EEG functional connectivity in infants at elevated familial likelihood for autism spectrum disorder / Scott HUBERTY ; Stefon VAN NOORDT ; James DESJARDINS ; Nicky WRIGHT ; Julie SCORAH ; Sara Jane WEBB ; Mayada ELSABBAGH in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 37 p. Titre : EEG functional connectivity in infants at elevated familial likelihood for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Scott HUBERTY, Auteur ; Stefon VAN NOORDT, Auteur ; James DESJARDINS, Auteur ; Nicky WRIGHT, Auteur ; Julie SCORAH, Auteur ; Sara Jane WEBB, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : 37 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Many studies have reported that autism spectrum disorder (ASD) is associated with atypical structural and functional connectivity. However, we know relatively little about the development of these differences in infancy. METHODS: We used a high-density electroencephalogram (EEG) dataset pooled from two independent infant sibling cohorts, to characterize such neurodevelopmental deviations during the first years of life. EEG was recorded at 6 and 12 months of age in infants at typical (N=92) or elevated likelihood for ASD (N=90), determined by the presence of an older sibling with ASD. We computed the functional connectivity between cortical sources of EEG during video watching using the corrected imaginary part of phase-locking values. RESULTS: Our main analysis found no significant association between functional connectivity and ASD, showing only significant effects for age, sex, age-sex interaction, and site. Given these null results, we performed an exploratory analysis and observed, at 12 months, a negative correlation between functional connectivity and ADOS calibrated severity scores for restrictive and repetitive behaviors (RRB). LIMITATIONS: The small sample of ASD participants inherent to sibling studies limits diagnostic group comparisons. Also, results from our secondary exploratory analysis should be considered only as potential relationships to further explore, given their increased vulnerability to false positives. CONCLUSIONS: These results are inconclusive concerning an association between EEG functional connectivity and ASD in infancy. Exploratory analyses provided preliminary support for a relationship between RRB and functional connectivity specifically, but these preliminary observations need corroboration on larger samples. En ligne : http://dx.doi.org/10.1186/s13229-023-00570-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] EEG functional connectivity in infants at elevated familial likelihood for autism spectrum disorder [Texte imprimé et/ou numérique] / Scott HUBERTY, Auteur ; Stefon VAN NOORDT, Auteur ; James DESJARDINS, Auteur ; Nicky WRIGHT, Auteur ; Julie SCORAH, Auteur ; Sara Jane WEBB, Auteur ; Mayada ELSABBAGH, Auteur . - 37 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 37 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Many studies have reported that autism spectrum disorder (ASD) is associated with atypical structural and functional connectivity. However, we know relatively little about the development of these differences in infancy. METHODS: We used a high-density electroencephalogram (EEG) dataset pooled from two independent infant sibling cohorts, to characterize such neurodevelopmental deviations during the first years of life. EEG was recorded at 6 and 12 months of age in infants at typical (N=92) or elevated likelihood for ASD (N=90), determined by the presence of an older sibling with ASD. We computed the functional connectivity between cortical sources of EEG during video watching using the corrected imaginary part of phase-locking values. RESULTS: Our main analysis found no significant association between functional connectivity and ASD, showing only significant effects for age, sex, age-sex interaction, and site. Given these null results, we performed an exploratory analysis and observed, at 12 months, a negative correlation between functional connectivity and ADOS calibrated severity scores for restrictive and repetitive behaviors (RRB). LIMITATIONS: The small sample of ASD participants inherent to sibling studies limits diagnostic group comparisons. Also, results from our secondary exploratory analysis should be considered only as potential relationships to further explore, given their increased vulnerability to false positives. CONCLUSIONS: These results are inconclusive concerning an association between EEG functional connectivity and ASD in infancy. Exploratory analyses provided preliminary support for a relationship between RRB and functional connectivity specifically, but these preliminary observations need corroboration on larger samples. En ligne : http://dx.doi.org/10.1186/s13229-023-00570-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Global prevalence of autism: A systematic review update / Jinan ZEIDAN in Autism Research, 15-5 (May 2022)  

Public ISBD [article]  inAutism Research > 15-5 (May 2022) . - p.778-790 Titre : Global prevalence of autism: A systematic review update Type de document : Texte imprimé et/ou numérique Auteurs : Jinan ZEIDAN, Auteur ; Eric FOMBONNE, Auteur ; Julie SCORAH, Auteur ; Alaa IBRAHIM, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Afiqah YUSUF, Auteur ; Andy SHIH, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : p.778-790 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/epidemiology  Child  Ethnicity  Female  Humans  Male  Population Surveillance/methods  Prevalence  autism  methodology  risk factors  social determinants  time trends Index. décimale : PER Périodiques Résumé : Prevalence estimates of autism are essential for informing public policy, raising awareness, and developing research priorities. Using a systematic review, we synthesized estimates of the prevalence of autism worldwide. We examined factors accounting for variability in estimates and critically reviewed evidence relevant for hypotheses about biological or social determinants (viz., biological sex, sociodemographic status, ethnicity/race, and nativity) potentially modifying prevalence estimates of autism. We performed the search in November 2021 within Medline for studies estimating autism prevalence, published since our last systematic review in 2012. Data were extracted by two independent researchers. Since 2012, 99 estimates from 71 studies were published indicating a global autism prevalence that ranges within and across regions, with a median prevalence of 100/10,000 (range: 1.09/10,000 to 436.0/10,000). The median male-to-female ratio was 4.2. The median percentage of autism cases with co-occurring intellectual disability was 33.0%. Estimates varied, likely reflecting complex and dynamic interactions between patterns of community awareness, service capacity, help seeking, and sociodemographic factors. A limitation of this review is that synthesizing methodological features precludes a quality appraisal of studies. Our findings reveal an increase in measured autism prevalence globally, reflecting the combined effects of multiple factors including the increase in community awareness and public health response globally, progress in case identification and definition, and an increase in community capacity. Hypotheses linking factors that increase the likelihood of developing autism with variations in prevalence will require research with large, representative samples and comparable autism diagnostic criteria and case-finding methods in diverse world regions over time. LAY SUMMARY: We reviewed studies of the prevalence of autism worldwide, considering the impact of geographic, ethnic, and socioeconomic factors on prevalence estimates. Approximately 1/100 children are diagnosed with autism spectrum disorder around the world. Prevalence estimates increased over time and varied greatly within and across sociodemographic groups. These findings reflect changes in the definition of autism and differences in the methodology and contexts of prevalence studies. En ligne : http://dx.doi.org/10.1002/aur.2696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Global prevalence of autism: A systematic review update [Texte imprimé et/ou numérique] / Jinan ZEIDAN, Auteur ; Eric FOMBONNE, Auteur ; Julie SCORAH, Auteur ; Alaa IBRAHIM, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Afiqah YUSUF, Auteur ; Andy SHIH, Auteur ; Mayada ELSABBAGH, Auteur . - p.778-790. Langues : Anglais (eng) in Autism Research > 15-5 (May 2022) . - p.778-790 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/epidemiology  Child  Ethnicity  Female  Humans  Male  Population Surveillance/methods  Prevalence  autism  methodology  risk factors  social determinants  time trends Index. décimale : PER Périodiques Résumé : Prevalence estimates of autism are essential for informing public policy, raising awareness, and developing research priorities. Using a systematic review, we synthesized estimates of the prevalence of autism worldwide. We examined factors accounting for variability in estimates and critically reviewed evidence relevant for hypotheses about biological or social determinants (viz., biological sex, sociodemographic status, ethnicity/race, and nativity) potentially modifying prevalence estimates of autism. We performed the search in November 2021 within Medline for studies estimating autism prevalence, published since our last systematic review in 2012. Data were extracted by two independent researchers. Since 2012, 99 estimates from 71 studies were published indicating a global autism prevalence that ranges within and across regions, with a median prevalence of 100/10,000 (range: 1.09/10,000 to 436.0/10,000). The median male-to-female ratio was 4.2. The median percentage of autism cases with co-occurring intellectual disability was 33.0%. Estimates varied, likely reflecting complex and dynamic interactions between patterns of community awareness, service capacity, help seeking, and sociodemographic factors. A limitation of this review is that synthesizing methodological features precludes a quality appraisal of studies. Our findings reveal an increase in measured autism prevalence globally, reflecting the combined effects of multiple factors including the increase in community awareness and public health response globally, progress in case identification and definition, and an increase in community capacity. Hypotheses linking factors that increase the likelihood of developing autism with variations in prevalence will require research with large, representative samples and comparable autism diagnostic criteria and case-finding methods in diverse world regions over time. LAY SUMMARY: We reviewed studies of the prevalence of autism worldwide, considering the impact of geographic, ethnic, and socioeconomic factors on prevalence estimates. Approximately 1/100 children are diagnosed with autism spectrum disorder around the world. Prevalence estimates increased over time and varied greatly within and across sociodemographic groups. These findings reflect changes in the definition of autism and differences in the methodology and contexts of prevalence studies. En ligne : http://dx.doi.org/10.1002/aur.2696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

The time has come for living systematic reviews in autism research / Mayada ELSABBAGH in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1187-1188 Titre : The time has come for living systematic reviews in autism research Type de document : Texte imprimé et/ou numérique Auteurs : Mayada ELSABBAGH, Auteur ; Afiqah YUSUF, Auteur ; Jinan ZEIDAN, Auteur ; Julie SCORAH, Auteur ; Eric FOMBONNE, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Andy SHIH, Auteur Article en page(s) : p.1187-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] The time has come for living systematic reviews in autism research [Texte imprimé et/ou numérique] / Mayada ELSABBAGH, Auteur ; Afiqah YUSUF, Auteur ; Jinan ZEIDAN, Auteur ; Julie SCORAH, Auteur ; Eric FOMBONNE, Auteur ; Maureen S. DURKIN, Auteur ; Shekhar SAXENA, Auteur ; Andy SHIH, Auteur . - p.1187-1188. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1187-1188 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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