Allostasis and allostatic load in the context of poverty in early childhood / Clancy BLAIR in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.845-857 Titre : Allostasis and allostatic load in the context of poverty in early childhood Type de document : texte imprimé Auteurs : Clancy BLAIR, Auteur ; C. Cybele RAVER, Auteur ; Douglas A. GRANGER, Auteur ; W. Roger MILLS-KOONCE, Auteur ; Leah C. HIBEL, Auteur ; THE FAMILY LIFE PROJECT KEY INVESTIGATORS, Auteur Année de publication : 2011 Article en page(s) : p.845-857 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This paper examined the relation of early environmental adversity associated with poverty to child resting or basal level of cortisol in a prospective longitudinal sample of 1135 children seen at 7, 15, 24, 35, and 48 months of age. We found main effects for poor housing quality, African American ethnicity, and low positive caregiving behavior in which each was uniquely associated with an overall higher level of cortisol from age 7 to 48 months. We also found that two aspects of the early environment in the context of poverty, adult exits from the home and perceived economic insufficiency, were related to salivary cortisol in a time-dependent manner. The effect for the first of these, exits from the home, was consistent with the principle of allostatic load in which the effects of adversity on stress physiology accumulate over time. The effect for perceived economic insufficiency was one in which insufficiency was associated with higher levels of cortisol in infancy but with a typical but steeper decline in cortisol with age at subsequent time points. En ligne : http://dx.doi.org/10.1017/S0954579411000344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Allostasis and allostatic load in the context of poverty in early childhood [texte imprimé] / Clancy BLAIR, Auteur ; C. Cybele RAVER, Auteur ; Douglas A. GRANGER, Auteur ; W. Roger MILLS-KOONCE, Auteur ; Leah C. HIBEL, Auteur ; THE FAMILY LIFE PROJECT KEY INVESTIGATORS, Auteur . - 2011 . - p.845-857. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.845-857 Index. décimale : PER Périodiques Résumé : This paper examined the relation of early environmental adversity associated with poverty to child resting or basal level of cortisol in a prospective longitudinal sample of 1135 children seen at 7, 15, 24, 35, and 48 months of age. We found main effects for poor housing quality, African American ethnicity, and low positive caregiving behavior in which each was uniquely associated with an overall higher level of cortisol from age 7 to 48 months. We also found that two aspects of the early environment in the context of poverty, adult exits from the home and perceived economic insufficiency, were related to salivary cortisol in a time-dependent manner. The effect for the first of these, exits from the home, was consistent with the principle of allostatic load in which the effects of adversity on stress physiology accumulate over time. The effect for perceived economic insufficiency was one in which insufficiency was associated with higher levels of cortisol in infancy but with a typical but steeper decline in cortisol with age at subsequent time points. En ligne : http://dx.doi.org/10.1017/S0954579411000344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Child behavior problems among cocaine-exposed toddlers: Indirect and interactive effects / Rina Das EIDEN in Development and Psychopathology, 23-2 (May 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-2 (May 2011) . - p.539-550 Titre : Child behavior problems among cocaine-exposed toddlers: Indirect and interactive effects Type de document : texte imprimé Auteurs : Rina Das EIDEN, Auteur ; Douglas A. GRANGER, Auteur ; Pamela SCHUETZE, Auteur ; Yvette VEIRA, Auteur Année de publication : 2011 Article en page(s) : p.539-550 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the role of maternal psychopathology and maternal warmth as mediators of the association between prenatal cocaine and other substance exposure and toddler behavior problems. It was also hypothesized that infant cortisol reactivity and environmental risk may moderate these associations. Participants were 220 caregiver–infant dyads (119 cocaine exposed, 101 not cocaine exposed; 49% boys). Mother–infant dyads were recruited at delivery with assessments at 4–8 weeks and 7, 13, and 18 months of child ages. Results yielded no direct associations between prenatal cocaine/other substance exposure and toddler behavior problems, but significant indirect associations between prenatal cigarette/alcohol exposure and toddler behavior problems at 18 months. With regard to moderation, results indicated an indirect association between prenatal cocaine exposure and toddler behavior problems via lower maternal warmth for children with higher, but not lower, cortisol reactivity at 7 months. Results suggest potential pathways to toddler behavior problems among children at high biological risk. En ligne : http://dx.doi.org/10.1017/S0954579411000058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Child behavior problems among cocaine-exposed toddlers: Indirect and interactive effects [texte imprimé] / Rina Das EIDEN, Auteur ; Douglas A. GRANGER, Auteur ; Pamela SCHUETZE, Auteur ; Yvette VEIRA, Auteur . - 2011 . - p.539-550. Langues : Anglais (eng) in Development and Psychopathology > 23-2 (May 2011) . - p.539-550 Index. décimale : PER Périodiques Résumé : This study examined the role of maternal psychopathology and maternal warmth as mediators of the association between prenatal cocaine and other substance exposure and toddler behavior problems. It was also hypothesized that infant cortisol reactivity and environmental risk may moderate these associations. Participants were 220 caregiver–infant dyads (119 cocaine exposed, 101 not cocaine exposed; 49% boys). Mother–infant dyads were recruited at delivery with assessments at 4–8 weeks and 7, 13, and 18 months of child ages. Results yielded no direct associations between prenatal cocaine/other substance exposure and toddler behavior problems, but significant indirect associations between prenatal cigarette/alcohol exposure and toddler behavior problems at 18 months. With regard to moderation, results indicated an indirect association between prenatal cocaine exposure and toddler behavior problems via lower maternal warmth for children with higher, but not lower, cortisol reactivity at 7 months. Results suggest potential pathways to toddler behavior problems among children at high biological risk. En ligne : http://dx.doi.org/10.1017/S0954579411000058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Cortisol profiles and clinical severity in MECP2 duplication syndrome / Sarika U. PETERS in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Cortisol profiles and clinical severity in MECP2 duplication syndrome Type de document : texte imprimé Auteurs : Sarika U. PETERS, Auteur ; Cary FU, Auteur ; Jeffrey L. NEUL, Auteur ; Douglas A. GRANGER, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Biomarkers  Child  Child, Preschool  Chromosome Duplication  Female  Humans  Hydrocortisone/metabolism  Male  X-Linked Intellectual Disability/metabolism  Saliva  Severity of Illness Index  Young Adult Index. décimale : PER Périodiques Résumé : BACKGROUND: MECP2 duplication syndrome (MDS) is a rare X-linked genomic disorder primarily affecting males which is caused by interstitial chromosomal duplications at Xq28 encompassing the MECP2 gene. Core clinical features of MDS include choreiform movements, progressive spasticity, recurrent respiratory infections, developmental delays in the first 6 months of life, hypotonia, vasomotor disturbances, constipation, drooling, and bruxism. Prior studies suggest that HPA axis activity may be altered in MDS and measures of HPA axis activity may offer insight into disease severity. METHODS: To ascertain whether cortisol profiles are a potential biomarker of clinical severity, diurnal profiles of cortisol and the cortisol awakening response were examined from saliva samples in 31 participants with MDS (ages 2-24 years), and 27 of these samples were usable. Documentation of a positive diagnostic test for MECP2 duplication was required for entry into the study. Samples were collected on each of two consecutive weekdays at four time points during the day: immediately after waking, 30 min after waking, between 3 and 4 PM, and in the evening before bedtime. Correlations with duplication size, clinical severity, sleep problems, and behavior were also examined. RESULTS: Results revealed that a majority of participants with MDS exhibit a declining cortisol awakening response (n = 17). A declining CAR was significantly associated with increased clinical severity scores (r = - .508; p = .03), larger duplication size, waking later, and an increased number of hospitalizations for infections. CONCLUSIONS: Future mechanistic studies will have to determine whether the declining CAR in MDS is attributable to problems with "flip-flop switching" of regional brain activation (involving the suprachiasmatic nucleus and the hippocampus, and the HPA axis) that is responsible for the switch from reduced to increased adrenal sensitivity. Taken together, results suggest the possibility that cortisol profiles could potentially be a biomarker of clinical severity and utilized for the purposes of patient stratification for future clinical trials in MDS. En ligne : https://dx.doi.org/10.1186/s11689-020-09322-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Cortisol profiles and clinical severity in MECP2 duplication syndrome [texte imprimé] / Sarika U. PETERS, Auteur ; Cary FU, Auteur ; Jeffrey L. NEUL, Auteur ; Douglas A. GRANGER, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Adolescent  Biomarkers  Child  Child, Preschool  Chromosome Duplication  Female  Humans  Hydrocortisone/metabolism  Male  X-Linked Intellectual Disability/metabolism  Saliva  Severity of Illness Index  Young Adult Index. décimale : PER Périodiques Résumé : BACKGROUND: MECP2 duplication syndrome (MDS) is a rare X-linked genomic disorder primarily affecting males which is caused by interstitial chromosomal duplications at Xq28 encompassing the MECP2 gene. Core clinical features of MDS include choreiform movements, progressive spasticity, recurrent respiratory infections, developmental delays in the first 6 months of life, hypotonia, vasomotor disturbances, constipation, drooling, and bruxism. Prior studies suggest that HPA axis activity may be altered in MDS and measures of HPA axis activity may offer insight into disease severity. METHODS: To ascertain whether cortisol profiles are a potential biomarker of clinical severity, diurnal profiles of cortisol and the cortisol awakening response were examined from saliva samples in 31 participants with MDS (ages 2-24 years), and 27 of these samples were usable. Documentation of a positive diagnostic test for MECP2 duplication was required for entry into the study. Samples were collected on each of two consecutive weekdays at four time points during the day: immediately after waking, 30 min after waking, between 3 and 4 PM, and in the evening before bedtime. Correlations with duplication size, clinical severity, sleep problems, and behavior were also examined. RESULTS: Results revealed that a majority of participants with MDS exhibit a declining cortisol awakening response (n = 17). A declining CAR was significantly associated with increased clinical severity scores (r = - .508; p = .03), larger duplication size, waking later, and an increased number of hospitalizations for infections. CONCLUSIONS: Future mechanistic studies will have to determine whether the declining CAR in MDS is attributable to problems with "flip-flop switching" of regional brain activation (involving the suprachiasmatic nucleus and the hippocampus, and the HPA axis) that is responsible for the switch from reduced to increased adrenal sensitivity. Taken together, results suggest the possibility that cortisol profiles could potentially be a biomarker of clinical severity and utilized for the purposes of patient stratification for future clinical trials in MDS. En ligne : https://dx.doi.org/10.1186/s11689-020-09322-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children / Sharon A. KIDD in Journal of Autism and Developmental Disorders, 42-12 (December 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2648-2658 Titre : Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children Type de document : texte imprimé Auteurs : Sharon A. KIDD, Auteur ; Blythe A. CORBETT, Auteur ; Douglas A. GRANGER, Auteur ; W. Thomas BOYCE, Auteur ; Thomas F. ANDERS, Auteur ; Ira B. TAGER, Auteur Année de publication : 2012 Article en page(s) : p.2648-2658 Langues : Anglais (eng) Mots-clés : Autism  Children  Salivary cortisol  Salivary alpha-amylase  Diurnal  Variability Index. décimale : PER Périodiques Résumé : We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status' cortisol and sAA secretion levels were higher when IQ was lower. En ligne : http://dx.doi.org/10.1007/s10803-012-1522-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184 [article] Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children [texte imprimé] / Sharon A. KIDD, Auteur ; Blythe A. CORBETT, Auteur ; Douglas A. GRANGER, Auteur ; W. Thomas BOYCE, Auteur ; Thomas F. ANDERS, Auteur ; Ira B. TAGER, Auteur . - 2012 . - p.2648-2658. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2648-2658 Mots-clés : Autism  Children  Salivary cortisol  Salivary alpha-amylase  Diurnal  Variability Index. décimale : PER Périodiques Résumé : We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, 3 months later, 6 months later). There were modest increases in waking cortisol and sAA levels in AUT relative to TYP, but the increases were not statistically significant. Important differences were observed in cortisol and sAA variability between AUT and TYP. There was also a graded response among AUT by functional status' cortisol and sAA secretion levels were higher when IQ was lower. En ligne : http://dx.doi.org/10.1007/s10803-012-1522-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184

Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol / Catherine B. STROUD in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.509-524 Titre : Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol Type de document : texte imprimé Auteurs : Catherine B. STROUD, Auteur ; Frances S. CHEN, Auteur ; Leah D. DOANE, Auteur ; Douglas A. GRANGER, Auteur Article en page(s) : p.509-524 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research suggests that early adversity places individuals at risk for psychopathology across the life span. Guided by concepts of allostasis and allostatic load, the present study examined whether early adversity contributes to the development of subsequent internalizing symptoms through its association with traitlike individual differences in hypothalamic–pituitary–adrenal axis regulation. Early adolescent girls (n = 113; M age = 12.30 years) provided saliva samples at waking, 30 min postwaking, and bedtime over 3 days (later assayed for cortisol). Objective contextual stress interviews with adolescents and their mothers were used to assess the accumulation of nine types of early adversity within the family environment. Greater early adversity predicted subsequent increases in internalizing symptoms through lower levels of latent trait cortisol. Traitlike individual differences in hypothalamic–pituitary–adrenal axis activity may be among the mechanisms through which early adversity confers risk for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579418000044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol [texte imprimé] / Catherine B. STROUD, Auteur ; Frances S. CHEN, Auteur ; Leah D. DOANE, Auteur ; Douglas A. GRANGER, Auteur . - p.509-524. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.509-524 Index. décimale : PER Périodiques Résumé : Research suggests that early adversity places individuals at risk for psychopathology across the life span. Guided by concepts of allostasis and allostatic load, the present study examined whether early adversity contributes to the development of subsequent internalizing symptoms through its association with traitlike individual differences in hypothalamic–pituitary–adrenal axis regulation. Early adolescent girls (n = 113; M age = 12.30 years) provided saliva samples at waking, 30 min postwaking, and bedtime over 3 days (later assayed for cortisol). Objective contextual stress interviews with adolescents and their mothers were used to assess the accumulation of nine types of early adversity within the family environment. Greater early adversity predicted subsequent increases in internalizing symptoms through lower levels of latent trait cortisol. Traitlike individual differences in hypothalamic–pituitary–adrenal axis activity may be among the mechanisms through which early adversity confers risk for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579418000044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Greater fear reactivity and psychophysiological hyperactivity among infants with later conduct problems and callous-unemotional traits / W. Roger MILLS-KOONCE in Journal of Child Psychology and Psychiatry, 56-2 (February 2015)  

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Maternal sensitivity and adrenocortical functioning across infancy and toddlerhood: Physiological adaptation to context? / Daniel BERRY in Development and Psychopathology, 29-1 (February 2017)  

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Maternal sensitivity buffers the adrenocortical implications of intimate partner violence exposure during early childhood / Leah C. HIBEL in Development and Psychopathology, 23-2 (May 2011)  

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Stress response and the adolescent transition: Performance versus peer rejection stressors / Laura R. STROUD in Development and Psychopathology, 21-1 (January 2009)  

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Trajectories of maternal depressive symptoms over her child's life span: Relation to adrenocortical, cardiovascular, and emotional functioning in children / Brooks B. GUMP in Development and Psychopathology, 21-1 (January 2009)  

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