Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder / E. AARON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2417-2425 Titre : Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : E. AARON, Auteur ; A. MONTGOMERY, Auteur ; X. REN, Auteur ; Stephen GUTER, Auteur ; George M. ANDERSON, Auteur ; Ana M.D. CARNEIRO, Auteur ; S. JACOB, Auteur ; M. MOSCONI, Auteur ; G. N. PANDEY, Auteur ; E. COOK, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.2417-2425 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Biomarker  Hyperserotonemia  Receptor  Serotonin Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD. En ligne : https://dx.doi.org/10.1007/s10803-019-03989-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder [texte imprimé] / E. AARON, Auteur ; A. MONTGOMERY, Auteur ; X. REN, Auteur ; Stephen GUTER, Auteur ; George M. ANDERSON, Auteur ; Ana M.D. CARNEIRO, Auteur ; S. JACOB, Auteur ; M. MOSCONI, Auteur ; G. N. PANDEY, Auteur ; E. COOK, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur . - p.2417-2425. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2417-2425 Mots-clés : Autism spectrum disorder  Biomarker  Hyperserotonemia  Receptor  Serotonin Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD. En ligne : https://dx.doi.org/10.1007/s10803-019-03989-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

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