Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug / Johan F. SCHOEMAN in Developmental Medicine & Child Neurology, 26-6 (December 1994)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-6 (December 1994) . - p.749-755 Titre : Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug Type de document : Texte imprimé et/ou numérique Auteurs : Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur Année de publication : 1984 Article en page(s) : p.749-755 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy. Children stabilised on standard doses of CBZ alone showed a ratio of CBZ-10,11-EPOX/CBZ of 18.92 +/- 8.08, expressed as a percentage of the CBZ concentration, while those on multiple-drug therapy (with the exception of benzodiazepines and phenobarbitone) showed both increased values of CBZ-10,11-EPOX/CBZ ratio and increased absolute concentrations of CBZ-10,11-EPOX in plasma. These changes correlated with clinical side-effects which could not be attributed to CBZ itself or to the other drugs administered concurrently. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug [Texte imprimé et/ou numérique] / Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur . - 1984 . - p.749-755. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.749-755 Index. décimale : PER Périodiques Résumé : A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy. Children stabilised on standard doses of CBZ alone showed a ratio of CBZ-10,11-EPOX/CBZ of 18.92 +/- 8.08, expressed as a percentage of the CBZ concentration, while those on multiple-drug therapy (with the exception of benzodiazepines and phenobarbitone) showed both increased values of CBZ-10,11-EPOX/CBZ ratio and increased absolute concentrations of CBZ-10,11-EPOX in plasma. These changes correlated with clinical side-effects which could not be attributed to CBZ itself or to the other drugs administered concurrently. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy / Johan F. SCHOEMAN in Developmental Medicine & Child Neurology, 26-6 (December 1994)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-6 (December 1994) . - p.756-764 Titre : Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy Type de document : Texte imprimé et/ou numérique Auteurs : Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur Année de publication : 1984 Article en page(s) : p.756-764 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs. Side-effects were noted in 14 patients. When 25 patients treated with CBZ alone (group 1) were compared with 27 on CBZ and sodium valproate (group 2) and with 38 on CBZ and one or more other anticonvulsants (group 3), the incidence of side-effects was two in group 1 (of whom one patient had a toxic plasma level of CBZ), but 12 in groups 2 and 3 combined. In all but three of the 14 patients with side-effects, plasma levels of CBZ were within the 'therapeutic range'. A significant difference was found between the carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) levels in plasma and CBZ-10,11-EPOX/CBZ ratio in patients with and without side-effects. For five patients on CBZ and other drugs, changes in treatment resulted in changes in side-effects, and also in CBZ-10,11-EPOX levels. Three of these patients showed an interaction between CBZ and sodium valproate, with a correlation between plasma CBZ-10,11-EPOX and side-effects when either drug was introduced or withdrawn, the plasma levels of CBZ itself and of sodium valproate being within the 'therapeutic range'. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy [Texte imprimé et/ou numérique] / Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur . - 1984 . - p.756-764. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.756-764 Index. décimale : PER Périodiques Résumé : Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs. Side-effects were noted in 14 patients. When 25 patients treated with CBZ alone (group 1) were compared with 27 on CBZ and sodium valproate (group 2) and with 38 on CBZ and one or more other anticonvulsants (group 3), the incidence of side-effects was two in group 1 (of whom one patient had a toxic plasma level of CBZ), but 12 in groups 2 and 3 combined. In all but three of the 14 patients with side-effects, plasma levels of CBZ were within the 'therapeutic range'. A significant difference was found between the carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) levels in plasma and CBZ-10,11-EPOX/CBZ ratio in patients with and without side-effects. For five patients on CBZ and other drugs, changes in treatment resulted in changes in side-effects, and also in CBZ-10,11-EPOX levels. Three of these patients showed an interaction between CBZ and sodium valproate, with a correlation between plasma CBZ-10,11-EPOX and side-effects when either drug was introduced or withdrawn, the plasma levels of CBZ itself and of sodium valproate being within the 'therapeutic range'. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Intracranial pressure monitoring in tuberculous meningitis: clinical and computerized tomographic correlation / Johan F. SCHOEMAN in Developmental Medicine & Child Neurology, 27-5 (October 1985)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 27-5 (October 1985) . - p.644-654 Titre : Intracranial pressure monitoring in tuberculous meningitis: clinical and computerized tomographic correlation Type de document : Texte imprimé et/ou numérique Auteurs : Johan F. SCHOEMAN, Auteur ; Deon LE ROUX, Auteur ; Piet B. BEZUIDENHOUT, Auteur ; Peter R. DONALD, Auteur Année de publication : 1985 Article en page(s) : p.644-654 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Cerebrospinal fluid (CSF) pressure was monitored in 24 children with acute tuberculous meningitis. 19 had raised intracranial pressure (ICP) as reflected by increased baseline pressure, pressure waves (e.g. B-waves) and increased amplitude of the pulse wave. Correlation between clinical signs of raised ICP and monitored CSF pressure showed that clinical diagnosis of the presence and degree of raised ICP is unreliable, especially in children with a closed anterior fontanelle. Computerized tomographic (CT) scans showed that hydrocephalus was present in all children with raised CSF pressure. No direct correlation was found between the degree of hydrocephalus and the degree of raised ICP. The rôle of ICP monitoring in the diagnosis and management of raised ICP in children with tuberculous meningitis is discussed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=596 [article] Intracranial pressure monitoring in tuberculous meningitis: clinical and computerized tomographic correlation [Texte imprimé et/ou numérique] / Johan F. SCHOEMAN, Auteur ; Deon LE ROUX, Auteur ; Piet B. BEZUIDENHOUT, Auteur ; Peter R. DONALD, Auteur . - 1985 . - p.644-654. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 27-5 (October 1985) . - p.644-654 Index. décimale : PER Périodiques Résumé : Cerebrospinal fluid (CSF) pressure was monitored in 24 children with acute tuberculous meningitis. 19 had raised intracranial pressure (ICP) as reflected by increased baseline pressure, pressure waves (e.g. B-waves) and increased amplitude of the pulse wave. Correlation between clinical signs of raised ICP and monitored CSF pressure showed that clinical diagnosis of the presence and degree of raised ICP is unreliable, especially in children with a closed anterior fontanelle. Computerized tomographic (CT) scans showed that hydrocephalus was present in all children with raised CSF pressure. No direct correlation was found between the degree of hydrocephalus and the degree of raised ICP. The rôle of ICP monitoring in the diagnosis and management of raised ICP in children with tuberculous meningitis is discussed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=596

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