-clés : Autistic Disorder/complications/pathology  Cephalometry  Face/diagnostic imaging/pathology  Facial Asymmetry/diagnostic imaging/psychology  Female  Humans  Imaging, Three-Dimensional  Male  Phenotype  Photography  Young Adult  Autism  Facial asymmetry  Morphology  Neurodevelopment  Neurotypical Index. décimale : PER Périodiques Résumé : Atypical facial morphology, particularly increased facial asymmetry, has been identified in some individuals with Autism Spectrum Conditions (ASC). Many cognitive, behavioural and biological features associated with ASC also occur on a continuum in the general population. The aim of the present study was to examine subthreshold levels of autistic traits and facial morphology in non-autistic individuals. Facial asymmetry was measured using three-dimensional facial photogrammetry, and the Autism-spectrum Quotient was used to measure autistic-like traits in a community-ascertained sample of young adults (n?=?289). After accounting for covariates, there were no significant associations observed between autistic-like traits and facial asymmetry, suggesting that any potential facial morphology differences linked to ASC may be limited to the clinical condition. En ligne : http://dx.doi.org/10.1007/s10803-020-04661-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Correction to: The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population / M. C. W. ENGLISH in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 70 p. Titre : Correction to: The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population Type de document : Texte imprimé et/ou numérique Auteurs : M. C. W. ENGLISH, Auteur ; G. E. GIGNAC, Auteur ; Troy A. W. VISSER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; J. T. ENNS, Auteur ; M. T. MAYBERY, Auteur Article en page(s) : 70 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00475-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Correction to: The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population [Texte imprimé et/ou numérique] / M. C. W. ENGLISH, Auteur ; G. E. GIGNAC, Auteur ; Troy A. W. VISSER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; J. T. ENNS, Auteur ; M. T. MAYBERY, Auteur . - 70 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 70 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-021-00475-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Facial asymmetry in parents of children on the autism spectrum / D. W. TAN in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2260-2269 Titre : Facial asymmetry in parents of children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : D. W. TAN, Auteur ; S. Z. GILANI, Auteur ; Maryam BOUTRUS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. MIAN, Auteur ; D. SUTER, Auteur ; M. T. MAYBERY, Auteur Article en page(s) : p.2260-2269 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Child  Face/diagnostic imaging  Facial Asymmetry  Female  Humans  Middle Aged  Parents  autism spectrum disorder  broad autism phenotype  facial asymmetry  facial morphology  heritability  neurodevelopment Index. décimale : PER Périodiques Résumé : Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. Therefore, the aim of the current study was to examine whether a broad autism phenotype expresses as facial asymmetry among 192 biological parents of autistic individuals (134 mothers) compared to those of 163 age-matched adults without a family history of ASD (113 females). Using dense surface-modelling techniques on three dimensional facial images, we found evidence for greater facial asymmetry in parents of autistic individuals compared to age-matched adults in the comparison group (p =?0.046, d =?0.21 [0.002, 0.42]). Considering previous findings and the current results, we conclude that facial asymmetry expressed in the facial morphology of autistic children may be related to heritability factors. LAY ABSTRACT: In a previous study, we showed that autistic children presented with greater facial asymmetry than non-autistic children. In the current study, we examined the amount of facial asymmetry shown on three-dimensional facial images of 192 parents of autistic children compared to a control group consisting of 163 similarly aged adults with no known history of autism. Although parents did show greater levels of facial asymmetry than those in the control group, this effect is statistically small. We concluded that the facial asymmetry previously found in autistic children may be related to genetic factors. En ligne : http://dx.doi.org/10.1002/aur.2612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Facial asymmetry in parents of children on the autism spectrum [Texte imprimé et/ou numérique] / D. W. TAN, Auteur ; S. Z. GILANI, Auteur ; Maryam BOUTRUS, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. MIAN, Auteur ; D. SUTER, Auteur ; M. T. MAYBERY, Auteur . - p.2260-2269. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2260-2269 Mots-clés : Autism Spectrum Disorder/diagnostic imaging  Autistic Disorder  Child  Face/diagnostic imaging  Facial Asymmetry  Female  Humans  Middle Aged  Parents  autism spectrum disorder  broad autism phenotype  facial asymmetry  facial morphology  heritability  neurodevelopment Index. décimale : PER Périodiques Résumé : Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. Therefore, the aim of the current study was to examine whether a broad autism phenotype expresses as facial asymmetry among 192 biological parents of autistic individuals (134 mothers) compared to those of 163 age-matched adults without a family history of ASD (113 females). Using dense surface-modelling techniques on three dimensional facial images, we found evidence for greater facial asymmetry in parents of autistic individuals compared to age-matched adults in the comparison group (p =?0.046, d =?0.21 [0.002, 0.42]). Considering previous findings and the current results, we conclude that facial asymmetry expressed in the facial morphology of autistic children may be related to heritability factors. LAY ABSTRACT: In a previous study, we showed that autistic children presented with greater facial asymmetry than non-autistic children. In the current study, we examined the amount of facial asymmetry shown on three-dimensional facial images of 192 parents of autistic children compared to a control group consisting of 163 similarly aged adults with no known history of autism. Although parents did show greater levels of facial asymmetry than those in the control group, this effect is statistically small. We concluded that the facial asymmetry previously found in autistic children may be related to genetic factors. En ligne : http://dx.doi.org/10.1002/aur.2612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation / Maryam BOUTRUS in Autism Research, 12-12 (December)  

Public ISBD [article]  inAutism Research > 12-12 (December) . - p.1774-1783 Titre : Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation Type de document : Texte imprimé et/ou numérique Auteurs : Maryam BOUTRUS, Auteur ; S. Z. GILANI, Auteur ; Gail A. ALVARES, Auteur ; M. T. MAYBERY, Auteur ; D. W. TAN, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Année de publication : 2019 Article en page(s) : p.1774-1783 Langues : Anglais (eng) Mots-clés : autism  facial asymmetry  morphology  neurodevelopment  subgroups Index. décimale : PER Périodiques Résumé : A key research priority in the study of autism spectrum conditions (ASC) is the discovery of biological markers that may help to identify and elucidate etiologically distinct subgroups. One physical marker that has received increasing research attention is facial structure. Although there remains little consensus in the field, findings relating to greater facial asymmetry (FA) in ASC exhibit some consistency. As there is growing recognition of the importance of replicatory studies in ASC research, the aim of this study was to investigate the replicability of increased FA in autistic children compared to nonautistic peers. Using three-dimensional photogrammetry, this study examined FA in 84 autistic children, 110 typically developing children with no family history of the condition, and 49 full siblings of autistic children. In support of previous literature, significantly greater depth-wise FA was identified in autistic children relative to the two comparison groups. As a further investigation, increased lateral FA in autistic children was found to be associated with greater severity of ASC symptoms on the Autism Diagnostic Observation Schedule, second edition, specifically related to repetitive and restrictive behaviors. These outcomes provide an important and independent replication of increased FA in ASC, as well as a novel contribution to the field. Having confirmed the direction and areas of increased FA in ASC, these findings could motivate a search for potential underlying brain dysmorphogenesis. Autism Res 2019, 12: 1774-1783. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study looked at the amount of facial asymmetry (FA) in autistic children compared to typically developing children and children who have siblings with autism. The study found that autistic children, compared to the other two groups, had greater FA, and that increased FA was related to greater severity of autistic symptoms. The face and brain grow together during the earliest stages of development, and so findings of facial differences in autism might inform future studies of early brain differences associated with the condition. En ligne : http://dx.doi.org/10.1002/aur.2161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] Increased facial asymmetry in autism spectrum conditions is associated with symptom presentation [Texte imprimé et/ou numérique] / Maryam BOUTRUS, Auteur ; S. Z. GILANI, Auteur ; Gail A. ALVARES, Auteur ; M. T. MAYBERY, Auteur ; D. W. TAN, Auteur ; A. MIAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - 2019 . - p.1774-1783. Langues : Anglais (eng) in Autism Research > 12-12 (December) . - p.1774-1783 Mots-clés : autism  facial asymmetry  morphology  neurodevelopment  subgroups Index. décimale : PER Périodiques Résumé : A key research priority in the study of autism spectrum conditions (ASC) is the discovery of biological markers that may help to identify and elucidate etiologically distinct subgroups. One physical marker that has received increasing research attention is facial structure. Although there remains little consensus in the field, findings relating to greater facial asymmetry (FA) in ASC exhibit some consistency. As there is growing recognition of the importance of replicatory studies in ASC research, the aim of this study was to investigate the replicability of increased FA in autistic children compared to nonautistic peers. Using three-dimensional photogrammetry, this study examined FA in 84 autistic children, 110 typically developing children with no family history of the condition, and 49 full siblings of autistic children. In support of previous literature, significantly greater depth-wise FA was identified in autistic children relative to the two comparison groups. As a further investigation, increased lateral FA in autistic children was found to be associated with greater severity of ASC symptoms on the Autism Diagnostic Observation Schedule, second edition, specifically related to repetitive and restrictive behaviors. These outcomes provide an important and independent replication of increased FA in ASC, as well as a novel contribution to the field. Having confirmed the direction and areas of increased FA in ASC, these findings could motivate a search for potential underlying brain dysmorphogenesis. Autism Res 2019, 12: 1774-1783. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study looked at the amount of facial asymmetry (FA) in autistic children compared to typically developing children and children who have siblings with autism. The study found that autistic children, compared to the other two groups, had greater FA, and that increased FA was related to greater severity of autistic symptoms. The face and brain grow together during the earliest stages of development, and so findings of facial differences in autism might inform future studies of early brain differences associated with the condition. En ligne : http://dx.doi.org/10.1002/aur.2161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study / Andrew J. O. WHITEHOUSE in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Titre : Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; E. MATTES, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; M. SAWYER, Auteur ; R. M. JONES, Auteur ; C. E. PENNELL, Auteur ; J. A. KEELAN, Auteur ; M. HICKEY, Auteur Article en page(s) : p.25 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; E. MATTES, Auteur ; M. T. MAYBERY, Auteur ; Cheryl DISSANAYAKE, Auteur ; M. SAWYER, Auteur ; R. M. JONES, Auteur ; C. E. PENNELL, Auteur ; J. A. KEELAN, Auteur ; M. HICKEY, Auteur . - p.25. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.25 Index. décimale : PER Périodiques Résumé : UNLABELLED: BACKGROUND: Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured prenatal testosterone exposure and ASD. The current study sought to determine whether testosterone concentrations in umbilical cord blood are associated with a clinical diagnosis of ASD in a small number of children and with autistic-like traits in the general population. METHODS: Umbilical cord blood was collected from 707 children. Samples were analyzed for total (TT) and bioavailable (BioT) testosterone concentrations. Parent report indicated that five individuals had a clinical diagnosis of ASD. Those participants without a diagnosis were approached in early adulthood to complete the Autism-Spectrum Quotient (AQ), a self-report measure of autistic-like traits, with 184 males (M = 20.10 years; SD= 0.65 years) and 190 females (M = 19.92 years; SD=0.68 years) providing data. RESULTS: The BioT and TT concentrations of the five children diagnosed with ASD were within one standard-deviation of the sex-specific means. Spearman's rank-order coefficients revealed no significant correlations between TT levels and scores on any AQ scale among males (rho range: -.01 to .06) or females (rho value range: -.07 to .01). There was also no significant association between BioT or TT concentrations and AQ scores among males (rho value range: -.07 to .08) or females (rho value range: -.06 to .12). Males were more likely than females to have 'high' scores (upper decile) on the AQ scale relating pattern and detail processing. However, the likelihood of a high score on this scale was unrelated to BioT and TT concentrations in both males and females. CONCLUSIONS: These findings indicate that testosterone concentrations from umbilical cord blood are unrelated to autistic-like traits in the general population. However, the findings do not exclude an association between testosterone exposure in early intrauterine life and ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

A prospective study of fetal head growth, autistic traits and autism spectrum disorder / Laura M. E. BLANKEN in Autism Research, 11-4 (April 2018)  

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Sexually dimorphic facial features vary according to level of autistic-like traits in the general population / S. Z. GILANI in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population / M. C. W. ENGLISH in Molecular Autism, 12 (2021)  

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The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis / Gail A. ALVARES in Autism, 24-1 (January 2020)  

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The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study / E. S. JAMNADASS in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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