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Auteur Laura DE MAGISTRIS |
Documents disponibles écrits par cet auteur (2)
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Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children / Stefano GABRIELE in Autism Research, 9-7 (July 2016)
[article]
Titre : Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Stefano GABRIELE, Auteur ; Roberto SACCO, Auteur ; Laura ALTIERI, Auteur ; Cristina NERI, Auteur ; Andrea URBANI, Auteur ; Carmela BRAVACCIO, Auteur ; Maria Pia RICCIO, Auteur ; Maria Rosaria IOVENE, Auteur ; Francesca BOMBACE, Auteur ; Laura DE MAGISTRIS, Auteur ; Antonio M. PERSICO, Auteur Article en page(s) : p.752-759 Langues : Anglais (eng) Mots-clés : autism autism spectrum disorder biomarker constipation gut intestinal transit organic contaminants neurotoxicity Index. décimale : PER Périodiques Résumé : The uremic toxin p-cresol (4-methylphenol) is either of environmental origin or can be synthetized from tyrosine by cresol-producing bacteria present in the gut lumen. Elevated p-cresol amounts have been previously found in the urines of Italian and French autism spectrum disorder (ASD) children up until 8 years of age, and may be associated with autism severity or with the intensity of abnormal behaviors. This study aims to investigate the mechanism producing elevated urinary p-cresol in ASD. Urinary p-cresol levels were thus measured by High Performance Liquid Chromatography in a sample of 53 Italian ASD children assessed for (a) presence of Clostridium spp. strains in the gut by means of an in vitro fecal stool test and of Clostridium difficile-derived toxin A/B in the feces, (b) intestinal permeability using the lactulose/mannitol (LA/MA) test, (c) frequent use of antibiotics due to recurrent infections during the first 2 years of postnatal life, and (d) stool habits with the Bristol Stool Form Scale. Chronic constipation was the only variable significantly associated with total urinary p-cresol concentration (P < 0.05). No association was found with presence of Clostridium spp. in the gut flora (P?=?0.92), augmented intestinal permeability (P?=?0.18), or frequent use of antibiotics in early infancy (P?=?0.47). No ASD child was found to carry C. difficile in the gut or to release toxin A/B in the feces. In conclusion, urinary p-cresol levels are elevated in young ASD children with increased intestinal transit time and chronic constipation. Autism Res 2016, 9: 752–759. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1571 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Autism Research > 9-7 (July 2016) . - p.752-759[article] Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children [Texte imprimé et/ou numérique] / Stefano GABRIELE, Auteur ; Roberto SACCO, Auteur ; Laura ALTIERI, Auteur ; Cristina NERI, Auteur ; Andrea URBANI, Auteur ; Carmela BRAVACCIO, Auteur ; Maria Pia RICCIO, Auteur ; Maria Rosaria IOVENE, Auteur ; Francesca BOMBACE, Auteur ; Laura DE MAGISTRIS, Auteur ; Antonio M. PERSICO, Auteur . - p.752-759.
Langues : Anglais (eng)
in Autism Research > 9-7 (July 2016) . - p.752-759
Mots-clés : autism autism spectrum disorder biomarker constipation gut intestinal transit organic contaminants neurotoxicity Index. décimale : PER Périodiques Résumé : The uremic toxin p-cresol (4-methylphenol) is either of environmental origin or can be synthetized from tyrosine by cresol-producing bacteria present in the gut lumen. Elevated p-cresol amounts have been previously found in the urines of Italian and French autism spectrum disorder (ASD) children up until 8 years of age, and may be associated with autism severity or with the intensity of abnormal behaviors. This study aims to investigate the mechanism producing elevated urinary p-cresol in ASD. Urinary p-cresol levels were thus measured by High Performance Liquid Chromatography in a sample of 53 Italian ASD children assessed for (a) presence of Clostridium spp. strains in the gut by means of an in vitro fecal stool test and of Clostridium difficile-derived toxin A/B in the feces, (b) intestinal permeability using the lactulose/mannitol (LA/MA) test, (c) frequent use of antibiotics due to recurrent infections during the first 2 years of postnatal life, and (d) stool habits with the Bristol Stool Form Scale. Chronic constipation was the only variable significantly associated with total urinary p-cresol concentration (P < 0.05). No association was found with presence of Clostridium spp. in the gut flora (P?=?0.92), augmented intestinal permeability (P?=?0.18), or frequent use of antibiotics in early infancy (P?=?0.47). No ASD child was found to carry C. difficile in the gut or to release toxin A/B in the feces. In conclusion, urinary p-cresol levels are elevated in young ASD children with increased intestinal transit time and chronic constipation. Autism Res 2016, 9: 752–759. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1571 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients / Dario SINISCALCO in Journal of Autism and Developmental Disorders, 42-7 (July 2012)
[article]
Titre : The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur Année de publication : 2012 Article en page(s) : p.1403-1410 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Caspases Gene expression PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410[article] The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur . - 2012 . - p.1403-1410.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410
Mots-clés : Autism spectrum disorders Caspases Gene expression PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166