Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood / Yamna ALI in Autism, 23-3 (April 2019)  

Public ISBD [article]  inAutism > 23-3 (April 2019) . - p.584-593 Titre : Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Yamna ALI, Auteur ; Laura N. ANDERSON, Auteur ; Sharon SMILE, Auteur ; Yang CHEN, Auteur ; Cornelia M. BORKHOFF, Auteur ; Christine KOROSHEGYI, Auteur ; Gerald LEBOVIC, Auteur ; Patricia C. PARKIN, Auteur ; Catherine S. BIRKEN, Auteur ; Peter SZATMARI, Auteur ; Jonathon L. MAGUIRE, Auteur Article en page(s) : p.584-593 Langues : Anglais (eng) Mots-clés : 25-hydroxyvitamin D  autism spectrum disorder  early childhood  vitamin D Index. décimale : PER Périodiques Résumé : Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence?=?1.1%) over the observation period (average follow-up time?=?2.5?years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk?=?1.04, 95% confidence interval: 0.97, 1.11 per 10?nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk?=?1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk?=?0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361318756787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 [article] Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood [Texte imprimé et/ou numérique] / Yamna ALI, Auteur ; Laura N. ANDERSON, Auteur ; Sharon SMILE, Auteur ; Yang CHEN, Auteur ; Cornelia M. BORKHOFF, Auteur ; Christine KOROSHEGYI, Auteur ; Gerald LEBOVIC, Auteur ; Patricia C. PARKIN, Auteur ; Catherine S. BIRKEN, Auteur ; Peter SZATMARI, Auteur ; Jonathon L. MAGUIRE, Auteur . - p.584-593. Langues : Anglais (eng) in Autism > 23-3 (April 2019) . - p.584-593 Mots-clés : 25-hydroxyvitamin D  autism spectrum disorder  early childhood  vitamin D Index. décimale : PER Périodiques Résumé : Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence?=?1.1%) over the observation period (average follow-up time?=?2.5?years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk?=?1.04, 95% confidence interval: 0.97, 1.11 per 10?nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk?=?1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk?=?0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361318756787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

---

1 (1 - 1 / 1)