Social motivation in infancy is associated with familial recurrence of ASD / Natasha MARRUS in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.101-111 Titre : Social motivation in infancy is associated with familial recurrence of ASD Type de document : texte imprimé Auteurs : Natasha MARRUS, Auteur ; Kelly N. BOTTERON, Auteur ; Zoe HAWKS, Auteur ; John R. PRUETT, Auteur ; Jed T. ELISON, Auteur ; Joshua J. JACKSON, Auteur ; Lori MARKSON, Auteur ; Adam T. EGGEBRECHT, Auteur ; Catherine A. BURROWS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather Cody HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Joseph PIVEN, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.101-111 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  infancy  measurement  social motivation Index. décimale : PER Périodiques Résumé : Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation s course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation s importance to risk assessment and clarification of the ontogeny of ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Social motivation in infancy is associated with familial recurrence of ASD [texte imprimé] / Natasha MARRUS, Auteur ; Kelly N. BOTTERON, Auteur ; Zoe HAWKS, Auteur ; John R. PRUETT, Auteur ; Jed T. ELISON, Auteur ; Joshua J. JACKSON, Auteur ; Lori MARKSON, Auteur ; Adam T. EGGEBRECHT, Auteur ; Catherine A. BURROWS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather Cody HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Joseph PIVEN, Auteur ; John N. CONSTANTINO, Auteur . - p.101-111. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.101-111 Mots-clés : autism spectrum disorder  infancy  measurement  social motivation Index. décimale : PER Périodiques Résumé : Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation s course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation s importance to risk assessment and clarification of the ontogeny of ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

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