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Auteur Armando BERTONE |
Documents disponibles écrits par cet auteur (12)
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Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling / Armando BERTONE in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
[article]
Titre : Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling Type de document : Texte imprimé et/ou numérique Auteurs : Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur Année de publication : 2010 Article en page(s) : p.1541-1548 Langues : Anglais (eng) Mots-clés : Autism Fragile X syndrome Vision Neural networks Causal model Genetics Index. décimale : PER Périodiques Résumé : We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548[article] Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur . - 2010 . - p.1541-1548.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548
Mots-clés : Autism Fragile X syndrome Vision Neural networks Causal model Genetics Index. décimale : PER Périodiques Résumé : We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Atypical Face Perception in Autism: A Point of View? / Karine MORIN in Autism Research, 8-5 (October 2015)
[article]
Titre : Atypical Face Perception in Autism: A Point of View? Type de document : Texte imprimé et/ou numérique Auteurs : Karine MORIN, Auteur ; Jacalyn GUY, Auteur ; Claudine HABAK, Auteur ; Hugh R. WILSON, Auteur ; Linda PAGANI, Auteur ; Laurent MOTTRON, Auteur ; Armando BERTONE, Auteur Article en page(s) : p.497-506 Langues : Anglais (eng) Mots-clés : autism spectrum disorder face perception local global synthetic faces viewpoint change Index. décimale : PER Périodiques Résumé : Face perception is the most commonly used visual metric of social perception in autism. However, when found to be atypical, the origin of face perception differences in autism is contentious. One hypothesis proposes that a locally oriented visual analysis, characteristic of individuals with autism, ultimately affects performance on face tasks where a global analysis is optimal. The objective of this study was to evaluate this hypothesis by assessing face identity discrimination with synthetic faces presented with and without changes in viewpoint, with the former condition minimizing access to local face attributes used for identity discrimination. Twenty-eight individuals with autism and 30 neurotypical participants performed a face identity discrimination task. Stimuli were synthetic faces extracted from traditional face photographs in both front and 20° side viewpoints, digitized from 37 points to provide a continuous measure of facial geometry. Face identity discrimination thresholds were obtained using a two-alternative, temporal forced choice match-to-sample paradigm. Analyses revealed an interaction between group and condition, with group differences found only for the viewpoint change condition, where performance in the autism group was decreased compared to that of neurotypical participants. The selective decrease in performance for the viewpoint change condition suggests that face identity discrimination in autism is more difficult when access to local cues is minimized, and/or when dependence on integrative analysis is increased. These results lend support to a perceptual contribution of atypical face perception in autism. Autism Res 2015, 8: 497–506. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Autism Research > 8-5 (October 2015) . - p.497-506[article] Atypical Face Perception in Autism: A Point of View? [Texte imprimé et/ou numérique] / Karine MORIN, Auteur ; Jacalyn GUY, Auteur ; Claudine HABAK, Auteur ; Hugh R. WILSON, Auteur ; Linda PAGANI, Auteur ; Laurent MOTTRON, Auteur ; Armando BERTONE, Auteur . - p.497-506.
Langues : Anglais (eng)
in Autism Research > 8-5 (October 2015) . - p.497-506
Mots-clés : autism spectrum disorder face perception local global synthetic faces viewpoint change Index. décimale : PER Périodiques Résumé : Face perception is the most commonly used visual metric of social perception in autism. However, when found to be atypical, the origin of face perception differences in autism is contentious. One hypothesis proposes that a locally oriented visual analysis, characteristic of individuals with autism, ultimately affects performance on face tasks where a global analysis is optimal. The objective of this study was to evaluate this hypothesis by assessing face identity discrimination with synthetic faces presented with and without changes in viewpoint, with the former condition minimizing access to local face attributes used for identity discrimination. Twenty-eight individuals with autism and 30 neurotypical participants performed a face identity discrimination task. Stimuli were synthetic faces extracted from traditional face photographs in both front and 20° side viewpoints, digitized from 37 points to provide a continuous measure of facial geometry. Face identity discrimination thresholds were obtained using a two-alternative, temporal forced choice match-to-sample paradigm. Analyses revealed an interaction between group and condition, with group differences found only for the viewpoint change condition, where performance in the autism group was decreased compared to that of neurotypical participants. The selective decrease in performance for the viewpoint change condition suggests that face identity discrimination in autism is more difficult when access to local cues is minimized, and/or when dependence on integrative analysis is increased. These results lend support to a perceptual contribution of atypical face perception in autism. Autism Res 2015, 8: 497–506. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 Audiovisual temporal binding window narrows with age in autistic individuals / Armando BERTONE in Autism Research, 16-2 (February 2023)
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Titre : Audiovisual temporal binding window narrows with age in autistic individuals Type de document : Texte imprimé et/ou numérique Auteurs : Armando BERTONE, Auteur Article en page(s) : p.355-363 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Atypical sensory perception has been recognized in autistic individuals since its earliest descriptions and is now considered a key characteristic of autism. Although the integration of sensory information (multisensory integration; MSI) has been demonstrated to be altered in autism, less is known about how this perceptual process differs with age. This study aimed to assess the integration of audiovisual information across autistic children and adolescents. MSI was measured using a non-social, simultaneity judgment task. Variation in temporal sensitivity was evaluated via Gaussian curve fitting procedures, allowing us to compare the width of temporal binding windows (TBWs), where wider TBWs indicate less sensitivity to temporal alignment. We compared TBWs in age and IQ matched groups of autistic (n = 32) and neurotypical (NT; n = 73) children and adolescents. The sensory profile of all participants was also measured. Across all ages assessed (i.e., 6 through 18â€years), TBWs were negatively correlated with age in the autistic group. A significant correlation was not found in the NT group. When compared as a function of child (6-12â€years) and adolescent (13-18â€years) age groups, a significant interaction of group (autism vs NT) by age group was found, whereby TBWs became narrower with age in the autistic, but not neurotypical group. We also found a significant main effect of age and no significant main effect of group. Results suggest that TBW differences between autistic and neurotypical groups diminishes with increasing age, indicating an atypical developmental profile of MSI in autism which ameliorates across development. En ligne : https://doi.org/10.1002/aur.2860 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495
in Autism Research > 16-2 (February 2023) . - p.355-363[article] Audiovisual temporal binding window narrows with age in autistic individuals [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur . - p.355-363.
Langues : Anglais (eng)
in Autism Research > 16-2 (February 2023) . - p.355-363
Index. décimale : PER Périodiques Résumé : Abstract Atypical sensory perception has been recognized in autistic individuals since its earliest descriptions and is now considered a key characteristic of autism. Although the integration of sensory information (multisensory integration; MSI) has been demonstrated to be altered in autism, less is known about how this perceptual process differs with age. This study aimed to assess the integration of audiovisual information across autistic children and adolescents. MSI was measured using a non-social, simultaneity judgment task. Variation in temporal sensitivity was evaluated via Gaussian curve fitting procedures, allowing us to compare the width of temporal binding windows (TBWs), where wider TBWs indicate less sensitivity to temporal alignment. We compared TBWs in age and IQ matched groups of autistic (n = 32) and neurotypical (NT; n = 73) children and adolescents. The sensory profile of all participants was also measured. Across all ages assessed (i.e., 6 through 18â€years), TBWs were negatively correlated with age in the autistic group. A significant correlation was not found in the NT group. When compared as a function of child (6-12â€years) and adolescent (13-18â€years) age groups, a significant interaction of group (autism vs NT) by age group was found, whereby TBWs became narrower with age in the autistic, but not neurotypical group. We also found a significant main effect of age and no significant main effect of group. Results suggest that TBW differences between autistic and neurotypical groups diminishes with increasing age, indicating an atypical developmental profile of MSI in autism which ameliorates across development. En ligne : https://doi.org/10.1002/aur.2860 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 Brief Report: An Exploration of Cognitive Flexibility of Autistic Adolescents with Low Intelligence Using the Wisconsin Card Sorting Task / Stephanie Lock Man LUNG in Journal of Autism and Developmental Disorders, 53-4 (April 2023)
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Titre : Brief Report: An Exploration of Cognitive Flexibility of Autistic Adolescents with Low Intelligence Using the Wisconsin Card Sorting Task Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie Lock Man LUNG, Auteur ; Armando BERTONE, Auteur Article en page(s) : p.1726-1732 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Cognitive flexibility (CF) is the ability to shift between concepts or rules. Difficulty with CF is associated with autism (i.e., ASD) as it contributes to repetitive behaviours. However, little is known about CF skills of autistic adolescents with low intelligence. This study uses the Wisconsin Card Sorting Task (WCST) to assess the CF of 36 adolescents, all with a Weschler full-scale IQ between 50 and 85, 14 of whom had an ASD diagnosis. The results indicated no statistically significant differences in WCST performance between those with and without ASD. It was also found that performance IQ significantly contributed to the WCST performance in the ASD group only, suggesting an autism-specific role of non-verbal cognitive functioning in CF. En ligne : https://doi.org/10.1007/s10803-021-05134-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500
in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1726-1732[article] Brief Report: An Exploration of Cognitive Flexibility of Autistic Adolescents with Low Intelligence Using the Wisconsin Card Sorting Task [Texte imprimé et/ou numérique] / Stephanie Lock Man LUNG, Auteur ; Armando BERTONE, Auteur . - p.1726-1732.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1726-1732
Index. décimale : PER Périodiques Résumé : Cognitive flexibility (CF) is the ability to shift between concepts or rules. Difficulty with CF is associated with autism (i.e., ASD) as it contributes to repetitive behaviours. However, little is known about CF skills of autistic adolescents with low intelligence. This study uses the Wisconsin Card Sorting Task (WCST) to assess the CF of 36 adolescents, all with a Weschler full-scale IQ between 50 and 85, 14 of whom had an ASD diagnosis. The results indicated no statistically significant differences in WCST performance between those with and without ASD. It was also found that performance IQ significantly contributed to the WCST performance in the ASD group only, suggesting an autism-specific role of non-verbal cognitive functioning in CF. En ligne : https://doi.org/10.1007/s10803-021-05134-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 A Developmental Perspective of Global and Local Visual Perception in Autism Spectrum Disorder / J. GUY in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : A Developmental Perspective of Global and Local Visual Perception in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. GUY, Auteur ; Laurent MOTTRON, Auteur ; Claude BERTHIAUME, Auteur ; Armando BERTONE, Auteur Article en page(s) : p.2706-2720 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Development Global and local processing Interference Perception Vision Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) demonstrate superior performances on visuo-spatial tasks emphasizing local information processing; however, findings from studies involving hierarchical stimuli are inconsistent. Wide age ranges and group means complicate their interpretability. Children and adolescents with and without ASD completed a Navon task wherein they identified global and local stimuli composed of either consistent or inconsistent letters. Trajectories of reaction time in global and local conditions were similar within and between groups when consistent and inconsistent stimuli were considered together, but the effect of local-to-global interference was significantly higher in participants with than without ASD. Age was not a significant predictor of local-to-global interference, suggesting that this effect emerges in childhood and persists throughout adolescence in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2834-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2706-2720[article] A Developmental Perspective of Global and Local Visual Perception in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. GUY, Auteur ; Laurent MOTTRON, Auteur ; Claude BERTHIAUME, Auteur ; Armando BERTONE, Auteur . - p.2706-2720.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2706-2720
Mots-clés : Autism spectrum disorder Development Global and local processing Interference Perception Vision Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) demonstrate superior performances on visuo-spatial tasks emphasizing local information processing; however, findings from studies involving hierarchical stimuli are inconsistent. Wide age ranges and group means complicate their interpretability. Children and adolescents with and without ASD completed a Navon task wherein they identified global and local stimuli composed of either consistent or inconsistent letters. Trajectories of reaction time in global and local conditions were similar within and between groups when consistent and inconsistent stimuli were considered together, but the effect of local-to-global interference was significantly higher in participants with than without ASD. Age was not a significant predictor of local-to-global interference, suggesting that this effect emerges in childhood and persists throughout adolescence in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2834-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Epidemiology of Autism Spectrum Disorders / Lisa R. FRENCH
PermalinkFar visual acuity is unremarkable in autism: Do we need to focus on crowding? / Luc KEITA in Autism Research, 3-6 (December 2010)
PermalinkMultisensory Integration of Low-level Information in Autism Spectrum Disorder: Measuring Susceptibility to the Flash-Beep Illusion / Vanessa A. BAO in Journal of Autism and Developmental Disorders, 47-8 (August 2017)
PermalinkPostural Hypo-Reactivity in Autism is Contingent on Development and Visual Environment: A Fully Immersive Virtual Reality Study / Selma GREFFOU in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
PermalinkThe developmental trajectory of contrast sensitivity in autism spectrum disorder / Jacalyn GUY in Autism Research, 9-8 (August 2016)
PermalinkUsing Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions / Armando BERTONE in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
PermalinkWithin- and Cross-Modal Integration and Attention in the Autism Spectrum / Genevieve CHARBONNEAU in Journal of Autism and Developmental Disorders, 50-1 (January 2020)
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