Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder / Yu WANG ; Aihua Cao ; Jing WANG ; He Bai ; Tianci Liu ; Chenxi Sun ; Zhuoran Li ; Yuchun Tang ; Feifei Xu ; Shuwei Liu in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.83-97 Titre : Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur Article en page(s) : p.83-97 Langues : Anglais (eng) Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research [Texte imprimé et/ou numérique] / Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur . - p.83-97. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.83-97 Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents / Yan LI ; Wuxia BAI ; Yu WANG ; Yongmei LI ; Yixiang XIE ; Xiaoqian HUANG ; Huilin ZHU ; Xiaobing ZOU in Journal of Autism and Developmental Disorders, 54-9 (September 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3387-3399 Titre : Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Wuxia BAI, Auteur ; Yu WANG, Auteur ; Yongmei LI, Auteur ; Yixiang XIE, Auteur ; Xiaoqian HUANG, Auteur ; Huilin ZHU, Auteur ; Xiaobing ZOU, Auteur Article en page(s) : p.3387-3399 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: The Program for the Education and Enrichment of Relational Skills (PEERS®) is a group-based social skills training program for adolescents on the autism spectrum. Although the program has been shown to be effective in improving social skills in autistic adolescents, evidence of its effectiveness from the Mandarin-speaking Chinese population is sparse. The present study used a non-randomized, pre- and post-intervention research design to investigate the feasibility and cultural validity of the program, as well as examine the moderators of intervention outcomes. Methods: Thirty-three autistic adolescents with intelligence quotient above 70 (Mage = 13.57, SDage = 1.43; Male: Female 25:8) and their parents received 14 concurrent 90-minute sessions. Adolescents'autistic traits, challenging behaviors, emotional functioning, socio-cognitive process, social environment factors (school support), and caregivers'well-being were evaluated. Results: The findings suggest that with minor adjustments, the Mandarin version of PEERS® was generally acceptable and feasible for autistic adolescents and their parents. PEERS® may improve the social skills knowledge, reciprocal communication abilities, and emotional well-being of autistic adolescents. Also, participants with a higher level of school support, and parents with lower perceived subjective well-being at baseline may gain more benefits from PEERS®. The cultural adaptation and acceptability of the Mandarin Version of PEERS® were discussed. Conclusion: This feasibility study (Chinese Clinical Trial Registry: ChiCTR2200061417, 2022-06-23, retrospectively registered) provides a basis for further randomized control trials of the Mandarin version of PEERS®. En ligne : https://doi.org/10.1007/s10803-023-06056-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Wuxia BAI, Auteur ; Yu WANG, Auteur ; Yongmei LI, Auteur ; Yixiang XIE, Auteur ; Xiaoqian HUANG, Auteur ; Huilin ZHU, Auteur ; Xiaobing ZOU, Auteur . - p.3387-3399. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3387-3399 Index. décimale : PER Périodiques Résumé : Purpose: The Program for the Education and Enrichment of Relational Skills (PEERS®) is a group-based social skills training program for adolescents on the autism spectrum. Although the program has been shown to be effective in improving social skills in autistic adolescents, evidence of its effectiveness from the Mandarin-speaking Chinese population is sparse. The present study used a non-randomized, pre- and post-intervention research design to investigate the feasibility and cultural validity of the program, as well as examine the moderators of intervention outcomes. Methods: Thirty-three autistic adolescents with intelligence quotient above 70 (Mage = 13.57, SDage = 1.43; Male: Female 25:8) and their parents received 14 concurrent 90-minute sessions. Adolescents'autistic traits, challenging behaviors, emotional functioning, socio-cognitive process, social environment factors (school support), and caregivers'well-being were evaluated. Results: The findings suggest that with minor adjustments, the Mandarin version of PEERS® was generally acceptable and feasible for autistic adolescents and their parents. PEERS® may improve the social skills knowledge, reciprocal communication abilities, and emotional well-being of autistic adolescents. Also, participants with a higher level of school support, and parents with lower perceived subjective well-being at baseline may gain more benefits from PEERS®. The cultural adaptation and acceptability of the Mandarin Version of PEERS® were discussed. Conclusion: This feasibility study (Chinese Clinical Trial Registry: ChiCTR2200061417, 2022-06-23, retrospectively registered) provides a basis for further randomized control trials of the Mandarin version of PEERS®. En ligne : https://doi.org/10.1007/s10803-023-06056-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Exploring the impact of autistic traits and anxiety on visual attentional response to angry faces in adults with high autistic traits: An eye-movement study / Jiazuo HUO ; Yu WANG ; Jiabei BAI in Research in Autism Spectrum Disorders, 115 (July 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 115 (July 2024) . - p.102415 Titre : Exploring the impact of autistic traits and anxiety on visual attentional response to angry faces in adults with high autistic traits: An eye-movement study Type de document : Texte imprimé et/ou numérique Auteurs : Jiazuo HUO, Auteur ; Yu WANG, Auteur ; Jiabei BAI, Auteur Article en page(s) : p.102415 Langues : Anglais (eng) Mots-clés : High autistic traits  Visual attention  Angry face  Anxiety  Eye-tracking Index. décimale : PER Périodiques Résumé : This study investigated the impact of autistic traits and anxiety on the visual attentional response to angry faces among individuals with varying levels of autistic traits in the general population. Two experiments were conducted. In Experiment 1, eye-tracking methodology was used to compare 26 participants with high autistic traits to 26 individuals with low autistic traits. The latency of the first fixation on images of angry faces, neutral faces, and objects during a free viewing task was measured. Anxiety levels were assessed using the Self-rating Anxiety Scale. Experiment 2 utilized an overlap task to examine attentional response patterns toward angry faces in individuals with high and low autistic traits. The findings revealed that participants with high autistic traits displayed a longer latency to first fixation on angry faces during the free-viewing task compared to those with low autistic traits. However, no significant differences were observed for neutral faces and objects. In the overlap task, the group with high autistic traits demonstrated a significantly prolonged latency to first fixation on angry faces in peripheral positions when the central stimulus was a neutral face and the peripheral stimulus was an angry face, relative to the group with low autistic traits. Importantly, when taking anxiety traits into account as a covariate in both experiments, the previously observed group effects no longer remained significant. These results were discussed within the frameworks of social motivation theory and the autism continuum hypothesis. En ligne : https://doi.org/10.1016/j.rasd.2024.102415 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Exploring the impact of autistic traits and anxiety on visual attentional response to angry faces in adults with high autistic traits: An eye-movement study [Texte imprimé et/ou numérique] / Jiazuo HUO, Auteur ; Yu WANG, Auteur ; Jiabei BAI, Auteur . - p.102415. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 115 (July 2024) . - p.102415 Mots-clés : High autistic traits  Visual attention  Angry face  Anxiety  Eye-tracking Index. décimale : PER Périodiques Résumé : This study investigated the impact of autistic traits and anxiety on the visual attentional response to angry faces among individuals with varying levels of autistic traits in the general population. Two experiments were conducted. In Experiment 1, eye-tracking methodology was used to compare 26 participants with high autistic traits to 26 individuals with low autistic traits. The latency of the first fixation on images of angry faces, neutral faces, and objects during a free viewing task was measured. Anxiety levels were assessed using the Self-rating Anxiety Scale. Experiment 2 utilized an overlap task to examine attentional response patterns toward angry faces in individuals with high and low autistic traits. The findings revealed that participants with high autistic traits displayed a longer latency to first fixation on angry faces during the free-viewing task compared to those with low autistic traits. However, no significant differences were observed for neutral faces and objects. In the overlap task, the group with high autistic traits demonstrated a significantly prolonged latency to first fixation on angry faces in peripheral positions when the central stimulus was a neutral face and the peripheral stimulus was an angry face, relative to the group with low autistic traits. Importantly, when taking anxiety traits into account as a covariate in both experiments, the previously observed group effects no longer remained significant. These results were discussed within the frameworks of social motivation theory and the autism continuum hypothesis. En ligne : https://doi.org/10.1016/j.rasd.2024.102415 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Reduced Pupil Oscillation During Facial Emotion Judgment in People with Autism Spectrum Disorder / Sai SUN in Journal of Autism and Developmental Disorders, 53-5 (May 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.1963-1973 Titre : Reduced Pupil Oscillation During Facial Emotion Judgment in People with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sai SUN, Auteur ; Paula J. WEBSTER, Auteur ; Yu WANG, Auteur ; Hongbo YU, Auteur ; Rongjun YU, Auteur ; Shuo WANG, Auteur Article en page(s) : p.1963-1973 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) show abnormal face perception and emotion recognition. However, it remains largely unknown whether these differences are associated with abnormal physiological responses when viewing faces. In this study, we employed a sensitive emotion judgment task and conducted a detailed investigation of pupil dilation/constriction and oscillation in high-functioning adult participants with ASD and matched controls. We found that participants with ASD showed normal pupil constriction to faces; however, they demonstrated reduced pupil oscillation, which was independent of stimulus properties and participants' perception of the emotion. Together, our results have revealed an abnormal physiological response to faces in people with ASD, which may in turn be associated with impaired face perception previously found in many studies. En ligne : https://doi.org/10.1007/s10803-022-05478-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Reduced Pupil Oscillation During Facial Emotion Judgment in People with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sai SUN, Auteur ; Paula J. WEBSTER, Auteur ; Yu WANG, Auteur ; Hongbo YU, Auteur ; Rongjun YU, Auteur ; Shuo WANG, Auteur . - p.1963-1973. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.1963-1973 Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) show abnormal face perception and emotion recognition. However, it remains largely unknown whether these differences are associated with abnormal physiological responses when viewing faces. In this study, we employed a sensitive emotion judgment task and conducted a detailed investigation of pupil dilation/constriction and oscillation in high-functioning adult participants with ASD and matched controls. We found that participants with ASD showed normal pupil constriction to faces; however, they demonstrated reduced pupil oscillation, which was independent of stimulus properties and participants' perception of the emotion. Together, our results have revealed an abnormal physiological response to faces in people with ASD, which may in turn be associated with impaired face perception previously found in many studies. En ligne : https://doi.org/10.1007/s10803-022-05478-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

---

1 (1 - 4 / 4)