Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort / Lydia Gabriela SPEYER in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.948-956 Titre : Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort Type de document : Texte imprimé et/ou numérique Auteurs : Lydia Gabriela SPEYER, Auteur ; Samuel NEAVES, Auteur ; Hildigunnur Anna HALL, Auteur ; Gibran HEMANI, Auteur ; Michael Vincent LOMBARDO, Auteur ; Aja Louise MURRAY, Auteur ; Bonnie AUYEUNG, Auteur ; Michelle LUCIANO, Auteur Article en page(s) : p.948-956 Langues : Anglais (eng) Mots-clés : Adolescent  Child  Child, Preschool  Female  Humans  Longitudinal Studies  Male  Mothers  Multifactorial Inheritance  Pregnancy  Risk Factors  Smoking  Alspac  Joint mental health trajectories  externalizing  internalizing  polygenic risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. METHODS: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11,049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data were available for 7,127 children and 6,836 mothers. RESULTS: A 5-class model was judged optimal: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD and lower polygenic scores for IQ distinguished affected classes from the unaffected class. CONCLUSIONS: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Results thus add to existing evidence that internalizing and externalizing problems have mostly shared risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort [Texte imprimé et/ou numérique] / Lydia Gabriela SPEYER, Auteur ; Samuel NEAVES, Auteur ; Hildigunnur Anna HALL, Auteur ; Gibran HEMANI, Auteur ; Michael Vincent LOMBARDO, Auteur ; Aja Louise MURRAY, Auteur ; Bonnie AUYEUNG, Auteur ; Michelle LUCIANO, Auteur . - p.948-956. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.948-956 Mots-clés : Adolescent  Child  Child, Preschool  Female  Humans  Longitudinal Studies  Male  Mothers  Multifactorial Inheritance  Pregnancy  Risk Factors  Smoking  Alspac  Joint mental health trajectories  externalizing  internalizing  polygenic risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. METHODS: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11,049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data were available for 7,127 children and 6,836 mothers. RESULTS: A 5-class model was judged optimal: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD and lower polygenic scores for IQ distinguished affected classes from the unaffected class. CONCLUSIONS: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Results thus add to existing evidence that internalizing and externalizing problems have mostly shared risk factors. En ligne : http://dx.doi.org/10.1111/jcpp.13549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland / Iain HARDIE in Journal of Child Psychology and Psychiatry, 66-1 (January 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.30-40 Titre : Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland Type de document : Texte imprimé et/ou numérique Auteurs : Iain HARDIE, Auteur ; Aja MURRAY, Auteur ; Josiah KING, Auteur ; Hildigunnur Anna HALL, Auteur ; Emily LUEDECKE, Auteur ; Louise MARRYAT, Auteur ; Lucy THOMPSON, Auteur ; Helen MINNIS, Auteur ; Philip WILSON, Auteur ; Bonnie AUYEUNG, Auteur Article en page(s) : p.30-40 Langues : Anglais (eng) Mots-clés : Child development  maternal factors  prenatal  infection  CNS Index. décimale : PER Périodiques Résumé : Background Previous research has linked prenatal maternal infections to later childhood developmental outcomes and socioemotional difficulties. However, existing studies have relied on retrospectively self-reported survey data, or data on hospital-recorded infections only, resulting in gaps in data collection. Methods This study used a large linked administrative health dataset, bringing together data from birth records, hospital records, prescriptions and routine child health reviews for 55,856 children born in Greater Glasgow 95% CI: 1.19?1.42). This was broadly consistent across all developmental outcome types and appeared to be specifically linked to infections occurring in pregnancy trimesters 2 (OR: 1.34; 95% CI: 1.07?1.67) and 3 (OR: 1.33; 95% CI: 1.21?1.47), that is the trimesters in which foetal brain myelination occurs. Infection-related prescriptions were not associated with any clear increase in odds of having at least one developmental concern after confounder/covariate adjustment (OR: 1.03; 95% CI: 0.98?1.08), but were associated with slightly increased odds of concerns specifically related to personal-social (OR: 1.12; 95% CI: 1.03?1.22) and emotional-behavioural-attention (OR: 1.15; 95% CI: 1.08?1.22) development. Conclusions Prenatal infections, particularly those which are hospital-diagnosed (and likely more severe), are associated with early childhood developmental outcomes. Prevention of prenatal infections, and monitoring of support needs of affected children, may improve childhood development, but causality remains to be established. En ligne : https://dx.doi.org/10.1111/jcpp.14028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Prenatal maternal infections and early childhood developmental outcomes: analysis of linked administrative health data for Greater Glasgow & Clyde, Scotland [Texte imprimé et/ou numérique] / Iain HARDIE, Auteur ; Aja MURRAY, Auteur ; Josiah KING, Auteur ; Hildigunnur Anna HALL, Auteur ; Emily LUEDECKE, Auteur ; Louise MARRYAT, Auteur ; Lucy THOMPSON, Auteur ; Helen MINNIS, Auteur ; Philip WILSON, Auteur ; Bonnie AUYEUNG, Auteur . - p.30-40. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.30-40 Mots-clés : Child development  maternal factors  prenatal  infection  CNS Index. décimale : PER Périodiques Résumé : Background Previous research has linked prenatal maternal infections to later childhood developmental outcomes and socioemotional difficulties. However, existing studies have relied on retrospectively self-reported survey data, or data on hospital-recorded infections only, resulting in gaps in data collection. Methods This study used a large linked administrative health dataset, bringing together data from birth records, hospital records, prescriptions and routine child health reviews for 55,856 children born in Greater Glasgow 95% CI: 1.19?1.42). This was broadly consistent across all developmental outcome types and appeared to be specifically linked to infections occurring in pregnancy trimesters 2 (OR: 1.34; 95% CI: 1.07?1.67) and 3 (OR: 1.33; 95% CI: 1.21?1.47), that is the trimesters in which foetal brain myelination occurs. Infection-related prescriptions were not associated with any clear increase in odds of having at least one developmental concern after confounder/covariate adjustment (OR: 1.03; 95% CI: 0.98?1.08), but were associated with slightly increased odds of concerns specifically related to personal-social (OR: 1.12; 95% CI: 1.03?1.22) and emotional-behavioural-attention (OR: 1.15; 95% CI: 1.08?1.22) development. Conclusions Prenatal infections, particularly those which are hospital-diagnosed (and likely more severe), are associated with early childhood developmental outcomes. Prevention of prenatal infections, and monitoring of support needs of affected children, may improve childhood development, but causality remains to be established. En ligne : https://dx.doi.org/10.1111/jcpp.14028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Within-family relations of mental health problems across childhood and adolescence / Lydia Gabriela SPEYER in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1288-1296 Titre : Within-family relations of mental health problems across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Lydia Gabriela SPEYER, Auteur ; Hildigunnur Anna HALL, Auteur ; Yuzhan HANG, Auteur ; Claire HUGHES, Auteur ; Aja Louise MURRAY, Auteur Article en page(s) : p.1288-1296 Langues : Anglais (eng) Mots-clés : Child  Male  Child, Preschool  Adolescent  Humans  Female  Child Behavior Disorders/psychology  Family Relations  Child Behavior/psychology  Cohort Studies  Mental Health  Longitudinal Studies  Millennium Cohort Study  Parental mental health  externalising  internalising  within-family Index. décimale : PER Périodiques Résumé : BACKGROUND: While transactional models suggest that parent and child mental health reciprocally influence one another over development, research has largely focused on parent-to-child effects. Additionally, it is not known whether observed associations hold when appropriate statistical tools are used to operationalise within-family dynamics. METHODS: We investigated within-family mental health dynamics using autoregressive latent trajectory models with structured residuals, stratified by child gender. Parental psychological distress was assessed using the Kessler (K6) scale, and children's internalising and externalising problems were assessed using the Strengths and Difficulties Questionnaire. Both measures were administered at the age 3, 5, 7, 11, 14 and 17 waves of the Millennium Cohort Study (N=10,746, ~50% female). RESULTS: Maternal psychological distress was positively associated with subsequent internalising and externalising problems for girls but only with internalising problems for boys. Paternal psychological distress was associated with boys' later internalising and externalising problems during early adolescence. Among boys, internalising problems were associated with later maternal psychological distress, while externalising problems were associated with later paternal psychological distress. Among girls, internalising problems were associated with subsequent paternal psychological distress, while externalising problems were associated with later maternal psychological distress. Finally, maternal and paternal psychological distress showed negative bidirectional associations in early childhood but positive associations in middle childhood and early adolescence. CONCLUSIONS: Findings support a transactional model of family mental health, with both child-to-parent and parent-to-child effects playing a role in the development of mental health difficulties. Mental health intervention efforts should, therefore, target the whole family system. En ligne : http://dx.doi.org/10.1111/jcpp.13572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Within-family relations of mental health problems across childhood and adolescence [Texte imprimé et/ou numérique] / Lydia Gabriela SPEYER, Auteur ; Hildigunnur Anna HALL, Auteur ; Yuzhan HANG, Auteur ; Claire HUGHES, Auteur ; Aja Louise MURRAY, Auteur . - p.1288-1296. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1288-1296 Mots-clés : Child  Male  Child, Preschool  Adolescent  Humans  Female  Child Behavior Disorders/psychology  Family Relations  Child Behavior/psychology  Cohort Studies  Mental Health  Longitudinal Studies  Millennium Cohort Study  Parental mental health  externalising  internalising  within-family Index. décimale : PER Périodiques Résumé : BACKGROUND: While transactional models suggest that parent and child mental health reciprocally influence one another over development, research has largely focused on parent-to-child effects. Additionally, it is not known whether observed associations hold when appropriate statistical tools are used to operationalise within-family dynamics. METHODS: We investigated within-family mental health dynamics using autoregressive latent trajectory models with structured residuals, stratified by child gender. Parental psychological distress was assessed using the Kessler (K6) scale, and children's internalising and externalising problems were assessed using the Strengths and Difficulties Questionnaire. Both measures were administered at the age 3, 5, 7, 11, 14 and 17 waves of the Millennium Cohort Study (N=10,746, ~50% female). RESULTS: Maternal psychological distress was positively associated with subsequent internalising and externalising problems for girls but only with internalising problems for boys. Paternal psychological distress was associated with boys' later internalising and externalising problems during early adolescence. Among boys, internalising problems were associated with later maternal psychological distress, while externalising problems were associated with later paternal psychological distress. Among girls, internalising problems were associated with subsequent paternal psychological distress, while externalising problems were associated with later maternal psychological distress. Finally, maternal and paternal psychological distress showed negative bidirectional associations in early childhood but positive associations in middle childhood and early adolescence. CONCLUSIONS: Findings support a transactional model of family mental health, with both child-to-parent and parent-to-child effects playing a role in the development of mental health difficulties. Mental health intervention efforts should, therefore, target the whole family system. En ligne : http://dx.doi.org/10.1111/jcpp.13572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

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