Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis / Miriam I. MARTINI in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Titre : Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis Type de document : texte imprimé Auteurs : Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1170-1181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990 2015 with a clinical autism diagnosis (N 72,331, nfemales 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010 2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange 1.29 [1.18, 1.41] 10.69 [8.06, 14.17]), except psychotic disorders (OR 0.91 [0.78, 1.06]) and ADHD (OR 0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010 2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1% 88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange 1.45 [1.30, 1.62] 2.37 [1.93, 2.90]), and males for psychotic disorders (OR 0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis [texte imprimé] / Miriam I. MARTINI, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Isabell BRIKELL, Auteur ; Zheng CHANG, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Sven BÖLTE, Auteur ; Francesca HAPPE, Auteur ; Mark J. TAYLOR, Auteur . - p.1170-1181. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1170-1181 Mots-clés : Autism spectrum disorder  sex differences  psychiatric diagnoses  follow-up study Index. décimale : PER Périodiques Résumé : Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990 2015 with a clinical autism diagnosis (N 72,331, nfemales 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010 2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis). Results In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange 1.29 [1.18, 1.41] 10.69 [8.06, 14.17]), except psychotic disorders (OR 0.91 [0.78, 1.06]) and ADHD (OR 0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010 2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1% 88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange 1.45 [1.30, 1.62] 2.37 [1.93, 2.90]), and males for psychotic disorders (OR 0.60 [0.44, 0.81]). Conclusions Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care. En ligne : https://doi.org/10.1111/jcpp.14130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.711-718 Titre : Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden Type de document : texte imprimé Auteurs : Qi CHEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Arvid SJÖLANDER, Auteur ; Eva SERLACHIUS, Auteur ; Samuele CORTESE, Auteur ; Stephen V. FARAONE, Auteur ; Catarina ALMQVIST, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.711-718 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  obesity  family factors  genetics Index. décimale : PER Périodiques Résumé : Background Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. Methods By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973–1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973–2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings. Results Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05–1.24; obesity: OR = 1.42, 95% CI = 1.24–1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04–1.22; obesity: OR = 1.38, 95% CI = 1.21–1.57). The results were similar across sex of the siblings. Conclusions Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity – a population-based familial coaggregation study in Sweden [texte imprimé] / Qi CHEN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Arvid SJÖLANDER, Auteur ; Eva SERLACHIUS, Auteur ; Samuele CORTESE, Auteur ; Stephen V. FARAONE, Auteur ; Catarina ALMQVIST, Auteur ; Henrik LARSSON, Auteur . - p.711-718. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.711-718 Mots-clés : Attention-deficit/hyperactivity disorder  obesity  family factors  genetics Index. décimale : PER Périodiques Résumé : Background Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood. Methods By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973–1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973–2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings. Results Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05–1.24; obesity: OR = 1.42, 95% CI = 1.24–1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04–1.22; obesity: OR = 1.38, 95% CI = 1.21–1.57). The results were similar across sex of the siblings. Conclusions Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Social Cognition in Autism and Other Neurodevelopmental Disorders: A Co-twin Control Study / Johan ISAKSSON in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2838-2848 Titre : Social Cognition in Autism and Other Neurodevelopmental Disorders: A Co-twin Control Study Type de document : texte imprimé Auteurs : Johan ISAKSSON, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Elodie CAUVET, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Karl LUNDIN, Auteur ; Janina NEUFELD, Auteur ; Charlotte WILLFORS, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.2838-2848 Langues : Anglais (eng) Mots-clés : Adhd  Autism spectrum disorder  Movie for the assessment of social cognition  Ratss  Twins Index. décimale : PER Périodiques Résumé : Alterations in social cognition (SC) are hypothesized to underlie social communication and interaction challenges in autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear. We examined SC in 196 twins with ASD, other neurodevelopmental disorders or typical development using the naturalistic Movie for the Assessment of Social Cognition. Autism and its severity were assessed with the Autism Diagnostic Observation Schedule-2, and autistic traits with the Social Responsiveness Scale-2. Using within twin-pair regression models, controlling for age, sex, IQ, and unmeasured familial confounders such as genetic background and shared-environment, SC correlated with ASD diagnosis, autism severity, and autistic traits. Our findings highlight the importance of SC alterations in autism and suggest a non-shared environmental impact on the association. En ligne : http://dx.doi.org/10.1007/s10803-019-04001-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Social Cognition in Autism and Other Neurodevelopmental Disorders: A Co-twin Control Study [texte imprimé] / Johan ISAKSSON, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Elodie CAUVET, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Karl LUNDIN, Auteur ; Janina NEUFELD, Auteur ; Charlotte WILLFORS, Auteur ; Sven BÖLTE, Auteur . - p.2838-2848. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2838-2848 Mots-clés : Adhd  Autism spectrum disorder  Movie for the assessment of social cognition  Ratss  Twins Index. décimale : PER Périodiques Résumé : Alterations in social cognition (SC) are hypothesized to underlie social communication and interaction challenges in autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear. We examined SC in 196 twins with ASD, other neurodevelopmental disorders or typical development using the naturalistic Movie for the Assessment of Social Cognition. Autism and its severity were assessed with the Autism Diagnostic Observation Schedule-2, and autistic traits with the Social Responsiveness Scale-2. Using within twin-pair regression models, controlling for age, sex, IQ, and unmeasured familial confounders such as genetic background and shared-environment, SC correlated with ASD diagnosis, autism severity, and autistic traits. Our findings highlight the importance of SC alterations in autism and suggest a non-shared environmental impact on the association. En ligne : http://dx.doi.org/10.1007/s10803-019-04001-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins / Albert CASTELLHEIM in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.966-972 Titre : The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins Type de document : texte imprimé Auteurs : Albert CASTELLHEIM, Auteur ; Sebastian LUNDSTROM, Auteur ; Mattias MOLIN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; I. Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.966-972 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorders  ADHD  general anesthesia  congenital abnormalities  system diseases Index. décimale : PER Périodiques Résumé : Background The role of general anesthetics as a risk factor for possible neurodevelopmental disorders (NDDs) in humans is unresolved. The investigation of the role of anesthetics in the development of postgeneral anesthesia (anesthesia onward) NDDs has proven to be complicated, partly because of the inherent confounding in clinical cohort studies, and partly by the fact that anesthetics are only one part in the complex process of anesthesia-surgery. Methods Utilizing the Swedish databases Child and Adolescent Twins Study in Sweden (CATSS) and National Patient Register (NPR), we investigated twins discordant for anesthesia, born between 1997 and 2004 for traits of NDDs. We identified 68 twin pairs discordant for anesthesia and explored traits of Attention-Deficit/Hyperactivity Disorder (ADHD), Learning Disability (LD), and Autism Spectrum Disorder (ASD) in them while simultaneously taking congenital abnormalities and systemic disorders (CSDs) into account. We analyzed the possible effect of anesthesia on neurodevelopmental problems, and we analyzed the within-pair differences using conditional linear regression. Results Twins with a recorded episode of anesthesia had higher traits of NDDs than twins without; similarly twins with CSDs had higher mean scores on all traits than twins without CSDs. The within-pair analyses suggested that exposure to anesthesia was associated with higher scores of ADHD (regression coefficient 1.02 and 95% confidence intervals: 0.27 1.78) in monozygotic (MZ) twins discordant for anesthesia. This effect remained when adjusting for congenital abnormalities. Discussion Our finding that traits of ADHD were slightly associated with anesthesia in a genetically sensitive design is in need of replication and warrants further investigation. Future studies should aim to elucidate mechanisms behind this possible association (e.g. anesthetics doses, age at exposure, exposure duration). En ligne : https://doi.org/10.1111/jcpp.12885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins [texte imprimé] / Albert CASTELLHEIM, Auteur ; Sebastian LUNDSTROM, Auteur ; Mattias MOLIN, Auteur ; Ralf KUJA-HALKOLA, Auteur ; I. Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur . - p.966-972. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.966-972 Mots-clés : Neurodevelopmental disorders  ADHD  general anesthesia  congenital abnormalities  system diseases Index. décimale : PER Périodiques Résumé : Background The role of general anesthetics as a risk factor for possible neurodevelopmental disorders (NDDs) in humans is unresolved. The investigation of the role of anesthetics in the development of postgeneral anesthesia (anesthesia onward) NDDs has proven to be complicated, partly because of the inherent confounding in clinical cohort studies, and partly by the fact that anesthetics are only one part in the complex process of anesthesia-surgery. Methods Utilizing the Swedish databases Child and Adolescent Twins Study in Sweden (CATSS) and National Patient Register (NPR), we investigated twins discordant for anesthesia, born between 1997 and 2004 for traits of NDDs. We identified 68 twin pairs discordant for anesthesia and explored traits of Attention-Deficit/Hyperactivity Disorder (ADHD), Learning Disability (LD), and Autism Spectrum Disorder (ASD) in them while simultaneously taking congenital abnormalities and systemic disorders (CSDs) into account. We analyzed the possible effect of anesthesia on neurodevelopmental problems, and we analyzed the within-pair differences using conditional linear regression. Results Twins with a recorded episode of anesthesia had higher traits of NDDs than twins without; similarly twins with CSDs had higher mean scores on all traits than twins without CSDs. The within-pair analyses suggested that exposure to anesthesia was associated with higher scores of ADHD (regression coefficient 1.02 and 95% confidence intervals: 0.27 1.78) in monozygotic (MZ) twins discordant for anesthesia. This effect remained when adjusting for congenital abnormalities. Discussion Our finding that traits of ADHD were slightly associated with anesthesia in a genetically sensitive design is in need of replication and warrants further investigation. Future studies should aim to elucidate mechanisms behind this possible association (e.g. anesthetics doses, age at exposure, exposure duration). En ligne : https://doi.org/10.1111/jcpp.12885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study / Ebba DU RIETZ in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.959-968 Titre : Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study Type de document : texte imprimé Auteurs : Ebba DU RIETZ, Auteur ; Andreas JANGMO, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Ewa AHNEMARK, Auteur ; Tamara WERNER-KIECHLE, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.959-968 Langues : Anglais (eng) Mots-clés : Adhd  comorbidity  cost  epidemiology  healthcare Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally in individuals who continue to have ADHD-related contact with health services (persisters) and those who do not (remitters). METHODS: We prospectively followed a cohort (N = 445,790) born 1987-1990 from the ages of 18 to 26 years. Data on healthcare utilization were obtained from the Swedish National Patient Register (inpatient and outpatient care) and the Prescribed Drug Register (medication prescriptions). RESULTS: Mean annual costs per capita from multimorbidity was €890 ($1,223) in individuals with a childhood ADHD diagnosis (persisters/remitters: €1,060[$1,456]/€609[$837]) and €304 ($418) in individuals without. Costs were largely driven by inpatient hospital admissions, mainly from drug abuse and injuries. Healthcare utilization and costs of psychiatric and somatic disorders at 18 years was significantly higher in individuals with childhood ADHD compared to those without. These group differences remained stable or increased across young adulthood for most outcomes and were generally larger in women than in men. ADHD remitters continued to show significantly greater healthcare utilization and costs compared to individuals without childhood ADHD, although their profiles were not as severe as ADHD persisters. CONCLUSIONS: Childhood ADHD has long-term associations with both psychiatric and somatic disorders. Findings demonstrate the individual and societal burden of ADHD in adulthood and highlight the importance of continued support from childhood-adolescent to adult health services and early prevention of multimorbidity. Findings also point to specific targets for intervention that may be effective, such as drug abuse and injuries. En ligne : http://dx.doi.org/10.1111/jcpp.13206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register-based study [texte imprimé] / Ebba DU RIETZ, Auteur ; Andreas JANGMO, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Zheng CHANG, Auteur ; Brian M. D'ONOFRIO, Auteur ; Ewa AHNEMARK, Auteur ; Tamara WERNER-KIECHLE, Auteur ; Henrik LARSSON, Auteur . - p.959-968. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.959-968 Mots-clés : Adhd  comorbidity  cost  epidemiology  healthcare Index. décimale : PER Périodiques Résumé : BACKGROUND: A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally in individuals who continue to have ADHD-related contact with health services (persisters) and those who do not (remitters). METHODS: We prospectively followed a cohort (N = 445,790) born 1987-1990 from the ages of 18 to 26 years. Data on healthcare utilization were obtained from the Swedish National Patient Register (inpatient and outpatient care) and the Prescribed Drug Register (medication prescriptions). RESULTS: Mean annual costs per capita from multimorbidity was €890 ($1,223) in individuals with a childhood ADHD diagnosis (persisters/remitters: €1,060[$1,456]/€609[$837]) and €304 ($418) in individuals without. Costs were largely driven by inpatient hospital admissions, mainly from drug abuse and injuries. Healthcare utilization and costs of psychiatric and somatic disorders at 18 years was significantly higher in individuals with childhood ADHD compared to those without. These group differences remained stable or increased across young adulthood for most outcomes and were generally larger in women than in men. ADHD remitters continued to show significantly greater healthcare utilization and costs compared to individuals without childhood ADHD, although their profiles were not as severe as ADHD persisters. CONCLUSIONS: Childhood ADHD has long-term associations with both psychiatric and somatic disorders. Findings demonstrate the individual and societal burden of ADHD in adulthood and highlight the importance of continued support from childhood-adolescent to adult health services and early prevention of multimorbidity. Findings also point to specific targets for intervention that may be effective, such as drug abuse and injuries. En ligne : http://dx.doi.org/10.1111/jcpp.13206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders / Laura GHIRARDI in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

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