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Auteur Henning TIEMEIER |
Documents disponibles écrits par cet auteur (25)
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Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation / Rosa H. MULDER in Development and Psychopathology, 29-2 (May 2017)
[article]
Titre : Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation Type de document : Texte imprimé et/ou numérique Auteurs : Rosa H. MULDER, Auteur ; Jolien RIJLAARSDAM, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Frank C. VERHULST, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur Article en page(s) : p.491-503 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The parent–child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenal axis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity. En ligne : http://dx.doi.org/10.1017/s095457941700013x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305
in Development and Psychopathology > 29-2 (May 2017) . - p.491-503[article] Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation [Texte imprimé et/ou numérique] / Rosa H. MULDER, Auteur ; Jolien RIJLAARSDAM, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Frank C. VERHULST, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur . - p.491-503.
Langues : Anglais (eng)
in Development and Psychopathology > 29-2 (May 2017) . - p.491-503
Index. décimale : PER Périodiques Résumé : The parent–child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenal axis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity. En ligne : http://dx.doi.org/10.1017/s095457941700013x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 Modeling the malleable mental health trajectory - a commentary on Oldehinkel and Ormel (2023) / Henning TIEMEIER in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)
[article]
Titre : Modeling the malleable mental health trajectory - a commentary on Oldehinkel and Ormel (2023) Type de document : Texte imprimé et/ou numérique Auteurs : Henning TIEMEIER, Auteur Article en page(s) : p.503-505 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In their Annual Research Review titled 'Stability of psychopathology: Lessons learned from longitudinal population surveys' (Oldehinkel & Ormel, Journal of Child Psychology and Psychiatry, 2022) argue that psychological and psychiatric researchers should not only compare groups but also focus on the within-person variability using repeated measurements in longitudinal studies to advance our understanding of emotional and behavioral problems. I argue adopting such within-person approaches might also change how we think about causality and might lead us to more successful intervention research. En ligne : https://doi.org/10.1111/jcpp.13766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501
in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.503-505[article] Modeling the malleable mental health trajectory - a commentary on Oldehinkel and Ormel (2023) [Texte imprimé et/ou numérique] / Henning TIEMEIER, Auteur . - p.503-505.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.503-505
Index. décimale : PER Périodiques Résumé : In their Annual Research Review titled 'Stability of psychopathology: Lessons learned from longitudinal population surveys' (Oldehinkel & Ormel, Journal of Child Psychology and Psychiatry, 2022) argue that psychological and psychiatric researchers should not only compare groups but also focus on the within-person variability using repeated measurements in longitudinal studies to advance our understanding of emotional and behavioral problems. I argue adopting such within-person approaches might also change how we think about causality and might lead us to more successful intervention research. En ligne : https://doi.org/10.1111/jcpp.13766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study / T. VAN BATENBURG-EDDES in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)
[article]
Titre : Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study Type de document : Texte imprimé et/ou numérique Auteurs : T. VAN BATENBURG-EDDES, Auteur ; M. J. BRION, Auteur ; J. HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; D. A. LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.591-600 Langues : Anglais (eng) Mots-clés : Parental depression or anxiety child attention problems cohort studies intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196
in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600[article] Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study [Texte imprimé et/ou numérique] / T. VAN BATENBURG-EDDES, Auteur ; M. J. BRION, Auteur ; J. HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; D. A. LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur . - p.591-600.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600
Mots-clés : Parental depression or anxiety child attention problems cohort studies intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population / Philip R. JANSEN in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)
[article]
Titre : Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Philip R. JANSEN, Auteur ; Tinca J. C. POLDERMAN, Auteur ; Koen BOLHUIS, Auteur ; Jan VAN DER ENDE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Daniëlle POSTHUMA, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.39-47 Langues : Anglais (eng) Mots-clés : Polygenic scores psychiatric disorders educational attainment childhood behaviour Index. décimale : PER Périodiques Résumé : Background Genome-wide association studies in adults have identified numerous genetic variants related to psychiatric disorders and related traits, such as schizophrenia and educational attainment. However, the effects of these genetic variants on behaviour in the general population remain to be fully understood, particularly in younger populations. We investigated whether polygenic scores of five psychiatric disorders and educational attainment are related to emotional and behaviour problems during early childhood. Methods From the Generation R Study, we included participants with available genotype data and behavioural problems measured with the Child Behavior Checklist (CBCL) at the age of 3 (n = 1,902), 6 (n = 2,202) and 10 years old (n = 1,843). Polygenic scores were calculated for five psychiatric disorders and educational attainment. These polygenic scores were tested for an association with the broadband internalizing and externalizing problem scales and the specific CBCL syndrome scale scores. Results Analysis of the CBCL broadband scales showed that the schizophrenia polygenic score was associated with significantly higher internalizing scores at 3, 6 and 10 years and higher externalizing scores at age 3 and 6. The educational attainment polygenic score was associated with lower externalizing scores at all time points and lower internalizing scores at age 3. No associations were observed for the polygenic scores of bipolar disorder, major depressive disorder and autism spectrum disorder. Secondary analyses of specific syndrome scores showed that the schizophrenia polygenic score was strongly related to the Thought Problems scores. A negative association was observed between the educational attainment polygenic score and Attention Problems scores across all age groups. Conclusions Polygenic scores for adult psychiatric disorders and educational attainment are associated with variation in emotional and behavioural problems already at a very early age. En ligne : http://dx.doi.org/10.1111/jcpp.12759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.39-47[article] Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population [Texte imprimé et/ou numérique] / Philip R. JANSEN, Auteur ; Tinca J. C. POLDERMAN, Auteur ; Koen BOLHUIS, Auteur ; Jan VAN DER ENDE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Daniëlle POSTHUMA, Auteur ; Henning TIEMEIER, Auteur . - p.39-47.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.39-47
Mots-clés : Polygenic scores psychiatric disorders educational attainment childhood behaviour Index. décimale : PER Périodiques Résumé : Background Genome-wide association studies in adults have identified numerous genetic variants related to psychiatric disorders and related traits, such as schizophrenia and educational attainment. However, the effects of these genetic variants on behaviour in the general population remain to be fully understood, particularly in younger populations. We investigated whether polygenic scores of five psychiatric disorders and educational attainment are related to emotional and behaviour problems during early childhood. Methods From the Generation R Study, we included participants with available genotype data and behavioural problems measured with the Child Behavior Checklist (CBCL) at the age of 3 (n = 1,902), 6 (n = 2,202) and 10 years old (n = 1,843). Polygenic scores were calculated for five psychiatric disorders and educational attainment. These polygenic scores were tested for an association with the broadband internalizing and externalizing problem scales and the specific CBCL syndrome scale scores. Results Analysis of the CBCL broadband scales showed that the schizophrenia polygenic score was associated with significantly higher internalizing scores at 3, 6 and 10 years and higher externalizing scores at age 3 and 6. The educational attainment polygenic score was associated with lower externalizing scores at all time points and lower internalizing scores at age 3. No associations were observed for the polygenic scores of bipolar disorder, major depressive disorder and autism spectrum disorder. Secondary analyses of specific syndrome scores showed that the schizophrenia polygenic score was strongly related to the Thought Problems scores. A negative association was observed between the educational attainment polygenic score and Attention Problems scores across all age groups. Conclusions Polygenic scores for adult psychiatric disorders and educational attainment are associated with variation in emotional and behavioural problems already at a very early age. En ligne : http://dx.doi.org/10.1111/jcpp.12759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype / Jolien RIJLAARSDAM in Autism Research, 10-3 (March 2017)
[article]
Titre : Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Article en page(s) : p.430-438 Langues : Anglais (eng) Mots-clés : DNA methylation oxytocin receptor gene (OXTR) autistic traits stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Autism Research > 10-3 (March 2017) . - p.430-438[article] Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - p.430-438.
Langues : Anglais (eng)
in Autism Research > 10-3 (March 2017) . - p.430-438
Mots-clés : DNA methylation oxytocin receptor gene (OXTR) autistic traits stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 A prospective study of heart rate and externalising behaviours in young children / Bram DIERCKX in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)
PermalinkPsychotic experiences and future school performance in childhood: a population-based cohort study / Lisa R STEENKAMP in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)
PermalinkRecognition of scared faces and the serotonin transporter gene in young children: the Generation R Study / Eszter SZEKELY in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)
PermalinkThe bidirectional pathways between internalizing and externalizing problems and academic performance from 6 to 18 years / Jan VAN DER ENDE in Development and Psychopathology, 28-3 (August 2016)
PermalinkVariations in maternal 5-HTTLPR affect observed sensitive parenting / Rolieke A. M. CENTS in Journal of Child Psychology and Psychiatry, 55-9 (September 2014)
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