Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits / Jannath BEGUM-ALI in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Titre : Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits Type de document : Texte imprimé et/ou numérique Auteurs : Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.1057-1067 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits [Texte imprimé et/ou numérique] / Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur . - p.1057-1067. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism / Greg PASCO ; Jannath Begum ALI ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2184-2197 Titre : Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism Type de document : Texte imprimé et/ou numérique Auteurs : Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2184-2197 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism [Texte imprimé et/ou numérique] / Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur . - p.2184-2197. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2184-2197 Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Attitudes of the autism community to early autism research / Sue FLETCHER-WATSON in Autism, 21-1 (January 2017)  

Public ISBD [article]  inAutism > 21-1 (January 2017) . - p.61-74 Titre : Attitudes of the autism community to early autism research Type de document : Texte imprimé et/ou numérique Auteurs : Sue FLETCHER-WATSON, Auteur ; Fabio APICELLA, Auteur ; Bonnie AUYEUNG, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; Natasha CHERICONI, Auteur ; Inês C CONCEIÇÃO, Auteur ; Kim DAVIES, Auteur ; Teresa FARRONI, Auteur ; Marie GOMOT, Auteur ; Emily JONES, Auteur ; Anett KAALE, Auteur ; Katarzyna KAPICA, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Kenneth LARSEN, Auteur ; Jeremy LEFORT-BESNARD, Auteur ; Joëlle MALVY, Auteur ; Sara DIOS MANSO DE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Inbal MILLO, Auteur ; Natercia MIRANDA, Auteur ; Greg PASCO, Auteur ; Ewa PISULA, Auteur ; Marija RALEVA, Auteur ; Bernadette ROGE, Auteur ; Erica SALOMONE, Auteur ; Synnve SCHJØLBERG, Auteur ; Przemys?aw TOMALSKI, Auteur ; Astrid M VICENTE, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : p.61-74 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  development  ethics  infancy  public engagement Index. décimale : PER Périodiques Résumé : Investigation into the earliest signs of autism in infants has become a significant sub-field of autism research. This work invokes specific ethical concerns such as use of ‘at-risk’ language, communicating study findings to parents and the future perspective of enrolled infants when they reach adulthood. This study aimed to ground this research field in an understanding of the perspectives of members of the autism community. Following focus groups to identify topics, an online survey was distributed to autistic adults, parents of children with autism and practitioners in health and education settings across 11 European countries. Survey respondents (n?=?2317) were positively disposed towards early autism research, and there was significant overlap in their priorities for the field and preferred language to describe infant research participants. However, there were also differences including overall less favourable endorsement of early autism research by autistic adults relative to other groups and a dislike of the phrase ‘at-risk’ to describe infant participants, in all groups except healthcare practitioners. The findings overall indicate that the autism community in Europe is supportive of early autism research. Researchers should endeavour to maintain this by continuing to take community perspectives into account. En ligne : http://dx.doi.org/10.1177/1362361315626577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Attitudes of the autism community to early autism research [Texte imprimé et/ou numérique] / Sue FLETCHER-WATSON, Auteur ; Fabio APICELLA, Auteur ; Bonnie AUYEUNG, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; Natasha CHERICONI, Auteur ; Inês C CONCEIÇÃO, Auteur ; Kim DAVIES, Auteur ; Teresa FARRONI, Auteur ; Marie GOMOT, Auteur ; Emily JONES, Auteur ; Anett KAALE, Auteur ; Katarzyna KAPICA, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Kenneth LARSEN, Auteur ; Jeremy LEFORT-BESNARD, Auteur ; Joëlle MALVY, Auteur ; Sara DIOS MANSO DE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Inbal MILLO, Auteur ; Natercia MIRANDA, Auteur ; Greg PASCO, Auteur ; Ewa PISULA, Auteur ; Marija RALEVA, Auteur ; Bernadette ROGE, Auteur ; Erica SALOMONE, Auteur ; Synnve SCHJØLBERG, Auteur ; Przemys?aw TOMALSKI, Auteur ; Astrid M VICENTE, Auteur ; Nurit YIRMIYA, Auteur . - p.61-74. Langues : Anglais (eng) in Autism > 21-1 (January 2017) . - p.61-74 Mots-clés : autism spectrum disorder  development  ethics  infancy  public engagement Index. décimale : PER Périodiques Résumé : Investigation into the earliest signs of autism in infants has become a significant sub-field of autism research. This work invokes specific ethical concerns such as use of ‘at-risk’ language, communicating study findings to parents and the future perspective of enrolled infants when they reach adulthood. This study aimed to ground this research field in an understanding of the perspectives of members of the autism community. Following focus groups to identify topics, an online survey was distributed to autistic adults, parents of children with autism and practitioners in health and education settings across 11 European countries. Survey respondents (n?=?2317) were positively disposed towards early autism research, and there was significant overlap in their priorities for the field and preferred language to describe infant research participants. However, there were also differences including overall less favourable endorsement of early autism research by autistic adults relative to other groups and a dislike of the phrase ‘at-risk’ to describe infant participants, in all groups except healthcare practitioners. The findings overall indicate that the autism community in Europe is supportive of early autism research. Researchers should endeavour to maintain this by continuing to take community perspectives into account. En ligne : http://dx.doi.org/10.1177/1362361315626577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Book Reviews / Greg PASCO in Autism, 4-1 (March 2000)  

Public ISBD [article]  inAutism > 4-1 (March 2000) . - p.104-105 Titre : Book Reviews Type de document : Texte imprimé et/ou numérique Auteurs : Greg PASCO, Auteur Article en page(s) : p.104-105 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361300004001008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=208 [article] Book Reviews [Texte imprimé et/ou numérique] / Greg PASCO, Auteur . - p.104-105. Langues : Anglais (eng) in Autism > 4-1 (March 2000) . - p.104-105 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361300004001008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=208

Book Reviews / Greg PASCO in Autism, 5-3 (September 2001)  

Public ISBD [article]  inAutism > 5-3 (September 2001) . - p.324-325 Titre : Book Reviews Type de document : Texte imprimé et/ou numérique Auteurs : Greg PASCO, Auteur Article en page(s) : p.324-325 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361301005003009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209 [article] Book Reviews [Texte imprimé et/ou numérique] / Greg PASCO, Auteur . - p.324-325. Langues : Anglais (eng) in Autism > 5-3 (September 2001) . - p.324-325 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361301005003009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209

Building on Early Foundations into School: Communication and Language / Greg PASCO

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Comparison of Parent Questionnaires, Examiner-Led Assessment and Parents' Concerns at 14 Months of Age as Indicators of Later Diagnosis of Autism / Greg PASCO in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

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Developmental trajectories in infants and pre-school children with Neurofibromatosis 1 / Hannah SLEVIN in Molecular Autism, 15 (2024)  

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Early Language Profiles in Infants at High-Risk for Autism Spectrum Disorders / Kristelle HUDRY in Journal of Autism and Developmental Disorders, 44-1 (January 2014)  

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Infant excitation/inhibition balance interacts with executive attention to predict autistic traits in childhood / Virginia CARTER LENO in Molecular Autism, 13 (2022)  

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Infant sleep predicts trajectories of social attention and later autism traits / Jannath BEGUM-ALI in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

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Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD / Anna GUI in Development and Psychopathology, 32-4 (October 2020)  

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Mid-childhood autism sibling recurrence in infants with a family history of autism / Rowan ARTHUR ; Greg PASCO ; Elizabeth SHEPHARD ; Bosiljka MILOSAVLJEVIC ; Jannath Begum ALI ; Andrew PICKLES ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN ; The BASIS/STAARS TEAM in Autism Research, 17-7 (July 2024)  

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Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder / Elizabeth SHEPHARD in Autism Research, 10-3 (March 2017)  

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Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze-following task / Rachael BEDFORD in Autism Research, 17-11 (November 2024)  

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