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Auteur Gayle C. WINDHAM |
Documents disponibles écrits par cet auteur (12)
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Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? / Sumi HOSHIKO in Autism Research, 4-6 (December 2011)
[article]
Titre : Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Type de document : Texte imprimé et/ou numérique Auteurs : Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur Année de publication : 2012 Article en page(s) : p.456-463 Langues : Anglais (eng) Mots-clés : epidemiology autism thyroid environment hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Autism Research > 4-6 (December 2011) . - p.456-463[article] Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? [Texte imprimé et/ou numérique] / Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur . - 2012 . - p.456-463.
Langues : Anglais (eng)
in Autism Research > 4-6 (December 2011) . - p.456-463
Mots-clés : epidemiology autism thyroid environment hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
[article]
Titre : Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur Article en page(s) : p.1621-1632 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Developmental screening M-CHAT ASQ Hispanics Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632[article] Autism and Developmental Screening in a Public, Primary Care Setting Primarily Serving Hispanics: Challenges and Results [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Karen S. SMITH, Auteur ; Nila ROSEN, Auteur ; Meredith C. ANDERSON, Auteur ; Judith K. GRETHER, Auteur ; Richard B. COOLMAN, Auteur ; Stephen HARRIS, Auteur . - p.1621-1632.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1621-1632
Mots-clés : Autism spectrum disorders Developmental screening M-CHAT ASQ Hispanics Children’s health Index. décimale : PER Périodiques Résumé : We implemented screening of children 16–30 months of age (n = 1,760) from a typically under-served, primarily Hispanic, population, at routine pediatric appointments using the modified checklist for autism in toddlers (M-CHAT) and Ages and Stages Questionnaire. Screen positive rates of 26 and 39 %, respectively, were higher than previous reports. Hispanics were more likely to score M-CHAT positive than non-Hispanics (adjusted OR 1.7, 95 % CI 1.2–2.4), as were those screened in Spanish. About 30 % of screen-positive children were referred for further assessment, but only half were seen. Thus screening in this population is feasible, but may require additional resources. Attention to the cultural applicability of screening instruments, as well as to explaining the results or need for additional services to parents, is critical to serve the growing Hispanic population. En ligne : http://dx.doi.org/10.1007/s10803-014-2032-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 46-2 (February 2016)
[article]
Titre : Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur Année de publication : 2016 Article en page(s) : p.478-488 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Steroid hormones Estrogen Alpha-fetoprotein hCG Prenatal screening Estriol Index. décimale : PER Périodiques Résumé : We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-015-2587-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488[article] Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur . - 2016 . - p.478-488.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488
Mots-clés : Autism spectrum disorder Steroid hormones Estrogen Alpha-fetoprotein hCG Prenatal screening Estriol Index. décimale : PER Périodiques Résumé : We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-015-2587-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Autism spectrum disorders in relation to parental occupation in technical fields / Gayle C. WINDHAM in Autism Research, 2-4 (August 2009)
[article]
Titre : Autism spectrum disorders in relation to parental occupation in technical fields Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur Année de publication : 2009 Article en page(s) : p.183-191 Langues : Anglais (eng) Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937
in Autism Research > 2-4 (August 2009) . - p.183-191[article] Autism spectrum disorders in relation to parental occupation in technical fields [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Judith K. GRETHER, Auteur ; Karen FESSEL, Auteur . - 2009 . - p.183-191.
Langues : Anglais (eng)
in Autism Research > 2-4 (August 2009) . - p.183-191
Mots-clés : autism parental-occupation broader-autism-phenotype risk-factors Index. décimale : PER Périodiques Résumé : A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring systemizing skills, and suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech occupations (6.7%) than mothers of controls (4.0%, P=0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other white collar occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. En ligne : http://dx.doi.org/10.1002/aur.84 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics / Gayle C. WINDHAM in Journal of Autism and Developmental Disorders, 41-10 (October 2011)
[article]
Titre : Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics Type de document : Texte imprimé et/ou numérique Auteurs : Gayle C. WINDHAM, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Karen S. SMITH, Auteur ; John COLLINS, Auteur ; Judith K. GRETHER, Auteur Année de publication : 2011 Article en page(s) : p.1362-1372 Langues : Anglais (eng) Mots-clés : Autism ASD Prevalence Surveillance Demographics Index. décimale : PER Périodiques Résumé : Using standardized methods for multi-source surveillance, we calculated the prevalence of autism spectrum disorders (ASD) among children born in a racially diverse region in 1994 or 1996 as 4.7/1000 live births. Children with ASD before age 9 were identified through chart abstraction at health-related sources; three-quarters were being served by the state-wide Department of Developmental Services. In adjusted models, we found a male:female ratio of 6:1, a doubling of ASD prevalence among children of older mothers (40+), and lower prevalence with lower paternal education. Children of Black or Hispanic mothers had lower prevalence than those of White, non-Hispanic mothers, but these differences were attenuated after adjustment. Prevalence in children of Asian mothers was similar to Whites. Potential under-counting is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1160-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143
in Journal of Autism and Developmental Disorders > 41-10 (October 2011) . - p.1362-1372[article] Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Meredith C. ANDERSON, Auteur ; Lisa A. CROEN, Auteur ; Karen S. SMITH, Auteur ; John COLLINS, Auteur ; Judith K. GRETHER, Auteur . - 2011 . - p.1362-1372.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-10 (October 2011) . - p.1362-1372
Mots-clés : Autism ASD Prevalence Surveillance Demographics Index. décimale : PER Périodiques Résumé : Using standardized methods for multi-source surveillance, we calculated the prevalence of autism spectrum disorders (ASD) among children born in a racially diverse region in 1994 or 1996 as 4.7/1000 live births. Children with ASD before age 9 were identified through chart abstraction at health-related sources; three-quarters were being served by the state-wide Department of Developmental Services. In adjusted models, we found a male:female ratio of 6:1, a doubling of ASD prevalence among children of older mothers (40+), and lower prevalence with lower paternal education. Children of Black or Hispanic mothers had lower prevalence than those of White, non-Hispanic mothers, but these differences were attenuated after adjustment. Prevalence in children of Asian mothers was similar to Whites. Potential under-counting is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1160-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development / Alison B. SINGER in Journal of Autism and Developmental Disorders, 46-11 (November 2016)
PermalinkNeonatal thyroid hormone levels in association with autism spectrum disorder / Kristen LYALL in Autism Research, 10-4 (April 2017)
PermalinkPeri-Pregnancy Cannabis Use and Autism Spectrum Disorder in the Offspring: Findings from the Study to Explore Early Development / Carolyn G. DIGUISEPPI in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
PermalinkPolyunsaturated Fatty Acids in Newborn Bloodspots: Associations With Autism Spectrum Disorder and Correlation With Maternal Serum Levels / Anna BOSTWICK in Autism Research, 13-9 (September 2020)
PermalinkThe Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder / Eric RUBENSTEIN in Journal of Autism and Developmental Disorders, 47-10 (October 2017)
PermalinkThe Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network / Diana SCHENDEL in Journal of Autism and Developmental Disorders, 42-10 (October 2012)
PermalinkUse of Birth Certificates to Examine Maternal Occupational Exposures and Autism Spectrum Disorders in Offspring / Gayle C. WINDHAM in Autism Research, 6-1 (February 2013)
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