Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 40-9 (September 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Titre : Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study Type de document : Texte imprimé et/ou numérique Auteurs : Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur Année de publication : 2010 Article en page(s) : p.1080-1093 Langues : Anglais (eng) Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study [Texte imprimé et/ou numérique] / Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur . - 2010 . - p.1080-1093. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised / Ulrika ROINE in Autism - Open Access, 3-1 (March 2013)  

Public ISBD [article]  inAutism - Open Access > 3-1 (March 2013) . - 9 p. Titre : Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis. Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study. Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too. Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders. En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur . - 2013 . - 9 p. Langues : Anglais (eng) in Autism - Open Access > 3-1 (March 2013) . - 9 p. Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis. Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study. Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too. Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders. En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2162-2180 Titre : Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening Type de document : Texte imprimé et/ou numérique Auteurs : Marja-Leena MATTILA, Auteur ; Katja JUSSILA, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Risto BLOIGU, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur ; Irma MOILANEN, Auteur Année de publication : 2012 Article en page(s) : p.2162-2180 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Asperger’s syndrome  Autism  Autism Spectrum Screening Questionnaire  ASSQ  Validation Index. décimale : PER Périodiques Résumé : We assessed the validity and determined cut-off scores for the Finnish Autism Spectrum Screening Questionnaire (ASSQ). A population sample of 8-year-old children (n = 4,408) was rated via the ASSQ by parents and/or teachers, and a subgroup of 104 children was examined via structured interview, semi-structured observation, IQ measurement, school observation, and medical records. Autism spectrum disorders (ASDs) were diagnosed following DSM-IV-TR criteria. A search for hospital-registered ASDs was performed. For Finnish higher-functioning primary school-aged, 7- to 12-year-olds, the optimal cut-off score was 30 in clinical settings and 28 in total population screening using summed ASSQ scores of parents’ and teachers’ ratings. Determining appropriate cut-off scores in ASD screening in different languages and in different cultures is of utmost importance. En ligne : http://dx.doi.org/10.1007/s10803-012-1464-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening [Texte imprimé et/ou numérique] / Marja-Leena MATTILA, Auteur ; Katja JUSSILA, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Risto BLOIGU, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur ; Irma MOILANEN, Auteur . - 2012 . - p.2162-2180. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2162-2180 Mots-clés : Autism spectrum disorder  Asperger’s syndrome  Autism  Autism Spectrum Screening Questionnaire  ASSQ  Validation Index. décimale : PER Périodiques Résumé : We assessed the validity and determined cut-off scores for the Finnish Autism Spectrum Screening Questionnaire (ASSQ). A population sample of 8-year-old children (n = 4,408) was rated via the ASSQ by parents and/or teachers, and a subgroup of 104 children was examined via structured interview, semi-structured observation, IQ measurement, school observation, and medical records. Autism spectrum disorders (ASDs) were diagnosed following DSM-IV-TR criteria. A search for hospital-registered ASDs was performed. For Finnish higher-functioning primary school-aged, 7- to 12-year-olds, the optimal cut-off score was 30 in clinical settings and 28 in total population screening using summed ASSQ scores of parents’ and teachers’ ratings. Determining appropriate cut-off scores in ASD screening in different languages and in different cultures is of utmost importance. En ligne : http://dx.doi.org/10.1007/s10803-012-1464-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

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