Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system / H. KUMAZAKI in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 6p. Titre : Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur Article en page(s) : 6p. Langues : Anglais (eng) Mots-clés : Adolescent  Aerosols  Autism Spectrum Disorder/physiopathology/psychology  Caproates  Case-Control Studies  Child  Diagnostic Equipment  Equipment Design  Female  Humans  Hypesthesia/etiology/physiopathology/psychology  Male  Odorants  Olfactory Perception/physiology  Pentanols  Pulsatile Flow  Sensory Thresholds/physiology  Autism spectrum disorder  Laboratory-based studies  Olfaction  Olfactory detection threshold  Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur . - 6p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 6p. Mots-clés : Adolescent  Aerosols  Autism Spectrum Disorder/physiopathology/psychology  Caproates  Case-Control Studies  Child  Diagnostic Equipment  Equipment Design  Female  Humans  Hypesthesia/etiology/physiopathology/psychology  Male  Odorants  Olfactory Perception/physiology  Pentanols  Pulsatile Flow  Sensory Thresholds/physiology  Autism spectrum disorder  Laboratory-based studies  Olfaction  Olfactory detection threshold  Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 49-8 (August 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3462-3469 Titre : Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur Article en page(s) : p.3462-3469 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Olfactory adaptation  Pulse ejection system  Social impairment  Typical development Index. décimale : PER Périodiques Résumé : Olfactory adaptation is an important process that allows the individual to adjust to changes in the environment. This process has been proposed to be aberrant in individuals with autism spectrum disorders (ASD). However, few studies have examined olfactory adaptation in children with ASD. We examined olfactory adaptation in children with ASD and typically developing (TD) children using a pulse ejection system, which resolved problems associated with previous laboratory-based olfactory psychophysical studies. Nine children with ASD and nine TD children participated in this study and all participants completed the entire experiment. Using this system, we found that the TD group showed greater adaptation than the ASD group. Our results provide a better understanding of olfactory adaptation in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04053-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur . - p.3462-3469. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3462-3469 Mots-clés : Autism spectrum disorders  Olfactory adaptation  Pulse ejection system  Social impairment  Typical development Index. décimale : PER Périodiques Résumé : Olfactory adaptation is an important process that allows the individual to adjust to changes in the environment. This process has been proposed to be aberrant in individuals with autism spectrum disorders (ASD). However, few studies have examined olfactory adaptation in children with ASD. We examined olfactory adaptation in children with ASD and typically developing (TD) children using a pulse ejection system, which resolved problems associated with previous laboratory-based olfactory psychophysical studies. Nine children with ASD and nine TD children participated in this study and all participants completed the entire experiment. Using this system, we found that the TD group showed greater adaptation than the ASD group. Our results provide a better understanding of olfactory adaptation in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04053-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Developmental changes in normal cranial measurements by computed tomography / Y. FUKUYAMA in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.425-432 Titre : Developmental changes in normal cranial measurements by computed tomography Type de document : Texte imprimé et/ou numérique Auteurs : Y. FUKUYAMA, Auteur ; M. MIYAO, Auteur ; T. ISHIZU, Auteur ; H. MARUYAMA, Auteur Année de publication : 1979 Article en page(s) : p.425-432 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Computed tomography (CT) scans were examined for 89 selected patients in an attempt to establish normal values at various ages for longitudinal and transverse diameters of the brain, the greatest distance between the right and left sides of the anterior horn of the lateral ventricle, the width of the lateral ventricles in the region of the caudate nuclei, and the greatest width of the third ventricle. The patients' ages ranged from less than one year to over 40 years. These measurements and their ratios to one another are reported. The cerebral longitudinal fissure, Sylvian fissure and subarachnoid space were evident to some degree below the age of two years, especially below the age of one year, and again above the age of 40 years. The cortical sulcus was occasionally found to have a width of less than 1.9mm below the age of one year and above the age of 40 years. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Developmental changes in normal cranial measurements by computed tomography [Texte imprimé et/ou numérique] / Y. FUKUYAMA, Auteur ; M. MIYAO, Auteur ; T. ISHIZU, Auteur ; H. MARUYAMA, Auteur . - 1979 . - p.425-432. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.425-432 Index. décimale : PER Périodiques Résumé : Computed tomography (CT) scans were examined for 89 selected patients in an attempt to establish normal values at various ages for longitudinal and transverse diameters of the brain, the greatest distance between the right and left sides of the anterior horn of the lateral ventricle, the width of the lateral ventricles in the region of the caudate nuclei, and the greatest width of the third ventricle. The patients' ages ranged from less than one year to over 40 years. These measurements and their ratios to one another are reported. The cerebral longitudinal fissure, Sylvian fissure and subarachnoid space were evident to some degree below the age of two years, especially below the age of one year, and again above the age of 40 years. The cortical sulcus was occasionally found to have a width of less than 1.9mm below the age of one year and above the age of 40 years. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2590-2592 Titre : Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; M. KIKUCHI, Auteur ; Y. YOSHIMURA, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur Article en page(s) : p.2590-2592 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Identification  Odor  Olfactory  Visual distractor Index. décimale : PER Périodiques Résumé : Understanding the nature of olfactory abnormalities is crucial for optimal interventions in children with autism spectrum disorders (ASD). However, previous studies that have investigated odor identification in children with ASD have produced inconsistent results. The ability to correctly identify an odor relies heavily on visual inputs in the general population. We tested odor identification in eight children with ASD and eight age-matched children with typical development (TD). After confirming that all children were able to identify each odor without visual input, we measured odor identification under the visual-distractor condition. Odor identification was hindered by visual distractors for all children with ASD but was not affected in all children with TD. Our results improve understanding of odor identification in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3511-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; M. KIKUCHI, Auteur ; Y. YOSHIMURA, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur . - p.2590-2592. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2590-2592 Mots-clés : Autism spectrum disorders  Identification  Odor  Olfactory  Visual distractor Index. décimale : PER Périodiques Résumé : Understanding the nature of olfactory abnormalities is crucial for optimal interventions in children with autism spectrum disorders (ASD). However, previous studies that have investigated odor identification in children with ASD have produced inconsistent results. The ability to correctly identify an odor relies heavily on visual inputs in the general population. We tested odor identification in eight children with ASD and eight age-matched children with typical development (TD). After confirming that all children were able to identify each odor without visual input, we measured odor identification under the visual-distractor condition. Odor identification was hindered by visual distractors for all children with ASD but was not affected in all children with TD. Our results improve understanding of odor identification in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3511-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

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