Personalized at-home neurofeedback compared to long-acting methylphenidate in children with ADHD: NEWROFEED, a European randomized noninferiority trial / D. PURPER-OUAKIL in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.187-198 Titre : Personalized at-home neurofeedback compared to long-acting methylphenidate in children with ADHD: NEWROFEED, a European randomized noninferiority trial Type de document : Texte imprimé et/ou numérique Auteurs : D. PURPER-OUAKIL, Auteur ; H. BLASCO-FONTECILLA, Auteur ; T. ROS, Auteur ; Eric ACQUAVIVA, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; E. BOUSQUET, Auteur ; A. BUSSALB, Auteur ; M. DELHAYE, Auteur ; R. DELORME, Auteur ; R. DRECHSLER, Auteur ; A. GOUJON, Auteur ; A. HÄGE, Auteur ; A. KAISER, Auteur ; L. MAYAUD, Auteur ; K. MECHLER, Auteur ; C. MENACHE, Auteur ; O. REVOL, Auteur ; F. TAGWERKER, Auteur ; S. WALITZA, Auteur ; A. M. WERLING, Auteur ; Stéphanie BIOULAC, Auteur ; Daniel BRANDEIS, Auteur Article en page(s) : p.187-198 Langues : Anglais (eng) Mots-clés : Attention-deficit hyperactivity disorder  methylphenidate  neurofeedback  randomized clinical trial Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofeedback is considered a promising intervention for the treatment of attention-deficit hyperactivity disorder (ADHD). NEWROFEED is a prospective, multicentre, randomized (3:2), reference drug-controlled trial in children with ADHD aged between 7 and 13?years. The main objective of NEWROFEED was to demonstrate the noninferiority of personalized at-home neurofeedback (NF) training versus methylphenidate in the treatment of children with ADHD. METHODS: The NF group (n?=?111) underwent eight visits and two treatment phases of 16 to 20 at-home sessions with down-training of the theta/beta ratio (TBR) for children with high TBR and enhancing the sensorimotor rhythm (SMR) for the others. The control group (n?=?67) received optimally titrated long-acting methylphenidate. The primary endpoint was the change between baseline and endpoint in the Clinician ADHD-RS-IV total score in the per-protocol population (90 NF/59 controls). TRIAL REGISTRATION: US National Institute of Health, ClinicalTrials.gov #NCT02778360. RESULTS: Our study failed to demonstrate noninferiority of NF versus methylphenidate (mean between-group difference 8.09 90% CI [8.09; 10.56]). However, both treatment groups showed significant pre-post improvements in core ADHD symptoms and in a broader range of problems. Reduction in the Clinician ADHD-RS-IV total score between baseline and final visit (D90) was 26.7% (SMD?=?0.89) in the NF and 46.9% (SMD?=?2.03) in the control group. NF effects increased whereas those of methylphenidate were stable between intermediate and final visit. CONCLUSIONS: Based on clinicians' reports, the effects of at-home NF were inferior to those of methylphenidate as a stand-alone treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Personalized at-home neurofeedback compared to long-acting methylphenidate in children with ADHD: NEWROFEED, a European randomized noninferiority trial [Texte imprimé et/ou numérique] / D. PURPER-OUAKIL, Auteur ; H. BLASCO-FONTECILLA, Auteur ; T. ROS, Auteur ; Eric ACQUAVIVA, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; E. BOUSQUET, Auteur ; A. BUSSALB, Auteur ; M. DELHAYE, Auteur ; R. DELORME, Auteur ; R. DRECHSLER, Auteur ; A. GOUJON, Auteur ; A. HÄGE, Auteur ; A. KAISER, Auteur ; L. MAYAUD, Auteur ; K. MECHLER, Auteur ; C. MENACHE, Auteur ; O. REVOL, Auteur ; F. TAGWERKER, Auteur ; S. WALITZA, Auteur ; A. M. WERLING, Auteur ; Stéphanie BIOULAC, Auteur ; Daniel BRANDEIS, Auteur . - p.187-198. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.187-198 Mots-clés : Attention-deficit hyperactivity disorder  methylphenidate  neurofeedback  randomized clinical trial Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofeedback is considered a promising intervention for the treatment of attention-deficit hyperactivity disorder (ADHD). NEWROFEED is a prospective, multicentre, randomized (3:2), reference drug-controlled trial in children with ADHD aged between 7 and 13?years. The main objective of NEWROFEED was to demonstrate the noninferiority of personalized at-home neurofeedback (NF) training versus methylphenidate in the treatment of children with ADHD. METHODS: The NF group (n?=?111) underwent eight visits and two treatment phases of 16 to 20 at-home sessions with down-training of the theta/beta ratio (TBR) for children with high TBR and enhancing the sensorimotor rhythm (SMR) for the others. The control group (n?=?67) received optimally titrated long-acting methylphenidate. The primary endpoint was the change between baseline and endpoint in the Clinician ADHD-RS-IV total score in the per-protocol population (90 NF/59 controls). TRIAL REGISTRATION: US National Institute of Health, ClinicalTrials.gov #NCT02778360. RESULTS: Our study failed to demonstrate noninferiority of NF versus methylphenidate (mean between-group difference 8.09 90% CI [8.09; 10.56]). However, both treatment groups showed significant pre-post improvements in core ADHD symptoms and in a broader range of problems. Reduction in the Clinician ADHD-RS-IV total score between baseline and final visit (D90) was 26.7% (SMD?=?0.89) in the NF and 46.9% (SMD?=?2.03) in the control group. NF effects increased whereas those of methylphenidate were stable between intermediate and final visit. CONCLUSIONS: Based on clinicians' reports, the effects of at-home NF were inferior to those of methylphenidate as a stand-alone treatment. En ligne : http://dx.doi.org/10.1111/jcpp.13462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Short-term trajectories of restricted and repetitive behaviors in minimally verbal children with autism spectrum disorder / C. HARROP in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1789-1799 Titre : Short-term trajectories of restricted and repetitive behaviors in minimally verbal children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : C. HARROP, Auteur ; K. STERRETT, Auteur ; W. SHIH, Auteur ; R. LANDA, Auteur ; A. KAISER, Auteur ; Connie KASARI, Auteur Article en page(s) : p.1789-1799 Langues : Anglais (eng) Mots-clés : Aged  Autism Spectrum Disorder/complications/epidemiology  Child  Child, Preschool  Cognition  Humans  language  minimally verbal  repetitive behaviors Index. décimale : PER Périodiques Résumé : Very little is known about the 30% of children with Autism Spectrum Disorder (ASD) who remain minimally verbal when they enter school. Restricted and repetitive behaviors (RRBs) are well-characterized in younger, preschool, and toddler samples. However, the prevalence and impact of RRBs has not been characterized in older, minimally verbal children. The goal of this study was to characterize this core diagnostic feature in minimally verbal children with ASD ages 5-8?years over a 9-month period to better understand how these behaviors manifest in this crucially understudied population. RRBs were coded from caregiver-child interactions (CCX) at four timepoints. Upon entry into the study, children demonstrated an average of 17 RRBs during a 10-min CCX. The most common category was Verbal. RRBs remained constant over 6?months; however, a slight reduction was observed at the final timepoint. Compared to prior literature on younger samples, minimally verbal children with ASD demonstrated higher rates of RRBs and higher rates of verbal RRBs. Further work is required to understand the function and impact of RRBs in minimally verbal children. LAY ABSTRACT: Approximately one-third of children with autism spectrum disorder (ASD) remain minimally verbal at the time of school entry. In this study, we sought to characterize the presence of restricted and repetitive behaviors (RRBs) in school-aged children (5-8) who were minimally verbal. Compared to prior studies, minimally verbal children with ASD had higher frequencies of RRBs and demonstrated a different profile of behaviors, including more verbal RRBs. En ligne : http://dx.doi.org/10.1002/aur.2528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Short-term trajectories of restricted and repetitive behaviors in minimally verbal children with autism spectrum disorder [Texte imprimé et/ou numérique] / C. HARROP, Auteur ; K. STERRETT, Auteur ; W. SHIH, Auteur ; R. LANDA, Auteur ; A. KAISER, Auteur ; Connie KASARI, Auteur . - p.1789-1799. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1789-1799 Mots-clés : Aged  Autism Spectrum Disorder/complications/epidemiology  Child  Child, Preschool  Cognition  Humans  language  minimally verbal  repetitive behaviors Index. décimale : PER Périodiques Résumé : Very little is known about the 30% of children with Autism Spectrum Disorder (ASD) who remain minimally verbal when they enter school. Restricted and repetitive behaviors (RRBs) are well-characterized in younger, preschool, and toddler samples. However, the prevalence and impact of RRBs has not been characterized in older, minimally verbal children. The goal of this study was to characterize this core diagnostic feature in minimally verbal children with ASD ages 5-8?years over a 9-month period to better understand how these behaviors manifest in this crucially understudied population. RRBs were coded from caregiver-child interactions (CCX) at four timepoints. Upon entry into the study, children demonstrated an average of 17 RRBs during a 10-min CCX. The most common category was Verbal. RRBs remained constant over 6?months; however, a slight reduction was observed at the final timepoint. Compared to prior literature on younger samples, minimally verbal children with ASD demonstrated higher rates of RRBs and higher rates of verbal RRBs. Further work is required to understand the function and impact of RRBs in minimally verbal children. LAY ABSTRACT: Approximately one-third of children with autism spectrum disorder (ASD) remain minimally verbal at the time of school entry. In this study, we sought to characterize the presence of restricted and repetitive behaviors (RRBs) in school-aged children (5-8) who were minimally verbal. Compared to prior studies, minimally verbal children with ASD had higher frequencies of RRBs and demonstrated a different profile of behaviors, including more verbal RRBs. En ligne : http://dx.doi.org/10.1002/aur.2528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Symbolic Play in School-Aged Minimally Verbal Children with Autism Spectrum Disorder / Y. C. CHANG in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1436-1445 Titre : Symbolic Play in School-Aged Minimally Verbal Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Y. C. CHANG, Auteur ; W. SHIH, Auteur ; R. LANDA, Auteur ; A. KAISER, Auteur ; Connie KASARI, Auteur Article en page(s) : p.1436-1445 Langues : Anglais (eng) Mots-clés : Autism  Jasper  Language  Minimally verbal  Play Index. décimale : PER Périodiques Résumé : Few interventions exist for school-aged minimally verbal children with autism spectrum disorder (ASD). Even though play skills are associated with children's production of language, few studies have focused on play for minimally verbal children. Fifty-eight minimally verbal children with ASD received a naturalistic developmental behavioral intervention. Children were randomized to receive a speech generating device in the context of the intervention or not. Children in both conditions improved in play skills at exit. Children demonstrated an increase in play skills in proximal (sessions) and distal (during blind assessment) contexts. Minimally verbal children with ASD can improve their play skills within a targeted intervention. Increases in symbolic play were associated with increases in expressive language skills. En ligne : http://dx.doi.org/10.1007/s10803-017-3388-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Symbolic Play in School-Aged Minimally Verbal Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Y. C. CHANG, Auteur ; W. SHIH, Auteur ; R. LANDA, Auteur ; A. KAISER, Auteur ; Connie KASARI, Auteur . - p.1436-1445. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1436-1445 Mots-clés : Autism  Jasper  Language  Minimally verbal  Play Index. décimale : PER Périodiques Résumé : Few interventions exist for school-aged minimally verbal children with autism spectrum disorder (ASD). Even though play skills are associated with children's production of language, few studies have focused on play for minimally verbal children. Fifty-eight minimally verbal children with ASD received a naturalistic developmental behavioral intervention. Children were randomized to receive a speech generating device in the context of the intervention or not. Children in both conditions improved in play skills at exit. Children demonstrated an increase in play skills in proximal (sessions) and distal (during blind assessment) contexts. Minimally verbal children with ASD can improve their play skills within a targeted intervention. Increases in symbolic play were associated with increases in expressive language skills. En ligne : http://dx.doi.org/10.1007/s10803-017-3388-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

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