A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates? / Xuejuan NING ; Mina HOSSEINI ; Lisa A. CROEN ; Robert M. JOSEPH ; Margaret R. KARAGAS ; Christine LADD-ACOSTA ; Rebecca LANDA ; Daniel S. MESSINGER ; Craig J. NEWSCHAFFER ; Ruby NGUYEN ; Sally OZONOFF ; T. Michael O'SHEA ; Rebecca J. SCHMIDT ; Cindy O. TREVINO ; Kristen LYALL in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2050-2058 Titre : A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates? Type de document : texte imprimé Auteurs : Xuejuan NING, Auteur ; Mina HOSSEINI, Auteur ; Lisa A. CROEN, Auteur ; Robert M. JOSEPH, Auteur ; Margaret R. KARAGAS, Auteur ; Christine LADD-ACOSTA, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Ruby NGUYEN, Auteur ; Sally OZONOFF, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Cindy O. TREVINO, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2050-2058 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prior work developed a shortened 16-item version of the Social Responsiveness Scale (SRS), a quantitative measure of social communication and autism spectrum disorder (ASD)-related traits. However, its properties for use in risk factor estimation have not been fully tested compared to the full SRS. We compared the associations between gestational age (previously established risk factor for ASD) and the 65-item "full" and 16-item "short" versions of the SRS to test the shortened version s ability to capture associations in epidemiologic analyses of ASD risk factors. En ligne : https://doi.org/10.1007/s10803-023-06020-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates? [texte imprimé] / Xuejuan NING, Auteur ; Mina HOSSEINI, Auteur ; Lisa A. CROEN, Auteur ; Robert M. JOSEPH, Auteur ; Margaret R. KARAGAS, Auteur ; Christine LADD-ACOSTA, Auteur ; Rebecca LANDA, Auteur ; Daniel S. MESSINGER, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Ruby NGUYEN, Auteur ; Sally OZONOFF, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Cindy O. TREVINO, Auteur ; Kristen LYALL, Auteur . - p.2050-2058. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2050-2058 Index. décimale : PER Périodiques Résumé : Prior work developed a shortened 16-item version of the Social Responsiveness Scale (SRS), a quantitative measure of social communication and autism spectrum disorder (ASD)-related traits. However, its properties for use in risk factor estimation have not been fully tested compared to the full SRS. We compared the associations between gestational age (previously established risk factor for ASD) and the 65-item "full" and 16-item "short" versions of the SRS to test the shortened version s ability to capture associations in epidemiologic analyses of ASD risk factors. En ligne : https://doi.org/10.1007/s10803-023-06020-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Comparing autism phenotypes in children born extremely preterm and born at term / Robert M. JOSEPH in Autism Research, 16-3 (March 2023)  

Public ISBD [article]  inAutism Research > 16-3 (March 2023) . - p.653-666 Titre : Comparing autism phenotypes in children born extremely preterm and born at term Type de document : texte imprimé Auteurs : Robert M. JOSEPH, Auteur ; Emily R. LAI, Auteur ; Somer L. BISHOP, Auteur ; Joe YI, Auteur ; Margaret L. BAUMAN, Auteur ; Jean A. FRAZIER, Auteur ; Hudson P. Jr SANTOS, Auteur ; Laurie M. DOUGLAS, Auteur ; Karl C.K. KUBAN, Auteur ; Rebecca C. FRY, Auteur ; T. Michael O'SHEA, Auteur Article en page(s) : p.653-666 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Children born preterm are at increased risk for autism spectrum disorder (ASD). There is limited knowledge about whether ASD phenotypes in children born preterm differ from children born at term. The objective of this study was to compare ASD core symptoms and associated characteristics among extremely preterm (EP) and term-born children with ASD. EP participants (n = 59) from the Extremely Low Gestational Age Newborn Study who met diagnostic criteria for ASD at approximately 10 years of age were matched with term-born participants from the Simons Simplex Collection on age, sex, spoken language level, and nonverbal IQ. Core ASD symptomatology was evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Developmental milestones, anthropometrics, seizure disorder, and psychiatric symptoms were also investigated. The EP group had lower parent-reported symptom scores on ADI-R verbal communication, specifically stereotyped language, and restricted, repetitive behaviors. There were no between-group differences on ADI-R nonverbal communication and ADI-R reciprocal social interaction or with direct observation on the ADOS-2. The EP group was more likely to have delayed speech milestones and lower physical growth parameters. Results from female-only analyses were similar to those from whole-group analyses. In sum, behavioral presentation was similar between EP and IQ- and sex-matched term-born children assessed at age 10 years, with the exception of less severe retrospectively reported stereotyped behaviors, lower physical growth parameters, and increased delays in language milestones among EP-born children with ASD. En ligne : https://doi.org/10.1002/aur.2885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Comparing autism phenotypes in children born extremely preterm and born at term [texte imprimé] / Robert M. JOSEPH, Auteur ; Emily R. LAI, Auteur ; Somer L. BISHOP, Auteur ; Joe YI, Auteur ; Margaret L. BAUMAN, Auteur ; Jean A. FRAZIER, Auteur ; Hudson P. Jr SANTOS, Auteur ; Laurie M. DOUGLAS, Auteur ; Karl C.K. KUBAN, Auteur ; Rebecca C. FRY, Auteur ; T. Michael O'SHEA, Auteur . - p.653-666. Langues : Anglais (eng) in Autism Research > 16-3 (March 2023) . - p.653-666 Index. décimale : PER Périodiques Résumé : Abstract Children born preterm are at increased risk for autism spectrum disorder (ASD). There is limited knowledge about whether ASD phenotypes in children born preterm differ from children born at term. The objective of this study was to compare ASD core symptoms and associated characteristics among extremely preterm (EP) and term-born children with ASD. EP participants (n = 59) from the Extremely Low Gestational Age Newborn Study who met diagnostic criteria for ASD at approximately 10 years of age were matched with term-born participants from the Simons Simplex Collection on age, sex, spoken language level, and nonverbal IQ. Core ASD symptomatology was evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Developmental milestones, anthropometrics, seizure disorder, and psychiatric symptoms were also investigated. The EP group had lower parent-reported symptom scores on ADI-R verbal communication, specifically stereotyped language, and restricted, repetitive behaviors. There were no between-group differences on ADI-R nonverbal communication and ADI-R reciprocal social interaction or with direct observation on the ADOS-2. The EP group was more likely to have delayed speech milestones and lower physical growth parameters. Results from female-only analyses were similar to those from whole-group analyses. In sum, behavioral presentation was similar between EP and IQ- and sex-matched term-born children assessed at age 10 years, with the exception of less severe retrospectively reported stereotyped behaviors, lower physical growth parameters, and increased delays in language milestones among EP-born children with ASD. En ligne : https://doi.org/10.1002/aur.2885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm / Hudson P. Jr SANTOS in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) Titre : Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm Type de document : texte imprimé Auteurs : Hudson P. Jr SANTOS, Auteur ; Arjun BHATTACHARYA, Auteur ; Robert M. JOSEPH, Auteur ; Lisa SMEESTER, Auteur ; Karl C.K. KUBAN, Auteur ; Carmen J. MARSIT, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca C. FRY, Auteur Langues : Anglais (eng) Mots-clés : Differential expression analysis  Epigenome-wide association  Multi-omic aggregation  Placental gene regulation  Prenatal neurodevelopmental programming  Social and cognitive impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born extremely preterm are at heightened risk for intellectual and social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence for a key role of the placenta in prenatal developmental programming, suggesting that the placenta may, in part, contribute to origins of neurodevelopmental outcomes. METHODS: We examined associations between placental transcriptomic and epigenomic profiles and assessed their ability to predict intellectual and social impairment at age 10 years in 379 children from the Extremely Low Gestational Age Newborn (ELGAN) cohort. Assessment of intellectual ability (IQ) and social function was completed with the Differential Ability Scales-II and Social Responsiveness Scale (SRS), respectively. Examining IQ and SRS allows for studying ASD risk beyond the diagnostic criteria, as IQ and SRS are continuous measures strongly correlated with ASD. Genome-wide mRNA, CpG methylation and miRNA were assayeds with the Illumina Hiseq 2500, HTG EdgeSeq miRNA Whole Transcriptome Assay, and Illumina EPIC/850 K array, respectively. We conducted genome-wide differential analyses of placental mRNA, miRNA, and CpG methylation data. These molecular features were then integrated for a predictive analysis of IQ and SRS outcomes using kernel aggregation regression. We lastly examined associations between ASD and the multi-omic-predicted component of IQ and SRS. RESULTS: Genes with important roles in neurodevelopment and placental tissue organization were associated with intellectual and social impairment. Kernel aggregations of placental multi-omics strongly predicted intellectual and social function, explaining approximately 8% and 12% of variance in SRS and IQ scores via cross-validation, respectively. Predicted in-sample SRS and IQ showed significant positive and negative associations with ASD case-control status. LIMITATIONS: The ELGAN cohort comprises children born pre-term, and generalization may be affected by unmeasured confounders associated with low gestational age. We conducted external validation of predictive models, though the sample size (N = 49) and the scope of the available out-sample placental dataset are limited. Further validation of the models is merited. CONCLUSIONS: Aggregating information from biomarkers within and among molecular data types improves prediction of complex traits like social and intellectual ability in children born extremely preterm, suggesting that traits within the placenta-brain axis may be omnigenic. En ligne : http://dx.doi.org/10.1186/s13229-020-00402-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm [texte imprimé] / Hudson P. Jr SANTOS, Auteur ; Arjun BHATTACHARYA, Auteur ; Robert M. JOSEPH, Auteur ; Lisa SMEESTER, Auteur ; Karl C.K. KUBAN, Auteur ; Carmen J. MARSIT, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca C. FRY, Auteur. Langues : Anglais (eng) in Molecular Autism > 11 (2020) Mots-clés : Differential expression analysis  Epigenome-wide association  Multi-omic aggregation  Placental gene regulation  Prenatal neurodevelopmental programming  Social and cognitive impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born extremely preterm are at heightened risk for intellectual and social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence for a key role of the placenta in prenatal developmental programming, suggesting that the placenta may, in part, contribute to origins of neurodevelopmental outcomes. METHODS: We examined associations between placental transcriptomic and epigenomic profiles and assessed their ability to predict intellectual and social impairment at age 10 years in 379 children from the Extremely Low Gestational Age Newborn (ELGAN) cohort. Assessment of intellectual ability (IQ) and social function was completed with the Differential Ability Scales-II and Social Responsiveness Scale (SRS), respectively. Examining IQ and SRS allows for studying ASD risk beyond the diagnostic criteria, as IQ and SRS are continuous measures strongly correlated with ASD. Genome-wide mRNA, CpG methylation and miRNA were assayeds with the Illumina Hiseq 2500, HTG EdgeSeq miRNA Whole Transcriptome Assay, and Illumina EPIC/850 K array, respectively. We conducted genome-wide differential analyses of placental mRNA, miRNA, and CpG methylation data. These molecular features were then integrated for a predictive analysis of IQ and SRS outcomes using kernel aggregation regression. We lastly examined associations between ASD and the multi-omic-predicted component of IQ and SRS. RESULTS: Genes with important roles in neurodevelopment and placental tissue organization were associated with intellectual and social impairment. Kernel aggregations of placental multi-omics strongly predicted intellectual and social function, explaining approximately 8% and 12% of variance in SRS and IQ scores via cross-validation, respectively. Predicted in-sample SRS and IQ showed significant positive and negative associations with ASD case-control status. LIMITATIONS: The ELGAN cohort comprises children born pre-term, and generalization may be affected by unmeasured confounders associated with low gestational age. We conducted external validation of predictive models, though the sample size (N = 49) and the scope of the available out-sample placental dataset are limited. Further validation of the models is merited. CONCLUSIONS: Aggregating information from biomarkers within and among molecular data types improves prediction of complex traits like social and intellectual ability in children born extremely preterm, suggesting that traits within the placenta-brain axis may be omnigenic. En ligne : http://dx.doi.org/10.1186/s13229-020-00402-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm / Weifang LIU in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm Type de document : texte imprimé Auteurs : Weifang LIU, Auteur ; Quan SUN, Auteur ; Le HUANG, Auteur ; Arjun BHATTACHARYA, Auteur ; Geoffery W. WANG, Auteur ; Xianming TAN, Auteur ; Karl C.K. KUBAN, Auteur ; Robert M. JOSEPH, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca C. FRY, Auteur ; Yun LI, Auteur ; Hudson P. Jr SANTOS, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Brain  Child  Child, Preschool  Cognitive Dysfunction/genetics  DNA-Binding Proteins  Genome-Wide Association Study  Humans  Infant, Extremely Premature/psychology  Infant, Newborn  Muscle Proteins  Prospective Studies  TEA Domain Transcription Factors  Transcription Factors  Young Adult  Cognitive impairment  Genetic mechanisms  Genome-wide association study (GWAS)  Latent profile analysis (LPA)  Neurodevelopment  Preterm children Index. décimale : PER Périodiques Résumé : BACKGROUND: Although survival rates for infants born extremely preterm (gestation < 28 weeks) have improved significantly in recent decades, neurodevelopmental impairment remains a major concern. Children born extremely preterm remain at high risk for cognitive impairment from early childhood to adulthood. However, there is limited evidence on genetic factors associated with cognitive impairment in this population. METHODS: First, we used a latent profile analysis (LPA) approach to characterize neurocognitive function at age 10 for children born extremely preterm. Children were classified into two groups: (1) no or low cognitive impairment, and (2) moderate-to-severe cognitive impairment. Second, we performed TOPMed-based genotype imputation on samples with genotype array data (n = 528). Third, we then conducted a genome-wide association study (GWAS) for LPA-inferred cognitive impairment. Finally, computational analysis was conducted to explore potential mechanisms underlying the variant x LPA association. RESULTS: We identified two loci reaching genome-wide significance (p value < 5e-8): TEA domain transcription factor 4 (TEAD4 at rs11829294, p value = 2.40e-8) and syntaxin 18 (STX18 at rs79453226, p value = 1.91e-8). Integrative analysis with brain expression quantitative trait loci (eQTL), chromatin conformation, and epigenomic annotations suggests tetraspanin 9 (TSPAN9) and protein arginine methyltransferase 8 (PRMT8) as potential functional genes underlying the GWAS signal at the TEAD4 locus. CONCLUSIONS: We conducted a novel computational analysis by utilizing an LPA-inferred phenotype with genetics data for the first time. This study suggests that rs11829294 and its LD buddies have potential regulatory roles on genes that could impact neurocognitive impairment for extreme preterm born children. En ligne : https://dx.doi.org/10.1186/s11689-022-09429-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm [texte imprimé] / Weifang LIU, Auteur ; Quan SUN, Auteur ; Le HUANG, Auteur ; Arjun BHATTACHARYA, Auteur ; Geoffery W. WANG, Auteur ; Xianming TAN, Auteur ; Karl C.K. KUBAN, Auteur ; Robert M. JOSEPH, Auteur ; T. Michael O'SHEA, Auteur ; Rebecca C. FRY, Auteur ; Yun LI, Auteur ; Hudson P. Jr SANTOS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adolescent  Brain  Child  Child, Preschool  Cognitive Dysfunction/genetics  DNA-Binding Proteins  Genome-Wide Association Study  Humans  Infant, Extremely Premature/psychology  Infant, Newborn  Muscle Proteins  Prospective Studies  TEA Domain Transcription Factors  Transcription Factors  Young Adult  Cognitive impairment  Genetic mechanisms  Genome-wide association study (GWAS)  Latent profile analysis (LPA)  Neurodevelopment  Preterm children Index. décimale : PER Périodiques Résumé : BACKGROUND: Although survival rates for infants born extremely preterm (gestation < 28 weeks) have improved significantly in recent decades, neurodevelopmental impairment remains a major concern. Children born extremely preterm remain at high risk for cognitive impairment from early childhood to adulthood. However, there is limited evidence on genetic factors associated with cognitive impairment in this population. METHODS: First, we used a latent profile analysis (LPA) approach to characterize neurocognitive function at age 10 for children born extremely preterm. Children were classified into two groups: (1) no or low cognitive impairment, and (2) moderate-to-severe cognitive impairment. Second, we performed TOPMed-based genotype imputation on samples with genotype array data (n = 528). Third, we then conducted a genome-wide association study (GWAS) for LPA-inferred cognitive impairment. Finally, computational analysis was conducted to explore potential mechanisms underlying the variant x LPA association. RESULTS: We identified two loci reaching genome-wide significance (p value < 5e-8): TEA domain transcription factor 4 (TEAD4 at rs11829294, p value = 2.40e-8) and syntaxin 18 (STX18 at rs79453226, p value = 1.91e-8). Integrative analysis with brain expression quantitative trait loci (eQTL), chromatin conformation, and epigenomic annotations suggests tetraspanin 9 (TSPAN9) and protein arginine methyltransferase 8 (PRMT8) as potential functional genes underlying the GWAS signal at the TEAD4 locus. CONCLUSIONS: We conducted a novel computational analysis by utilizing an LPA-inferred phenotype with genetics data for the first time. This study suggests that rs11829294 and its LD buddies have potential regulatory roles on genes that could impact neurocognitive impairment for extreme preterm born children. En ligne : https://dx.doi.org/10.1186/s11689-022-09429-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium / Lisa KURTH in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium Type de document : texte imprimé Auteurs : Lisa KURTH, Auteur ; T. Michael O'SHEA, Auteur ; Irina BURD, Auteur ; Anne L. DUNLOP, Auteur ; Lisa CROEN, Auteur ; Greta WILKENING, Auteur ; Ting-Ju HSU, Auteur ; Stephan EHRHARDT, Auteur ; Arvind PALANISAMY, Auteur ; Monica MCGRATH, Auteur ; Marie L. CHURCHILL, Auteur ; Daniel WEINBERGER, Auteur ; Marco GRADOS, Auteur ; Dana DABELEA, Auteur Langues : Anglais (eng) Mots-clés : Humans  Female  Pregnancy  Oxytocin  Male  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Child  Body Mass Index  Autism Spectrum Disorder/epidemiology/etiology  Prenatal Exposure Delayed Effects  Adult  Pregnancy in Obesity/epidemiology  Child, Preschool  Cohort Studies  Obesity/epidemiology  Adhd  Asd  Autism  Bmi  Neurodevelopment  Obesity  Synthetic oxytocin Index. décimale : PER Périodiques Résumé : BACKGROUND: Synthetic oxytocin (sOT) is frequently administered during parturition. Studies have raised concerns that fetal exposure to sOT may be associated with altered brain development and risk of neurodevelopmental disorders. In a large and diverse sample of children with data about intrapartum sOT exposure and subsequent diagnoses of two prevalent neurodevelopmental disorders, i.e., attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), we tested the following hypotheses: (1) Intrapartum sOT exposure is associated with increased odds of child ADHD or ASD; (2) associations differ across sex; (3) associations between intrapartum sOT exposure and ADHD or ASD are accentuated in offspring of mothers with pre-pregnancy obesity. METHODS: The study sample comprised 12,503 participants from 44 cohort sites included in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Mixed-effects logistic regression analyses were used to estimate the association between intrapartum sOT exposure and offspring ADHD or ASD (in separate models). Maternal obesity (pre-pregnancy BMI ≥ 30 kg/m(2)) and child sex were evaluated for effect modification. RESULTS: Intrapartum sOT exposure was present in 48% of participants. sOT exposure was not associated with increased odds of ASD (adjusted odds ratio [aOR] 0.86; 95% confidence interval [CI], 0.71-1.03) or ADHD (aOR 0.89; 95% CI, 0.76-1.04). Associations did not differ by child sex. Among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of offspring ADHD (aOR 0.72; 95% CI, 0.55-0.96). No association was found among mothers without obesity (aOR 0.97; 95% CI, 0.80-1.18). CONCLUSIONS: In a large, diverse sample, we found no evidence of an association between intrapartum exposure to sOT and odds of ADHD or ASD in either male or female offspring. Contrary to our hypothesis, among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of child ADHD diagnosis. En ligne : https://dx.doi.org/10.1186/s11689-024-09540-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium [texte imprimé] / Lisa KURTH, Auteur ; T. Michael O'SHEA, Auteur ; Irina BURD, Auteur ; Anne L. DUNLOP, Auteur ; Lisa CROEN, Auteur ; Greta WILKENING, Auteur ; Ting-Ju HSU, Auteur ; Stephan EHRHARDT, Auteur ; Arvind PALANISAMY, Auteur ; Monica MCGRATH, Auteur ; Marie L. CHURCHILL, Auteur ; Daniel WEINBERGER, Auteur ; Marco GRADOS, Auteur ; Dana DABELEA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Female  Pregnancy  Oxytocin  Male  Attention Deficit Disorder with Hyperactivity/epidemiology/etiology  Child  Body Mass Index  Autism Spectrum Disorder/epidemiology/etiology  Prenatal Exposure Delayed Effects  Adult  Pregnancy in Obesity/epidemiology  Child, Preschool  Cohort Studies  Obesity/epidemiology  Adhd  Asd  Autism  Bmi  Neurodevelopment  Obesity  Synthetic oxytocin Index. décimale : PER Périodiques Résumé : BACKGROUND: Synthetic oxytocin (sOT) is frequently administered during parturition. Studies have raised concerns that fetal exposure to sOT may be associated with altered brain development and risk of neurodevelopmental disorders. In a large and diverse sample of children with data about intrapartum sOT exposure and subsequent diagnoses of two prevalent neurodevelopmental disorders, i.e., attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), we tested the following hypotheses: (1) Intrapartum sOT exposure is associated with increased odds of child ADHD or ASD; (2) associations differ across sex; (3) associations between intrapartum sOT exposure and ADHD or ASD are accentuated in offspring of mothers with pre-pregnancy obesity. METHODS: The study sample comprised 12,503 participants from 44 cohort sites included in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Mixed-effects logistic regression analyses were used to estimate the association between intrapartum sOT exposure and offspring ADHD or ASD (in separate models). Maternal obesity (pre-pregnancy BMI ≥ 30 kg/m(2)) and child sex were evaluated for effect modification. RESULTS: Intrapartum sOT exposure was present in 48% of participants. sOT exposure was not associated with increased odds of ASD (adjusted odds ratio [aOR] 0.86; 95% confidence interval [CI], 0.71-1.03) or ADHD (aOR 0.89; 95% CI, 0.76-1.04). Associations did not differ by child sex. Among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of offspring ADHD (aOR 0.72; 95% CI, 0.55-0.96). No association was found among mothers without obesity (aOR 0.97; 95% CI, 0.80-1.18). CONCLUSIONS: In a large, diverse sample, we found no evidence of an association between intrapartum exposure to sOT and odds of ADHD or ASD in either male or female offspring. Contrary to our hypothesis, among mothers with pre-pregnancy obesity, sOT exposure was associated with lower odds of child ADHD diagnosis. En ligne : https://dx.doi.org/10.1186/s11689-024-09540-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts / Irva HERTZ-PICCIOTTO in Autism Research, 15-3 (March 2022)  

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A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm / Anastasia N. FREEDMAN in Autism Research, 16-5 (May 2023)  

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Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood / Agnieszka MLODNICKA in Development and Psychopathology, 37-2 (May 2025)  

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Prevalence and associated features of autism spectrum disorder in extremely low gestational age newborns at age 10 years / Robert M. JOSEPH in Autism Research, 10-2 (February 2017)  

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Trajectories of attention problems in preschoolers born very preterm / Francisco Xavier CASTELLANOS ; Brian S. CARTER ; Jennifer CHECK ; Jennifer HELDERMAN ; Julie A. HOFHEIMER ; Elisabeth C. MCGOWAN ; Charles R. NEAL ; Steven L. PASTYRNAK ; Lynne M. SMITH ; T. Michael O'SHEA ; Carmen J. MARSIT ; Barry M. LESTER in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

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