Intraindividual phenotyping of depression in high-risk youth: An application of a multilevel hidden Markov model / Qimin LIU in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1262-1271 Titre : Intraindividual phenotyping of depression in high-risk youth: An application of a multilevel hidden Markov model Type de document : Texte imprimé et/ou numérique Auteurs : Qimin LIU, Auteur ; David COLE, Auteur ; Tiffany TRAN, Auteur ; Meghan QUINN, Auteur ; Elisabeth MCCAULEY, Auteur ; Guy DIAMOND, Auteur ; Judy GARBER, Auteur Article en page(s) : p.1262-1271 Langues : Anglais (eng) Mots-clés : Markov processes  depression  developmental psychopathology  intraindividual differences  longitudinal Index. décimale : PER Périodiques Résumé : Background:Traditionally, depression phenotypes have been defined based on interindividual differences that distinguish between subgroups of individuals expressing distinct depressive symptoms often from cross-sectional data. Alternatively, depression phenotypes can be defined based on intraindividual differences, differentiating between transitory states of distinct symptoms profiles that a person transitions into or out of over time. Such within-person phenotypic states are less examined, despite their potential significance for understanding and treating depression.Methods:The current study used intensive longitudinal data of youths (N = 120) at risk for depression. Clinical interviews (at baseline, 4, 10, 16, and 22 months) yielded 90 weekly assessments. We applied a multilevel hidden Markov model to identify intraindividual phenotypes of weekly depressive symptoms for at-risk youth.Results:Three intraindividual phenotypes emerged: a low-depression state, an elevated-depression state, and a cognitive-physical-symptom state. Youth had a high probability of remaining in the same state over time. Furthermore, probabilities of transitioning from one state to another did not differ by age or ethnoracial minority status; girls were more likely than boys to transition from a low-depression state to either the elevated-depression state or the cognitive-physical symptom state. Finally, these intraindividual phenotypes and their dynamics were associated with comorbid externalizing symptoms.Conclusion:Identifying these states as well as the transitions between them characterizes how symptoms of depression change over time and provide potential directions for intervention efforts En ligne : https://dx.doi.org/10.1017/S0954579423000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Intraindividual phenotyping of depression in high-risk youth: An application of a multilevel hidden Markov model [Texte imprimé et/ou numérique] / Qimin LIU, Auteur ; David COLE, Auteur ; Tiffany TRAN, Auteur ; Meghan QUINN, Auteur ; Elisabeth MCCAULEY, Auteur ; Guy DIAMOND, Auteur ; Judy GARBER, Auteur . - p.1262-1271. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1262-1271 Mots-clés : Markov processes  depression  developmental psychopathology  intraindividual differences  longitudinal Index. décimale : PER Périodiques Résumé : Background:Traditionally, depression phenotypes have been defined based on interindividual differences that distinguish between subgroups of individuals expressing distinct depressive symptoms often from cross-sectional data. Alternatively, depression phenotypes can be defined based on intraindividual differences, differentiating between transitory states of distinct symptoms profiles that a person transitions into or out of over time. Such within-person phenotypic states are less examined, despite their potential significance for understanding and treating depression.Methods:The current study used intensive longitudinal data of youths (N = 120) at risk for depression. Clinical interviews (at baseline, 4, 10, 16, and 22 months) yielded 90 weekly assessments. We applied a multilevel hidden Markov model to identify intraindividual phenotypes of weekly depressive symptoms for at-risk youth.Results:Three intraindividual phenotypes emerged: a low-depression state, an elevated-depression state, and a cognitive-physical-symptom state. Youth had a high probability of remaining in the same state over time. Furthermore, probabilities of transitioning from one state to another did not differ by age or ethnoracial minority status; girls were more likely than boys to transition from a low-depression state to either the elevated-depression state or the cognitive-physical symptom state. Finally, these intraindividual phenotypes and their dynamics were associated with comorbid externalizing symptoms.Conclusion:Identifying these states as well as the transitions between them characterizes how symptoms of depression change over time and provide potential directions for intervention efforts En ligne : https://dx.doi.org/10.1017/S0954579423000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

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